4.7 Article

Dissolving microneedle transdermal patch loaded with Risedronate sodium and Ursolic acid bipartite nanotransfersomes to combat osteoporosis: Optimization, characterization, in vitro and ex vivo assessment

期刊

出版社

ELSEVIER
DOI: 10.1016/j.ijpharm.2023.123335

关键词

Dissolving microneedles; Transdermal delivery; Risedronate sodium; Ursolic acid; Osteoporosis; Nanotransfersomes

向作者/读者索取更多资源

Osteoporosis is a fatal bone disease that contributes significantly to human mortality and economic burden. A microneedle transdermal patch loaded with optimized formulation nanotransfersomes containing Risedronate Sodium and Ursolic acid has been developed to improve osteoporosis treatment.
Osteoporosis is a fatal bone-wearing malady and a substantial reason behind the impermanence of human life and economic burden. Risedronate Sodium along with Ursolic acid has been studied to ameliorate osteoporosis. To bypass problems associated with bioavailability, we have developed a microneedle transdermal patch loaded with optimized formulation nanotransfersomes. It was optimized using three factor, three-level Central composite design with independent variables namely, the concentration of phospholipid, surfactant, and sonication time on dependent variables (vesicle size, entrapment efficiency and Polydispersity index). Vesicles of size 271.9 & PLUSMN; 8.45 nm with PDI 0.184 & PLUSMN; 0.01, having entrapment efficiency of 86.12 & PLUSMN; 5.20% and 85.65 & PLUSMN; 4.88% for RIS and UA respectively were observed. In vitro release study showed the sustained release pattern with 78.16 & PLUSMN; 1.12% and 75.72 & PLUSMN; 1.01% release of RIS and UA respectively. Dissolving MN patch prepared from gelatin was found to have good strength and folding endurance with uniform drug content (98.68 & PLUSMN; 0.004%). Ex vivo permeation study revealed that up to 80% of the drug can be permeated within 24 h. CLSM analysis was also performed to show penetration of RU-NTRs. From the results obtained, we can conclude that dissolving MN patch loaded with RU-NTRs has great potential than its conventional counterpart.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据