Edge-centric functional network analyses reveal disrupted network configuration in autism spectrum disorder

Background: Neuroscientific evidence suggests that the pathological symptoms associated with autism spectrum disorders (ASD) are not confined to a single brain region but involve networks of the brain on a larger spatial scale. Analyzing diagrams of edge-edge interactions could provide important perspectives on the organization and function of complex systems. Methods: Resting-state fMRI data from 238 ASD patients and 311 healthy controls (HCs) were included in the current study. We used the thalamus as the mediating node to calculate the edge functional connectivity (eFC) of the brain network and compared the ASD subjects and HCs. Results: Compared with the HCs, the ASD subjects exhibited abnormalities in the central node thalamus and four brain regions (amygdala, nucleus accumbens, pallidum and hippocampus), as well as in the eFC formed by the inferior frontal gyrus (IFG) (or middle temporal gyrus (MTG)). In addition, ASD subjects showed variable characteristics of the eFC between nodes in different networks. Conclusions: The changes in these brain regions may be due to the disturbance in the reward system, which leads to coherence in the instantaneous comovement of the functional connections formed by these brain regions in ASD. This notion also reveals a functional network feature between the cortical and subcortical regions in ASD.

Automated summary

Neuroscientific evidence suggests that the pathological symptoms associated with autism spectrum disorders (ASD) involve networks of the brain on a larger spatial scale. Analyzing edge-edge interactions can provide important insights on the organization and function of complex systems. Using resting-state fMRI data, this study compares brain connectivity in 238 ASD patients and 311 healthy controls, finding abnormalities in key brain regions and functional connections that may be related to disturbances in the reward system and functional network features in ASD.