4.3 Review

Modern therapies of nonsmall cell lung cancer

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Article Biochemical Research Methods

A Simple and Highly Sensitive Naked-Eye Analysis of EGFR 19del via CRISPR/Cas12a Triggered No-Nonspecific Nucleic Acid Amplification

Chunfeng Feng et al.

Summary: This study developed a novel naked-eye assay for detecting EGFR 19del mutation in non-small-cell lung cancer (NSCLC) using CRISPR/Cas12a-triggered nucleic acid amplification (NAA) and rolling circle amplification (RCA) technologies. The assay showed high sensitivity, selectivity, and anti-interference ability, and demonstrated consistency with real-time quantitative polymerase chain reaction (qPCR) and sequencing results, offering a promising strategy for noninvasive diagnosis and treatment guidance of cancer.

ACS SYNTHETIC BIOLOGY (2022)

Article Oncology

SHOC2 Is a Critical Modulator of Sensitivity to EGFR-TKIs in Non-Small Cell Lung Cancer Cells

Hideki Terai et al.

Summary: The study identified SHOC2 as a key modulator of sensitivity to EGFR-TKI treatment in NSCLC, with potential as a therapeutic target or biomarker for predicting sensitivity in patients with EGFR mutation-positive NSCLC. This finding could potentially improve treatment strategies for NSCLC patients with EGFR mutations.

MOLECULAR CANCER RESEARCH (2021)

Review Pharmacology & Pharmacy

Combination therapy with PD-1/PD-L1 blockade in non-small cell lung cancer: strategies and mechanisms

Mu-Yang Huang et al.

Summary: While PD-1/PD-L1 immunotherapy has been approved for treating NSCLC, only a modest population of patients benefit from it, with some experiencing relapse and progression. Combination therapy emerges as an effective way to broaden beneficiaries and overcome resistance, although challenges need to be addressed.

PHARMACOLOGY & THERAPEUTICS (2021)

Article

Robot-Assisted Thoracic Surgery in Non-small Cell Lung Cancer

Jun Hee Lee et al.

Journal of Chest Surgery (2021)

Review Biotechnology & Applied Microbiology

CRISPR-Cas deployment in non-small cell lung cancer for target screening, validations, and discoveries

K. Sreedurgalakshmi et al.

Summary: Advancements in CRISPR-Cas systems have greatly accelerated genome research, particularly in the field of cancer research. The use of CRISPR-Cas has led to the development of new methods for drug target validations and the discovery of novel therapeutic targets through genome-wide screens. Additionally, CRISPR-based approaches are being explored for the development of novel anticancer combination therapies.

CANCER GENE THERAPY (2021)

Review Cardiac & Cardiovascular Systems

Long-term and short-term outcomes of robot- versus video-assisted anatomic lung resection in lung cancer: a systematic review and meta-analysis

Han Wu et al.

Summary: Comparing the long-term and short-term outcomes of robot-assisted thoracic surgery (RATS) and video-assisted thoracic surgery (VATS) for anatomic lung resection, it was found that the RATS group had a longer disease-free survival and lower 30-day mortality rate than the VATS group. There were no significant differences in postoperative complications, conversion rate to open surgery, and lymph node upstaging between the two groups.

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY (2021)

Article Critical Care Medicine

Camrelizumab plus carboplatin and pemetrexed versus chemotherapy alone in chemotherapy-naive patients with advanced non-squamous non-small-cell lung cancer (CameL): a randomised, open-label, multicentre, phase 3 trial

Caicun Zhou et al.

Summary: The study showed a statistically significant and clinically meaningful improvement in progression-free survival with camrelizumab plus chemotherapy compared to chemotherapy alone, making it a promising first-line treatment option for Chinese patients with advanced non-squamous NSCLC without EGFR and ALK alterations, with further long-term outcomes and confirmatory testing still ongoing.

LANCET RESPIRATORY MEDICINE (2021)

Article Multidisciplinary Sciences

Role of caveolin-1 as a biomarker for radiation resistance and tumor aggression in lung cancer

Dominic Leiser et al.

