期刊
JOURNAL OF CLINICAL PHARMACOLOGY
卷 -, 期 -, 页码 -出版社
WILEY
DOI: 10.1002/jcph.2300
关键词
hypothyroidism; hypoxia-inducible factor prolyl-hydroxylase inhibitor; Japanese Adverse Drug Event Report; renal anemia; roxadustat
HIF-PHI is a novel treatment for renal anemia that increases erythropoietin production but may also lead to hypothyroidism. This study used the Japanese Adverse Drug Event Report database to analyze the clinical impact of HIF-PHIs on thyroid function and found a disproportional signal for hypothyroidism with roxadustat. Monitoring of thyroid function should be conducted during roxadustat administration.
Hypoxia-inducible factor prolyl-hydroxylase inhibitor (HIF-PHI) is a novel agent for the treatment of renal anemia. HIF-PHI increases endogenous erythropoietin production by inhibiting the degradation of an erythropoietin transcription factor. Although beneficial effects are expected from HIF-PHI, its novel mechanism raises concerns regarding the risk of potential adverse events. The cases of hypothyroidism, which had not been reported in clinical trials, were reported after the administration of roxadustat in a real-world setting. However, the effects of HIF-PHIs on thyroid function have not yet been fully evaluated. This study aimed to assess the clinical impact of HIF-PHIs on thyroid function using the Japanese Adverse Drug Event Report database, a spontaneous reporting system in Japan, because HIF-PHIs were made available in Japan before they were available in other countries. Although a disproportionality signal for hypothyroidism was detected with roxadustat (reporting odds ratio [ROR]:22.1, 95% confidence interval [CI]:18.3-26.7, no signals were detected with another HIF-PHI, daprodustat (ROR:1.3, 95%CI:0.3-5.4), and epoetin beta pegol (ROR:1.2, 95%CI:0.5-2.7). Signals of hypothyroidism due to roxadustat were also detected regardless of age or sex. Approximately 50% of hypothyroidism cases were reported within 50 days of starting roxadustat use. These results indicate that roxadustat use may be related to the development of hypothyroidism. The need for monitoring of thyroid function should be alerted during roxadustat administration regardless of age or sex.
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