Insoluble Dietary Fiber from Okara Combined with Intermittent Fasting Treatment Synergistically Confers Antiobesity Effects by Regulating Gut Microbiota and Its Metabolites

Article Chemistry, Applied

Phenolics from noni (Morinda citrifolia L.) fruit alleviate obesity in high fat diet-fed mice via modulating the gut microbiota and mitigating intestinal damage

Ruimin Wang et al.

Summary: The phenolic extract of noni fruit (NFE) inhibits obesity by improving gut microbiota disorder, barrier function, and inflammation.

FOOD CHEMISTRY (2023)

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Article Biochemistry & Molecular Biology

Protective effect and mechanism of lactoferrin combined with hypoxia against high-fat diet induced obesity and non-alcoholic fatty liver disease in mice

Jiang-Xue Wu et al.

Summary: This study explored a new way to control weight and improve fatty liver, namely, living in hypoxia environment and supplement with lactoferrin (Lf). Results showed that interventions combining Lf and hypoxia treatments showed better effect against obesity and NAFLD than hypoxia treatment alone. The interventions achieved these effects by restoring gut microbiota composition and bile acid profile.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2023)

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Article Agriculture, Multidisciplinary

D-Arabitol Ameliorates Obesity and Metabolic Disorders via the Gut Microbiota-SCFAs-WAT Browning Axis

Xiaolan Li et al.

Summary: D-arabitol, found in mushrooms, lichens, and higher fungi, may alleviate visceral fat accumulation and insulin resistance due to its low calorie and glycemic index. This study reveals that D-arabitol improves body weight gain and fat accumulation through the gut microbiota-SCFAs-WAT browning axis, by increasing the abundance of certain genera and promoting the production of short-chain fatty acids.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2023)

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Article Chemistry, Applied

Polysaccharides from Artocarpus heterophyllus Lam. (jackfruit) pulp alleviate obesity by modulating gut microbiota in high fat diet-induced rats

Shunjiang Zeng et al.

Summary: Polysaccharides, especially jackfruit pulp polysaccharides (JFP-Ps), have the ability to modulate intestinal flora and alleviate obesity. In this study, JFP-Ps were found to inhibit weight gain, improve lipid profile, increase the diversity of intestinal flora, reverse dysbiosis caused by high-fat diet, and enhance the antioxidant capacity of obese rats by promoting the growth of specific bacteria. These findings suggest that JFP-Ps may be a promising prebiotic for the treatment of obesity.

FOOD HYDROCOLLOIDS (2023)

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Article Food Science & Technology

The intervention effects of konjac glucomannan with different molecular weights on high-fat and high-fructose diet-fed obese mice based on the regulation of gut microbiota

Qian Liu et al.

Summary: This study investigated the effects of konjac glucomannan with different molecular weights on high-fat and high-fructose diet-induced obese mice. The results showed that konjac glucomannan with higher molecular weight reduced body weight and improved insulin resistance. It also inhibited lipid accumulation in the liver by regulating gene expression. Furthermore, konjac glucomannan at different molecular weights caused changes in gut microbial diversity. These findings provide a scientific basis for the development and utilization of konjac resources.

FOOD RESEARCH INTERNATIONAL (2023)

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Article Agriculture, Multidisciplinary

Prevention of High-Fat-Diet-Induced Dyslipidemia by Lactobacillus plantarum LP104 through Mediating Bile Acid Enterohepatic Axis Circulation and Intestinal Flora

Yu Wang et al.

Summary: This study aimed to investigate the mechanism of Lactobacillus plantarum LP104 in alleviating dyslipidemia induced by a high-fat diet. The results showed that oral administration of LP104 reduced body weight gain, body fat, and serum hepatic dyslipidemia in mice. LP104 treatment increased the concentrations of certain bile acids and suppressed specific signaling pathways, leading to the synthesis of new bile acids and cholesterol efflux. Moreover, LP104 intervention promoted the rebalance of intestinal flora and its correlation with bile acid signaling molecules. These findings suggest that LP104 has the potential to be used as a natural functional food for dyslipidemia prevention.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2023)

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Article Microbiology

The metabolic, protective, and immune functions of Akkermansia muciniphila

Reza Ghotaslou et al.

Summary: Numerous studies have shown the beneficial effects of Akkermansia muciniphila, a member of the gut microbiota, on human health. It is associated with various disorders and diseases, such as obesity, fatty liver disease, diabetes, and behavioral disorders, while also providing protective effects against pathogens, improving gut permeability, and enhancing immune responses. This review comprehensively evaluates the impact of A. muciniphila on host health from metabolic, protective, and immune perspectives, and explores the underlying mechanisms.

