METTL3-mediated m6A modification of circRNF220 modulates miR-330-5p/survivin axis to promote osteosarcoma progression

Article Cell Biology

Circ-CTNNB1 drives aerobic glycolysis and osteosarcoma progression via m6A modification through interacting with RBM15

Feng Yang et al.

Summary: This study reveals that circ-CTNNB1 is highly expressed in osteosarcoma and promotes aerobic glycolysis and progression of the disease through interaction with RBM15 and m6A modification.

CELL PROLIFERATION (2023)

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Article Oncology

Association of survivin positive circulating tumor cell levels with immune escape and prognosis of osteosarcoma

Jili Lu et al.

Summary: The purpose of this study was to investigate the role of survivin protein in circulating tumor cells (CTCs) of osteosarcoma (OS) and its association with immune cell infiltration and disease prognosis. The findings suggest that survivin protein plays a key role in immune escape of CTCs and the presence of survivin(+) CTCs may serve as a promising prognostic factor in OS patients.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2023)

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Review Cell Biology

CircRNA-miRNA networks in regulating bone disease

Wei Huang et al.

Summary: Circular RNA (circRNA) is a type of endogenous noncoding RNA that forms a closed loop structure, resistant to RNA exonuclease and maintaining stability, playing an active role in regulating physiological or pathological processes by modulating gene expression.

JOURNAL OF CELLULAR PHYSIOLOGY (2022)

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Review Cell Biology

The Roles of Noncoding RNAs in the Development of Osteosarcoma Stem Cells and Potential Therapeutic Targets

Jinxin Liu et al.

Summary: This review article describes the role of noncoding RNAs in regulating the development of cancer stem cells (CSCs) in osteosarcoma. The study found that miRNAs, lncRNAs, and circRNAs play crucial roles in the regulation of CSCs development and potential mechanisms.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Article Oncology

Silencing circOMA1 Inhibits Osteosarcoma Progression by Sponging miR-1294 to Regulate c-Myc Expression

Yubo Shi et al.

Summary: This study reveals that circOMA1 is upregulated in osteosarcoma and functions as an oncogene by mediating the miR-1294/c-Myc pathway, promoting osteosarcoma progression.

FRONTIERS IN ONCOLOGY (2022)

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Article Multidisciplinary Sciences

Butein promotes ubiquitination-mediated survivin degradation inhibits tumor growth and overcomes chemoresistance

Xin Dong et al.

Summary: Survivin is frequently overexpressed in human malignancies and is associated with poor prognosis. This study shows that survivin is highly expressed in nasopharyngeal carcinoma (NPC) tumor tissues. Depleting survivin with shRNA inhibits NPC cell viability, colony formation, and in vivo tumorigenesis. Butein, identified through natural product screening, reduces survivin protein level and promotes its ubiquitination-mediated degradation by enhancing the interaction between survivin and E3 ligase Fbxl7. Butein also suppresses Akt-Wee1-CDK1 signaling, decreases survivin Thr34 phosphorylation, and exhibits strong in vivo anti-tumor activity.

SCIENTIFIC REPORTS (2022)

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Review Cell Biology

Current Status and Prospects of Targeted Therapy for Osteosarcoma

Zunguo Hu et al.

Summary: Osteosarcoma is a highly malignant tumor with mechanisms that are not well understood. Current treatment methods are ineffective, while targeted therapy is becoming an important direction for development.

CELLS (2022)

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Article Multidisciplinary Sciences

Survivin promotes a glycolytic switch in CD4+ T cells by suppressing the transcription of PFKFB3 in rheumatoid arthritis

Malin C. Erlandsson et al.

Summary: This study reveals the important role of nuclear survivin in maintaining the effector phenotype of IFN gamma-producing T cells through the regulation of glucose utilization. It provides a new strategy to counteract IFN gamma-dependent inflammation in autoimmunity.

ISCIENCE (2022)

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Review Biochemistry & Molecular Biology

Regulation of Molecular Targets in Osteosarcoma Treatment

Betul Celik et al.

Summary: Osteosarcoma is the most common malignant bone tumor affecting adolescents and young adults, requiring the development of novel targeted therapies for relapse cases. RNA interference technologies show promise in cancer treatment by silencing overexpressed genes to induce apoptosis in tumor cells.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Pharmacology & Pharmacy

Immune checkpoint inhibitors in osteosarcoma: A hopeful and challenging future

Zeng Zhang et al.

Summary: Osteosarcoma is the most common malignant tumor in the musculoskeletal system, mainly occurring in adolescents, with high mortality and disability rates. Immunotherapy, specifically immune checkpoint inhibitors, has shown promising prognoses for osteosarcoma treatment, but there are still challenges and potential side effects. Researchers are working on overcoming these issues and developing new treatment methods.

FRONTIERS IN PHARMACOLOGY (2022)

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Review Genetics & Heredity

Non-coding RNAs as potential biomarkers in osteosarcoma

Lijuan Fan et al.

