4.6 Review

Advances in bio-immunotherapy for castration-resistant prostate cancer

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Article Oncology

GM-CSF elicits antibodies to tumor-associated proteins when used as a prostate cancer vaccine adjuvant

Hemanth K. Potluri et al.

Summary: Antibody responses to off-target cancer-associated proteins may not necessarily indicate antigen spread, especially in vaccine strategies that use GM-CSF as an adjuvant. Evaluating T cell responses to non-target antigens is a preferred approach for detecting immune-mediated antigen spread following immunotherapies.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2022)

Review Oncology

Development of Delivery Systems for Local Administration of Cytokines/Cytokine Gene-Directed Therapeutics: Modern Oncologic Implications

Jhalak Dholakia et al.

Summary: Cytokine therapy has the potential to enhance cancer treatment by modulating the immune system. Recent development of novel delivery systems aims to overcome systemic toxicities and administration challenges associated with unmodified cytokine therapy, thus increasing therapeutic activity. Expanding research in these systems may advance immune oncology and represent the next frontier of cytokine-based immuno-oncology.

CURRENT ONCOLOGY REPORTS (2022)

Article Medicine, Research & Experimental

Real-World Effectiveness of Sipuleucel-T on Overall Survival in Men with Advanced Prostate Cancer Treated with Androgen Receptor-Targeting Agents

Jason M. Hafron et al.

Summary: This real-world study on the treatment of mCRPC indicates that patients receiving sipuleucel-T and ARTAs have a longer median overall survival compared to those receiving ARTA monotherapy, suggesting that leveraging mechanisms of action can be beneficial in treating patients with mCRPC.

ADVANCES IN THERAPY (2022)

Review Pharmacology & Pharmacy

Current and emerging therapies for neuroendocrine prostate cancer

Busola Ruth Alabi et al.

Summary: Neuroendocrine prostate cancer is an aggressive variant of prostate cancer with poor outcomes. This review discusses current therapies and potential emerging treatments for this type of cancer.

PHARMACOLOGY & THERAPEUTICS (2022)

Article Radiology, Nuclear Medicine & Medical Imaging

Immune-Checkpoint Blockade Enhances 225Ac-PSMA617 Efficacy in a Mouse Model of Prostate Cancer

Johannes Czernin et al.

Summary: PSMA RNT and PD-1 blockade showed synergistic effects in improving therapeutic outcomes in a mouse model of prostate cancer, extending time to progression and survival compared to monotherapies.

JOURNAL OF NUCLEAR MEDICINE (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Oncology

Boosting immune response with GM-CSF optimizes primary cryotherapy outcomes in the treatment of prostate cancer: a prospective randomized clinical trial

Al Baha Barqawi et al.

Summary: The study investigated the impact of prostate cryotherapy and immunomodulation with GMCSF on tumor-specific T- and B-cell responses in prostate cancer patients. Results showed that the treatment group had higher levels of cancer antigen-related antibodies and enhanced prostate antigen-specific T-cell responses compared to the control group. This suggests a potential therapeutic effect of adjuvant immunotherapy in conjunction with cryotherapy for prostate cancer treatment.

PROSTATE CANCER AND PROSTATIC DISEASES (2021)

Article Oncology

Clinical and immunologic impact of short-course enzalutamide alone and with immunotherapy in non-metastatic castration sensitive prostate cancer

Ravi A. Madan et al.

Summary: This study evaluated the potential synergy of immunotherapy and enzalutamide in non-metastatic castration sensitive prostate cancer (nmCSPC), as well as the immunologic impact of enzalutamide on men with normal testosterone levels. Results showed that three months of enzalutamide without androgen deprivation therapy (ADT) induced significant PSA control and had an impact on immune profiles.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Article Oncology

Pembrolizumab with or without enzalutamide in selected populations of men with previously untreated metastatic castration-resistant prostate cancer harbouring programmed cell death ligand-1 staining: a retrospective study

Huanyi Lin et al.

Summary: This retrospective study evaluated the survival outcomes of pembrolizumab (PEM) plus enzalutamide (ENZ) versus PEM alone in men with previously untreated metastatic castration-resistant prostate cancer (mCRPC) harbouring programmed cell death ligand-1 (PD-L1) staining. The study found that the combination treatment of PEM and ENZ significantly increased overall survival and progression-free survival compared to PEM alone, with a manageable safety profile.

BMC CANCER (2021)

Article Oncology

Combined CTLA-4 and PD-L1 blockade in patients with chemotherapy-naive metastatic castration-resistant prostate cancer is associated with increased myeloid and neutrophil immune subsets in the bone microenvironment

Sumit K. Subudhi et al.

