☆ 4.7 Review

Pterostilbene as a Therapeutic Alternative for Central Nervous System Disorders: A Review of the Current Status and Perspectives

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Plant Sciences

Therapeutic potential of Polygala saponins in neurological diseases

Li Zhang et al.

Summary: Polygala genus and its major bioactive component, Polygala saponins, have shown therapeutic potential in various neurological diseases, exhibiting neuroprotective effects and modulating inflammation and oxidative stress. However, Polygala saponins can induce gastrointestinal toxicity, which can be ameliorated using specific processing methods.

PHYTOMEDICINE (2023)

添加到收藏夹

Article Plant Sciences

Pterostilbene participates in TLR4-mediated inflammatory response and autophagy-dependent A beta(1-42) endocytosis in Alzheimer's disease

Jikai Xu et al.

Summary: This study found that pterostilbene, a compound isolated from Chinese dragon's blood, can reduce inflammation in Alzheimer's disease (AD). The study demonstrated that pterostilbene can improve learning and memory abilities in AD transgenic mice and reduce microglial activation and A beta aggregation in their hippocampus. This is achieved by blocking the interaction of TLR4 and MD2 to suppress TLR4-mediated inflammation.

PHYTOMEDICINE (2023)

添加到收藏夹

Article Immunology

Pterostilbene attenuates microglial inflammation and brain injury after intracerebral hemorrhage in an OPA1-dependent manner

Yang Wu et al.

Summary: Pterostilbene attenuates neuroinflammation and brain injury after intracerebral hemorrhage (ICH) in mice, potentially through regulating microglial mitochondrial dynamics.

FRONTIERS IN IMMUNOLOGY (2023)

添加到收藏夹

Review Cell Biology

Biomarkers used in Alzheimer's disease diagnosis, treatment, and prevention

Yacoubou Abdoul Razak Mahaman et al.

Summary: Alzheimer's disease is a neurodegenerative disease associated with aging and is considered a global public health threat. The disease is characterized by specific histological features and clinical symptoms, but drug therapies targeting these features have proven to be ineffective. Early diagnosis and treatment are crucial, and the use of reliable biomarkers can aid in accurate diagnosis and evaluation of related pathologies.

AGEING RESEARCH REVIEWS (2022)

添加到收藏夹

Review Pathology

The Immune Response in Multiple Sclerosis

Sofia Rodriguez Murua et al.

Summary: Multiple sclerosis is a chronic disease affecting the central nervous system, characterized by immune dysregulation and resulting in demyelination, neuronal damage, and degeneration. Genetic and environmental factors are believed to play a role in the onset and progression of this disease.

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2022)

添加到收藏夹

Review Medicine, Research & Experimental

Nrf2/Keap1/ARE signaling: Towards specific regulation

Alexey Ulasov et al.

Summary: The Nrf2 transcription factor regulates the expression of genes involved in cell defense against oxidative stress, which is associated with various diseases. The interactions between Nrf2 and Keap1 protein play a crucial role in this regulation. The activation of the Nrf2 system is considered as a promising strategy to treat diseases related to oxidative stress, including COVID-19. Two approaches are being developed to inactivate the Keap1 guardian function and enhance Nrf2 activity.

LIFE SCIENCES (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Glioma targeted therapy: insight into future of molecular approaches

Keyang Yang et al.

Summary: Gliomas are common brain tumors originating from glial cells. Treatment and prognosis differ significantly depending on the type of glioma. Traditional targeted therapy approaches have faced challenges, while new methods such as immunotherapy and the tumor microenvironment are gaining interest. More clinical trials are needed to evaluate the feasibility of personalized targeted therapy.

MOLECULAR CANCER (2022)

添加到收藏夹

Review Chemistry, Medicinal

Ginsenosides in central nervous system diseases: Pharmacological actions, mechanisms, and therapeutics

Jing Lu et al.

Summary: This review summarizes the potential pathways by which ginsenosides affect the pathogenesis of central nervous system diseases (CNSDs), including antioxidant effects, anti-inflammatory effects, anti-apoptotic effects, and nerve protection. Ginsenosides have been shown to prevent various CNSDs, such as neurodegenerative diseases, cerebral ischemia injury, and depression.

PHYTOTHERAPY RESEARCH (2022)

添加到收藏夹

Article Cell Biology

ATRX loss in glioma results in dysregulation of cell-cycle phase transition and ATM inhibitor radio-sensitization

Tingtin Qin et al.

Summary: ATRX deficiency leads to dysregulation of cell-cycle phase transitions in high-grade glioma cells, resulting in increased sensitivity to irradiation. The study found that ATRX binds to the regulatory elements of cell-cycle phase transition genes and loss of ATRX leads to decreased expression of Checkpoint Kinase 1, leading to early release of G2/M entry after irradiation.

CELL REPORTS (2022)

添加到收藏夹

Article Geriatrics & Gerontology

Salidroside Ameliorates Alzheimer's Disease by Targeting NLRP3 Inflammasome-Mediated Pyroptosis

Yawen Cai et al.

Summary: This study found that Salidroside can slow down the progression of Alzheimer's disease by inhibiting NLRP3 inflammasome-mediated pyroptosis.

FRONTIERS IN AGING NEUROSCIENCE (2022)

添加到收藏夹

Review Neurosciences

Monoamine Oxidase-B Inhibitors for the Treatment of Parkinson's Disease: Past, Present, and Future

Yu-Yan Tan et al.

Summary: This review discusses the effects of MAO-B inhibitors on motor and non-motor symptoms in PD patients, their mechanism of action, and the future development of MAO-B inhibitor therapy.

JOURNAL OF PARKINSONS DISEASE (2022)

添加到收藏夹

Review Cell Biology

miR-124: A Promising Therapeutic Target for Central Nervous System Injuries and Diseases

Jinying Xu et al.

Summary: Studies have shown that microRNA-124 is closely related to the occurrence and development of pathology within the central nervous system. Understanding the molecular regulatory functions and effective delivery methods of miR-124 may hold potential for therapeutic targets in treating central nervous system injuries or diseases.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2022)

添加到收藏夹

Article Public, Environmental & Occupational Health

Primary stroke prevention worldwide: translating evidence into action

Mayowa O. Owolabi et al.

Summary: Stroke is a major global threat to life and disability, particularly in low- and middle-income countries that struggle to address its challenges. This article provides an overview of primary stroke prevention, estimating the cost and identifying deficiencies in guidelines and primary prevention approaches. Pragmatic solutions are offered, emphasizing the role of governments and population-wide strategies. Implementation of primary stroke prevention involves various stakeholders across the lifespan.

LANCET PUBLIC HEALTH (2022)

添加到收藏夹

Article Neurosciences

Serum Mature BDNF Level Is Associated with Remission Following ECT in Treatment-Resistant Depression

Marion Psomiades et al.

Summary: This study found that the level of mature BDNF (mBDNF) is associated with the efficacy of electroconvulsive therapy (ECT) for patients with treatment-resistant depression. Patients with higher baseline mBDNF levels were more likely to achieve remission after ECT sessions.

BRAIN SCIENCES (2022)

添加到收藏夹

Review Cell Biology

Oxidative stress: The core pathogenesis and mechanism of Alzheimer's disease

Renren Bai et al.

Summary: As the number of Alzheimer's disease (AD) patients increases, it poses great challenges to their families and society as a whole. While significant efforts have been made to understand the pathology of AD, the main pathogenesis remains elusive. Oxidative stress, as a crucial factor, plays a critical role in this disease by connecting different hypotheses and mechanisms.

AGEING RESEARCH REVIEWS (2022)

添加到收藏夹

Article Psychology, Clinical

Major Depression and Its Recurrences: Life Course Matters

Scott M. Monroe et al.

Summary: Major depression is a common and debilitating condition that affects individuals and public health worldwide. However, not all individuals with depression experience the same level of burden, as some will have recurrent episodes while others will not. This study proposes a subtype distinction to understand the origins and lifetime course of major depression. The lack of recognition of this distinction has hindered research and led to conceptual biases and methodological oversights. The implications of this research are discussed in terms of diagnostic controversies, treatment and prevention approaches, and improving the predictive strength of indicators for recurrences and recurrent depression.

ANNUAL REVIEW OF CLINICAL PSYCHOLOGY (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Atherosclerosis: Recent developments

Johan L. M. Bjoerkegren et al.

Summary: This article reviews the current understanding of the molecular, cellular, genetic, and environmental contributions to atherosclerosis and highlights recent developments and unexpected biological findings, such as the heterogeneity of inflammatory and smooth muscle cells in lesions, the roles of senescence and clonal hematopoiesis, and the links to the gut microbiome.