Summary: Osteosarcoma is a common malignant tumor that mainly affects children and adolescents. The lack of effective biomarkers makes it difficult to detect the disease in its early stages. However, studies have shown that non-coding RNAs play an important role in the tumorigenesis and progression of osteosarcoma, and can serve as novel biomarkers for diagnosis, treatment, and prognosis.

FRONTIERS IN GENETICS (2022)

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Review Genetics & Heredity

CircSMARCA5: A key circular RNA in various human diseases

Yi Zhu et al.

Summary: This review summarizes the biological roles of circSMARCA5 and its molecular mechanism of action in various diseases, as well as its potential as a biomarker and its correlation with patient prognosis and tumor TNM stage.

FRONTIERS IN GENETICS (2022)

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Article Medicine, General & Internal

Construction of a transcription factor-miRNA-mRNA interactive network elucidates underlying pathogenesis for osteosarcoma and validation by qRT-PCR

Fuxing Tang et al.

Summary: This study investigates the potential regulatory mechanism of transcription factor (TF)-miRNA-mRNA in osteosarcoma using bioinformatics methods and validates the findings through qRT-PCR. The study identifies differentially expressed miRNAs and genes and constructs a TF-miRNA-mRNA regulatory network. Two genes, LAMC1 and THBS1, in the network are found to have prognostic value. Survival analysis and experimental validation establish a TF-miRNA-mRNA sub-network, providing insights into the pathological mechanisms of osteosarcoma for diagnosis and treatment.

MEDICINE (2022)

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Article Cell Biology

Circ_SMAD4 promotes gastric carcinogenesis by activating wnt/β-catenin pathway

Liyan Wang et al.

Summary: This study revealed that circ_SMAD4 promotes gastric cancer tumorigenesis by activating the CTNNB1-dependent Wnt/beta-catenin pathway. The mechanism involves nuclear circ_SMAD4 recruiting TCF4 to facilitate CTNNB1 transcription, while cytoplasmic circ_SMAD4 sequestering miR-1276 to prevent CTNNB1 mRNA silencing. Rescue experiments confirmed that circ_SMAD4 accelerates GC cell growth through the miR-1276/TCF4-regulated CTNNB1 pathway.

CELL PROLIFERATION (2021)

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Review Engineering, Biomedical

Osteosarcoma: a review of current and future therapeutic approaches

Xin Zhao et al.

Summary: Osteosarcoma is a common primary bone malignancy that poses a serious threat to human health globally, characterized by high malignancy and rapid progression. The incidence of osteosarcoma has a bimodal distribution pattern with peaks in different age groups, mainly presenting as single lesions. This article summarizes the types, clinical diagnosis, and treatment methods of osteosarcoma.

BIOMEDICAL ENGINEERING ONLINE (2021)

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Article Biochemistry & Molecular Biology

CircRNF220, not its linear cognate gene RNF220, regulates cell growth and is associated with relapse in pediatric acute myeloid leukemia

Xiaodan Liu et al.

Summary: The circRNA circRNF220 showed high sensitivity and specificity in distinguishing pediatric AML, serving as a potential biomarker for accurate diagnosis and relapse prediction. Its function in inhibiting proliferation and promoting apoptosis in AML cells highlights its therapeutic potential. The mechanistic role of circRNF220 as a miR-30a sponge to regulate target genes MYSM1 and IER2 provides insights into AML pathogenesis and relapse mechanisms.

MOLECULAR CANCER (2021)

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Article Biochemistry & Molecular Biology

Comprehensive analyses of m6A regulators and interactive coding and non-coding RNAs across 32 cancer types

Sipeng Shen et al.

Summary: N6-methyladenosine (m6A) modification plays important roles in the development of cancers by interacting with coding and non-coding RNAs. This study identified three distinct m6A modification subtypes and constructed an individual-level m6A signature, which was associated with tumor microenvironment cell infiltration degrees and overall survival in various cancer types.

MOLECULAR CANCER (2021)

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Article Orthopedics

Blocking circ-CNST suppresses malignant behaviors of osteosarcoma cells and inhibits glycolysis through circ-CNST-miR-578-LDHA/PDK1 ceRNA networks

Rui Hu et al.

Summary: Circ-CNST plays a role in OS progression by upregulating LDHA and PDK1 while downregulating miR-578, leading to increased cell proliferation, colony formation, migration, and invasion. Blocking circ-CNST and restoring miR-578 can reverse these effects, offering a potential therapeutic target for OS.

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH (2021)

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Review Oncology

The role of non-coding RNAs in the regulation, diagnosis, prognosis and treatment of osteosarcoma (Review)

Gu Yang et al.

Summary: Osteosarcoma is an aggressive bone tumor with early metastasis potential and poor response to chemoradiotherapy. Non-coding RNAs have been shown to play a significant role in the initiation and progression of this tumor.

INTERNATIONAL JOURNAL OF ONCOLOGY (2021)

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Article Gastroenterology & Hepatology