☆ 4.7 Article

Primary cilium-mediated signaling cascade suppresses age-related biliary fibrosis

JOURNAL OF CELLULAR PHYSIOLOGY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Biology

LiverQuant: An Improved Method for Quantitative Analysis of Liver Pathology

Dominick J. Hellen et al.

Summary: The current methods for quantifying cells, gene expression, and fibrosis in liver histological slides lack standardization and rely on data acquired from random regions in each slide, leading to selection bias and limited data coverage. LiverQuant presents a method for quantifying whole-slide scans of digitized histologic images, providing a more comprehensive analysis of data elements. Compared to standard methodologies, LiverQuant offers increased speed and greater tissue area coverage, improving reliability and reproducibility of experimental results in liver histology research.

BIO-PROTOCOL (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Peripheral and central control of obesity by primary cilia

Yue Wu et al.

Journal of Genetics and Genomics (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

O-GlcNAcylation regulates phagocytosis by promoting Ezrin localization at the cell cortex

Song Yang et al.

Summary: O-GlcNAcylation plays a crucial role in cellular nutrient sensing and is involved in various physiological and pathological processes. The study demonstrates the involvement of O-GlcNAcylation in the regulation of phagocytosis. Mechanistic studies reveal that O-GlcNAc transferase interacts with Ezrin to catalyze its O-GlcNAcylation, promoting its localization to the cell cortex and facilitating efficient phagocytosis.

JOURNAL OF GENETICS AND GENOMICS (2023)

添加到收藏夹

Article Multidisciplinary Sciences

ANGPTL8 accelerates liver fibrosis mediated by HFD-induced inflammatory activity via LILRB2/ERK signaling pathways

Zongli Zhang et al.

Summary: This study investigated the role of ANGPTL8 in the progression of NAFLD-associated liver fibrosis induced by a high-fat diet. The findings showed that ANGPTL8 deficiency suppresses inflammation, hepatic steatosis, and liver fibrosis. Restoring liver-derived ANGPTL8 expression accelerates HFD-induced liver fibrosis. Additionally, the FDA-approved anti-diabetic drug metformin was found to inhibit HFD-induced liver fibrosis.

JOURNAL OF ADVANCED RESEARCH (2023)

添加到收藏夹

Article Gastroenterology & Hepatology

Liver-restricted deletion of the biliary atresia candidate gene Pkd1l1 causes bile duct dysmorphogenesis and ciliopathy

Dominick J. Hellen et al.

Summary: This study identified the Pkd1l1-deficient mouse model as a genetic link to the pathophysiology of biliary atresia. Through bile duct ligation, the model demonstrated features including bile duct dysmorphogenesis, peribiliary fibroinflammation, hepatic arteriopathy, and ciliopathy. This model provides researchers with an opportunity to gain a deeper understanding of the disorder and identify potential therapeutic targets.

HEPATOLOGY (2023)

添加到收藏夹

Article Gastroenterology & Hepatology

Melatonin receptor 1A, but not 1B, knockout decreases biliary damage and liver fibrosis during cholestatic liver injury

Nan Wu et al.

Summary: The study reveals that in cholestatic models, MT1 and MT2 melatonin receptors play different roles in the effects of melatonin on liver damage and fibrosis. Loss of MT1 can alleviate biliary and liver injury, while loss of MT2 exacerbates these parameters. Melatonin acts through MT1, and modulation of melatonin signaling can block GPR50/TGFβR1 binding to treat PSC.

HEPATOLOGY (2022)

添加到收藏夹

Review Gastroenterology & Hepatology

Mechanisms and molecules: What are the treatment targets for primary biliary cholangitis?

Marlyn J. Mayo

Summary: The treatment for primary biliary cholangitis (PBC) with ursodeoxycholic acid (UDCA) may not be sufficient for all patients, and new approaches are needed. This review discusses potential therapeutic targets in PBC and provides examples of specific agents under development for the treatment of PBC, including targets related to bile, inflammation, cell survival, and fibrosis.

HEPATOLOGY (2022)

添加到收藏夹

Article Endocrinology & Metabolism

Ciliary IFT88 Protects Coordinated Adolescent Growth Plate Ossification From Disruptive Physiological Mechanical Forces

Clarissa R. Coveney et al.

Summary: Compared with endochondral ossification, the coordinated arrest of growth defined by the narrowing and fusion of the cartilaginous growth plate is less understood. The primary cilia play a protective role in the ossification of the growth plate during adolescent skeletal maturation, and the absence of primary cilia disrupts chondrocyte differentiation, cartilage resorption, and mineralization, primarily in load-bearing regions.

