期刊
CHEMICAL COMMUNICATIONS
卷 51, 期 46, 页码 9567-9570出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc02149a
关键词
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资金
- NSFC [21474031, 21174040, 21025415]
- National Key Basic Research Program of China [2013CB834702]
A DT-diaphorase-activatable theranostic prodrug, which contains camptothecin, a self-immolative linker and a trigger group, has been developed for the detection of DT-diaphorase, tracking of drug release and selectively killing cancer cells over-expressed with DT-diaphorase. This strategy may offer a new approach for the development of enzyme-catalyzed theranostic anticancer therapeutics.
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