☆ 4.7 Article

Discovery of Novel Aminocyclobutanecarboxylic Acid Derivatives as Succinate Dehydrogenase Inhibitors

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Agriculture, Multidisciplinary

Design, Synthesis, and Fungicidal Evaluation of Novel N-Methoxy Pyrazole-4-Carboxamides as Potent Succinate Dehydrogenase Inhibitors

Hua Li et al.

Summary: Based on the binding mode of pydiflumetofen with SDH, the carbon-carbon double bond was introduced into pydiflumetofen to produce target compounds 6a-6o. The SAR study showed that the 2-position and 4-position in the terminal benzene were positively correlated with increased activity. Compound 6o exhibited good control effects against WPM, CPM, and SCR, showing its broad-spectrum property. Especially, compound 6o showed higher control effects against CPM and SCR compared to pydiflumetofen, indicating its potential for further development.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2023)

添加到收藏夹

Article Agriculture, Multidisciplinary

Multiple Mutations in SDHB and SDHC2 Subunits Confer Resistance to the Succinate Dehydrogenase Inhibitor Cyclobutrifluram in Fusarium fujikuroi

Zhaolin Xue et al.

Summary: Fusarium fujikuroi, a dominant phytopathogenic fungus causing rice bakanae disease, is shown to be inhibited by the novel succinate dehydrogenase inhibitor cyclobutrifluram. Mutations in FfSdhB (H248L/Y) and FfSdhC2 (G80R or A83V) were found to confer resistance to cyclobutrifluram in F. fujikuroi, leading to decreased affinity between the drug and FfSdhs.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2023)

添加到收藏夹

Article Agriculture, Multidisciplinary

Molecular Basis for the Selectivity of the Succinate Dehydrogenase Inhibitor Cyflumetofen between Pest and Predatory Mites

Jinhang Li et al.

Summary: Acaricides that inhibit mitochondrial succinate dehydrogenase (SDHI) have strong control over phytophagous mites but limited toxicity to predatory mites. This study reveals that the selectivity of SDHI acaricides is mainly due to the stronger inhibition on the SDH target in spider mites compared to predatory mites. The findings provide insights for the rational design of selective acaricides in integrated pest management.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2023)

添加到收藏夹

Review Chemistry, Multidisciplinary

Bcs1, a novel target for fungicide

Jingyu Zhan et al.

Summary: The mitochondrial respiratory chain is a crucial target for fungicide development due to its important role in cellular functions. However, the emergence of resistance to these fungicides has prompted the search for novel targets, with mitochondrial AAA protein Bcs1 being a promising candidate. Recent progress in understanding the structure and function of Bcs1 has provided new prospects for fungicide design.

FRONTIERS IN CHEMISTRY (2023)

添加到收藏夹

Article Multidisciplinary Sciences

Join the green team: Inducers of plant immunity in the plant disease sustainable control toolbox

Feng Zhu et al.

Journal of Advanced Research (2023)

添加到收藏夹

Review Biochemistry & Molecular Biology

Antifungal Drug Resistance: An Emergent Health Threat

Antonio Vitiello et al.

Summary: Fungal infections, especially drug-resistant forms like Candida and Aspergillus spp., are increasing in prevalence and causing severe diseases. This is primarily due to the growing number of immunocompromised patients and the emergence of resistant strains. Unlike bacterial infections which have a wide array of antimicrobial drugs, there are only a few classes of antifungal drugs available, leading to a limited therapeutic armamentarium. This review provides a comprehensive overview of systemic mycosis, current antifungal drug compounds, and the molecular mechanisms of antifungal resistance.

BIOMEDICINES (2023)

添加到收藏夹

Review Agriculture, Multidisciplinary

Comprehensive Overview of Carboxamide Derivatives as Succinate Dehydrogenase Inhibitors

Bo Luo et al.

Summary: This review summarizes the importance of carboxamide derivatives as SDHIs and the structure-activity relationships of their antifungal activities. It also introduces the reasons behind SDHIs resistance and potential solutions, as well as prospects the development trend of SDHIs fungicides.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2022)

添加到收藏夹

Article Agronomy

Design, synthesis, and fungicidal activity of novel N-substituted piperazine-containing phenylpyridines against cucumber downy mildew

Ying Xu et al.