CELL (2022)

添加到收藏夹

Article Agriculture, Multidisciplinary

Triad3A-Dependent TLR4 Ubiquitination and Degradation Contributes to the Anti-Inflammatory Effects of Pterostilbene on Vascular Dementia

Jikai Xu et al.

Summary: Pterostilbene can attenuate cognitive impairment in vascular dementia by reducing inflammation and promoting TLR4 degradation.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2022)

添加到收藏夹

Review Neurosciences

Microbiota in neuroinflammation and synaptic dysfunction: a focus on Alzheimer's disease

Diane Bairamian et al.

Summary: The gut microbiota is implicated in the control of brain functions through modulation of neuroinflammation and direct stimulation of neuronal activity via microglial and vagus nerve. This has important implications for neurodegenerative disorders such as Alzheimer's disease.

MOLECULAR NEURODEGENERATION (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

The synapse as a treatment avenue for Alzheimer's Disease

Lin Peng et al.

Summary: Alzheimer's disease is a neurodegenerative disorder that severely impairs memory and cognition. It is characterized by Aβ deposition, tau tangles, synaptic abnormalities, and dysfunctions. Targeting the synapse and early treatment windows hold promise for finding effective treatments for AD patients.

MOLECULAR PSYCHIATRY (2022)

添加到收藏夹

Article Neurosciences

Pterostilbene Protects the Optic Nerves and Retina in a Murine Model of Experimental Autoimmune Encephalomyelitis via Activation of SIRT1 Signaling

Jiangyuan Guo et al.

Summary: This study demonstrates that pterostilbene (PT) has a therapeutic effect on optic neuritis and retinal damage caused by multiple sclerosis (MS). PT alleviates the severity and delays the onset of experimental autoimmune encephalomyelitis (EAE), a model for MS. It reduces inflammation, protects the optic nerves and retina, and activates SIRT1 signaling pathway.

NEUROSCIENCE (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

SIRT1 Is Involved in the Neuroprotection of Pterostilbene Against Amyloid β 25-35-Induced Cognitive Deficits in Mice

Lin Zhu et al.

Summary: The study found that Pterostilbene (PTE) in blueberries has neuroprotective properties in the treatment of Alzheimer's disease, improving cognitive dysfunction and neuronal plasticity. Its mechanism may be related to inhibiting mitochondria-dependent apoptosis through the antioxidant effect regulated by SIRT1/Nrf2.

FRONTIERS IN PHARMACOLOGY (2022)

添加到收藏夹

Review Clinical Neurology

Matrix Metalloproteinase-9 as an Important Contributor to the Pathophysiology of Depression

Hongmin Li et al.

Summary: This review provides an updated and comprehensive summary of the probable roles of MMP-9 in depression with an emphasis on the mechanisms and potential of MMP-9 as a biomarker of depression.

FRONTIERS IN NEUROLOGY (2022)

添加到收藏夹

Article Plant Sciences

Evaluating Cannabis sativa L.'s neuroprotection potential: From bench to bedside

John Staton Laws III et al.

Summary: This review evaluated the neuroprotective potential of Cannabis sativa's active constituents for potential therapeutic use in dementia and Alzheimer's disease, emphasizing the significance of cannabis components as a novel treatment approach.

PHYTOMEDICINE (2022)

添加到收藏夹

Article Toxicology

Protective effect of pterostilbene in a streptozotocin-induced mouse model of Alzheimer's disease by targeting monoamine oxidase B

Qiushi Li et al.

Summary: Pterostilbene alleviates Alzheimer's disease (AD) symptoms, including memory impairment, amyloid beta (Aβ) accumulation, Tau hyperphosphorylation, neuronal death, oxidative stress, and inflammation, by regulating monoamine oxidase B (MAOB).

JOURNAL OF APPLIED TOXICOLOGY (2022)

添加到收藏夹

Review Immunology

Astrocytic and microglial cells as the modulators of neuroinflammation in Alzheimer's disease

Deepali Singh

Summary: Neuroinflammation is caused by the misfiring of immune cells in the central nervous system and can have both positive and negative effects on neurodevelopment and post-injury tissue. Chronic or uncontrolled inflammatory responses may lead to neurodegenerative diseases, while abnormal activation of glial cells can mediate neuroinflammation.

JOURNAL OF NEUROINFLAMMATION (2022)

添加到收藏夹

Review Medicine, Research & Experimental

Role of exosomes in the pathogenesis, diagnosis, and treatment of central nervous system diseases

Yishu Fan et al.

Summary: Exosomes, cell-derived extracellular vesicles, have been found to play a significant role in the pathogenesis and potential treatment of CNS diseases, by transferring biologically active molecules between different cells and delivering drugs across the blood brain barrier.

JOURNAL OF TRANSLATIONAL MEDICINE (2022)

添加到收藏夹

Review Cell Biology

Progress in Research on TLR4-Mediated Inflammatory Response Mechanisms in Brain Injury after Subarachnoid Hemorrhage

Lintao Wang et al.

Summary: Subarachnoid hemorrhage (SAH) is a common clinical neurological emergency with a relatively high incidence and often leads to severe adverse prognoses. Inflammatory response plays an important role in early nerve injury in SAH, with Toll-like receptor 4 (TLR4) playing a vital role in the inflammatory transduction pathway.

CELLS (2022)

添加到收藏夹

Review Cell Biology

Biological Effects and Mechanisms of Caspases in Early Brain Injury after Subarachnoid Hemorrhage

Yiwen Wu et al.

Summary: This review explores the role of caspases in subarachnoid hemorrhage (SAH) and their contribution to neurodegenerative diseases. By regulating multiple modes of cell death and mediating inflammatory responses, caspases play a significant role in the early stages of SAH. Therefore, understanding and targeting caspase-related pathways may improve the prognosis of SAH.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

添加到收藏夹

Review Neurosciences

Microglia-mediated neuroinflammation and neuroplasticity after stroke

Yuan Wang et al.

Summary: Stroke is a major cause of long-term disability and mortality worldwide. The immune system, particularly microglia, plays a crucial role in determining the condition of the brain following stroke. Microglia activation and polarization are important for brain damage and repair after ischemic stroke, but can have both detrimental and beneficial effects on neurological recovery.

FRONTIERS IN CELLULAR NEUROSCIENCE (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

ERK1/2 in immune signalling

Richard M. Lucas et al.

Summary: This article summarizes the important role of ERK1/2 in cell signaling, particularly in immune responses in immune cells. Additionally, it discusses the dysfunctional signaling of ERK1/2 in inflammatory diseases and explores the potential therapeutic benefits of targeting this pathway in inflammation.

BIOCHEMICAL SOCIETY TRANSACTIONS (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

AMPK and NRF2: Interactive players in the same team for cellular homeostasis?

Eleni Petsouki et al.

Summary: AMPK and NRF2 are key regulatory factors in cellular energy homeostasis and stress response, and they may interact and cooperate to readjust cellular homeostasis at the molecular level.

FREE RADICAL BIOLOGY AND MEDICINE (2022)

添加到收藏夹

Article Clinical Neurology

Genetic variations in GABA metabolism and epilepsy

Yan Feng et al.

Summary: Epilepsy is a brain disorder caused by an imbalance between neuronal excitation and inhibition. The most important inhibitory neurotransmitter in the brain, gamma-aminobutyric acid (GABA), plays a crucial role in the occurrence and development of epilepsy. Abnormalities in various aspects of GABA metabolism, including synthesis, transport, genes encoding GABA receptors, and inactivation, can contribute to epilepsy. Genetic mutations of GABA receptor encoding genes, such as GABRA1, GABRA2, GABRA5, GABRB1, GABRB2, GABRB3, GABRG2, and GABBR2, are commonly associated with epilepsy, leading to different clinical phenotypes by reducing receptor expression and GABA-evoked potentials. Mutations in the ABAT and ALDH5A1 genes, which encode enzymes involved in GABA metabolism, can result in symptoms related to their deficiency, such as epilepsy and cognitive impairment. Most genetic variations in GABA metabolism are accompanied by developmental disorders. Understanding the relationship between genetic variations in GABA metabolism and epilepsy is important for accurate diagnosis and treatment.

SEIZURE-EUROPEAN JOURNAL OF EPILEPSY (2022)

添加到收藏夹

Review Medicine, General & Internal

Management of psychiatric and cognitive complications in Parkinson's disease

Daniel Weintraub et al.

Summary: Neuropsychiatric symptoms in Parkinson's disease are often under-recognized and under-treated, but their management is crucial. Understanding the epidemiology, presentation, risk factors, neural substrate, and treatment strategies is important.

BMJ-BRITISH MEDICAL JOURNAL (2022)

添加到收藏夹

Review Medicine, Research & Experimental

Pharmacological effects of salidroside on central nervous system diseases

Meihua Jin et al.

