☆ 4.6 Article

Reactive nitrogen species inhibit branched chain alpha-ketoacid dehydrogenase complex and impact muscle cell metabolism

JOURNAL OF BIOLOGICAL CHEMISTRY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Biochemistry & Molecular Biology

Nitric oxide-driven modifications of lipoic arm inhibit α-ketoacid dehydrogenases

Gretchen L. Seim et al.

Summary: Pyruvate dehydrogenase complex (PDHC) and oxoglutarate dehydrogenase complex (OGDC), important players in cellular metabolism, can be inhibited by reactive nitrogen species (RNS) through covalent modification. This inhibition occurs during macrophage activation and leads to significant rewiring of cellular metabolism.

NATURE CHEMICAL BIOLOGY (2023)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Branched-chain amino acids in cardiovascular disease

Robert W. McGarrah et al.

Summary: This article reviews the research conducted in the past 15 years on branched-chain amino acid (BCAA) metabolism and its relationship with cardiovascular health. The findings suggest that impaired BCAA homeostasis is connected to the pathogenesis of cardiovascular diseases, including myocardial infarction and hypertension. The article also outlines the major factors regulating BCAA abundance and metabolic fate and discusses the epidemiological evidence linking BCAAs with various cardiovascular disease states.

NATURE REVIEWS CARDIOLOGY (2023)

添加到收藏夹

Review Cell Biology

The central moTOR of metabolism

Judith Simcox et al.

Summary: This review discusses the importance of protein kinase mechanistic target of rapamycin (mTOR) in metabolic regulation, its role in regulating the metabolism of the four macromolecular building blocks of the cell, and its impact on organismal physiology and aging. It also explores the potential clinical application of mTOR inhibitors in the treatment and prevention of age-related diseases.

DEVELOPMENTAL CELL (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

GAPDH S-nitrosation contributes to age-related sarcopenia through mediating apoptosis

Ting Xie et al.

Summary: Age-related sarcopenia, a condition characterized by muscle loss and impaired muscle function, is a significant public health issue in older adults. Recent research indicates that apoptotic signaling plays a critical role in the development of age-related sarcopenia. This study finds that elevated levels of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) S-nitrosation and apoptosis occur in natural aging sarcopenia, with S-nitrosated GAPDH translocating to the nucleus and contributing to the progression of sarcopenia. Further analysis reveals that GAPDH S-nitrosation increases with aging and identifies specific modification sites. Inhibition of iNOS or mutation of GAPDH S-nitrosation sites alleviates apoptosis, highlighting a potential therapeutic strategy for sarcopenia.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2022)

添加到收藏夹

Article Cell Biology

Extra-cardiac BCAA catabolism lowers blood pressure and protects from heart failure

Danielle Murashige et al.

Summary: Contrary to previous assumptions, activation of branched-chain amino acid (BCAA) oxidation actually increases in heart failure (HF) patients. Activation of cardiac BCAA oxidation does not protect from HF, but systemic activation does. Lowering plasma and cardiac BCAAs also does not confer significant protection. Surprisingly, BCAA catabolism leads to lower blood pressure independently of nitric oxide, suggesting a potential mechanism for cardioprotection in HF.

CELL METABOLISM (2022)

添加到收藏夹

Article Oncology

Disrupted NOS2 metabolism drives myoblast response to wasting-associated cytokines

Paige C. Arneson-Wissink et al.

Summary: Skeletal muscle wasting is a key driver of negative clinical outcomes and is associated with a range of pathologies including cancer. Cancer cachexia is a multi-factorial syndrome that includes skeletal muscle wasting, but remains understudied. Research suggests that amino acid metabolic disruption is linked to myoblast defects induced by cancer cell conditioned media.

EXPERIMENTAL CELL RESEARCH (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Whole-body metabolic fate of branched-chain amino acids

Megan C. Blair et al.

Summary: The oxidation of branched-chain amino acids (BCAAs) is tightly regulated in mammals via direct and indirect mechanisms. Most tissues are capable of BCAA oxidation, influenced by tissue-specific preference, mitochondria activity, and total tissue mass. Perturbations in BCAA oxidation have been linked to various diseases, highlighting the importance of BCAA homeostasis in overall health.