Summary: The study investigated the safety and tolerability of combined anti-CTLA-4 plus anti-PD-L1 therapy in chemotherapy-naive mCRPC patients with bone metastases. The results showed the potential activity of the treatment in a small number of patients, suggesting the need for further research to overcome resistance mechanisms within the prostate bone microenvironment.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Article Oncology

KEYNOTE-641: Phase III study of pembrolizumab plus enzalutamide for metastatic castration-resistant prostate cancer

Julie N. Graff et al.

Summary: The study outlines a Phase III trial, KEYNOTE-641, that aims to compare the efficacy and safety of pembrolizumab plus enzalutamide with that of enzalutamide plus placebo in men with metastatic castration-resistant prostate cancer (mCRPC).

FUTURE ONCOLOGY (2021)

Review Immunology

Sargramostim (rhu GM-CSF) as Cancer Therapy (Systematic Review) and An Immunomodulator. A Drug Before Its Time?

Hillard M. Lazarus et al.

Summary: Sargramostim accelerates hematologic recovery in diverse clinical settings and enhances anti-cancer responses with a favorable safety profile. Uses other than in hematologic recovery are less-well studied; more data are needed on immune-enhancing benefits.

FRONTIERS IN IMMUNOLOGY (2021)

Article Oncology

IL-7 expands lymphocyte populations and enhances immune responses to sipuleucel-T in patients with metastatic castration-resistant prostate cancer (mCRPC)

Russell K. Pachynski et al.

Summary: Treatment with rhIL-7 in patients with mCRPC after sip-T led to significant expansion of CD4+ and CD8+ T cells, as well as CD56(bright) natural killer cells, along with improved antigen-specific humoral and T cell proliferative responses over time. Additionally, analysis revealed increased expression of activation markers and beneficial cytokines.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Article Oncology

A randomized phase III trial of personalized peptide vaccination for castration-resistant prostate cancer progressing after docetaxel

Masanori Noguchi et al.

Summary: This study investigated the impact of personalized peptide vaccination (PPV) on overall survival (OS) in HLA-A24-positive patients with castration-resistant prostate cancer (CRPC) who failed docetaxel chemotherapy. The results showed that PPV did not prolong OS overall, but subgroup analysis revealed survival benefits in patients with a lower proportion of neutrophils or a higher proportion of lymphocytes at baseline.

ONCOLOGY REPORTS (2021)

Article Medicine, Research & Experimental

Next generation of anti-immune checkpoints antibodies

Nathalie Bonnefoy et al.

M S-MEDECINE SCIENCES (2020)

Article Radiology, Nuclear Medicine & Medical Imaging

Basic principles of immunotherapy

Georgia Schilling et al.

RADIOLOGE (2020)

Review Oncology

Immunotherapy for Hepatocellular Carcinoma: A 2021 Update

Christo Kole et al.

CANCERS (2020)

Review Medicine, Research & Experimental

Treatment of Advanced Prostate Cancer

Min Yuen Teo et al.

ANNUAL REVIEW OF MEDICINE, VOL 70 (2019)

Article Urology & Nephrology

Immunotherapy in Metastatic Castration-Resistant Prostate Cancer: Past and Future Strategies for Optimization

Melissa A. Reimers et al.

CURRENT UROLOGY REPORTS (2019)

Review Oncology

CAR-T cell therapy: a potential new strategy against prostate cancer

Giuseppe Schepisi et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

Review Biochemistry & Molecular Biology

Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape

Xianjie Jiang et al.

MOLECULAR CANCER (2019)

Article Medicine, General & Internal

Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma

Stephen J. Schuster et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Medicine, General & Internal

Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia

Jae H. Park et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Review Multidisciplinary Sciences

Cancer immunotherapy using checkpoint blockade

Antoni Ribas et al.

SCIENCE (2018)

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PD-1/PD-L1 pathway inhibitors in advanced prostate cancer

Pedro Isaacsson Velho et al.

EXPERT REVIEW OF CLINICAL PHARMACOLOGY (2018)

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Combination immunotherapy: Taking Cancer vaccines to the next Level

Jeremy M. Grenier et al.

FRONTIERS IN IMMUNOLOGY (2018)

Review Oncology

Cytokine release syndrome

Alexander Shimabukuro-Vornhagen et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2018)

Meeting Abstract Oncology

Cancer-related morbidity at the end of life in men with prostate cancer.

Divya Yerramilli et al.

JOURNAL OF CLINICAL ONCOLOGY (2018)

Review Biotechnology & Applied Microbiology

Application of atomic force microscopy in cancer research

Xiangying Deng et al.

JOURNAL OF NANOBIOTECHNOLOGY (2018)

Article Oncology

The androgen receptor: a biologically relevant vaccine target for the treatment of prostate cancer

Brian M. Olson et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2013)

Article Biotechnology & Applied Microbiology

Personalized peptide vaccination A novel immunotherapeutic approach for advanced cancer

Tetsuro Sasada et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2012)

Article Medicine, General & Internal

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

F. Stephen Hodi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)