MICROBIOLOGICAL RESEARCH (2023)

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Article Biochemistry & Molecular Biology

Gut microbiota mediates the anti-obesity effect of intermittent fasting by inhibiting intestinal lipid absorption

Hong Yang et al.

Summary: Intermittent fasting has been shown to improve obesity and diabetes-related metabolic disorders by changing the composition and metabolic function of intestinal microbes and inhibiting lipid absorption through PI3K/AKT signaling pathway. These findings provide new directions for the treatment of obesity and other metabolic disorders.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2023)

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Article Biochemistry & Molecular Biology

Polysaccharides from Fu brick tea ameliorate obesity by modulating gut microbiota and gut microbiota-related short chain fatty acid and amino acid metabolism

Mingzhi Zhu et al.

Summary: This study found that Fu brick tea polysaccharides (FBTPSs) can inhibit obesity, hyperlipidemia, and inflammation, improve intestinal barrier function, and alleviate gut microbiota dysbiosis in high-fat diet-fed rats. FBTPSs regulated the production of gut microbiota-related metabolites and influenced the short-chain fatty acid-GPR signaling pathway, showing their potential as prebiotic agents for the treatment of obesity and dysbiosis of gut microbiota.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2023)

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Article Chemistry, Applied

Fecal fermentation and high-fat diet-induced obesity mouse model confirmed exopolysaccharide from Weissella cibaria PFY06 can ameliorate obesity by regulating the gut microbiota

Yinzhuo Xie et al.

Summary: In this study, it was found that PFY06-EPS could improve obesity by improving the function of the gut microbiota. PFY06-EPS inhibited fat accumulation by promoting the secretion of endogenous gastrointestinal hormones and insulin and inhibiting the secretion of inflammatory factors. Moreover, PFY06-EPS also reversed obesity-induced microflora disorders and reduced endotoxemia to maintain intestinal barrier integrity.

CARBOHYDRATE POLYMERS (2023)

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Article Biochemistry & Molecular Biology

The effect of coffee consumption on glucose homeostasis and redox-inflammatory responses in high-fat diet-induced obese rats

Larissa Valadares Ramos et al.

Summary: The effects of coffee on glucose metabolism in obesity are controversial. Results showed that chronic coffee consumption did not ameliorate the negative effects on glucose metabolism induced by a high-fat diet, but it did improve antioxidant and anti-inflammatory responses, increase insulin secretion, and promote muscle glycogen synthesis.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2022)

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Article Agriculture, Dairy & Animal Science

Dietary fibers with different viscosity regulate lipid metabolism via ampk pathway: roles of gut microbiota and short-chain fatty acid

Yu Li et al.

Summary: Dietary fiber plays a crucial role in gastrointestinal health and its effect on goose growth and lipid levels varies with different viscosities. High viscosity fiber has a better lipid-lowering effect, while medium viscosity fiber provides better intestinal mucosal protection.

POULTRY SCIENCE (2022)

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Article Food Science & Technology

Effects of dietary fiber on human health

Yang He et al.

Summary: Dietary fiber has various physicochemical properties and exhibits physiological functions in reducing the risk of obesity, diabetes, cancer, and intestinal diseases.

FOOD SCIENCE AND HUMAN WELLNESS (2022)

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Article Food Science & Technology

Dose-dependent effects of apple pectin on alleviating high fat-induced obesity modulated by gut microbiota and SCFAs

Yuanyuan Zhao et al.

Summary: This study found a dose-dependent relationship between pectin intake and changes in body weight, fat accumulation, serum triglyceride levels, and acetate and propionate concentrations. Additionally, pectin was found to modulate the gut microbiota and enhance short-chain fatty acid production, leading to attenuations in colonic injury and liver steatosis.

FOOD SCIENCE AND HUMAN WELLNESS (2022)

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Review Medicine, Research & Experimental

The links between gut microbiota and obesity and obesity related diseases

Jiafeng Geng et al.

Summary: The obesity epidemic has become a global public health crisis, with the pathophysiological mechanisms still being unraveled. Gut microbiota plays a crucial role in obesity and related diseases, influencing obesity progression through changes in composition and metabolites, with potential therapeutic implications in targeting relevant metabolic pathways.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Article Chemistry, Applied

Insoluble yeast β-glucan attenuates high-fat diet-induced obesity by regulating gut microbiota and its metabolites

Xiaoxing Mo et al.

