Conformational perturbation of SARS-CoV-2 spike protein using N-acetyl cysteine: an exploration of probable mechanism of action to combat COVID-19

Spike protein is used to target human ACE2 receptor for viral fusion into the human cell. N-acetyl cysteine can interestingly inhibit this viral fusion process by increasing the probability of structural deformation of this viral spike protein. This process may indirectly reduce the intermolecular binding affinity between two enzymes

Automated summary

The spike protein is used to target the human ACE2 receptor for viral fusion into human cells. Interestingly, N-acetyl cysteine can inhibit this viral fusion process by increasing the likelihood of structural deformation of the spike protein. This process may indirectly decrease the intermolecular binding affinity between two enzymes.