Summary: This study presents the design and synthesis of a series of novel phenylpyridine derivatives. Bioassays demonstrated that most of these compounds exhibited excellent fungicidal activities against cucumber downy mildew (CDM). Among the phenylpyridine compounds, 2-(4-(4-(tert-butyl) benzyl)piperazin-1-yl)-6-phenylnicotinonitrile (C8) showed the highest activity, surpassing that of commercial fungicides. The molecular electrostatic potential analysis of compound C8 suggested its potential for hydrogen bonding and electrostatic interactions.

PEST MANAGEMENT SCIENCE (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

The research progress in and perspective of potential fungicides: Succinate dehydrogenase inhibitors

Shuqi Li et al.

Summary: Succinate dehydrogenase inhibitors (SDHIs) are a rapidly growing class of new fungicides with high activity and a broad spectrum. By inhibiting the activity of succinate dehydrogenase, they disrupt mitochondrial respiration and kill pathogenic fungi, making them popular among major pesticide companies worldwide for research and development.

BIOORGANIC & MEDICINAL CHEMISTRY (2021)

添加到收藏夹

Article Agriculture, Multidisciplinary

Azo-incorporating Increases Inhibitory Activity of Succinate Dehydrogenase

Wen Fu et al.

Summary: This study introduced a new fungicide developed using azo groups, with compound 9d showing improved antifungal activity and enzyme inhibition towards succinate dehydrogenase. The results suggest a new strategy for pesticide discovery through the incorporation of azobenzene derivatives.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

添加到收藏夹

News Item Chemistry, Multidisciplinary

Building bridges

Cara E. Brocklehurst et al.

NATURE CHEMISTRY (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

An intramolecular coupling approach to alkyl bioisosteres for the synthesis of multisubstituted bicycloalkyl boronates

Yangyang Yang et al.

Summary: This study presents a novel approach for the synthesis of multisubstituted BCPs via intramolecular cyclization, enabling the construction of underexplored multisubstituted BCPs from readily accessible cyclobutanones. The method demonstrates broad generality through the synthesis of a variety of other caged bicyclic molecules, highlighting the ability to enable the programmed and divergent synthesis of multisubstituted bicyclic hydrocarbons.

NATURE CHEMISTRY (2021)

添加到收藏夹

Article Agriculture, Multidisciplinary

Novel Pyrazole-4-acetohydrazide Derivatives Potentially Targeting Fungal Succinate Dehydrogenase: Design, Synthesis, Three-Dimensional Quantitative Structure-Activity Relationship, and Molecular Docking

Xiaobin Wang et al.

Summary: It has been found that the pyrazole-4-acetohydrazide derivatives targeting fungal SDH have high antifungal efficacy, with significantly superior performance compared to existing fungicides.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

添加到收藏夹

Article Agronomy

Synthesis and fungicidal activity of novel benzimidazole derivatives bearing pyrimidine-thioether moiety against Botrytis cinerea

Changxing Sun et al.

Summary: The study designed and synthesized novel benzimidazole derivatives with pyrimidine and thioether moieties, some of which showed higher fungicidal activities than carbendazim. Molecular docking and electrostatic potential analysis revealed the interaction mechanism between one compound (4m) and the target protein.

PEST MANAGEMENT SCIENCE (2021)

添加到收藏夹

Article Agronomy

Studies on the novel pyridine sulfide containing SDH based heterocyclic amide fungicide

Xuewen Hua et al.

PEST MANAGEMENT SCIENCE (2020)

添加到收藏夹

Review Agriculture, Multidisciplinary

Diaryl Ether: A Privileged Scaffold for Drug and Agrochemical Discovery

Tao Chen et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2020)

添加到收藏夹

Article Agriculture, Multidisciplinary

Discovery of Pyrazine-Carboxamide-Diphenyl-Ethers as Novel Succinate Dehydrogenase Inhibitors via Fragment Recombination

Hua Li et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2020)

添加到收藏夹

Article Agriculture, Multidisciplinary

Design, Synthesis, and Antifungal Activities of Novel Aromatic Carboxamides Containing a Diphenylamine Scaffold

Aigui Zhang et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2019)

添加到收藏夹

Article Multidisciplinary Sciences

A fungal substrate mimicking molecule suppresses plant immunity via an inter-kingdom conserved motif

Johana C. Misas Villamil et al.