Summary: Insoluble yeast beta-glucan (IYG), as a potential prebiotic, exhibited a protective effect on high-fat diet (HFD)-induced obesity by regulating gut dysbiosis and restoring metabolic abnormalities and intestinal inflammation.

CARBOHYDRATE POLYMERS (2022)

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Article Food Science & Technology

In vitro fecal fermentation characteristics of bamboo insoluble dietary fiber and its impacts on human gut microbiota

Qing Ge et al.

Summary: This study investigated the effects of insoluble dietary fiber (IDF) from bamboo on the production of short-chain fatty acids (SCFAs) and the composition of gut microbiota. The results showed that IDF could promote SCFAs production and alter the microbial composition in the gut.

FOOD RESEARCH INTERNATIONAL (2022)

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Article Agriculture, Multidisciplinary

Lactobacillus paracasei 24 Attenuates Lipid Accumulation in HighFat Diet-Induced Obese Mice by Regulating the Gut Microbiota

Zhijing Liu et al.

Summary: This study demonstrates that Lactobacillus paracasei 24 (LP24) can alleviate lipid accumulation in an obese mouse model induced by a high-fat diet. The alleviating effect is achieved through improving blood lipid levels and liver health by regulating the gut microbiota.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2022)

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Review Food Science & Technology

A critical review on interplay between dietary fibers and gut microbiota

Shuxin Ye et al.

Summary: This review provides a detailed classification of dietary fibers, their impact on gut microbiota, and the results of relevant studies. A diet rich in dietary fiber and whole grains can improve the gut environment and promote host health.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2022)

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Article Chemistry, Applied

The effects of dietary fibers from rice bran and wheat bran on gut microbiota: An overview

Wanzi Yao et al.

Summary: Dietary fibers from rice bran and wheat bran can modulate gut microbiota, enhance intestinal barrier function, regulate the immune system, and play an important role in human health.

FOOD CHEMISTRY-X (2022)

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Article Food Science & Technology

Insoluble dietary fiber of pear fruit pomace (Pyrus ussuriensis Maxim) consumption ameliorates alterations of the obesity-related features and gut microbiota caused by high-fat diet

Fei Peng et al.

Journal of Functional Foods (2022)

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Article Biochemistry & Molecular Biology

The crude guava polysaccharides ameliorate high-fat diet-induced obesity in mice via reshaping gut microbiota

Yuanyuan Li et al.

Summary: This study found that guava polysaccharide (GP) can improve obesity and metabolic disorders induced by a high-fat diet by regulating the gut microbiota. GP supplementation can reduce weight gain, visceral obesity, and levels of serum lipids. It also improves insulin resistance and prevents lipid accumulation and inflammation in the liver and adipose tissues. The study suggests that GP may have potential as a prebiotic in the nutraceutical and food industry.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Biochemistry & Molecular Biology

Sargassum fusiforme fucoidan ameliorates diet-induced obesity through enhancing thermogenesis of adipose tissues and modulating gut microbiota

Jihui Zuo et al.

Summary: The study found that Sargassum fusiforme fucoidan (Fuc) has therapeutic effects on diet-induced obesity in mice. It significantly reduces obesity, improves glucose tolerance and insulin sensitivity, and decreases fat accumulation and hepatic steatosis. The study also suggests that Fuc can remodel gut microbiota and increase energy expenditure to achieve its weight loss and hypolipidemic effects.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Biochemistry & Molecular Biology

The different effects of psyllium husk and orlistat on weight control, the amelioration of hypercholesterolemia and non-alcohol fatty liver disease in obese mice induced by a high-fat diet

Zhitong Deng et al.

Summary: This study compared the effects of psyllium husk and orlistat treatments on mice with high-fat diet-induced obesity. While orlistat had a greater impact on weight loss, psyllium husk was more effective in reducing serum and liver cholesterol and triglyceride levels. The two treatments had similar effects on body fat rate, gene expression in the liver, and regulation of bile acids, but differed in their impact on specific genes and fecal bile acid structures. Additionally, there were differences in the gut microbiota at the genus level, leading to variations in serum lipopolysaccharide levels.

FOOD & FUNCTION (2022)

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Article Agriculture, Multidisciplinary

Polyphenols from Fu Brick Tea Reduce Obesity via Modulation of Gut Microbiota and Gut Microbiota-Related Intestinal Oxidative Stress and Barrier Function

Fang Zhou et al.