Summary: This review tracks and summarizes studies from the past eight years, elucidating the pharmacological effects of Salidroside on inflammation, oxidative stress, apoptosis, autophagy, and neuronal regeneration, as well as assessing its regulatory effect on various signaling pathways.

BIOMEDICINE & PHARMACOTHERAPY (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

New Insights into Dietary Pterostilbene: Sources, Metabolism, and Health Promotion Effects

Sanjushree Nagarajan et al.

Summary: Pterostilbene, a compound found in blueberries, has diverse therapeutic potential and better pharmacodynamic features compared to resveratrol. It has become an attractive drug candidate for the treatment of diseases such as diabetes, cancer, cardiovascular disease, neurodegenerative disorders, and aging. This review article provides a comprehensive summary of its nutraceutical potential, mechanisms of action, sources, pharmacokinetics, and strategies to improve its dietary availability and bio-accessibility.

MOLECULES (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions

Chuan Qin et al.

Summary: Ischemic stroke, caused by interruption in cerebral blood flow, leads to severe neural injuries and is a major cause of death and disability worldwide. Understanding the pathophysiology and signaling pathways involved is crucial for developing new therapies.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Inflammation and atherosclerosis: signaling pathways and therapeutic intervention

Peng Kong et al.

Summary: Atherosclerosis is a chronic inflammatory vascular disease that can be promoted or inhibited by innate and adaptive immune responses. Several signaling pathways associated with the inflammatory response have been found to play important roles in the development and regression of atherosclerosis. Targeting inflammatory pathways may represent a new approach for the treatment of atherosclerotic diseases.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

The Dual Role of Low-Density Lipoprotein Receptor-Related Protein 1 in Atherosclerosis

Jiefang Chen et al.

Summary: LRP1 is a large endocytic and signaling receptor widely expressed in several tissues, with crucial roles in embryogenesis and development, yet its role in atherosclerosis remains controversial. It participates in diverse physiological and pathological processes, including plasma lipoprotein homeostasis, atherosclerosis, tumor evolution, and its dual role in vascular cells and immune cells is of interest for potential therapeutic targets.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

添加到收藏夹

Article Oncology

Elimination of Radiation-Induced Senescence in the Brain Tumor Microenvironment Attenuates Glioblastoma Recurrence

Eliot Fletcher-Sananikone et al.

Summary: This study reveals that radiation therapy-induced senescence in non-neoplastic brain cells promotes the growth of glioblastoma. Senescent astrocytes secrete factors like HGF to activate Met in glioma cells. Treatment with senolytic drugs can attenuate tumor growth by selectively killing senescent astrocytes.

CANCER RESEARCH (2021)

添加到收藏夹

Review Cell Biology

Opportunities and challenges of glioma organoids

Xiangdong Xu et al.

Summary: Glioma, the most common primary brain tumor with poor prognosis, requires an urgent platform to study its cell dynamics and develop effective treatments. Organoids, a 3D structure similar to human tissues, are considered the most suitable research platform for glioma research, overcoming the drawbacks of previous models and contributing to the diagnosis and treatment of glioma.

CELL COMMUNICATION AND SIGNALING (2021)

添加到收藏夹

Review Neurosciences

Emerging neuroprotective strategies for the treatment of ischemic stroke: An overview of clinical and preclinical studies

Surojit Paul et al.

Summary: Stroke is a major cause of disability and death globally, with an increasing incidence particularly in younger age groups and low to middle-income countries. While treatment options are limited, advancements in recanalization therapy have shown promise in helping patients recover from ischemic stroke. Development of neuroprotective agents for acute ischemic stroke is urgently needed to protect the brain, extend the therapeutic time window, and improve outcomes.

EXPERIMENTAL NEUROLOGY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Advances in Research of Adult Gliomas

Alina Finch et al.

Summary: This review discusses recent advances in understanding diffuse glioma development and progression, including the use of various models and techniques, as well as the understanding of glioma heterogeneity, gene expression and DNA methylation changes. It also covers current treatment options and future clinical trials aimed at improving early diagnosis and disease monitoring.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

PI3K/AKT/mTOR Signaling Pathway in Breast Cancer: From Molecular Landscape to Clinical Aspects

Daniela Miricescu et al.

Summary: Breast cancer is a complex disease with various factors contributing to its pathogenesis. Current research is focused on the PI3K/AKT/mTOR signaling pathway and related cancer mutations. Clinical trials are also evaluating the efficacy of inhibitors targeting these signaling pathways in breast cancer treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Food Science & Technology

Pterostilbene Alleviates Aβ1-42-Induced Cognitive Dysfunction via Inhibition of Oxidative Stress by Activating Nrf2 Signaling Pathway

Jikai Xu et al.

Summary: Pterostilbene alleviates Aβ(1-42)-induced cognitive dysfunction in mice possibly by inhibiting oxidative stress through the Nrf2 signaling pathway.

MOLECULAR NUTRITION & FOOD RESEARCH (2021)

添加到收藏夹

Review Clinical Neurology

Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?

Fangda Leng et al.

Summary: Microglial activation and neuroinflammation play important roles in Alzheimer's disease, affecting disease progression and pathologies. Current research focuses on the interplay between neuroinflammation and amyloid and tau pathologies, with a specific interest in modulating microglia as a therapeutic strategy for AD.

NATURE REVIEWS NEUROLOGY (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Pterostilbene and its nicotinate derivative ameliorated vascular endothelial senescence and elicited endothelium-dependent relaxations via activation of sirtuin 1

Lili Zhang et al.

Summary: The study demonstrated that pterostilbene and its derivatives can attenuate vascular endothelial cell senescence and induce endothelium-dependent relaxations via SIRT1 activation.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2021)

添加到收藏夹

Review Medicine, Research & Experimental

Influence of glutamate and GABA transport on brain excitatory/inhibitory balance

Sheila M. S. Sears et al.

Summary: An optimally functional brain requires a regulated and balanced combination of excitatory and inhibitory inputs. Imbalance in this interplay, as seen in various neurological disorders and developmental disorders, can lead to dysfunctional signaling and impaired cognitive or motor function. The neurotransmitters glutamate and GABA play a key role in controlling this balance at the cellular level.

EXPERIMENTAL BIOLOGY AND MEDICINE (2021)

添加到收藏夹

Review Geriatrics & Gerontology

Emerging roles of oxidative stress in brain aging and Alzheimer's disease

Andra Ionescu-Tucker et al.

Summary: Reactive oxygen species (ROS) are metabolic byproducts that can be toxic at high levels and have been linked to cognitive aging and neurodegenerative diseases. Therapeutics like antioxidants, caloric restriction, and physical activity can reduce oxidation and prevent cognitive decline in brain aging and AD. Long term physical activity shows promise in improving cognitive health by reducing ROS levels and promoting optimal function.

NEUROBIOLOGY OF AGING (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Antioxidant, anti-inflammatory and neuroprotective actions of resveratrol after experimental nervous system insults. Special focus on the molecular mechanisms involved

C. A. Miguel et al.

Summary: Secondary damage is a key factor in promoting cell death, neurodegeneration, and functional deficits following acute central nervous system insults. Resveratrol, a natural compound found in grape skin and red wine, has shown potential neuroprotective effects by modulating multiple pathways involved in antioxidant, anti-inflammatory, and anti-apoptotic processes.

NEUROCHEMISTRY INTERNATIONAL (2021)

添加到收藏夹

Review Medicine, General & Internal

Anxiety disorders

Brenda W. J. H. Penninx et al.

Summary: Anxiety disorders are the most common group of mental disorders, characterized by excessive fear, anxiety, and avoidance of perceived threats. Risk factors include genetic and environmental influences, with high rates of comorbidity with other mental disorders. Timely and accurate treatment is crucial for reducing the burden of anxiety disorders.

LANCET (2021)

添加到收藏夹

Review Endocrinology & Metabolism

Advances in biological therapies for dyslipidemias and atherosclerosis

Eftaxia-Konstantina Valanti et al.

Summary: Atherosclerosis is a multifactorial disease influenced by genetics, lifestyle, and environmental factors. Targeting genes involved in lipoprotein metabolism is considered a new approach for prevention and treatment. Multiple lipid lowering biological therapies have been approved by the FDA with impressive results in clinical trials.

METABOLISM-CLINICAL AND EXPERIMENTAL (2021)

添加到收藏夹

Review Clinical Neurology

Brain concentrations of glutamate and GABA in human epilepsy: A review

Gabrielle L. Sarlo et al.

Summary: The imbalance between excitation and inhibition in epilepsy is related to changes in glutamate and GABA levels, with most studies showing increased glutamate in epileptic regions. Future research should consider medication use, measure GABA, glutamate, and glutamine levels, use high-tesla strength MRI, and evaluate the timing of microdialysis further.

