期刊
JOURNAL OF COLLOID AND INTERFACE SCIENCE
卷 648, 期 -, 页码 457-472出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2023.05.172
关键词
NIR light-driven; Janus nanomotors; PA imaging; PTT; CDT; Accurate diagnosis
A novel near infrared light-driven Janus nanomotor is reported for active photoacoustic imaging and synergistic photothermal/chemodynamic therapy. The nanomotor exhibits autonomous motion and effectively adheres to and mechanically perforates tumor cells, enhancing tumor tissue permeability. It also catalyzes the production of reactive oxygen species to reduce oxidative stress in the tumor microenvironment.
Synthetic nanomotors have great application potential in deep tissue imaging and tumor treatment due to their active movement ability. Herein, a novel near infrared (NIR) light-driven Janus nanomotor is reported for active photoacoustic (PA) imaging and synergistic photothermal/chemodynamic therapy (PTT/CDT). Au nanoparticles (Au NPs) are sputtered on the half-sphere surface of copper-doped hollow cerium oxide nanoparticles after bovine serum albumin (BSA) modification. Such Janus nanomotors exhibit a rapid autonomous motion with a maximum speed of 110.6 & PLUSMN; 0.2 & mu;m/s under 808 nm laser irradiation with a density of 3.0 W/cm2. With the assistance of light-powered motion, the Au/Cu-CeO2@BSA nanomotors (ACCB Janus NMs) can effectively adhere to and mechanically perforate tumor cells, thereby causing the higher cellular uptake and significantly enhancing the tumor tissue permeability in the tumor microenvironment (TME). ACCB Janus NMs also exhibit high nanozyme activity that can catalyze the production of reactive oxygen species (ROS) to reduce the TME oxidative stress response. Meanwhile, the potential PA imaging capability of ACCB Janus NMs offer promise for early diagnosis of tumors due to the photothermal conversion efficiency of Au NPs. Therefore, the nanotherapeutic platform provides a new tool for effectively imaging of deep tumors site in vivo to achieve synergistic PTT/CDT and accurate diagnosis.
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