Summary: The study found that FBTP supplementation effectively reduced obesity in HFD-fed rats by improving intestinal oxidative stress and barrier function, as well as attenuating gut microbiota dysbiosis induced by HFD. Specific core microbes, including Akkermansia muciniphila, Alloprevotella, Bacteroides, and Faecalibaculum, were improved by FBTPs. The antiobesity effect of FBTPs was shown to be dependent on gut microbiota, as demonstrated by a fecal microbiota transplantation experiment.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

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Review Endocrinology & Metabolism

Insulin action, type 2 diabetes, and branched-chain amino acids: A two-way street

Phillip J. White et al.

Summary: The association of obesity and insulin resistance with increased levels of branched-chain and aromatic amino acids and decreased glycine levels is well-established. Human metabolomics and genetic studies have further confirmed these observations, with preclinical studies identifying mechanisms involved in amino acid homeostasis disruption and its connection to dysregulated glucose and lipid metabolism, particularly in the development of insulin resistance, type 2 diabetes, and cardiovascular diseases.

MOLECULAR METABOLISM (2021)

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Article Food Science & Technology

Flammulina velutipes mycorrhizae dietary fiber improves lipid metabolism disorders in obese mice through activating AMPK signaling pathway mediated by gut microbiota

Wenliang Wang et al.

Summary: Research shows that Flammulina velutipes dietary fiber can alleviate lipid metabolism disorders in obese mice by regulating the gut microbiota and activating the AMPK signaling pathway, leading to decreased lipid synthesis and increased lipid degradation.

FOOD BIOSCIENCE (2021)

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Article Multidisciplinary Sciences

Bacteroides spp. promotes branched-chain amino acid catabolism in brown fat and inhibits obesity

Naofumi Yoshida et al.

Summary: The gut microbiome plays a key role in regulating obesity, with BCAA metabolism in brown adipose tissue (BAT) being a potential target for addressing obesity. Modulating BCAA catabolism in BAT through pharmacological interventions and gut microbiota manipulation could offer therapeutic strategies against obesity.

ISCIENCE (2021)

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Article Microbiology

Diet, obesity, and the gut microbiome as determinants modulating metabolic outcomes in a non-human primate model

Tiffany M. Newman et al.

Summary: The study indicates that diet plays a major role in gut bacterial diversity, but changes in the abundance of specific bacterial taxa should be considered in conjunction with both diet and obesity. Interestingly, the presence of P. copri appears to be linked to metabolic dysfunction in Western diet-fed NHPs.

MICROBIOME (2021)

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Article Biochemistry & Molecular Biology

Crataegus pinnatifida polysaccharide alleviates colitis via modulation of gut microbiota and SCFAs metabolism

Ciliang Guo et al.

Summary: This study found that the polysaccharide HAW1-2 from hawthorn can alleviate colitis in mice by regulating inflammatory cytokines and inhibiting related molecular pathways. Additionally, HAW1-2 can modify the composition of gut microbiota, promoting the proliferation of beneficial bacteria and generating beneficial short-chain fatty acids to inhibit colitis.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Review Agriculture, Dairy & Animal Science

Gut microbiotada positive contributor in the process of intermittent fasting-mediated obesity control

Bohan Rong et al.

Summary: This paper focuses on the interaction between intermittent fasting and gut microbiota, highlighting the potential positive effects on host energy metabolism. It also discusses a potential recommended strain (Akkermansia muciniphila) and a regulatory pathway (circadian rhythm) for gut microbiota in improving host energy metabolism in IF.

ANIMAL NUTRITION (2021)

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Article Biochemistry & Molecular Biology

Preparation and characterization of soybean insoluble dietary fiber and its prebiotic effect on dyslipidemia and hepatic steatosis in high fat-fed C57BL/6J mice

Sainan Wang et al.

Summary: SIDF extracted from okara has a loose and porous structure with ideal oil-adsorption capacity and improved cholesterol adsorption. In vivo supplementation of IDF reduced serum lipid levels and hepatic fat accumulation by stimulating lipolysis, indicating its potential as a functional ingredient in food processing.

FOOD & FUNCTION (2021)

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Article Cardiac & Cardiovascular Systems

Obesity Phenotypes, Diabetes, and Cardiovascular Diseases

Marie-Eve Piche et al.

