Genetic liability to frailty in relation to functional outcome after ischemic stroke

Article Geriatrics & Gerontology

Frailty and stroke thrombectomy outcomes-an observational cohort study

Nevan Joyce et al.

Summary: Pre-stroke frailty is common in patients eligible for mechanical thrombectomy (MT) and is an important predictor of poor outcomes.

AGE AND AGEING (2022)

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Article Clinical Neurology

Premorbid frailty predicts short- and long-term outcomes of reperfusion treatment in acute stroke

Andrea Pilotto et al.

Summary: Frailty is an important factor that influences the clinical outcome of acute treatment of stroke, predicting short-term and long-term mortality and neurological recovery. Further studies are needed to evaluate the risk and benefit of reperfusion treatment in the growing elderly frail population.

JOURNAL OF NEUROLOGY (2022)

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Review Geriatrics & Gerontology

Prevalence and implications of frailty in acute stroke: systematic review & meta-analysis

Jennifer K. Burton et al.

Summary: Despite limited knowledge of frailty in stroke, studies show that frailty is common in patients with acute stroke and associated with poor outcomes.

AGE AND AGEING (2022)

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Article Geriatrics & Gerontology

Effect of frailty on outcomes of endovascular treatment for acute ischaemic stroke in older patients

Benjamin Y. Q. Tan et al.

Summary: This study investigated the impact of frailty on clinical outcomes in older patients (>70 years) undergoing endovascular thrombectomy (EVT) for acute ischemic stroke (AIS). The results showed that frailty was associated with poorer functional outcome at 90 days post-EVT, and there was a trend towards higher mortality rate and increased carer requirement in frail patients post discharge.

AGE AND AGEING (2022)

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Review Clinical Neurology

Frailty and cerebrovascular disease: Concepts and clinical implications for stroke medicine

Nicholas R. Evans et al.

Summary: Frailty is a distinctive health state that compromises older people's ability to deal with acute stressors due to age-related declines in physiological reserve. Even though frailty is closely associated with age, multimorbidity, and disability, it is a separate syndrome with poorer outcomes for various medical conditions.

INTERNATIONAL JOURNAL OF STROKE (2022)

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Article Clinical Neurology

Genetically predicted frailty index and risk of stroke and Alzheimer's disease

Weishi Liu et al.

Summary: The study conducted Mendelian randomization to examine the potential association between genetically predicted frailty and the risk of stroke and Alzheimer's disease. The results suggested a link between genetically predicted frailty and an increased risk of any stroke, particularly large artery atherosclerosis stroke. Further investigation is needed to understand the underlying mechanisms.

EUROPEAN JOURNAL OF NEUROLOGY (2022)

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Article Neurosciences

Frailty, Assessed by the Rockwood Clinical Frailty Scale and 1-Year Outcomes Following Ischaemic Stroke in a Non-Specialist UK Stroke Centre

Krupali Patel et al.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2022)

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Article Cardiac & Cardiovascular Systems

Frailty in cardiology: definition, assessment and clinical implications for general cardiology. A consensus document of the Council for Cardiology Practice (CCP), Association for Acute Cardio Vascular Care (ACVC), Association of Cardiovascular Nursing and Allied Professions (ACNAP), European Association of Preventive Cardiology (EAPC), European Heart Rhythm Association (EHRA), Council on Valvular Heart Diseases (VHD), Council on Hypertension (CHT), Council of Cardio-Oncology (CCO), Working Group (WG) Aorta and Peripheral Vascular Diseases, WG e-Cardiology, WG Thrombosis, of the European Society of Cardiology, European Primary Care Cardiology Society (EPCCS)

Dimitri Richter et al.

Summary: Frailty is a health condition that has a significant impact on healthcare systems, particularly in relation to advanced age, multimorbidity, and disability. It increases cardiovascular morbidity and mortality in both patients with and without known cardiovascular disease. However, there is still uncertainty surrounding the definitions, screening, assessment, and management of frailty.

EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY (2022)

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Article Clinical Neurology

Association of Pre-stroke Frailty With Prognosis of Elderly Patients With Acute Cerebral Infarction: A Cohort Study

Fuxia Yang et al.

Summary: The study revealed that pre-stroke frailty is an independent risk factor for 28-day mortality and 28-day or 1-year severe disability in elderly patients with acute cerebral infarction. Age, severity of cerebral infarction, and co-infection are also independent risk factors for 1-year mortality.

FRONTIERS IN NEUROLOGY (2022)

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Article Neurosciences

Estimating the causal effect of frailty index on vestibular disorders: A two-sample Mendelian randomization

Gui Xiao et al.

Summary: This study suggests a possible causal relationship between genetically predicted frailty index and an increased risk of vestibular disorders. Further investigation is needed to confirm the causal effects between frailty index and vestibular disorders. These findings highlight the importance of effectively managing frailty to minimize vestibular disorders and improve the quality of life for those affected.

FRONTIERS IN NEUROSCIENCE (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Beyond collaterals: brain frailty additionally improves prediction of clinical outcome in acute ischemic stroke

Jia-Ying Zhou et al.

Summary: This study found that cerebral small vessel disease (SVD) is not only determined by collaterals but also by brain frailty, including atrophy and lacunes, and that brain frailty has a significant impact on the clinical outcome of acute ischemic stroke (AIS) patients. Collaterals mediated part of the effects of atrophy on poor clinical outcomes, while the impact of lacunes on clinical outcomes was independent of collaterals. Including atrophy and lacunes in the classification model improved the prediction of stroke outcomes.

EUROPEAN RADIOLOGY (2022)

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Review Public, Environmental & Occupational Health

The utility of frailty indices in predicting the risk of health care associated infections: A systematic review

Carmela B. Cosentino et al.

Summary: This review found a potential association between frailty and the development of Health care associated infections (HAIs), suggesting that frailty poses a risk for the development of HAIs.

AMERICAN JOURNAL OF INFECTION CONTROL (2021)

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Review Medicine, General & Internal

Strengthening the Reporting of Observational Studies in Epidemiology Using Mendelian Randomization: The STROBE-MR Statement

Veronika W. Skrivankova et al.

Summary: The STROBE-MR Statement was developed to guide the reporting of MR studies by providing a checklist tailored to MR studies, which could improve the evaluation and interpretation of these studies by editors, peer reviewers, researchers, clinicians, and other readers.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Article Geriatrics & Gerontology

Relationship between pre-stroke frailty status and short-term functional outcome in older patients with acute stroke-A mediation analysis

Madoka Noguchi et al.

Summary: The study aimed to investigate the effects of pre-stroke frailty status on short-term functional outcome in older patients with acute stroke, finding that the relationship was mediated by disease severity and length of stay in the hospital.

ARCHIVES OF GERONTOLOGY AND GERIATRICS (2021)

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Article Cell Biology

A genome-wide association study of the frailty index highlights brain pathways in ageing

Janice L. Atkins et al.

Summary: Frailty is a common geriatric syndrome strongly associated with disability, mortality, and hospitalization, with a genetic basis suggested to have heritability estimates between 30 and 45%. This study identified 14 loci associated with the frailty index, with an estimated single nucleotide polymorphism (SNP) heritability of 11%, and a higher educational attainment genetic risk score was linked to lower levels of frailty.

AGING CELL (2021)

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Article Clinical Neurology

Utility of the Hospital Frailty Risk Score Derived From Administrative Data and the Association With Stroke Outcomes

Monique F. Kilkenny et al.

Summary: This study examined the association between a generic frailty risk score and patient outcomes following stroke/transient ischemic attack, finding that greater frailty was linked to worse outcomes. The Frailty Score showed similar precision to Charlson and Elixhauser indices in assessing risk-adjusted outcomes.

STROKE (2021)

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Article Geriatrics & Gerontology