期刊
CHEMICAL COMMUNICATIONS
卷 51, 期 8, 页码 1461-1464出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc08559k
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We disclose herein a highly enantioselective protocol for the Bronsted acid-catalyzed addition of indoles and phenols to in situ generated ortho-quinone methides which deliver broadly substituted diarylindolylmethanes and triarylmethanes, respectively, in a one-pot reaction under very mild conditions. A chiral phosphoric acid catalyst has been developed for this process serving to convert the starting ortho-hydroxybenzhydryl alcohols into the reactive ortho-quinone methides and to control the enantioselectivity of the carbon-carbon bond-forming event via hydrogen-bonding.
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