Summary: The study highlights the role of Caveolin-1 in radioresistance of lung cancer cells, as well as its contribution to tumor aggression. The heterogeneous expression of the CAV-1 gene in human lung cancer tissues is similar to its enhanced expression in human lung cancer cell line and mouse orthotopic xenograft models. Alterations in the CAV-1 gene have been linked to poor prognosis and survival in lung cancer patients.

PLOS ONE (2021)

Article Oncology

Robot-assisted thoracic surgery versus video-assisted thoracic surgery for lung lobectomy or segmentectomy in patients with non-small cell lung cancer: a meta-analysis

Jianglei Ma et al.

Summary: The meta-analysis results showed that RATS had more advantages over VATS in the treatment of NSCLC, including less blood loss, lower conversion rate, more lymph node harvest, and shorter postoperative chest tube drainage time.

BMC CANCER (2021)

Article Oncology

Five-Year Outcomes With Pembrolizumab Versus Chemotherapy for Metastatic Non-Small-Cell Lung Cancer With PD-L1 Tumor Proportion Score ≥ 50%

Martin Reck et al.

Summary: This study reports the first 5-year follow-up of a first-line immunotherapy trial for NSCLC, demonstrating that pembrolizumab provides a durable, clinically meaningful long-term overall survival benefit in first-line treatment of metastatic NSCLC with a PD-L1 tumor proportion score of at least 50%.

JOURNAL OF CLINICAL ONCOLOGY (2021)

Article Oncology

First-line nivolumab plus ipilimumab with two cycles of chemotherapy versus chemotherapy alone (four cycles) in advanced non-small-cell lung cancer: CheckMate 9LA 2-year update

M. Reck et al.

Summary: The updated data from the phase III CheckMate 9LA trial with a minimum 2-year follow-up show that first-line nivolumab plus ipilimumab with two cycles of chemotherapy continues to provide prolonged overall survival benefits over chemotherapy in advanced non-small-cell lung cancer patients, with manageable safety profile. Improved efficacy outcomes were observed in most subgroups with no new safety signals detected.

ESMO OPEN (2021)

Review Oncology

Safety and Efficacy of Neoadjuvant Immune Checkpoint Inhibitor Therapy in Patients with Resectable Non-small-Cell Lung Cancer: A Systematic Review

Ziran Zhao et al.

Summary: The systematic review concluded that neoadjuvant ICI therapy may be a safe and effective treatment option for patients with resectable NSCLC. When combined with chemotherapy, ICI appears to be more effective but also comes with more adverse events.

TARGETED ONCOLOGY (2021)

Article Oncology

Dose and fractionation schedules in radiotherapy for non-small cell lung cancer

Lucyna Kepka et al.

Summary: The issues of RT dose, fractionation, and treatment time in NSCLC have been extensively studied. Higher RT intensity may improve survival, but caution is needed when using it concurrently with chemotherapy. SBRT offers high local control in early-stage NSCLC, but may pose risks in centrally located tumors.

TRANSLATIONAL LUNG CANCER RESEARCH (2021)

Review Pharmacology & Pharmacy

A review on engineered magnetic nanoparticles in Non-Small-Cell lung carcinoma targeted therapy

Lindokuhle M. Ngema et al.

Summary: There is a growing demand for effective treatment options for non-small-cell lung carcinoma, with the focus on minimizing side effects and increasing efficacy. The development of targeted drug delivery systems and nanoparticle-based therapies could lead to more precise and effective treatments for NSCLC.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Article Oncology

Acquired Resistance to Third-Generation EGFR Tyrosine Kinase Inhibitors in Patients With De Novo EGFRT790M-Mutant NSCLC

Ha-Ram Park et al.

Summary: In this study, acquired resistance mechanisms to third-generation EGFR TKIs in NSCLC patients with de novo EGFRT790M mutation were investigated. Novel mutations such as MTORL1433S, EGFRC797S/L798I, and MET amplification were identified as mechanisms of acquired resistance. Osimertinib in combination with mTOR inhibitors showed efficacy in overcoming acquired resistance.

JOURNAL OF THORACIC ONCOLOGY (2021)

Article Oncology

Characterization of KRAS Mutation Subtypes in Non-small Cell Lung Cancer

Julia Judd et al.

Summary: The study characterized the genomic landscapes of KRAS-mutated non-small cell lung cancer in a large national cohort, revealing that different KRAS mutation subtypes have distinct co-occurring mutations and genomic landscapes.