JOURNAL OF BONE AND MINERAL RESEARCH (2022)

添加到收藏夹

Article Gastroenterology & Hepatology

Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity

Ahmed Ghallab et al.

Summary: This study revealed the mechanism by which acetaminophen overdose causes a breach of the blood-bile barrier, resulting in futile cycling of BAs and hepatocyte death.

JOURNAL OF HEPATOLOGY (2022)

添加到收藏夹

Article Oncology

RAF1-MEK/ERK pathway-dependent ARL4C expression promotes ameloblastoma cell proliferation and osteoclast formation

Shinsuke Fujii et al.

Summary: Ameloblastoma is a slow-growing odontogenic neoplasm with reported cases of successful treatment using a BRAF inhibitor. Recent research indicates a potential involvement of the MAPK pathway in Ameloblastoma development, with ARL4C expression possibly promoting tumorigenesis. Further investigation into the function of ARL4C in Ameloblastoma is needed.

JOURNAL OF PATHOLOGY (2022)

添加到收藏夹

Letter Cell Biology

NuMA forms condensates through phase separation to drive spindle pole assembly

Huixian Ma et al.

JOURNAL OF MOLECULAR CELL BIOLOGY (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Deletion of kif3a in CK19 positive cells leads to primary cilia loss, biliary cell proliferation and cystic liver lesions in TAA-treated mice

Jinbiao Chen et al.

Summary: Loss of primary cilia in biliary epithelial cells resulted in the formation of cystic lesions during TAA treatment, without affecting the progression to cirrhosis. The cystic structures showed increased cellular proliferation and decreased hepatocyte lobular proliferation. Loss of primary cilia initially decreased cell passage survival in biliary organoids, but this effect was diminished in later passages.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2022)

添加到收藏夹

Article Gastroenterology & Hepatology

Biliary organoids uncover delayed epithelial development and barrier function in biliary atresia

Surya P. Amarachintha et al.

Summary: The study investigated the mechanisms linked to abnormal cholangiocyte development in biliary atresia by generating biliary organoids from liver biopsies. The organoids showed evidence of halted epithelial development and structural defects in cholangiocyte-like cells from biliary atresia. Treatment with EGF and FGF2 resulted in the restoration of differentiation and functional markers, improved cell-cell junction, and decreased epithelial permeability in biliary atresia organoids.

HEPATOLOGY (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

ENKD1 promotes CP110 removal through competing with CEP97 to initiate ciliogenesis

Ting Song et al.

Summary: In this study, ENKD1 was identified as a centrosomal protein involved in the regulation of ciliogenesis. The research demonstrated the critical role of ENKD1 in ciliogenesis. The study revealed the protein-protein interactions between ENKD1, CP110, and CEP97, as well as the mechanism of action of ENKD1 during ciliogenesis.

EMBO REPORTS (2022)

添加到收藏夹

Article Cell Biology

The purinergic P2Y14 receptor links hepatocyte death to hepatic stellate cell activation and fibrogenesis in the liver

Ingmar Mederacke et al.

Summary: The study identifies P2Y14 ligands and receptors as a profibrogenic DAMP pathway that directly links cell death to fibrogenesis.

SCIENCE TRANSLATIONAL MEDICINE (2022)

添加到收藏夹

Article Rheumatology

Role of Ciliary Protein Intraflagellar Transport Protein 88 in the Regulation of Cartilage Thickness and Osteoarthritis Development in Mice

Clarissa R. Coveney et al.

Summary: The study demonstrates that IFT88 plays a chondroprotective role in articular cartilage by regulating cartilage calcification via maintenance of Hedgehog signaling, with exercise restoring cartilage thickness and signaling levels in a mouse model of osteoarthritis.

ARTHRITIS & RHEUMATOLOGY (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Targeting the HDAC6-Cilium Axis Ameliorates the Pathological Changes Associated with Retinopathy of Prematurity

Jie Ran et al.

Summary: Retinopathy of prematurity (ROP) is a major cause of childhood visual impairment and blindness. Histone deacetylase 6 (HDAC6)-mediated disassembly of photoreceptor cilia has been identified as an early event in the pathogenesis of ROP. Enhancing the expression of HDAC6 or blocking HDAC6-mediated cilium disassembly can protect mice from ROP-associated retinal defects.

ADVANCED SCIENCE (2022)

添加到收藏夹

Article Gastroenterology & Hepatology

Liver stiffness measurement by vibration-controlled transient elastography improves outcome prediction in primary biliary cholangitis

Christophe Corpechot et al.

Summary: In the largest ever study of LSM in patients with PBC, LSM assessed by VCTE improves prediction of survival beyond biochemical response, established prognostic scores, and age categories, independent of time. LSM can reasonably be regarded as a useful prognostic marker and a potential surrogate endpoint in PBC clinical trials.