SEIZURE-EUROPEAN JOURNAL OF EPILEPSY (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Role of PI3K in the Progression and Regression of Atherosclerosis

Yunyun Zhao et al.

Summary: PI3K is a key molecule in signal transduction, impacting multiple cellular pathways and playing a crucial role in various human diseases, particularly atherosclerosis.

FRONTIERS IN PHARMACOLOGY (2021)

添加到收藏夹

Review Neurosciences

Activation and Role of Astrocytes in Ischemic Stroke

Xin-Ya Shen et al.

Summary: Ischemic stroke leads to local brain tissue blood supply disorder, with astrocytes playing a crucial role in the response to the injury. Reactive astrocytes, activated after stroke, exhibit protective functions but also potentially harmful effects. Their spatial and temporal expression determines the diverse functions of astrocytes in the context of ischemic stroke's complex cascade reactions.

FRONTIERS IN CELLULAR NEUROSCIENCE (2021)

添加到收藏夹

Review Medicine, General & Internal

Epilepsy: A Clinical Overview

Tracey A. Milligan

Summary: The diagnosis and treatment of seizures and epilepsy is a common task of physicians, involving excluding underlying conditions and determining the type of epilepsy for effective medication control.

AMERICAN JOURNAL OF MEDICINE (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Neuroprotective and Anti-Inflammatory Effect of Pterostilbene Against Cerebral Ischemia/Reperfusion Injury via Suppression of COX-2

Wenjun Yan et al.

Summary: The study found that pterostilbene exhibited neuroprotective effects against cerebral ischemia in rats through anti-inflammatory mechanisms, improving body weight and glucose levels, reducing organ damage, lowering oxidative stress levels and inflammatory responses.

FRONTIERS IN PHARMACOLOGY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Astrocyte Activation in Neurovascular Damage and Repair Following Ischaemic Stroke

Adjanie Patabendige et al.

Summary: Ischaemic stroke can cause damage to the neurovasculature, leading to long-term motor and cognitive deficits. Current neuroprotective therapies are lacking, with many studies focusing on neurons and neglecting the important roles of other cells in the neurovascular unit, such as astrocytes.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Chemistry, Medicinal

Pterostilbene Improves Stress-Related Behaviors and Partially Reverses Underlying Neuroinflammatory and Hormonal Changes in Stress-Challenged Mice

Byoungjin Park et al.

Summary: The study showed that oral administration of pterostilbene significantly increased the time spent in open field and forced swimming tests in mice, elevated BDNF levels, reduced levels of inflammatory markers in the brain, and decreased plasma hormone levels related to stress. Pterostilbene also increased neuron numbers and reduced glial cell and inflammatory marker-labeled cell numbers in the hypothalamus, indicating its potential in modulating stress-related behaviors, neuroinflammation, and HPA axis hyperactivity.

JOURNAL OF MEDICINAL FOOD (2021)

添加到收藏夹

Review Multidisciplinary Sciences

The changing landscape of atherosclerosis

Peter Libby

Summary: Emerging evidence has led to a significant evolution of concepts related to atherosclerosis, with a shifting risk profile that is no longer limited to specific regions or demographics. Recent research has highlighted new risk factors and mechanisms underlying atherosclerosis, opening doors to potential therapeutic interventions for this widespread disease.

NATURE (2021)

添加到收藏夹

Review Clinical Neurology

Incidence and Prevalence of Drug-Resistant Epilepsy A Systematic Review and Meta-analysis

Bushra Sultana et al.

Summary: This study evaluated the incidence and prevalence of drug-resistant epilepsy (DRE) and found variations between populations. Multiple potential predictors and correlates of DRE were identified, providing important information for planning epilepsy services, including epilepsy surgery, for individuals with disabling seizures and DRE.

NEUROLOGY (2021)

添加到收藏夹

Review Cell Biology

Neuroprotective Phytochemicals in Experimental Ischemic Stroke: Mechanisms and Potential Clinical Applications

Hui Xu et al.

Summary: Ischemic stroke is a challenging disease with high mortality and disability rates, and phytochemicals have shown potential neuroprotective effects, making them valuable for neuroprotection mechanisms and potential clinical applications.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

添加到收藏夹

Article Plant Sciences

Oxymatrine improves blood-brain barrier integrity after cerebral ischemia-reperfusion injury by downregulating CAV1 and MMP9 expression

Yu Jiao-Yan et al.

Summary: Oxymatrine (OMT) has protective effects on neurological function and reduces blood-brain barrier permeability. OMT protects against ischemia-reperfusion injury through modulation of cellular damage and tight junction protein expression levels.

PHYTOMEDICINE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Pterostilbene promotes mitochondrial apoptosis and inhibits proliferation in glioma cells

Haijun Gao et al.

Summary: Pterostilbene (PTE) has shown anti-tumor effects on glioma cells by inhibiting proliferation, inducing apoptosis, and inhibiting migration through the generation of ROS and reduction of MMP. Activation of ERK 1/2 and JNK signaling pathways contribute to glioma cell apoptosis induced by PTE, which can be attenuated by specific inhibitors of these pathways.

SCIENTIFIC REPORTS (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Pterostilbene in Cancer Therapy

Elena Obrador et al.

Summary: Pterostilbene has shown effectiveness against melanoma by inhibiting adrenocorticotropic hormone production in the brain and promoting cancer cell death via lysosomal membrane permeabilization. It has been found to be safe when administered intravenously in mice, suggesting its potential as an adjuvant therapy in cancer treatment. Further research is needed to optimize its bioavailability and efficacy.

ANTIOXIDANTS (2021)

添加到收藏夹

Review Clinical Neurology

The Pharmacology and Clinical Efficacy of Antiseizure Medications: From Bromide Salts to Cenobamate and Beyond

Wolfgang Loescher et al.

Summary: Epilepsy is a common and disabling chronic neurological disorder, with antiseizure medications being the main treatment. There are multiple ASMs available for epilepsy therapy and they have diverse mechanisms of action. The goal of epilepsy therapy is to completely eliminate seizures, but this is not achievable in about one-third of patients.

CNS DRUGS (2021)

添加到收藏夹

Article Food Science & Technology

Pterostilbene prevents methylglyoxal-induced cytotoxicity in endothelial cells by regulating glyoxalase, oxidative stress and apoptosis

Dan Tang et al.

Summary: This study demonstrates that PTS can protect against MGO-induced endothelial cell cytotoxicity by regulating glyoxalase, oxidative stress, and apoptosis. PTS enhances GLO-1 levels and GSH content to activate the glyoxalase system, eliminates toxic MGO and AGEs, suppresses oxidative stress through Nrf2 activation, and alleviates apoptosis in HUVECs by inhibiting mitochondrial-dependent signaling cascades. These findings suggest that PTS may be beneficial in the treatment of diabetic vascular complications.

FOOD AND CHEMICAL TOXICOLOGY (2021)

添加到收藏夹

Review Genetics & Heredity

Lipid accumulation and novel insight into vascular smooth muscle cells in atherosclerosis

Yu-xiao Liu et al.

Summary: Atherosclerosis is a chronic and progressive disease that is crucial to cardiovascular health. Vascular smooth muscle cells (VSMCs) play a key role in atherosclerosis by undergoing phenotypic transformation and participating in various processes within plaques. Recent studies have highlighted the underestimated significance of VSMCs in atherosclerosis lesions and the importance of understanding lipid-loaded VSMCs and their regulatory mechanisms through advanced techniques.

JOURNAL OF MOLECULAR MEDICINE-JMM (2021)

添加到收藏夹

Review Medicine, Research & Experimental

A review on advances of treatment modalities for Alzheimer?s disease

Ewen Se Thoe et al.

Summary: Alzheimer's disease is a neurodegenerative disease characterized by progressive cognitive and memory impairment in older individuals. Current pharmaceutical treatments only target symptoms rather than the root cause of the disease, leading to a search for more effective therapeutic alternatives.Understanding the neuroprotective mechanisms of specific genes, antibodies, and nanoparticles is essential in designing novel therapeutic agents for Alzheimer's disease.

LIFE SCIENCES (2021)

添加到收藏夹

Review Cell Biology

Inflammation and Alzheimer's Disease: Mechanisms and Therapeutic Implications by Natural Products

Mashoque Ahmad Rather et al.

Summary: Alzheimer's disease is a neurodegenerative disorder with no clear causative event, making it challenging to diagnose and treat effectively. Recent research has focused on neuroinflammation as a target for therapy in order to slow down the progression of the disease.

MEDIATORS OF INFLAMMATION (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

The Nrf2 Pathway in Ischemic Stroke: A Review

Marcelo Farina et al.