NATURE COMMUNICATIONS (2019)

添加到收藏夹

Article Agriculture, Multidisciplinary

Synthesis of Thiazolium-Labeled 1,3,4-Oxadiazole Thioethers as Prospective Antimicrobials: In Vitro and in Vivo Bioactivity and Mechanism of Action

Ming-Wei Wang et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2019)

添加到收藏夹

Article Chemistry, Organic

TCFH-NMI: Direct Access to N-Acyl Imidazoliums for Challenging Amide Bond Formations

Gregory L. Beutner et al.

ORGANIC LETTERS (2018)

添加到收藏夹

Review Multidisciplinary Sciences

Worldwide emergence of resistance to antifungal drugs challenges human health and food security

Matthew C. Fisher et al.

SCIENCE (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Cooperative interactions between seed-borne bacterial and air-borne fungal pathogens on rice

Boknam Jung et al.

NATURE COMMUNICATIONS (2018)

添加到收藏夹

Article Chemistry, Medicinal

Design, synthesis and antifungal evaluation of novel pyrazole carboxamides with diarylamines scaffold as potent succinate dehydrogenase inhibitors

Aigui Zhang et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2018)

添加到收藏夹

Article Agriculture, Multidisciplinary

Structure-Based Discovery of Potential Fungicides as Succinate Ubiquinone Oxidoreductase Inhibitors

Li Xiong et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2017)

添加到收藏夹

Article Agronomy

Design, synthesis and biological evaluation of novel nicotinamide derivatives bearing a substituted pyrazole moiety as potential SDH inhibitors

Xian-Hai Lv et al.

PEST MANAGEMENT SCIENCE (2017)

添加到收藏夹

Article Agronomy

Biological characterization of fenpicoxamid, a new fungicide with utility in cereals and other crops

W. John Owen et al.

PEST MANAGEMENT SCIENCE (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Synthesis, fungicidal activity and phloem mobility of phenazine-1-carboxylic acid-alanine conjugates

Junfan Niu et al.

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

Synthesis and biological evaluation of novel pyrazole carboxamide with diarylamine-modified scaffold as potent antifungal agents

Xiao-Xiao Zhang et al.

CHINESE CHEMICAL LETTERS (2017)

添加到收藏夹

Article Chemistry, Medicinal

Discovery of a 2′-fluoro-2′-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties

Thorsten A. Kirschberg et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2017)

添加到收藏夹

Article Chemistry, Medicinal

Aza follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor. Part 1: Mitigating the genotoxic liability of an aniline metabolite

Pierre L. Beaulieu et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2015)

添加到收藏夹

Article Chemistry, Medicinal

New Frontiers in Druggability

Dima Kozakov et al.

JOURNAL OF MEDICINAL CHEMISTRY (2015)

添加到收藏夹

Article Agriculture, Multidisciplinary

Binding Difference of Fipronil with GABAARs in Fruitfly and Zebrafish: Insights from Homology Modeling, Docking, and Molecular Dynamics Simulation Studies

Nan Zheng et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2014)

添加到收藏夹

Review Biochemistry & Molecular Biology

Mitochondria: In Sickness and in Health

Jodi Nunnari et al.

CELL (2012)

添加到收藏夹

Article Chemistry, Multidisciplinary

Multiwfn: A multifunctional wavefunction analyzer

Tian Lu et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2012)

添加到收藏夹

Article Chemistry, Medicinal

Real External Predictivity of QSAR Models: How To Evaluate It? Comparison of Different Validation Criteria and Proposal of Using the Concordance Correlation Coefficient

Nicola Chirico et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2011)

添加到收藏夹

Article Chemistry, Medicinal

A Comparative Study on the Constitutive Properties of Marketed Pesticides

Gefei Hao et al.

MOLECULAR INFORMATICS (2011)

添加到收藏夹

Article Agriculture, Multidisciplinary

Primary Study on Mode of Action for Macrocyclic Fungicide Candidates (7B3, D1) against Rhizoctonia solani Kuhn

Xiaojing Yan et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2010)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.