MOLECULAR CANCER THERAPEUTICS (2021)

Article Medicine, General & Internal

Sotorasib for Lung Cancers with KRAS p.G12C Mutation

Ferdinandos Skoulidis et al.

Summary: In this phase 2 trial, sotorasib therapy led to a durable clinical benefit without new safety signals in patients with previously treated KRAS p.G12C-mutated NSCLC.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Review Cell Biology

The improbable targeted therapy: KRAS as an emerging target in non-small cell lung cancer (NSCLC)

Ravi Salgia et al.

Summary: KRAS, a common driver in solid tumors such as NSCLC, was initially considered undruggable due to lack of specific small-molecule inhibitors. However, with a better understanding of its transformation mechanisms and the development of immunological approaches targeting KRAS neoantigens, a race for approved therapies has emerged for KRAS mutant NSCLC patients.

CELL REPORTS MEDICINE (2021)

Article Respiratory System

Video-assisted versus open thoracotomy lobectomy: comparison on lymphadenectomy and survival in early stage of lung cancer

Dariusz A. Dziedzic et al.

Summary: Video-assisted lobectomy shows lower lymph node removal but better long-term survival outcomes compared to open thoracotomy, especially in left lower lobe and left upper lobe lobectomies.

JOURNAL OF THORACIC DISEASE (2021)

Review Oncology

Epidemiology of lung cancer

Krishna Chaitanya Thandra et al.

Summary: Lung cancer is the leading cause of global cancer incidence and mortality, with men being twice as likely as women to be diagnosed with lung cancer, and smoking accounting for up to 90% of lung cancer cases.

WSPOLCZESNA ONKOLOGIA-CONTEMPORARY ONCOLOGY (2021)

Article Oncology

LKB1 Deficiency Renders NSCLC Cells Sensitive to ERK Inhibitors

Elisa Caiola et al.

JOURNAL OF THORACIC ONCOLOGY (2020)

Review Biochemistry & Molecular Biology

CRISPR-Cas12a: Functional overview and applications

Bijoya Paul et al.

BIOMEDICAL JOURNAL (2020)

Article Biochemistry & Molecular Biology

Improved EGFR mutation detection sensitivity after enrichment by Cas9/sgRNA digestion and PCR amplification

Li Wang et al.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2020)

Review Chemistry, Medicinal

First line Immunotherapy for Non-Small Cell Lung Cancer

Nicola J. Nasser et al.

PHARMACEUTICALS (2020)

Article Oncology

Up-Regulated FGFR1 Expression as a Mediator of Intrinsic TKI Resistance in EGFR-Mutated NSCLC

Kristine Raaby Gammelgaard et al.

TRANSLATIONAL ONCOLOGY (2019)

Article Critical Care Medicine

YES1 Drives Lung Cancer Growth and Progression and Predicts Sensitivity to Dasatinib

Irati Garmendia et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2019)

Article Biochemistry & Molecular Biology

Targeting FGFR overcomes EMT-mediated resistance in EGFR mutant non-small cell lung cancer

Sana Raoof et al.

ONCOGENE (2019)

Article Oncology

Crizotinib in c-MET- or ROS1-positive NSCLC: results of the AcSe phase II trial

D. Moro-Sibilot et al.

ANNALS OF ONCOLOGY (2019)

Review Oncology

Targeting BRAF mutations in non-small cell lung cancer

Connor Gerard O'Leary et al.

TRANSLATIONAL LUNG CANCER RESEARCH (2019)

Review Medicine, General & Internal

Radiotherapy in Lung Cancer: Current and Future Role

Esengul Kocak Uzel et al.

MEDICAL BULLETIN OF SISLI ETFAL HOSPITAL (2019)

Article Medicine, General & Internal

Atezolizumab for First-Line Treatment of Metastatic Nonsquamous NSCLC

M. A. Socinski et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Review Oncology

ALK-rearrangement in non-small-cell lung cancer (NSCLC)

Xue Du et al.

THORACIC CANCER (2018)

Review Oncology

Making the first move in EGFR-driven or ALK-driven NSCLC: first-generation or next-generation TKI?

