Nickel-catalyzed direct thiolation of unactivated C(sp3)-H bonds with disulfides

The first nickel-catalyzed thiolation of unactivated C(sp(3))-H bonds with disulfides was described. This transformation uses (dppp) NiCl2 as a catalyst and BINOL as a ligand, which are efficient for the thiolation of beta-methyl C(sp(3))-H bonds of a broad range of aliphatic carboxamides. The reaction provides an efficient synthetic pathway to access diverse thioethers.