Summary: Ischemic stroke, the sudden loss of blood flow in specific area(s) of the brain, is a leading cause of permanent disability and death worldwide. The only approved pharmacological treatment, intravenous thrombolysis with recombinant tissue plasminogen activator, has limitations and does not address the complex oxidative events in the ischemic cascade. The transcription factor Nrf2 has been identified as a potential target to mitigate oxidative events and research has shown its protective role in experimental models of ischemic stroke.

MOLECULES (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Suppression of apoptosis in vascular endothelial cell, the promising way for natural medicines to treat atherosclerosis

Huxinyue Duan et al.

Summary: Endothelial cell apoptosis is the initial step in the development of atherosclerosis, with risk factors inducing excessive apoptosis. Natural medicines have great potential in treating atherosclerosis by inhibiting endothelial cell apoptosis.

PHARMACOLOGICAL RESEARCH (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Endothelial Dysfunction in Atherosclerotic Cardiovascular Diseases and Beyond: From Mechanism to Pharmacotherapies

Suowen Xu et al.

Summary: The endothelium, a cellular monolayer lining the blood vessel wall, plays a critical role in maintaining multiorgan health and homeostasis. Dysfunction of the vascular endothelium is associated with various diseases and is implicated in severe coronavirus disease 2019. Therapeutic approaches targeting endothelial dysfunction may have potential for treatment of cardiovascular and many other diseases.

PHARMACOLOGICAL REVIEWS (2021)

添加到收藏夹

Article Neurosciences

Anticonvulsant effect of pterostilbene and its influence on the anxiety- and depression-like behavior in the pentetrazol-kindled mice: behavioral, biochemical, and molecular studies

Dorota Nieoczym et al.

Summary: Pterostilbene exhibits anticonvulsant effects in a PTZ-induced kindling mouse model, possibly mediated through increasing GABA concentrations and reducing mRNA expression of BDNF and TNF-alpha. It shows potential as a candidate for a new antiseizure drug.

PSYCHOPHARMACOLOGY (2021)

添加到收藏夹

Review Immunology

Immune Cells in the BBB Disruption After Acute Ischemic Stroke: Targets for Immune Therapy?

Yan-mei Qiu et al.

Summary: Blood-Brain Barrier (BBB) disruption is a crucial pathophysiological process in acute ischemic stroke, where the rapid activation of immune cells plays a critical role. Infiltrating immune cells increase BBB permeability, causing microvascular disorder, but also promote BBB repair and angiogenesis. Understanding the inflammatory mechanisms behind BBB disruption can lead to the development of more effective therapeutics for acute ischemic stroke.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Review Medicine, General & Internal

Effects of Antidepressant Treatment on Neurotrophic Factors (BDNF and IGF-1) in Patients with Major Depressive Disorder (MDD)

Anna Mosiolek et al.

Summary: Major depressive disorder (MDD) is a multifactorial disease with ongoing research on the role of neurotrophic factors in its pathophysiology. Antidepressant treatment can modify serum levels of neurotrophins, such as BDNF, leading to clinical improvement of MDD. Further research is needed to understand the correlation between different antidepressant drugs and neurotrophic factor serum levels.

JOURNAL OF CLINICAL MEDICINE (2021)

添加到收藏夹

Review Cell Biology

Role of Nrf2 in Synaptic Plasticity and Memory in Alzheimer's Disease

Don A. Davies et al.

Summary: Nrf2 impairments in neurodegenerative disorders, such as Alzheimer's disease, lead to oxidative stress, while Nrf2 activators can reverse memory and synaptic plasticity impairments associated with AD.

CELLS (2021)

添加到收藏夹

Review Cell Biology

Applications of CRISPR-Cas9 Technology to Genome Editing in Glioblastoma Multiforme

Nadia Al-Sammarraie et al.

Summary: CRISPR-Cas9 genome editing is crucial in elucidating the genetic regulators of GBM, particularly in vitro systems for identifying novel transcriptional regulators, while in vivo research requires further exploration.

CELLS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Activation of Nrf2/HO-1 signaling: An important molecular mechanism of herbal medicine in the treatment of atherosclerosis via the protection of vascular endothelial cells from oxidative stress

Qing Zhang et al.

Summary: This study summarized natural compounds that exert protective effects against oxidative stress in vascular endothelial cells (ECs), including phenylpropanoids, flavonoids, terpenoids, and alkaloids. These compounds alleviate EC apoptosis by activating the Nrf2/HO-1 signaling pathway, showing potential for the treatment of atherosclerosis.

JOURNAL OF ADVANCED RESEARCH (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Linking Oxidative Stress and Proteinopathy in Alzheimer's Disease

Chanchal Sharma et al.

Summary: Proteinopathy and excessive production of reactive oxygen species are key factors contributing to neuronal toxicity in Alzheimer's disease. Beta-amyloid and tau proteins play a significant role in proteinopathy in AD, which is closely related to ROS production. The mechanisms of proteinopathy and ROS production work together to drive the pathology observed in aging brains, ultimately leading to oxidative stress and neurodegeneration.

ANTIOXIDANTS (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

NADPH Oxidases (NOX): An Overview from Discovery, Molecular Mechanisms to Physiology and Pathology

Annelise Vermot et al.

Summary: NADPH oxidase (NOX) enzymes, which produce reactive oxygen species (ROS), play crucial roles in physiological processes such as immune defense, protein post-translational processing, cellular signaling, gene expression regulation, and cell differentiation. However, dysregulation of NOX can lead to various severe pathologies, making them potential therapeutic targets. Understanding the molecular mechanisms behind NOX regulation and ROS production is essential for investigating human diseases and developing new treatments.

ANTIOXIDANTS (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Oxidative Stress and Beta Amyloid in Alzheimer's Disease. Which Comes First: The Chicken or the Egg?

Elena Tamagno et al.

Summary: The pathogenesis of Alzheimer's disease involves the accumulation of beta amyloid and vulnerability of the brain to oxidative stress, which are linked to each other. It is difficult to determine which comes first, Aβ or oxidative stress. Evidence suggests that oxidative stress occurs early in the development of Alzheimer's disease and plays a crucial role in the manifestation of clinical and pathological symptoms.

ANTIOXIDANTS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Cerebroprotective effect of pterostilbene against global cerebral ischemia in rats

Mohd Muazzam Khan et al.

Summary: The study demonstrated that oral administration of pterostilbene significantly improved neurobehavioral alterations caused by ischemia-reperfusion injury in rats, while also reducing oxidative damage and maintaining normal brain function.

HELIYON (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Pattern recognition receptors in health and diseases

Danyang Li et al.

Summary: Pattern recognition receptors (PRRs) are a class of receptors that can directly recognize specific molecular structures on pathogens, apoptotic host cells, and damaged senescent cells, bridging nonspecific immunity and specific immunity. Through the recognition and binding of ligands, PRRs can produce immunoprotective effects against infections and tumors. Research on PRRs and their ligands has greatly enhanced understanding of the signaling pathways involved, providing insights for the treatment of immune-related diseases and tumors.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

添加到收藏夹

Article Psychiatry

When Anxiety and Depression Coexist: The Role of Differential Diagnosis Using Clinimetric Criteria

Fiammetta Cosci et al.

Summary: Depressive and anxiety disorders frequently coexist and their relationship is complex and multifaceted, requiring different treatment approaches based on individual patient presentations.

PSYCHOTHERAPY AND PSYCHOSOMATICS (2021)

添加到收藏夹

Article Integrative & Complementary Medicine

Mangiferin inhibited neuroinflammtion through regulating microglial polarization and suppressing NF-kappa B, NLRP3 pathway

Lei Li-Yan et al.

Summary: The study showed that mangiferin significantly reduced the production of inflammatory cytokines and oxidative products, promoted the polarization of BV2 cells towards anti-inflammatory, and inhibited the activation of NF-kappa B and NLRP3 signaling pathways. Therefore, mangiferin has anti-neuroinflammatory properties by regulating microglial macrophage polarization and suppressing NF-kappa B and NLRP3 signaling pathways.

CHINESE JOURNAL OF NATURAL MEDICINES (2021)

添加到收藏夹

Review Chemistry, Medicinal

Parkinson's Disease: A Review from Pathophysiology to Treatment

Bianca L. B. Marino et al.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2020)

添加到收藏夹

Article Medicine, Research & Experimental

Pterostilbene reduces endothelial cell injury in vascular arterial walls by regulating the Nrf2-mediated AMPK/STAT3 pathway in an atherosclerosis rat model

Tieyu Tang et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2020)

添加到收藏夹

Review Agriculture, Multidisciplinary

Occurrence, Bioavailability, Anti-inflammatory, and Anticancer Effects of Pterostilbene

Wei-Sheng Lin et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2020)

添加到收藏夹

Article Agriculture, Multidisciplinary

Effects of Selected Resveratrol Analogues on Activation and Polarization of Lipopolysaccharide-Stimulated BV-2 Microglial Cells

Liang Wang et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2020)

添加到收藏夹

Review Agriculture, Multidisciplinary

Chemistry of Pterostilbene and Its Metabolic Effects

Hyunsook Kim et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2020)

添加到收藏夹

Review Chemistry, Multidisciplinary

Small-Molecule Modulators of Toll-like Receptors

Yibo Wang et al.