JOURNAL OF HEPATOLOGY (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Primary cilia in satellite cells are the mechanical sensors for muscle hypertrophy

Weijun Li et al.

Summary: Skeletal muscle atrophy is associated with aging and other factors. Mature muscle cells from skeletal muscle satellite cells play a crucial role in repairing muscle tissue. Exercise therapy promotes muscle hypertrophy and strength. This study demonstrates that the primary cilium in skeletal muscle cells acts as a mechanical sensor and promotes exercise-induced muscle hypertrophy through the Hedgehog signaling pathway.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Fibroblast GSK-3α Promotes Fibrosis via RAF-MEK-ERK Pathway in the Injured Heart

Prachi Umbarkar et al.

Summary: This study reveals the important role of cardiac fibroblast-GSK-3 alpha in myocardial fibrosis and heart failure, and identifies the molecular mechanism underlying this role through fibroblast kinome mapping. The results suggest that GSK-3 alpha plays a critical role in fibroblast transformation and fibrotic remodeling, independently of the canonical TGF-beta 1-SMAD3 pathway.

CIRCULATION RESEARCH (2022)

添加到收藏夹

Review Cell Biology

Cytoskeletal networks in primary cilia: Current knowledge and perspectives

Ruixin Ge et al.

Summary: Primary cilia function as sensory organelles that monitor extracellular signals and transduce them into intracellular responses. Actin and microtubule networks play critical roles in primary ciliogenesis and maintenance. Targeting cytoskeleton-associated proteins may be a promising therapeutic strategy for treating ciliopathies.

JOURNAL OF CELLULAR PHYSIOLOGY (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Biliary NIK promotes ductular reaction and liver injury and fibrosis in mice

Zhiguo Zhang et al.

Summary: Upregulation of biliary NIK promotes ductular reaction, liver inflammation, and liver fibrosis. Inhibition of biliary NIK blocks these pathological alterations by modulating secretion of cholangiokines.

NATURE COMMUNICATIONS (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Generation of functional ciliated cholangiocytes from human pluripotent stem cells

Mina Ogawa et al.

Summary: The study identifies key pathways regulating cholangiocyte maturation and successfully generates functional cholangiocytes with mature characteristics, enhancing their potential for therapeutic applications in biliary diseases.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Editorial Material Multidisciplinary Sciences

A non-mitotic role for Eg5 in regulating cilium formation and sonic hedgehog signaling

Jie Ran et al.

SCIENCE BULLETIN (2021)

添加到收藏夹

Article Medicine, General & Internal

Biliary Atresia-emerging diagnostic and therapy opportunities

Urban Lendahl et al.

Summary: This review discusses recent progress in understanding liver development and potential pathomechanisms of Biliary Atresia. It also highlights current and emerging diagnostic opportunities, as well as translation breakthroughs in therapy development for this devastating pediatric cholangiopathy.

EBIOMEDICINE (2021)

添加到收藏夹

Article Gastroenterology & Hepatology

Limb expression 1-like (LIX1L) protein promotes cholestatic liver injury by regulating bile acid metabolism

Jie Li et al.

Summary: The study reveals increased expression of LIX1L in cholestatic liver diseases, with deficiency alleviating cholestatic liver injury, suggesting that LIX1L and miR-1913p may be promising therapeutic targets.

JOURNAL OF HEPATOLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

A cilium-independent role for intraflagellar transport 88 in regulating angiogenesis

Yang Yang et al.

Summary: Endothelial cilia are microtubule-based hair-like protrusions in blood vessels that function as fluid mechanosensors to regulate vascular hemodynamics. In this study, depletion of key proteins responsible for ciliogenesis reveals a cilium-independent role for IFT88 in mammalian angiogenesis. IFT88 regulates angiogenesis by promoting microtubule stability and influencing the migration, polarization, proliferation, and oriented division of vascular endothelial cells. The findings suggest that IFT88 plays a crucial role in angiogenesis through its actions in microtubule-based cellular processes, separate from its role in ciliogenesis.

SCIENCE BULLETIN (2021)

添加到收藏夹

Review Cell Biology

Multifaceted roles of centrosomes in development, health, and disease

Feifei Qi et al.

Summary: The centrosome, a membrane-less organelle consisting of centrioles and pericentriolar material, plays crucial roles in cell shaping, division, migration, and is closely linked to various human diseases. Understanding the functions of centrosomes in development and health may provide insights into disease mechanisms and potential therapeutic targets.

JOURNAL OF MOLECULAR CELL BIOLOGY (2021)

添加到收藏夹

Article Medicine, General & Internal

Identification of a wide spectrum of ciliary gene mutations in nonsyndromic biliary atresia patients implicates ciliary dysfunction as a novel disease mechanism

Wai-Yee Lam et al.

