期刊
JOURNAL OF CELL SCIENCE
卷 136, 期 18, 页码 -出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.260985
关键词
Shear stress; Fluid shear stress; Biomechanics; Cytoskeleton
类别
Shear stress plays a vital role in normal physiology and malignancy, affecting tissue behavior and important biomedical processes such as wound healing, cancer, and fibrosis. Understanding how cells react and adapt to shear stress is crucial.
Shear stress is essential for normal physiology and malignancy. Common physiological processes - such as blood flow, particle flow in the gut, or contact between migratory cell clusters and their substrate - produce shear stress that can have an impact on the behavior of different tissues. In addition, shear stress has roles in processes of biomedical interest, such as wound healing, cancer and fibrosis induced by soft implants. Thus, understanding how cells react and adapt to shear stress is important. In this Review, we discuss in vivo and in vitro data obtained from vascular and epithelial models; highlight the insights these have afforded regarding the general mechanisms through which cells sense, transduce and respond to shear stress at the cellular levels; and outline how the changes cells experience in response to shear stress impact tissue organization. Finally, we discuss the role of shear stress in collective cell migration, which is only starting to be appreciated. We review our current understanding of the effects of shear stress in the context of embryo development, cancer and fibrosis, and invite the scientific community to further investigate the role of shear stress in these scenarios. transcriptional et 2009). (FSS; most be focus addressing non-fluid modeling. non-physiological Fluid The blood endothelial on vessel. (arterioles,
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