Comparison of pulsed-field ablation versus very high power short duration-ablation for pulmonary vein isolation

Article Cardiac & Cardiovascular Systems

Pulsed Field Ablation for the Treatment of Atrial Fibrillation: PULSED AF Pivotal Trial

Atul E. Verma et al.

Summary: Pulsed field ablation is an effective and safe method for treating patients with atrial fibrillation. It has comparable effectiveness to traditional catheter ablation but with a lower rate of complications.

CIRCULATION (2023)

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Article Cardiac & Cardiovascular Systems

Safety and Effectiveness of Pulsed Field Ablation to Treat Atrial Fibrillation: One-Year Outcomes From the MANIFEST-PF Registry

Mohit K. Turagam et al.

Summary: Pulsed field ablation is a novel nonthermal cardiac ablation modality that uses ultra-rapid electrical pulses to cause cell death. Its safety and effectiveness in clinical care are still unknown.

CIRCULATION (2023)

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Letter Cardiac & Cardiovascular Systems

Pulsed-field ablation versus single-catheter high-power short-duration radiofrequency ablation for atrial fibrillation: Procedural characteristics, myocardial injury, and mid-term outcomes

Patrick Badertscher et al.

HEART RHYTHM (2023)

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Article Cardiac & Cardiovascular Systems

Safe and effective delivery of high-power, short-duration radiofrequency ablation lesions with a flexible-tip ablation catheter

Leon M. Ptaszek et al.

Summary: In this study, the safety and efficacy of high-power, short-duration (HPSD) radiofrequency ablation (RFA) were compared with low-power, long-duration (LPLD) RFA in pulmonary vein isolation (PVI). The results showed that the investigational ablation catheter used in HPSD RFA achieved faster ablation time compared to LPLD RFA, and both types of ablation effectively isolated the pulmonary veins.

HEART RHYTHM O2 (2023)

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Article Cardiac & Cardiovascular Systems

Multi-national survey on the methods, efficacy, and safety on the post-approval clinical use of pulsed field ablation (MANIFEST-PF)

Emmanuel Ekanem et al.

Summary: This study investigated the real-world performance of the approved PFA catheter in a large cohort of unselected patients and found that PFA was effective for treating atrial fibrillation with a safety profile consistent with preferential tissue ablation. However, the occurrence of generic catheter complications highlights the need for continuous improvement in efficacy and safety.

EUROPACE (2022)

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Article Cardiac & Cardiovascular Systems

Cerebral safety after pulsed field ablation for paroxysmal atrial fibrillation

Nico Reinsch et al.

Summary: Pulsed field ablation (PFA) is a safe and effective treatment modality for paroxysmal atrial fibrillation (AF) patients, with a low incidence of asymptomatic thromboembolic cerebral events or lesions. In this study, PFA did not result in any neurological deficits and the majority of patients had normal cerebral MRI scans. The occurrence of a small cerebellar lesion in one patient was transient and resolved during follow-up.

HEART RHYTHM (2022)

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Article Cardiac & Cardiovascular Systems

2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS)

Gerhard Hindricks et al.

EUROPEAN HEART JOURNAL (2021)

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Article Medicine, General & Internal

Cryoballoon Ablation as Initial Therapy for Atrial Fibrillation

Oussama M. Wazni et al.

Summary: In this multicenter trial, cryoballoon ablation as initial therapy was found to be superior to drug therapy in preventing atrial arrhythmia recurrence in patients with paroxysmal atrial fibrillation. Serious procedure-related adverse events were uncommon.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Medicine, General & Internal

Cryoablation or Drug Therapy for Initial Treatment of Atrial Fibrillation

Jason G. Andrade et al.

Summary: In patients with symptomatic, paroxysmal atrial fibrillation, catheter cryoballoon ablation was associated with a significantly lower rate of atrial fibrillation recurrence compared to antiarrhythmic drug therapy. The ablation group also had better outcomes in terms of atrial tachyarrhythmia occurrence and atrial fibrillation burden.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Review Cardiac & Cardiovascular Systems

High-power short duration vs. conventional radiofrequency ablation of atrial fibrillation: a systematic review and meta-analysis

Venkatesh Ravi et al.

Summary: High-power short-duration radiofrequency ablation (HPSD RFA) showed better procedural effectiveness compared to conventional RFA in patients with atrial fibrillation, with similar safety and shorter procedural duration.

EUROPACE (2021)

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Article Cardiac & Cardiovascular Systems

Pulsed Field Ablation of Paroxysmal Atrial Fibrillation 1-Year Outcomes of IMPULSE, PEFCAT, and PEFCAT II

Vivek Y. Reddy et al.

Summary: Durable pulmonary vein isolation using pulsed field ablation results in low rate of atrial arrhythmia recurrence and acceptable safety, with excellent PV isolation durability.

JACC-CLINICAL ELECTROPHYSIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems