Selective COX-2 inhibitors after bariatric surgery: Celecoxib, etoricoxib and etodolac post-bariatric solubility/dissolution and pharmacokinetics

Article Surgery

Implementation of a standardized multimodal pain regimen significantly reduces postoperative inpatient opioid utilization in patients undergoing bariatric surgery

Wen Hui Tan et al.

Summary: This study investigates the use of opioids in bariatric surgery patients and finds that implementing a standardized opioid-sparing protocol and educational program significantly reduces inpatient opioid utilization.

SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES (2023)

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Article Pharmacology & Pharmacy

Lamotrigine therapy in patients after bariatric surgery: Potentially hampered solubility and dissolution

Daniel Porat et al.

Summary: Bariatric surgery can affect the oral exposure of drugs, especially marginally soluble weak bases like lamotrigine. Research found that post-surgery gastric conditions led to decreased solubility of lamotrigine, impacting the dissolution of higher dose tablets in particular. Close monitoring of drug absorption is recommended after bariatric surgery based on these findings.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

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Article Surgery

Radiographic Measurement of Gastric Remnant Volume After Laparoscopic Sleeve Gastrectomy: Assessment of Reproducibility and Correlation with Weight Loss

Malgorzata Deregowska-Cylke et al.

Summary: The study evaluated the reproducibility of different radiographic methods of GRV calculation and found a significant negative correlation between GRV and weight loss after LSG surgery.

OBESITY SURGERY (2022)

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Review Pharmacology & Pharmacy

Implications of Bariatric Surgery on the Pharmacokinetics of Antiretrovirals in People Living with HIV

Leena Zino et al.

Summary: Bariatric surgery can have impacts on the pharmacokinetics of antiretroviral drugs, which may result in subtherapeutic exposure and the risk of treatment failure. Some characteristics of antiretrovirals make them more susceptible to the effects of bariatric surgery. Pharmacokinetic studies are crucial in this population to guide the selection of appropriate antiretroviral treatment.

CLINICAL PHARMACOKINETICS (2022)

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Review Surgery

Changes in Gastric Inhibitory Polypeptide (GIP) After Roux-en-Y Gastric Bypass in Obese Patients: a Meta-analysis

Zhiguang Gao et al.

Summary: This meta-analysis found that fasting GIP levels decreased significantly after RYGB in obese patients, especially in diabetic individuals. The decrease in fasting glucose and postprandial GIP levels was also observed. Factors such as weight loss, gastric pouch volume, and limb length did not show a significant correlation with fasting GIP decrease.

OBESITY SURGERY (2022)

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Article Surgery

Prediction Factors of Early Postoperative Bleeding after Bariatric Surgery

Mahdieh Golzarand et al.

Summary: Through studying the predictors of postoperative bleeding, we found that the type of surgery, history of intragastric balloon, and oral non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs) were positively associated with the occurrence of bleeding, while staple line oversewing was inversely related to the odds of bleeding.

OBESITY SURGERY (2022)

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Article Surgery

Nonsteroid anti-inflammatory drugs and the risk of peptic ulcers after gastric bypass and sleeve gastrectomy

Martin L. Skogar et al.

Summary: This study investigated the association between NSAID exposure and peptic ulcers after laparoscopic RYGB and SG surgeries. The results showed that long-term NSAID use (>=30 days) after RYGB was a significant risk factor for the development of peptic ulcers, while no association was found between NSAID exposure and peptic ulcers after SG.

SURGERY FOR OBESITY AND RELATED DISEASES (2022)

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Article Medicine, Research & Experimental

Antiallergic Treatment of Bariatric Patients: Potentially Hampered Solubility/Dissolution and Bioavailability of Loratadine, but Not Desloratadine, Post-Bariatric Surgery

Daniel Porat et al.

Summary: This study investigated the impact of gastrointestinal changes after bariatric surgery on the solubility of loratadine/desloratadine. The results showed that the solubility of loratadine was significantly decreased post-surgery, while desloratadine maintained complete dissolution. Desloratadine should be preferred over loratadine in bariatric patients.

MOLECULAR PHARMACEUTICS (2022)

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Letter Surgery

Influence of Bariatric Surgery on Levetiracetam Clinical Effectiveness: Case Series

Nadia Margolin et al.

OBESITY SURGERY (2022)

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Review Surgery

Carbamazepine Therapy After Bariatric Surgery: Eight Sleeve Gastrectomy Cases and Review of the Literature

Daniel Porat et al.

Summary: This study investigated the use of CBZ medication among patients undergoing bariatric surgery and found a decrease in CBZ levels post-surgery, with some patients experiencing significant worsening of their condition. Therefore, altered CBZ levels may occur for at least a year after bariatric surgery.

OBESITY SURGERY (2022)

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Article Pharmacology & Pharmacy

A Simple One-Parameter Percent Dissolved Versus Time Dissolution Equation that Accommodates Sink and Non-sink Conditions via Drug Solubility and Dissolution Volume

James E. Polli

Summary: This article explores the effects of non-sink conditions in dissolution and proposes a dissolution equation that accommodates these conditions. By fitting and simulating the dissolution profiles of poorly water-soluble drugs, the Polli dissolution equation is derived and characterized.

AAPS JOURNAL (2022)

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Review Public, Environmental & Occupational Health

Drug absorption in bariatric surgery patients: A narrative review

Abdullah Abdulaziz Alalwan et al.

Summary: Bariatric surgery can lead to changes in drug absorption, with some studies showing decreased absorption, a few showing increased absorption, and others showing unchanged absorption. The unpredictability of drug absorption may stem from various factors, and pharmacist involvement and close patient monitoring can help prevent sub-/supratherapeutic responses.

HEALTH SCIENCE REPORTS (2022)

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Article Medicine, Research & Experimental

Short- and long-term effects of body weight loss following calorie restriction and gastric bypass on CYP3A-activity - a non-randomized three-armed controlled trial

Kine Eide Kvitne et al.

Summary: This study compared the effects of RYGB and calorie restriction on CYP3A activity, finding that neither RYGB surgery nor weight loss impacted the absolute bioavailability or clearance of midazolam in the short term. In the long term, both RYGB and diet groups showed a decrease in absolute bioavailability of midazolam, suggesting that CYP3A activity recovery is not solely dependent on weight loss through RYGB.

CTS-CLINICAL AND TRANSLATIONAL SCIENCE (2022)

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Article Surgery

Nonsteroid anti-inflammatory drugs and the risk of peptic ulcers after gastric bypass and sleeve gastrectomy

Martin L. Skogar et al.

Summary: The study found that continuous use of NSAIDs for >= 30 days after RYGB surgery is a significant risk factor for the development of peptic ulcers, while short-term use (<30 days) is not associated with this risk.

SURGERY FOR OBESITY AND RELATED DISEASES (2022)

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Review Rheumatology

Rheumatoid Arthritis Pathogenesis, Prediction, and Prevention: An Emerging Paradigm Shift

Kevin D. Deane et al.

Summary: The prevention of RA is a critical topic, involving predicting individuals who may develop clinically apparent RA in the future and discussions on clinical trials for prevention. Studies aimed at delaying or preventing clinically apparent IA/RA onset have gained attention, as making prevention of RA a future public health strategy has become a focus.

ARTHRITIS & RHEUMATOLOGY (2021)

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Article Behavioral Sciences

The effect of weight reduction surgery on the efficacy and tolerability of epilepsy pharmacotherapy

James D. Triplett et al.

Summary: The majority of patients with epilepsy undergoing bariatric surgery experience no change in seizure frequency, but a minority may experience medication side effects or worsened seizure tendency. Pre-and post-surgical serum concentrations should be monitored in patients with epilepsy receiving antiseizure drugs.

EPILEPSY & BEHAVIOR (2021)

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Article Medicine, General & Internal

Metabolic surgery versus conventional medical therapy in patients with type 2 diabetes: 10-year follow-up of an open-label, single-centre, randomised controlled trial

Geltrude Mingrone et al.

LANCET (2021)

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Article Pharmacology & Pharmacy

Stomach pH before vs. after different bariatric surgery procedures: Clinical implications for drug delivery

Daniel Porat et al.

Summary: The study found that gastric pH increases after certain bariatric procedures, which may have significant effects on post-bariatric oral drug delivery and treatment. Special care should be taken when using pH-dependent drugs after bariatric surgery, and the use of pH-independent formulations is recommended.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2021)

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Article Pharmacology & Pharmacy

Can NSAIDs and Acetaminophen Effectively Replace Opioid Treatment Options for Acute Pain?

Joseph Pergolizzi et al.

Summary: The use of opioid analgesia for acute pain has raised concerns due to the public health crisis of opioid overdose, leading clinicians to explore nonopioid alternatives such as NSAIDs and acetaminophen. Recent clinical trials have shown that combination therapy using a small amount of opioid together with a nonopioid pain reliever can effectively reduce opioid consumption while providing adequate analgesia. Overall, while short-term use of opioids may be appropriate under close clinical supervision, there is a trend towards preferring nonopioid therapy or combination therapy in the treatment of acute pain.

EXPERT OPINION ON PHARMACOTHERAPY (2021)

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Review Multidisciplinary Sciences

Cardiovascular safety of celecoxib in rheumatoid arthritis and osteoarthritis patients: A systematic review and meta-analysis

Bai-Ru Cheng et al.

Summary: Celecoxib is relatively safe in patients with rheumatoid arthritis and osteoarthritis, showing benefits in terms of all-cause mortality and cardiovascular mortality compared to non-selective non-steroidal anti-inflammatory drugs. However, there is no significant difference in the risk of other cardiovascular events compared to non-selective NSAIDs or placebo.

PLOS ONE (2021)

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Article Surgery

The use of nonsteroidal anti-inflammatory drugs after sleeve gastrectomy

Alan Begian et al.

Summary: This study aimed to investigate the rate of NSAID use and associated complications in patients who underwent sleeve gastrectomy (SG). The findings revealed that a significant proportion of patients continued to use NSAIDs after SG, with some using them frequently. These results highlight the potential risks of NSAID use in SG patients, suggesting a need for caution among healthcare providers.

SURGERY FOR OBESITY AND RELATED DISEASES (2021)

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Article Gastroenterology & Hepatology

Adaptations in gastrointestinal physiology after sleeve gastrectomy and Roux-en-Y gastric bypass

Nele Steenackers et al.

Lancet Gastroenterology & Hepatology (2021)

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Review Pharmacology & Pharmacy

Oral drug dosing following bariatric surgery: General concepts and specific dosing advice

Jurjen S. Kingma et al.

Summary: Bariatric surgery can affect the absorption and metabolism of drugs, leading to earlier and potentially higher peak concentrations of orally administered drugs with inconsistent effects on concentrations and exposure. Prescribing liquid formulations to bariatric patients is beneficial, although the high sugar content may be a concern. While exposure to some drugs remains unchanged, the timing after surgery can impact drug absorption profiles.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2021)

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Article Medicine, General & Internal

Managing the Unpredictable: Mechanistic Analysis and Clinical Recommendations for Lamotrigine Treatment after Bariatric Surgery

Daniel Porat et al.

Summary: This article investigates the impact of bariatric surgery on the drug lamotrigine, highlighting the challenges in its use post-surgery and the potential for varying effects on drug plasma levels. It concludes with clinical recommendations to ensure better patient care and emphasize the need for extra caution with these patients.

JOURNAL OF CLINICAL MEDICINE (2021)

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Article Pharmacology & Pharmacy

Optimized In Silico Modeling of Drug Absorption after Gastric Bypass: The Case of Metformin

Arik Dahan et al.

Summary: Experimental validation of the regional-dependent drug absorption changes after bariatric surgery provides important data for predicting drug absorption. It is crucial to consider the permeability of different intestinal segments post-surgery in simulation predictions to more accurately predict drug absorption after gastric bypass.

PHARMACEUTICS (2021)

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Review Pharmacology & Pharmacy

The Effects of Bariatric Surgery and Gastrectomy on the Absorption of Drugs, Vitamins, and Mineral Elements

Milosz Miedziaszczyk et al.

Summary: Bariatric surgery and gastrectomy alter the pharmacokinetic parameters of oral medications, often resulting in a shortened time to maximum plasma concentration and decreased maximum plasma concentration. Vitamin and mineral deficiencies are commonly observed in these patient groups. It is recommended to use tested drugs and monitor them for these patients.

PHARMACEUTICS (2021)

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Article Chemistry, Medicinal

Evaluating the Impact of Physiological Properties of the Gastrointestinal Tract On Drug In Vivo Performance Using Physiologically Based Biopharmaceutics Modeling and Virtual Clinical Trials

Rebeka Jereb et al.

Summary: This study investigates the impact of gastrointestinal physiology on drug bioperformance, showing that variations in pH, fluid volume, bile salt concentration, and transit time can affect drug dissolution and absorption. By developing physiologically based absorption models and conducting virtual clinical trials, the study explores the reasons for variability in drug bioperformance between subjects and proposes ways to optimize drug design and efficacy based on these findings.

JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

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Article Surgery

Long-Term Efficacy of Bariatric Surgery for the Treatment of Super-Obesity: Comparison of SG, RYGB, and OAGB

Tien-Chou Soong et al.

Summary: This study compared the safety, long-term weight loss, and adverse events of three commonly performed bariatric procedures in super-obese patients. The results showed that OAGB had better weight loss results compared to SG, while SG had a lower rate of remission in dyslipidemia.

OBESITY SURGERY (2021)

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Article Medicine, General & Internal

Managing postoperative pain in adult outpatients: a systematic review and meta-analysis comparing codeine with NSAIDs

Matthew Choi et al.

Summary: In comparison to codeine, NSAIDs are more effective in managing postoperative pain for adult outpatients, resulting in better pain scores, global assessments, and fewer adverse effects, including bleeding events.

CANADIAN MEDICAL ASSOCIATION JOURNAL (2021)

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Article Medicine, Research & Experimental

Improving Dissolution Behavior and Oral Absorption of Drugs with pH-Dependent Solubility Using pH Modifiers: A Physiologically Realistic Mass Transport Analysis

Niloufar Salehi et al.

Summary: Orally dosed drugs need to dissolve in the GI tract before absorption, and in vivo drug dissolution depends on factors such as pH, residence time, and drug properties. Manipulating environmental pH with pH-modifying agents can enhance the dissolution of ionizable drugs. The selection of suitable pH modifiers can improve the dissolution rate and extent of monobasic and dibasic drug compounds under high-gastric pH conditions.

MOLECULAR PHARMACEUTICS (2021)

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Article Microbiology

Case Report of Increased Exposure to Antiretrovirals following Sleeve Gastrectomy

Sarah Israel et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2020)

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Review Rheumatology

Obesity and its role in the management of rheumatoid and psoriatic arthritis

Luca Moroni et al.

CLINICAL RHEUMATOLOGY (2020)

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Editorial Material Medicine, General & Internal

Medication Management after Bariatric Surgery: Providing Optimal Patient Care

Daniel Porat et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Article Surgery

Combined Laparoscopic Revision of the Gastric Pouch and Distalization of the Roux Limb After Failure of Weight Loss Following Roux-en-Y Gastric Bypass

Tarek Debs et al.

OBESITY SURGERY (2020)

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Article Pharmacology & Pharmacy

Effect of thickener on disintegration, dissolution and permeability of common drug products for elderly patients

Alejandro Ruiz-Picazo et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2020)

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Article Medicine, General & Internal

Lithium toxicity with prolonged neurologic sequelae following sleeve gastrectomy A case report and review of literature

Yi-Hsin Lin et al.

MEDICINE (2020)

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Article Pharmacology & Pharmacy

Physiologically Based Pharmacokinetic Modeling of Transdermal Selegiline and Its Metabolites for the Evaluation of Disposition Differences between Healthy and Special Populations

Santosh Kumar Puttrevu et al.

PHARMACEUTICS (2020)

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Article Rheumatology

Association between Overweight/Obesity and Clinical Activity in Rheumatoid Arthritis

Jose Alvarez-Nemegyei et al.

REUMATOLOGIA CLINICA (2020)

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Article Surgery

Assessment of the Correlation Between Preoperative and Immediate Postoperative Gastric Volume and Weight Loss After Sleeve Gastrectomy Using Computed Tomography Volumetry

Hosam Elbanna et al.

WORLD JOURNAL OF SURGERY (2019)

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Review Pharmacology & Pharmacy

Celecoxib for the treatment of musculoskeletal arthritis

Marco Krasselt et al.

EXPERT OPINION ON PHARMACOTHERAPY (2019)

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Review Endocrinology & Metabolism

The influence of bariatric surgery on oral drug bioavailability in patients with obesity: A systematic review

Philip Carlo Angeles et al.

OBESITY REVIEWS (2019)

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Article Surgery

Ketorolac Use Shortens Hospital Length of Stay After Bariatric Surgery: a Single-Center 5-Year Experience

Kamyar Hariri et al.

OBESITY SURGERY (2019)

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Article Medicine, General & Internal

Increased Paracetamol Bioavailability after Sleeve Gastrectomy: A Crossover Pre- vs. Post-Operative Clinical Trial

Daniel Porat et al.

JOURNAL OF CLINICAL MEDICINE (2019)

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Review Pharmacology & Pharmacy

Perioperative Opioid-sparing Strategies: Utility of Conventional NSAIDs in Adults

Luc Martinez et al.

CLINICAL THERAPEUTICS (2019)

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Review Surgery

Lithium Toxicity with Severe Bradycardia Post Sleeve Gastrectomy: a Case Report and Review of the Literature

Arik Dahan et al.

OBESITY SURGERY (2019)

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Article Surgery

Multimodal Postoperative Pain Control Is Effective and Reduces Opioid Use After Laparoscopic Roux-en-Y Gastric Bypass

Ryan D. Horsley et al.

OBESITY SURGERY (2019)

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Article Surgery

Safety and Efficacy of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Used for Analgesia After Bariatric Surgery: A Retrospective Case-Control Study

Hicham Abou Zeid et al.

OBESITY SURGERY (2019)

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Editorial Material Surgery

Oral levothyroxine therapy postbariatric surgery: Biopharmaceutical aspects and clinical effects

Carmil Azran et al.

SURGERY FOR OBESITY AND RELATED DISEASES (2019)

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Article Multidisciplinary Sciences

Short- and medium-term impact of bariatric surgery on the activities of CYP2D6, CYP3A4, CYP2C9, and CYP1A2 in morbid obesity

Jose Rodriguez-Morato et al.

SCIENTIFIC REPORTS (2019)

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Review Pharmacology & Pharmacy

Physiologically Based Pharmacokinetic Model Qualification and Reporting Procedures for Regulatory Submissions: A Consortium Perspective

Mohamad Shebley et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2018)

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Article Chemistry, Medicinal

The Combination of GIS and Biphasic to Better Predict In Vivo Dissolution of BCS Class IIb Drugs, Ketoconazole and Raloxifene

Yasuhiro Tsume et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2018)

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Article Surgery

Obesity Management Task Force of the European Association for the Study of Obesity Released Practical Recommendations for the Post-Bariatric Surgery Medical Management

Luca Busetto et al.

OBESITY SURGERY (2018)

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Article Multidisciplinary Sciences

Stability Study of Etoricoxib a Selective Cyclooxygenase-2 Inhibitor by a New Single and Rapid Reversed Phase HPLC Method

Muhammad Alzweiri et al.

SYMMETRY-BASEL (2018)

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Article Pharmacology & Pharmacy

Reverse Translation in PBPK and QSP: Going Backwards in Order to Go Forward With Confidence

Amin Rostami-Hodjegan

CLINICAL PHARMACOLOGY & THERAPEUTICS (2018)

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Article Surgery

Changes in Gastric Volume and Their Implications for Weight Loss after Laparoscopic Sleeve Gastrectomy

Manuel Ferrer-Marquez et al.

OBESITY SURGERY (2017)

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Review Pharmacology & Pharmacy

In vitro biphasic dissolution tests and their suitability for establishing in vitro-in vivo correlations: A historical review

Aude Pestieau et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2017)

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Article Anesthesiology

Nonsteroidal anti-inflammatory drugs for postoperative pain control after lumbar spine surgery: A meta-analysis of randomized controlled trials

Zhifeng Zhang et al.

JOURNAL OF CLINICAL ANESTHESIA (2017)

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Article Medicine, Research & Experimental

Dual Level Statistical Investigation of Equilibrium Solubility in Simulated Fasted and Fed Intestinal Fluid

Bayan E. Ainousah et al.

MOLECULAR PHARMACEUTICS (2017)

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Article Medicine, Research & Experimental

Magnetic Resonance Imaging Quantification of Fasted State Colonic Liquid Pockets in Healthy Humans

Kathryn Murray et al.

MOLECULAR PHARMACEUTICS (2017)

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Article Medicine, General & Internal

Weight and Metabolic Outcomes 12 Years after Gastric Bypass

Ted D. Adams et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

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Review Endocrinology & Metabolism

Practical Recommendations of the Obesity Management Task Force of the European Association for the Study of Obesity for the Post-Bariatric Surgery Medical Management

Luca Busetto et al.

OBESITY FACTS (2017)

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Article Pharmacology & Pharmacy

Instrumentation of Flow-Through USP IV Dissolution Apparatus to Assess Poorly Soluble Basic Drug Products: a Technical Note

Alice Paprskarova et al.

AAPS PHARMSCITECH (2016)

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Article Gastroenterology & Hepatology

Higher plasma motilin levels in obese patients decrease after Roux-en-Y gastric bypass surgery and regulate hunger

E. Deloose et al.

GUT (2016)

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Article Chemistry, Multidisciplinary

Dissolution Performance of High Drug Loading Celecoxib Amorphous Solid Dispersions Formulated with Polymer Combinations

Tian Xie et al.

PHARMACEUTICAL RESEARCH (2016)

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Article Surgery

Risk Factors for Marginal Ulcer After Gastric Bypass Surgery for Obesity: A Population-based Cohort Study

Emma Sverden et al.

ANNALS OF SURGERY (2016)

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Review Geriatrics & Gerontology

Obesity and osteoarthritis

Kunal Kulkarni et al.

MATURITAS (2016)

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Article Endocrinology & Metabolism

Oral drug therapy following bariatric surgery: an overview of fundamentals, literature and clinical recommendations

Carmil Azran et al.

OBESITY REVIEWS (2016)

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Article Surgery

NSAID Use after Bariatric Surgery: a Randomized Controlled Intervention Study

Jan Peter Yska et al.

OBESITY SURGERY (2016)

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Article Rheumatology

Association Between Overweight and Obesity and Risk of Clinically Diagnosed Knee, Hip, and Hand Osteoarthritis

Carlen Reyes et al.

ARTHRITIS & RHEUMATOLOGY (2016)

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Article Pharmacology & Pharmacy

The mechanism for increasing the oral bioavailability of poorly water-soluble drugs using uniform mesoporous carbon spheres as a carrier

Tianyi Wang et al.

DRUG DELIVERY (2016)

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Article Orthopedics

Do COX-2 inhibitors provide additional pain relief and anti-inflammatory effects in patients with rheumatoid arthritis who are on biological disease-modifying anti-rheumatic drugs and/or corticosteroids? Post-hoc analyses from a randomized clinical trial with etoricoxib

Tore K. Kvien et al.

BMC MUSCULOSKELETAL DISORDERS (2015)

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Article Pharmacology & Pharmacy

Drug disposition and modelling before and after gastric bypass: immediate and controlled-release metoprolol formulations

Ina Gesquiere et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2015)

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Article Pharmacology & Pharmacy

The use of captisol (SBE7-β-CD) in oral solubility-enabling formulations: Comparison to HPβCD and the solubility-permeability interplay

Avital Beig et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2015)

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Article Pharmacology & Pharmacy

Application of Absorption Modeling to Predict Bioequivalence Outcome of Two Batches of Etoricoxib Tablets

Amitava Mitra et al.

AAPS PHARMSCITECH (2015)

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Article Medicine, Research & Experimental

Quantification of Gastrointestinal Liquid Volumes and Distribution Following a 240 mL Dose of Water in the Fasted State

Deanna M. Mudie et al.

MOLECULAR PHARMACEUTICS (2014)

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Article Pharmacology & Pharmacy

Deciding on Success Criteria for Predictability of Pharmacokinetic Parameters from In Vitro Studies: An Analysis Based on In Vivo Observations

Khaled Abduljalil et al.

DRUG METABOLISM AND DISPOSITION (2014)

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Article Pharmacology & Pharmacy

The interaction of nifedipine with selected cyclodextrins and the subsequent solubility-permeability trade-off

Avital Beig et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2013)

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Article Pharmacology & Pharmacy

Evaluation of an In Silico PBPK Post-Bariatric Surgery Model through Simulating Oral Drug Bioavailability of Atorvastatin and Cyclosporine

A. S. Darwich et al.

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY (2013)

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Article Biotechnology & Applied Microbiology

Celecoxib pathways: pharmacokinetics and pharmacodynamics

Li Gong et al.

PHARMACOGENETICS AND GENOMICS (2012)

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Article Pharmacology & Pharmacy

Practical use of the regression offset approach for the prediction of in vivo intrinsic clearance from hepatocytes

Anna-Karin Sohlenius-Sternbeck et al.

XENOBIOTICA (2012)

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Article Toxicology

Obesity and knee osteoarthritis

Ryan Lee et al.

INFLAMMOPHARMACOLOGY (2012)

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Article Pharmacology & Pharmacy

Chemical and in vitro enzymatic stability of newly synthesized celecoxib lipophilic and hydrophilic amides

Amjad M. Qandil et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2011)

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Article Pharmacology & Pharmacy

Prediction of food effects on the absorption of celecoxib based on biorelevant dissolution testing coupled with physiologically based pharmacokinetic modeling

Yasushi Shono et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2009)

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Article Pharmacology & Pharmacy

Computer simulations using GastroPlus™ to justify a biowaiver for etoricoxib solid oral drug products

Arthur Okumu et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2009)

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Article Medicine, Research & Experimental

Toward an Increased Understanding of the Barriers to Colonic Drug Absorption in Humans: Implications for Early Controlled Release Candidate Assessment

Christer Tannergren et al.

MOLECULAR PHARMACEUTICS (2009)

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Review Pharmacology & Pharmacy

Clinical use and pharmacological properties of selective COX-2 inhibitors

Shaojun Shi et al.

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2008)

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Article Gastroenterology & Hepatology

Predictors of endoscopic findings after Roux-en-Y gastric bypass

Jason A. Wilson et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2006)

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Article Chemistry, Medicinal

In vitro dissolution studies of sodium diclofenac granules coated with Eudragit L-30D-55® by fluidized-bed system

O. S. Silva et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2006)

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