ACCOUNTS OF CHEMICAL RESEARCH (2020)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Crosstalk between ER stress, NLRP3 inflammasome, and inflammation

Wei Li et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Caspase-8: The double-edged sword

Ranadip Mandal et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2020)

添加到收藏夹

Review Oncology

Immunotherapy for glioma: Current management and future application

Shengchao Xu et al.

CANCER LETTERS (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Understanding MAPK Signaling Pathways in Apoptosis

Jicheng Yue et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Review Medicine, Research & Experimental

Immune responses to stroke: mechanisms, modulation, and therapeutic potential

Costantino Iadecolar et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

添加到收藏夹

Article Clinical Neurology

Pediatric Glioma Outcomes: Predictors of Early Mortality

Xingwang Zhou et al.

WORLD NEUROSURGERY (2020)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Pterostilbene induces Nrf2/HO-1 and potentially regulates NF-κB and JNK-Akt/mTOR signaling in ischemic brain injury in neonatal rats

Qinghuang Zeng et al.

3 BIOTECH (2020)

添加到收藏夹

Review Neurosciences

Mitochondria dysfunction in the pathogenesis of Alzheimer's disease: recent advances

Wenzhang Wang et al.

MOLECULAR NEURODEGENERATION (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

The Novel Role of PPAR Alpha in the Brain: Promising Target in Therapy of Alzheimer's Disease and Other Neurodegenerative Disorders

Sylwia Wojtowicz et al.

NEUROCHEMICAL RESEARCH (2020)

添加到收藏夹

Review Cell Biology

Inflammation and Oxidative Stress in Multiple Sclerosis: Consequences for Therapy Development

Valentina Pegoretti et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Icariside II attenuates cerebral ischemia/reperfusion-induced blood-brain barrier dysfunction in rats via regulating the balance of MMP9/TIMP1

Mu-bo Liu et al.

ACTA PHARMACOLOGICA SINICA (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Matrix Metalloproteinases as Biomarkers of Atherosclerotic Plaque Instability

Wioletta Olejarz et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Involvement of p38 MAPK in Synaptic Function and Dysfunction

Chiara Falcicchia et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Review Immunology

Interaction of Microglia and Astrocytes in the Neurovascular Unit

Li-rong Liu et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹

Review Behavioral Sciences

Key Mechanisms and Potential Targets of the NLRP3 Inflammasome in Neurodegenerative Diseases

Yadi Guan et al.

FRONTIERS IN INTEGRATIVE NEUROSCIENCE (2020)

添加到收藏夹

Review Cell Biology

ERK signalling: a master regulator of cell behaviour, life and fate

Hugo Lavoie et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

添加到收藏夹

Article Cell Biology

Pterostilbene Attenuates Cocultured BV-2 Microglial Inflammation-Mediated SH-SY5Y Neuronal Oxidative Injury via SIRT-1 Signalling

Qiang Zhu et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

添加到收藏夹

Article Medicine, Research & Experimental

Pterostilbene reduces endothelial cell apoptosis by regulation of the Nrf2-mediated TLR-4/MyD88/NF-κB pathway in a rat model of atherosclerosis

Xiaowei Xiong et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Pterostilbene complexed with cyclodextrin exerts antimicrobial and anti-inflammatory effects

Yi Rong Ivan Lim et al.

SCIENTIFIC REPORTS (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer

Luca Colucci-D'Amato et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Review Medicine, Research & Experimental

The role of CREB and BDNF in neurobiology and treatment of Alzheimer's disease

Meysam Amidfar et al.

LIFE SCIENCES (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Comparative Effects of Pterostilbene and Its Parent Compound Resveratrol on Oxidative Stress and Inflammation in Steatohepatitis Induced by High-Fat High-Fructose Feeding

Saioa Gomez-Zorita et al.

ANTIOXIDANTS (2020)

添加到收藏夹

Review Cell Biology

The involvement of NLRP3 inflammasome in the treatment of Alzheimer's disease

Ya-Shuo Feng et al.

AGEING RESEARCH REVIEWS (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Can We Treat Neuroinflammation in Alzheimer's Disease?

Sandra Sanchez-Sarasua et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Comprehensive Review on Alzheimer's Disease: Causes and Treatment

Zeinab Breijyeh et al.

MOLECULES (2020)

添加到收藏夹

Review Oncology

Characterizing Cell Stress and GRP78 in Glioma to Enhance Tumor Treatment

Kristie Liu et al.

FRONTIERS IN ONCOLOGY (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Recent Advances in Synthesis, Bioactivity, and Pharmacokinetics of Pterostilbene, an Important Analog of Resveratrol

Yeju Liu et al.

MOLECULES (2020)

添加到收藏夹

Review Pharmacology & Pharmacy

The uses of resveratrol for neurological diseases treatment and insights for nanotechnology based-drug delivery systems

Bruno Fonseca-Santos et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

添加到收藏夹

Article Clinical Neurology

Epilepsy-Definition, Classification, Pathophysiology, and Epidemiology

Jessica Falco-Walter

SEMINARS IN NEUROLOGY (2020)

添加到收藏夹

Review Cell Biology

Mechanisms of Acupuncture in the Regulation of Oxidative Stress in Treating Ischemic Stroke

Xin-Tong Su et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study

Hui Yu et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Pterostilbene alleviates cerebral ischemia and reperfusion injury in rats by modulating microglial activation

Jingyu Liu et al.

FOOD & FUNCTION (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Comparison of the effects of resveratrol and its derivative pterostilbene on hepatic oxidative stress and mitochondrial dysfunction in piglets challenged with diquat

Hao Zhang et al.

FOOD & FUNCTION (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Tissue-specific regulation of cytochrome c by post-translational modifications: respiration, the mitochondrial membrane potential, ROS, and apoptosis

Hasini A. Kalpage et al.

FASEB JOURNAL (2019)

添加到收藏夹

Review Neurosciences

The sinister face of heme oxygenase-1 in brain aging and disease

Hyman M. Schipper et al.

PROGRESS IN NEUROBIOLOGY (2019)

添加到收藏夹

Review Cell Biology

Microglia in Alzheimer's disease: A target for immunotherapy

Shoutang Wang et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2019)

添加到收藏夹

Review Medicine, General & Internal

Epilepsy in adults

Roland D. Thijs et al.

LANCET (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Targeting PI3K in cancer: mechanisms and advances in clinical trials

Jing Yang et al.

MOLECULAR CANCER (2019)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities

Magnus Back et al.

NATURE REVIEWS CARDIOLOGY (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Anticonvulsant Activity of Pterostilbene in Zebrafish and Mouse Acute Seizure Tests

Dorota Nieoczym et al.

NEUROCHEMICAL RESEARCH (2019)

添加到收藏夹

Review Immunology

Activation of microglia and astrocytes: a roadway to neuroinflammation and Alzheimer's disease

Darshpreet Kaur et al.

INFLAMMOPHARMACOLOGY (2019)

添加到收藏夹

Review Medical Laboratory Technology

Clinical aspects of Alzheimer's disease

Martina Zverova

CLINICAL BIOCHEMISTRY (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Resveratrol and Vascular Function

Huige Li et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

添加到收藏夹

Review Nanoscience & Nanotechnology

Curcumin-loaded nanoparticles: a novel therapeutic strategy in treatment of central nervous system disorders

Hanie Yavarpour-Bali et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Vascular smooth muscle cells in atherosclerosis

Gemma L. Basatemur et al.

NATURE REVIEWS CARDIOLOGY (2019)

添加到收藏夹

Review Cell Biology

Targeting Early Atherosclerosis: A Focus on Oxidative Stress and Inflammation

Patricia Marchio et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

添加到收藏夹

Review Clinical Neurology

Early Brain Injury After Poor-Grade Subarachnoid Hemorrhage

Verena Rass et al.

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Cytochrome c: An extreme multifunctional protein with a key role in cell fate

Roberto Santucci et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Selecting an Appropriate Animal Model of Depression

Yuanzhen Hao et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

添加到收藏夹

Review Biology

Nature brings new avenues to the therapy of central nervous system diseases-An overview of possible treatments derived from natural products

Junchi Zhang et al.

SCIENCE CHINA-LIFE SCIENCES (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Creatine for the Treatment of Depression

Brent M. Kious et al.

BIOMOLECULES (2019)

添加到收藏夹

Review Neurosciences

Sexually dimorphic microglia and ischemic stroke

Nadine Kerr et al.

CNS NEUROSCIENCE & THERAPEUTICS (2019)

添加到收藏夹

Article Agriculture, Multidisciplinary

Pterostilbene Attenuates Experimental Atherosclerosis through Restoring Catalase-Mediated Redox Balance in Vascular Smooth Muscle Cells

Wei Wang et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2019)

添加到收藏夹

Review Nutrition & Dietetics

Oxidative Stress in Cardiovascular Diseases: Still a Therapeutic Target?

Thomas Senoner et al.

NUTRIENTS (2019)

添加到收藏夹

Article Immunology

Pterostilbene Attenuates Astrocytic Inflammation and Neuronal Oxidative Injury After Ischemia-Reperfusion by Inhibiting NF-κB Phosphorylation

Haixiao Liu et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹

Review Cell & Tissue Engineering

White Matter Injury in Early Brain Injury after Subarachnoid Hemorrhage

Jinwei Pang et al.

CELL TRANSPLANTATION (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Endothelial cell apoptosis and the role of endothelial cell-derived extracellular vesicles in the progression of atherosclerosis

Stephanie Paone et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2019)

添加到收藏夹

Review Engineering, Biomedical

Nanomaterial-based blood-brain-barrier (BBB) crossing strategies

Jinbing Xie et al.

BIOMATERIALS (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

p62/SQSTM1: 'Jack of all trades' in health and cancer

Pablo Sanchez-Martin et al.

FEBS JOURNAL (2019)

添加到收藏夹

Review Neurosciences

Treatment Combinations for Alzheimer's Disease: Current and Future Pharmacotherapy Options

Jeffrey L. Cummings et al.

JOURNAL OF ALZHEIMERS DISEASE (2019)

添加到收藏夹

Review Clinical Neurology

Metabolic reprogramming in the pathogenesis of glioma: Update

Kenta Masui et al.

NEUROPATHOLOGY (2019)

添加到收藏夹

Article Neurosciences

Pterostilbene, an active component of the dragon's blood extract, acts as an antidepressant in adult rats

Liang Yang et al.

PSYCHOPHARMACOLOGY (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Microglia in Central Nervous System Inflammation and Multiple Sclerosis Pathology

Sofie Voet et al.

TRENDS IN MOLECULAR MEDICINE (2019)

添加到收藏夹

Article Cell Biology

Neuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke

Changjun Yang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2019)

添加到收藏夹

Article Oncology

Catalpol induces cell activity to promote axonal regeneration via the PI3K/AKT/mTOR pathway in vivo and in vitro stroke model

Jinghuan Wang et al.

ANNALS OF TRANSLATIONAL MEDICINE (2019)

添加到收藏夹

Review Immunology

Molecular mechanisms underlying prostaglandin E2-exacerbated inflammation and immune diseases

Kyoshiro Tsuge et al.

INTERNATIONAL IMMUNOLOGY (2019)

添加到收藏夹

Review Immunology

The NLRP3 inflammasome: molecular activation and regulation to therapeutics

Karen V. Swanson et al.

NATURE REVIEWS IMMUNOLOGY (2019)

添加到收藏夹

Article Cell Biology

Blood-brain barrier dysfunction in ischemic stroke: targeting tight junctions and transporters for vascular protection

Wazir Abdullahi et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Nrf2-Keap1 signaling in oxidative and reductive stress

Ilaria Bellezza et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Antiobesity molecular mechanisms of action: Resveratrol and pterostilbene

Min-Hsiung Pan et al.

BIOFACTORS (2018)

添加到收藏夹

Article Medicine, Research & Experimental

Schisandrin A prevents oxidative stress-induced DNA damage and apoptosis by attenuating ROS generation in C2C12 cells

Yung Hyun Choi

BIOMEDICINE & PHARMACOTHERAPY (2018)

添加到收藏夹

Review Oncology

The multifaceted role of glutathione S-transferases in cancer

Anupam Chatterjee et al.

CANCER LETTERS (2018)

添加到收藏夹

Review Pharmacology & Pharmacy

Heme Oxygenase-1: Clinical Relevance in Ischemic Stroke

Daniel Bereczki et al.

CURRENT PHARMACEUTICAL DESIGN (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Migration/Invasion of Malignant Gliomas and Implications for Therapeutic Treatment

Ching-Ann Liu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Biological Activities of Stilbenoids

Bolanle C. Akinwumi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

添加到收藏夹

Review Neurosciences

Oxidative Stress, Amyloid-beta Peptide, and Altered Key Molecular Pathways in the Pathogenesis and Progression of Alzheimer's Disease

D. Allan Butterfield et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

添加到收藏夹

Review Neurosciences

Multimodal Neuroimaging in Alzheimer's Disease: Early Diagnosis, Physiopathological Mechanisms, and Impact of Lifestyle

Gael Chetelat

JOURNAL OF ALZHEIMERS DISEASE (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Pterostilbene inhibits amyloid--induced neuroinflammation in a microglia cell line by inactivating the NLRP3/caspase-1 inflammasome pathway

Qiushi Li et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2018)

添加到收藏夹

Review Medicine, General & Internal

The management of epilepsy in children and adults

Piero Perucca et al.

MEDICAL JOURNAL OF AUSTRALIA (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Pterostilbene and 4-Methoxyresveratrol Inhibited Lipopolysaccharide-Induced Inflammatory Response in RAW264.7 Macrophages

Yun Yao et al.

MOLECULES (2018)

添加到收藏夹

Review Cell Biology

Nrf2 at the heart of oxidative stress and cardiac protection

Qin M. Chen et al.

PHYSIOLOGICAL GENOMICS (2018)

添加到收藏夹

Review Clinical Neurology

The cerebellum in fear and anxiety-related disorders

Josep Moreno-Rius

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2018)

添加到收藏夹

Article Neurosciences

Blood-brain barrier dysfunction and recovery after ischemic stroke

Xiaoyan Jiang et al.

PROGRESS IN NEUROBIOLOGY (2018)

添加到收藏夹

Review Medical Laboratory Technology

Nrf2-p62 autophagy pathway and its response to oxidative stress in hepatocellular carcinoma

Desiree Bartolini et al.

TRANSLATIONAL RESEARCH (2018)

添加到收藏夹

Review Neurosciences

Clinical Research on Alzheimer's Disease: Progress and Perspectives

Bin-Lu Sun et al.

NEUROSCIENCE BULLETIN (2018)

添加到收藏夹

Review Nutrition & Dietetics

Toll-Like Receptors: Regulators of the Immune Response in the Human Gut

Hubert Hug et al.

NUTRIENTS (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Oxidative stress and the amyloid beta peptide in Alzheimer's disease

C. Cheignon et al.

REDOX BIOLOGY (2018)

添加到收藏夹

Article Medicine, General & Internal

The Diagnosis and Treatment of Anxiety Disorders

Andreas Stroehle et al.

DEUTSCHES ARZTEBLATT INTERNATIONAL (2018)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Matrix metalloproteinases in pro-atherosclerotic arterial remodeling

Veronika A. Myasoedova et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2018)

添加到收藏夹

Review Medicine, General & Internal

Depression

Gin S. Malhi et al.

LANCET (2018)

添加到收藏夹

Article Cell Biology

Uric Acid Protects against Focal Cerebral Ischemia/Reperfusion-Induced Oxidative Stress via Activating Nrf2 and Regulating Neurotrophic Factor Expression

Bai-liu Ya et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)

添加到收藏夹

Article Medicine, General & Internal

Multiple sclerosis

Massimo Filippi et al.

NATURE REVIEWS DISEASE PRIMERS (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Resveratrol provides neuroprotection by regulating the JAK2/STAT3/PI3K/AKT/mTOR pathway after stroke in rats

Yongying Hou et al.

GENES & DISEASES (2018)

添加到收藏夹

Review Clinical Neurology

Alzheimer's Disease and NQO1: Is there a Link?

Jamuna Chhetri et al.

CURRENT ALZHEIMER RESEARCH (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Targeting cancer stem cells and signaling pathways by resveratrol and pterostilbene

Lingling Zhang et al.

BIOFACTORS (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Research Progress on the Relationship between Atherosclerosis and Inflammation

Yuhua Zhu et al.

BIOMOLECULES (2018)

添加到收藏夹

Review Medicine, Research & Experimental

Neurotrophin signalling: novel insights into mechanisms and pathophysiology

Mariela Mitre et al.