CIRCULATION RESEARCH (2020)

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Article Agriculture, Multidisciplinary

Threonine, but Not Lysine and Methionine, Reduces Fat Accumulation by Regulating Lipid Metabolism in Obese Mice

Qingquan Ma et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2020)

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Article Food Science & Technology

Serum metabolomics analysis of the intervention effect of whole grain oats on insulin resistance induced by high-fat diet in rats

Meng Zhao et al.

FOOD RESEARCH INTERNATIONAL (2020)

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Article Endocrinology & Metabolism

Protein, amino acids and obesity treatment

Mathilde Simonson et al.

REVIEWS IN ENDOCRINE & METABOLIC DISORDERS (2020)

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Article Food Science & Technology

Polyphenolic-enriched peach peels extract regulates lipid metabolism and improves the gut microbiota composition in high fat diet-fed mice

Juan Kan et al.

JOURNAL OF FUNCTIONAL FOODS (2020)

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Article Biotechnology & Applied Microbiology

Gut microbiota phenotypes of obesity

Maggie A. Stanislawski et al.

NPJ BIOFILMS AND MICROBIOMES (2019)

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Review Microbiology

The Impact of Dietary Fiber on Gut Microbiota in Host Health and Disease

Kassem Makki et al.

CELL HOST & MICROBE (2018)

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Article Endocrinology & Metabolism

Connection Between BMI-Related Plasma Metabolite Profile and Gut Microbiota

Filip Ottosson et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2018)

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Article Microbiology

The Gut Microbiota of Healthy Chilean Subjects Reveals a High Abundance of the Phylum Verrucomicrobia

Sayaka Fujio-Vejar et al.

FRONTIERS IN MICROBIOLOGY (2017)

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Article Endocrinology & Metabolism

The effects of intermittent compared to continuous energy restriction on glycaemic control in type 2 diabetes; a pragmatic pilot trial

S. Carter et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2016)

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Review Endocrinology & Metabolism

Short-chain fatty acids in control of body weight and insulin sensitivity

Emanuel E. Canfora et al.

NATURE REVIEWS ENDOCRINOLOGY (2015)

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Article Microbiology

The gut microbiota of Colombians differs from that of Americans, Europeans and Asians

Juan S. Escobar et al.

BMC MICROBIOLOGY (2014)

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Article Biochemistry & Molecular Biology

Human Genetics Shape the Gut Microbiome

Julia K. Goodrich et al.

CELL (2014)

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Article Gastroenterology & Hepatology

Correlations between colonic crypt mucin chemotype, inflammatory grade and Desulfovibrio species in ulcerative colitis

G. Lennon et al.

COLORECTAL DISEASE (2014)

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Review Medical Laboratory Technology

Intermittent fasting vs daily calorie restriction for type 2 diabetes prevention: a review of human findings

Adrienne R. Barnosky et al.

TRANSLATIONAL RESEARCH (2014)

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Review Biochemistry & Molecular Biology

Mammalian P4-ATPases and ABC transporters and their role in phospholipid transport

Jonathan A. Coleman et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2013)

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Article Multidisciplinary Sciences

Richness of human gut microbiome correlates with metabolic markers

Emmanuelle Le Chatelier et al.

NATURE (2013)

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Article Chemistry, Applied

Development of a headspace solid-phase microextraction gas chromatography-mass spectrometric method for the determination of short-chain fatty acids from intestinal fermentation

F. Bianchi et al.

FOOD CHEMISTRY (2011)

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Review Nutrition & Dietetics

Propionate as a health-promoting microbial metabolite in the human gut

Elham Hosseini et al.

NUTRITION REVIEWS (2011)

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Review Biochemistry & Molecular Biology

The ABC transporters in lipid flux and atherosclerosis

Iryna Voloshyna et al.

PROGRESS IN LIPID RESEARCH (2011)

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Article Biotechnology & Applied Microbiology

Metagenomic biomarker discovery and explanation

Nicola Segata et al.

GENOME BIOLOGY (2011)

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Review Gastroenterology & Hepatology

Review article: the role of butyrate on colonic function

H. M. Hamer et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2008)

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Article Multidisciplinary Sciences

Microbial ecology - Human gut microbes associated with obesity

Ruth E. Ley et al.

NATURE (2006)

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Article Gastroenterology & Hepatology

Design and validation of a histological scoring system for nonalcoholic fatty liver disease

DE Kleiner et al.

HEPATOLOGY (2005)

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Insoluble Dietary Fiber from Okara Combined with Intermittent Fasting Treatment Synergistically Confers Antiobesity Effects by Regulating Gut Microbiota and Its Metabolites

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