BIOCHEMICAL JOURNAL (2021)

添加到收藏夹

Review Endocrinology & Metabolism

Insulin action, type 2 diabetes, and branched-chain amino acids: A two-way street

Phillip J. White et al.

Summary: The association of obesity and insulin resistance with increased levels of branched-chain and aromatic amino acids and decreased glycine levels is well-established. Human metabolomics and genetic studies have further confirmed these observations, with preclinical studies identifying mechanisms involved in amino acid homeostasis disruption and its connection to dysregulated glucose and lipid metabolism, particularly in the development of insulin resistance, type 2 diabetes, and cardiovascular diseases.

MOLECULAR METABOLISM (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Pharmacological or genetic inhibition of iNOS prevents cachexia-mediated muscle wasting and its associated metabolism defects

Jason Sadek et al.

Summary: The study reveals that iNOS induces muscle wasting in cachexia by disrupting mitochondrial function and energy production processes. Clinically tested iNOS inhibitor GW274150 shows protective effects against muscle wasting in septic and cancer cachexia models.

EMBO MOLECULAR MEDICINE (2021)

添加到收藏夹

Review Physiology

The Role of Skeletal Muscle in The Pathogenesis of Altered Concentrations of Branched-Chain Amino Acids (Valine, Leucine, and Isoleucine) in Liver Cirrhosis, Diabetes, and Other Diseases

Milan Holecek

Summary: The article discusses the dominant role of skeletal muscle in the catabolism of branched-chain amino acids (BCAAs) and the pathogenesis of their altered levels in liver cirrhosis and diabetes. It also highlights inconsistent alterations in BCAA levels in disorders with systemic inflammatory response syndrome (SIRS), due to contradictory effects on muscles. Further studies are needed to clarify the role of BCAA metabolism alterations and the potential outcomes of BCAA supplementation in specific diseases.

PHYSIOLOGICAL RESEARCH (2021)

添加到收藏夹

Review Physiology

Branched-chain Amino Acids: Catabolism in Skeletal Muscle and Implications for Muscle and Whole-body Metabolism

Gagandeep Mann et al.

Summary: BCAAs are crucial for skeletal muscle and whole-body anabolism and energy balance, but elevated levels and impaired metabolism may lead to chronic diseases like insulin resistance. Research is focusing on mechanisms regulating BCAA metabolism and its impact on muscle and whole-body metabolism.

FRONTIERS IN PHYSIOLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase

Erika M. Palmieri et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Article Multidisciplinary Sciences

ABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex

Peter S. J. Bailey et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Review Physiology

Branched Chain Amino Acids

Michael Neinast et al.

ANNUAL REVIEW OF PHYSIOLOGY, VOL 81 (2019)

添加到收藏夹

Article Cell Biology

Quantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids

Michael D. Neinast et al.

CELL METABOLISM (2019)

添加到收藏夹

Article Endocrinology & Metabolism

Two-stage metabolic remodelling in macrophages in response to lipopolysaccharide and interferon-γ stimulation

Gretchen L. Seim et al.

NATURE METABOLISM (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Lipoic acid metabolism and mitochondrial redox regulation

Ashley Solmonson et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

添加到收藏夹

Article Medicine, Research & Experimental

The AMPK agonist 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation-associated cachectic muscle wasting

Derek T. Hall et al.

EMBO MOLECULAR MEDICINE (2018)

添加到收藏夹

Article Medicine, Research & Experimental

STAT3 promotes IFNγ/TNFα-induced muscle wasting in an NF-κB-dependent and IL-6-independent manner

Jennifer F. Ma et al.

EMBO MOLECULAR MEDICINE (2017)

添加到收藏夹

Review Oncology

The α-ketoglutarate dehydrogenase complex in cancer metabolic plasticity

Renaud Vatrinet et al.

CANCER & METABOLISM (2017)

添加到收藏夹

Article Cell Biology

A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III

Nunziata Maio et al.

CELL METABOLISM (2017)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure

Haipeng Sun et al.