CLINICAL SCIENCE (2017)

添加到收藏夹

Article Neurosciences

Pterostilbene ameliorates intracerebroventricular streptozotocin induced memory decline in rats

Bhagyashree Naik et al.

COGNITIVE NEURODYNAMICS (2017)

添加到收藏夹

Article Neurosciences

Pterostilbene Attenuates Early Brain Injury Following Subarachnoid Hemorrhage via Inhibition of the NLRP3 Inflammasome and Nox2-Related Oxidative Stress

Haixiao Liu et al.

MOLECULAR NEUROBIOLOGY (2017)

添加到收藏夹

Review Oncology

Advances in the molecular genetics of gliomas - implications for classification and therapy

Guido Reifenberger et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2017)

添加到收藏夹

Review Neurosciences

Efficacy of Antidepressants for Depression in Alzheimer's Disease: Systematic Review and Meta-Analysis

Vasiliki Orgeta et al.

JOURNAL OF ALZHEIMERS DISEASE (2017)

添加到收藏夹

Article Neurosciences

Mitochondrial function in hypoxic ischemic injury and influence of aging

P. Benson Ham et al.

PROGRESS IN NEUROBIOLOGY (2017)

添加到收藏夹

Article Toxicology

The effect of resveratrol, its naturally occurring derivatives and tannic acid on the induction of cell cycle arrest and apoptosis in rat C6 and human T98G glioma cell lines

Malgorzata Zielinska-Przyjemska et al.

TOXICOLOGY IN VITRO (2017)

添加到收藏夹

Article Neurosciences

HO-1 Signaling Activation by Pterostilbene Treatment Attenuates Mitochondrial Oxidative Damage Induced by Cerebral Ischemia Reperfusion Injury

Yang Yang et al.

MOLECULAR NEUROBIOLOGY (2016)

添加到收藏夹

Article Medicine, Research & Experimental

Pterostilbene, a novel natural plant conduct, inhibits high fat-induced atherosclerosis inflammation via NF-κB signaling pathway in Toll-like receptor 5 (TLR5) deficient mice

Yuan Zhang et al.

BIOMEDICINE & PHARMACOTHERAPY (2016)

添加到收藏夹

Review Neurosciences

Brain-derived Neurotrophic Factor (BDNF)-TrkB Signaling in Inflammation-related Depression and Potential Therapeutic Targets

Ji-chun Zhang et al.

CURRENT NEUROPHARMACOLOGY (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Pterostilbene exerts an anti-inflammatory effect via regulating endoplasmic reticulum stress in endothelial cells

Jun Liu et al.

CYTOKINE (2016)

添加到收藏夹

Article Pharmacology & Pharmacy

Promising therapeutic potential of pterostilbene and its mechanistic insight based on preclinical evidence

Ramoji Kosuru et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2016)

添加到收藏夹

Article Developmental Biology

Neuroprotective actions of pterostilbene on hypoxic-ischemic brain damage in neonatal rats through upregulation of heme oxygenase-1

Dan Li et al.

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE (2016)

添加到收藏夹

Review Clinical Neurology

The oral health of people with anxiety and depressive disorders a systematic review and meta-analysis

Steve Kisely et al.

JOURNAL OF AFFECTIVE DISORDERS (2016)

添加到收藏夹

Review Behavioral Sciences

GABA-ergic cell therapy for epilepsy: Advances, limitations and challenges

Ashok K. Shetty et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2016)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Production of highly bioactive resveratrol analogues pterostilbene and piceatannol in metabolically engineered grapevine cell cultures

Ascension Martinez-Marquez et al.

PLANT BIOTECHNOLOGY JOURNAL (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Effects of piceatannol and pterostilbene against β-amyloid-induced apoptosis on the PI3K/Akt/Bad signaling pathway in PC12 cells

Zheng Fu et al.

FOOD & FUNCTION (2016)

添加到收藏夹

Article Food Science & Technology

Pterostilbene Inhibits Vascular Smooth Muscle Cells Migration and Matrix Metalloproteinase-2 through Modulation of MAPK Pathway

Hsing-Chun Lin et al.

JOURNAL OF FOOD SCIENCE (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

Pterostilbene suppressed irradiation-resistant glioma stem cells by modulating GRP78/miR-205 axis

Thanh-Tuan Huynh et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2015)

添加到收藏夹

Article Chemistry, Analytical

UPLC-MS method for quantification of pterostilbene and its application to comparative study of bioavailability and tissue distribution in normal and Lewis lung carcinoma bearing mice

Li Deng et al.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2015)

添加到收藏夹

Review Biochemistry & Molecular Biology

Effects of pterostilbene and resveratrol on brain and behavior

Shibu M. Poulose et al.

NEUROCHEMISTRY INTERNATIONAL (2015)

添加到收藏夹

Article Behavioral Sciences

Orally administrated pterostilbene attenuates acute cerebral ischemia-reperfusion injury in a dose- and time-dependent manner in mice

Yu Zhou et al.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2015)

添加到收藏夹

Article Plant Sciences

Pterostilbene, an Active Constituent of Blueberries, Stimulates Nitric Oxide Production via Activation of Endothelial Nitric Oxide Synthase in Human Umbilical Vein Endothelial Cells

Seong Hoon Park et al.

PLANT FOODS FOR HUMAN NUTRITION (2015)

添加到收藏夹

Article Food Science & Technology

Pharmacokinetics and tissue distribution of pterostilbene in the rat

Michele Azzolini et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2014)

添加到收藏夹

Article Clinical Neurology

Pterostilbene attenuates lipopolysaccharide-induced learning and memory impairment possibly via inhibiting microglia activation and protecting neuronal injury in mice

Yue Hou et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2014)

添加到收藏夹

Review Biochemistry & Molecular Biology

Role of the peroxisome proliferator-activated receptors (PPAR)-α, β/δ and γ triad in regulation of reactive oxygen species signaling in brain

Stepan Aleshin et al.

BIOLOGICAL CHEMISTRY (2013)

添加到收藏夹

Article Food Science & Technology

Pharmacokinetics of pterostilbene in Sprague-Dawley rats: The impacts of aqueous solubility, fasting, dose escalation, and dosing route on bioavailability

Samuel Chao Ming Yeo et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2013)

添加到收藏夹

Article Plant Sciences

Anxiolytic Action of Pterostilbene: Involvement of Hippocampal ERK Phosphorylation

Md. Al Rahim et al.

PLANTA MEDICA (2013)

添加到收藏夹

Article Toxicology

Analysis of Safety from a Human Clinical Trial with Pterostilbene

Daniel M. Riche et al.

JOURNAL OF TOXICOLOGY (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

Pterostilbene protects vascular endothelial cells against oxidized low-density lipoprotein-induced apoptosis in vitro and in vivo

Lu Zhang et al.

APOPTOSIS (2012)

添加到收藏夹

Review Agriculture, Multidisciplinary

Influence of Berry Polyphenols on Receptor Signaling and Cell-Death Pathways: Implications for Breast Cancer Prevention

Harini S. Aiyer et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2012)

添加到收藏夹

Article Geriatrics & Gerontology

Low-dose pterostilbene, but not resveratrol, is a potent neuromodulator in aging and Alzheimer's disease

Jaewon Chang et al.

NEUROBIOLOGY OF AGING (2012)

添加到收藏夹

Article Oncology

Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats

Izet M. Kapetanovic et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2011)

添加到收藏夹

Article Oncology

Anti-inflammatory Action of Pterostilbene Is Mediated through the p38 Mitogen-Activated Protein Kinase Pathway in Colon Cancer Cells

Shiby Paul et al.

CANCER PREVENTION RESEARCH (2009)

添加到收藏夹

Article Agriculture, Multidisciplinary

Dietary Administration of High Doses of Pterostilbene and Quercetin to Mice Is Not Toxic

M. J. Ruiz et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2009)

添加到收藏夹

Article Psychiatry

Role of extracellular signal-regulated kinase signal transduction pathway in anxiety

Fu Ailing et al.

JOURNAL OF PSYCHIATRIC RESEARCH (2008)

添加到收藏夹

Article Neurosciences

Regulatory mechanisms of fear extinction and depression-like behavior

Natalie C. Tronson et al.

NEUROPSYCHOPHARMACOLOGY (2008)

添加到收藏夹

Article Agriculture, Multidisciplinary

Pterostilbene, a new agonist for the peroxisome proliferator-activated receptor α-isoform, lowers plasma lipoproteins and cholesterol in hypercholesterolemic hamsters

AM Rimando et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2005)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Oxidized low density lipoprotein Potentiation of Fas-induced apoptosis through lectin-like oxidized-low density lipoprotein receptor-1 in human umbilical vascular endothelial cells

T Imanishi et al.

CIRCULATION JOURNAL (2002)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.