Gonzalo Recondo et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

Article Medicine, General & Internal

Brigatinib versus Crizotinib in ALK-Positive Non-Small-Cell Lung Cancer

D. R. Camidge et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Multidisciplinary Sciences

Pan-tumor genomic biomarkers for PD-1 checkpoint blockade-based immunotherapy

Razvan Cristescu et al.

SCIENCE (2018)

Article Biotechnology & Applied Microbiology

ALK and ROS 1 concurrent with EGFR mutation in patients with lung adenocarcinoma

Yanjiao Mao et al.

ONCOTARGETS AND THERAPY (2017)

Review Medicine, Research & Experimental

ALK: a tyrosine kinase target for cancer therapy

Vijaykumar R. Holla et al.

COLD SPRING HARBOR MOLECULAR CASE STUDIES (2017)

Article Respiratory System

Possible adverse effects of immunotherapy in non-small cell lung cancer; treatment and follow-up of three cases

Paul Zarogoulidis et al.

RESPIRATORY MEDICINE CASE REPORTS (2017)

Review Respiratory System

Immunotherapy for lung cancer

Antonius Steven et al.

RESPIROLOGY (2016)

Review Oncology

Epigenetics in lung cancer diagnosis and therapy

Aditi Mehta et al.

CANCER AND METASTASIS REVIEWS (2015)

Article Medical Laboratory Technology

Epigenetics of lung cancer

Scott M. Langevin et al.

TRANSLATIONAL RESEARCH (2015)

Article Pharmacology & Pharmacy

Targeting Angiogenesis in Squamous Non-Small Cell Lung Cancer

Bilal Piperdi et al.

Article Immunology

IL-2: The First Effective Immunotherapy for Human Cancer

Steven A. Rosenberg

JOURNAL OF IMMUNOLOGY (2014)

Review Biotechnology & Applied Microbiology

CRISPR-Cas systems for editing, regulating and targeting genomes

Jeffry D. Sander et al.

NATURE BIOTECHNOLOGY (2014)

Review Oncology

Maintenance Chemotherapy for Advanced Non-Small-Cell Lung Cancer: New Life for an Old Idea

David E. Gerber et al.

JOURNAL OF CLINICAL ONCOLOGY (2013)

Review Multidisciplinary Sciences

RNA-guided genetic silencing systems in bacteria and archaea

Blake Wiedenheft et al.

NATURE (2012)

Article Medicine, Research & Experimental

Tumor Endothelial Cells

Andrew C. Dudley

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)

Review Oncology

Targeted Therapies for Lung Cancer Clinical Experience and Novel Agents

Jill E. Larsen et al.

CANCER JOURNAL (2011)

Article Respiratory System

Lung Cancer: Epidemiology, Etiology, and Prevention

Charles S. Dela Cruz et al.

CLINICS IN CHEST MEDICINE (2011)

Article Oncology

Respiratory Gating Techniques for Optimization of Lung Cancer Radiotherapy

Philippe Giraud et al.

JOURNAL OF THORACIC ONCOLOGY (2011)

Review Cell Biology

VEGFs and receptors involved in angiogenesis versus lymphangiogenesis

Marja Lohela et al.

CURRENT OPINION IN CELL BIOLOGY (2009)

Review Oncology

Image-guided radiation therapy for non-small cell lung cancer

Joe Y. Chang et al.

JOURNAL OF THORACIC ONCOLOGY (2008)

Review Oncology

Mechanisms of adverse effects of anti-VEGF therapy for cancer

T. Kamba et al.

BRITISH JOURNAL OF CANCER (2007)

Review Biochemistry & Molecular Biology

Molecular and functional diversity of vascular endothelial growth factors

Yasuo Yamazaki et al.

MOLECULAR DIVERSITY (2006)

Article Oncology

Vascular endothelial growth factor signaling pathways: Therapeutic perspective

Marcin Kowanetz et al.

CLINICAL CANCER RESEARCH (2006)

Review Biochemistry & Molecular Biology

The role of VEGF receptors in angiogenesis;: complex partnerships

S Cébe-Suarez et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2006)

Article Oncology

VEGF as a key mediator of angiogenesis in cancer

P Carmeliet

ONCOLOGY (2005)

Review Biochemistry & Molecular Biology

Mechanisms of angiogenesis and arteriogenesis

P Carmeliet

NATURE MEDICINE (2000)