CIRCULATION (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Induction of mitochondrial reactive oxygen species production by GSH mediated S-glutathionylation of 2-oxoglutarate dehydrogenase

Ryan J. Mailloux et al.

REDOX BIOLOGY (2016)

添加到收藏夹

Review Biochemistry & Molecular Biology

Signaling and stress: The redox landscape in NOS2 biology

Douglas D. Thomas et al.

FREE RADICAL BIOLOGY AND MEDICINE (2015)

添加到收藏夹

Review Peripheral Vascular Disease

Mechanisms and consequences of endothelial nitric oxide synthase dysfunction in hypertension

Qiang Li et al.

JOURNAL OF HYPERTENSION (2015)

添加到收藏夹

Review Biochemistry & Molecular Biology

The Pyruvate Dehydrogenase Complexes: Structure-based Function and Regulation

Mulchand S. Patel et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

添加到收藏夹

Review Endocrinology & Metabolism

Branched-chain amino acids in metabolic signalling and insulin resistance

Christopher J. Lynch et al.

NATURE REVIEWS ENDOCRINOLOGY (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Identification of S-nitroso-CoA reductases that regulate protein S-nitrosylation

Puneet Anand et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

Reversible inactivation of dihydrolipoamide dehydrogenase by mitochondrial hydrogen peroxide

Liang-Jun Yan et al.

FREE RADICAL RESEARCH (2013)

添加到收藏夹

Article Chemistry, Analytical

Metabolomic Analysis and Visualization Engine for LC-MS Data

Eugene Melamud et al.

ANALYTICAL CHEMISTRY (2010)

添加到收藏夹

Article Biochemistry & Molecular Biology

Reversible inhibition of α-ketoglutarate dehydrogenase by hydrogen peroxide:: Glutathionylation and protection of lipoic acid

Milana A. B. Applegate et al.

BIOCHEMISTRY (2008)

添加到收藏夹

Article Biochemistry & Molecular Biology

A novel branched-chain amino acid metabolon - Protein-protein interactions in a supramolecular complex

Mohammad Mainul Islam et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

添加到收藏夹

Article Biochemical Research Methods

Histochemical staining and quantification of dihydrolipoamide dehydrogenase diaphorase activity using blue native PAGE

Liang-Jun Yan et al.

ELECTROPHORESIS (2007)

添加到收藏夹

Article Biochemical Research Methods

Organelle isolation: functional mitochondria from mouse liver, muscle and cultured filroblasts

Christian Frezza et al.

NATURE PROTOCOLS (2007)

添加到收藏夹

Article Biochemistry & Molecular Biology

NF-κB-mediated MyoD decay during muscle wasting requires nitric oxide synthase mRNA stabilization, HuR protein, and nitric oxide release

S Di Marco et al.

MOLECULAR AND CELLULAR BIOLOGY (2005)

添加到收藏夹

Review Immunology

Nox enzymes and the biology of reactive oxygen

JD Lambeth

NATURE REVIEWS IMMUNOLOGY (2004)

添加到收藏夹

Review Biochemistry & Molecular Biology

Biological chemistry of reactive oxygen and nitrogen and radiation-induced signal transduction mechanisms

RB Mikkelsen et al.

ONCOGENE (2003)

添加到收藏夹

Article Biochemistry & Molecular Biology

Inactivation of the 2-oxo acid dehydrogenase complexes upon generation of intrinsic radical species

VI Bunik et al.

EUROPEAN JOURNAL OF BIOCHEMISTRY (2002)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Induction of iNOS expression in skeletal muscle by IL-1β and NFκB activation:: an in vitro and in vivo study

V Adams et al.

CARDIOVASCULAR RESEARCH (2002)

添加到收藏夹

Article Cell Biology

Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways

C Rommel et al.

NATURE CELL BIOLOGY (2001)

添加到收藏夹

Article Chemistry, Medicinal

Preparation and properties of S-nitroso-L-cysteine ethyl ester, an intracellular nitrosating agent

R Clancy et al.

JOURNAL OF MEDICINAL CHEMISTRY (2001)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.