Comment on 'A comparative analysis of antidepressant and anti-suicidal effects of repeated ketamine infusions in elderly and younger adults with depression'

Review Chemistry, Medicinal

Effect of Ketamine on Sleep in Treatment-Resistant Depression: A Systematic Review

Aleksander Kwasny et al.

Summary: Depression is a debilitating disease with sleep disturbances as a common residual symptom. Ketamine, a novel antidepressant, has shown rapid onset of action and antisuicidal effect, but its impact on sleep-wake and circadian rhythm alterations is not well understood. This systematic review aims to research the impact of ketamine on sleep disturbances in depression.

PHARMACEUTICALS (2023)

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Article Clinical Neurology

A comparative analysis of antidepressant and anti-suicidal effects of repeated ketamine infusions in elderly and younger adults with depression

Wei Zheng et al.

Summary: This study investigates the safety and antidepressant effects of multi-infusion ketamine treatment in elderly and young adults with depression. The results suggest that elderly patients with depression have a lower response to ketamine compared to younger patients, although there were no significant differences in other assessment measures between the two groups.

JOURNAL OF AFFECTIVE DISORDERS (2023)

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Review Neurosciences

A wake-up call: Sleep physiology and related translational discrepancies in studies of rapid-acting antidepressants

Okko Alitalo et al.

Summary: Depression often coexists with sleep problems, and treatments targeting sleep can contribute to clinical improvement. However, studies on rapid-acting antidepressants have largely overlooked the crucial role of sleep. This oversight may have implications for the interpretation and application of the drugs' efficacy.

PROGRESS IN NEUROBIOLOGY (2021)

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Review Psychology, Clinical