Tuberculosis and Bacillus Calmette-Guerin Disease in Patients with Chronic Granulomatous Disease: an Experience from a Tertiary Care Center in North India

Article Multidisciplinary Sciences

Imaging characteristics of pulmonary BCG/TB infection in patients with chronic granulomatous disease

Qiong Yao et al.

Summary: This study assessed the imaging of pulmonary BCG/TB infection in CGD patients. The researchers found that pulmonary BCG infection was more common than TB in CGD patients, but less severe.

SCIENTIFIC REPORTS (2022)

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Editorial Material Pediatrics

A 3-year-old girl with an axillary lymph node

Esther Vaugon et al.

PAEDIATRICS & CHILD HEALTH (2022)

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Article

Incidence of lymphadenitis following bacillus calmette – Guerin (BCG) vaccination in north Indian children

S. Rangesh et al.

Indian Journal of Tuberculosis (2021)

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Article Hematology

Hematologically important mutations: The autosomal forms of chronic granulomatous disease (third update)

Dirk Roos et al.

Summary: Chronic granulomatous disease (CGD) is an immunodeficiency disorder caused by mutations in genes encoding leukocyte NADPH oxidase components, leading to recurrent bacterial and fungal infections. Mutations in genes such as CYBA, NCF1, NCF2, NCF4, CYBC1, and RAC2 can result in CGD-like symptoms by affecting the production of reactive oxygen species necessary for pathogen killing by phagocytic leukocytes.

BLOOD CELLS MOLECULES AND DISEASES (2021)

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Article Immunology

Spectrum of Inborn errors of immunity in a cohort of 90 patients presenting with complications to BCG vaccination in India

Reetika Malik Yadav et al.

Summary: This study reported a spectrum of primary immunodeficiency disorders diagnosed in Indian patients with complications from BCG vaccination. The majority of cases had underlying IEI, with disseminated BCGosis strongly predicting this condition. Even localized symptoms may indicate the presence of IEI.

SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2021)

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Article Immunology

Clinical, Immunological, and Molecular Profile of Chronic Granulomatous Disease: A Multi-Centric Study of 236 Patients From India

Amit Rawat et al.

Summary: Chronic granulomatous disease (CGD) is a rare genetic disorder in India, with a higher proportion of autosomal recessive (AR) CGD compared to Western countries, and regional variations in types of AR-CGD. Clinical profiles and mortality rates are similar in both X-linked and AR-CGD, possibly due to milder forms of AR-CGD being overlooked.

FRONTIERS IN IMMUNOLOGY (2021)

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Letter Immunology

Disseminated Tuberculosis in a Patient with Autosomal Recessive p47phox Chronic Granulomatous Disease

Ximena Leon-Lara et al.

JOURNAL OF CLINICAL IMMUNOLOGY (2021)

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Article Hematology

Hematologically important mutations: X-linked chronic granulomatous disease (fourth update)

Dirk Roos et al.

Summary: Chronic Granulomatous Disease (CGD) is a rare immunodeficiency disorder characterized by a lack of superoxide production due to NADPH oxidase deficiency, leading to ineffective microbial killing. Majority of patients have mutations in the CYBB gene, while variations in the G6PD gene may also result in similar symptoms.

BLOOD CELLS MOLECULES AND DISEASES (2021)

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Article Immunology

Differential diagnosis of primary immunodeficiency in patients with BCGitis and BCGosis: A single-centre study

Elif Soyak Aytekin et al.

Summary: BCG infections are more common in patients with primary immunodeficiency disease (PIDD). This study found that nearly all patients with BCGosis and around half of patients with BCGitis have underlying PIDD. Clinical features such as parental consanguinity, axillary lymphadenopathy, mycobacterial lung disease, hepatomegaly, and growth retardation are important in diagnosing PIDD.

SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2021)

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Review Allergy