Summary: The study identified rare deleterious ciliary gene mutations in 31.5% of nonsyndromic BA patients. Functional analysis showed absence of cilia in BA livers with KIF3B and TTC17 mutations, and knockdown of PCNT, KIF3B and TTC17 resulted in reduced number of cilia in patients. Additionally, engineered zebrafish knockouts of KIF3B, PCNT and TTC17 displayed reduced biliary flow.

EBIOMEDICINE (2021)

添加到收藏夹

Article Physiology

Decreased IFT88 expression with primary cilia shortening causes mitochondrial dysfunction in cisplatin-induced tubular injury

Rie Fujii et al.

Summary: The shortening of primary cilia and decreased expression of IFT88 in cisplatin-induced AKI may contribute to tubular injury and mitochondrial dysfunction, highlighting the importance of organelle cross-talk in the pathogenesis of kidney disease. These findings suggest new therapeutic avenues for treating acute kidney injury.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2021)

添加到收藏夹

Review Critical Care Medicine

Primary ciliary dyskinesia in the genomics age

Jane S. Lucas et al.

LANCET RESPIRATORY MEDICINE (2020)

添加到收藏夹

Article Cell Biology

Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis

Bishuang Cai et al.

CELL METABOLISM (2020)

添加到收藏夹

Article Urology & Nephrology

Genetic reduction of cilium length by targeting intraflagellar transport 88 protein impedes kidney and liver cyst formation in mouse models of autosomal polycystic kidney disease

Lina Shao et al.

KIDNEY INTERNATIONAL (2020)

添加到收藏夹

Article Gastroenterology & Hepatology

Primary Biliary Cholangitis: 2018 Practice Guidance from the American Association for the Study of Liver Diseases

Keith D. Lindor et al.

HEPATOLOGY (2019)

添加到收藏夹

Article Gastroenterology & Hepatology

Burden of liver diseases in the world

Sumeet K. Asrani et al.

JOURNAL OF HEPATOLOGY (2019)

添加到收藏夹

Article Gastroenterology & Hepatology

Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis

Anissa A. Widjaja et al.

GASTROENTEROLOGY (2019)

添加到收藏夹

Review Gastroenterology & Hepatology

Pathobiology of inherited biliary diseases: a roadmap to understand acquired liver diseases

Luca Fabris et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)

添加到收藏夹

Review Cell Biology

Small GTPases in hedgehog signalling: emerging insights into the disease mechanisms of Rab23-mediated and Arl13b-mediated ciliopathies

Catherine H. H. Hor et al.

CURRENT OPINION IN GENETICS & DEVELOPMENT (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Decoding human fetal liver haematopoiesis

Dorin-Mirel Popescu et al.

NATURE (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Mechanism and Regulation of Centriole and Cilium Biogenesis

David K. Breslow et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 88 (2019)

添加到收藏夹

Review Pediatrics

Liver fibrosis in biliary atresia

Wen-Jun Shen et al.

WORLD JOURNAL OF PEDIATRICS (2019)

添加到收藏夹

Article Critical Care Medicine

Primary Ciliary Dyskinesia (PCD)

Adam Shapiro et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2018)

添加到收藏夹

Article Cell & Tissue Engineering

Chronic Liver Injury Induces Conversion of Biliary Epithelial Cells into Hepatocytes

Xing Deng et al.

CELL STEM CELL (2018)

添加到收藏夹

Article Gastroenterology & Hepatology

MicroRNA (miR)-433 and miR-22 dysregulations induce histone-deacetylase-6 overexpression and ciliary loss in cholangiocarcinoma

Adrian P. Mansini et al.

HEPATOLOGY (2018)

添加到收藏夹

Article Gastroenterology & Hepatology

Intrahepatic bile duct primary cilia in biliary atresia

Roberta Frassetto et al.

HEPATOLOGY RESEARCH (2018)

添加到收藏夹

Editorial Material Multidisciplinary Sciences

Building better bile ducts

Fotios Sampaziotis

SCIENCE (2018)

添加到收藏夹

Review Pharmacology & Pharmacy

Targeting ERK, an Achilles' Heel of the MAPK pathway, in cancer therapy

Feifei Liu et al.

ACTA PHARMACEUTICA SINICA B (2018)

添加到收藏夹

Review Gastroenterology & Hepatology

Liver regeneration - mechanisms and models to clinical application

Stuart J. Forbes et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2016)

添加到收藏夹

Review Gastroenterology & Hepatology

Primary Biliary Cirrhosis

Keith D. Lindor et al.

HEPATOLOGY (2009)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.