4.2 Review

A Systematic Review and Meta-Analysis: Safety and Efficacy of Cediranib in the Treatment of Cancer Patients

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Oncology

Efficacy and safety of olaparib in the treatment of platinum-sensitive recurrent ovarian cancer: a systematic review and meta-analysis

Yan Wang et al.

Summary: This systematic review and meta-analysis demonstrated that Olaparib has a positive effect on platinum-sensitive recurrent ovarian cancer in terms of progression and overall survival, although it also increases the risk of adverse events.

EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY (2022)

Article Oncology

ICON 9-an international phase III randomized study to evaluate the efficacy of maintenance therapy with olaparib and cediranib or olaparib alone in patients with relapsed platinum-sensitive ovarian cancer following a response to platinum-based chemotherapy

Osnat Elyashiv et al.

Summary: The ICON9 trial aims to investigate the efficacy of maintenance treatment with cediranib and olaparib in recurrent ovarian cancer, with an estimated completion of recruitment in 2024 and presentation of results in 2025.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2021)

Article Medicine, General & Internal

Randomised phase II trial of olaparib, chemotherapy or olaparib and cediranib in patients with platinum-resistant ovarian cancer (OCTOVA): a study protocol

Anita Mansouri et al.

Summary: This study aims to conduct a randomized trial on patients with ovarian, fallopian tube, or primary peritoneal cancer who relapsed within 12 months of platinum-based chemotherapy, to investigate the efficacy and tolerability of novel agents for treatment.

BMJ OPEN (2021)

Review Oncology

Optimal Therapies for Recurrent Glioblastoma: A Bayesian Network Meta-Analysis

Wenlin Chen et al.

Summary: The study compared and ranked active therapies in recurrent GBM, with BEV plus CCNU and regorafenib identified as primary recommendations for treatment due to their higher efficacy on objective response rate, 6-month progression-free survival rate, and overall survival. BEV monotherapy or combination with active drug therapies were also found to be advantageous for ORR and 6-m PFS rate. TTF plus BEV showed relatively higher SUCRA value in overall survival, indicating a potential for further investigation in future studies.

FRONTIERS IN ONCOLOGY (2021)

Article Oncology

Cediranib in addition to chemotherapy for women with relapsed platinum-sensitive ovarian cancer (ICON6): overall survival results of a phase III randomised trial

J. A. Ledermann et al.

Summary: The study demonstrated the significant impact of cediranib in improving progression-free survival in patients with recurrent ovarian cancer when used in combination with chemotherapy. Although there was a slight improvement in overall survival, the trial's premature termination affected the power of the analysis. Further research is needed to explore cediranib's potential in treating recurrent ovarian cancer.

ESMO OPEN (2021)

Review Oncology

Rationale for combination PARP inhibitor and antiangiogenic treatment in advanced epithelial ovarian cancer: A review

Angeles Alvarez Secord et al.

Summary: PARP inhibitors and antiangiogenics have shown activity in women with advanced ovarian cancer, and combination therapy can enhance their efficacy. The combination of PARP inhibitors and antiangiogenics demonstrates good safety and efficacy in women with newly diagnosed and recurrent ovarian cancer. Further clarification is needed to determine which patients are suitable for monotherapy or combination therapy in the future.

GYNECOLOGIC ONCOLOGY (2021)

Article Cell Biology

Cediranib suppresses homology-directed DNA repair through down-regulation of BRCA1/2 and RAD51

Alanna R. Kaplan et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

Article Oncology

Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods

J. Ferlay et al.

INTERNATIONAL JOURNAL OF CANCER (2019)

Review Pharmacology & Pharmacy

Clinical Pharmacokinetics and Pharmacodynamics of Cediranib

Weifeng Tang et al.

CLINICAL PHARMACOKINETICS (2017)

Review Pharmacology & Pharmacy

Targeting tyrosine-kinases in ovarian cancer

Matteo Morotti et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2013)

Article Medicine, General & Internal

The Cochrane Collaboration's tool for assessing risk of bias in randomised trials

Julian P. T. Higgins et al.

BMJ-BRITISH MEDICAL JOURNAL (2011)