期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 647, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2023.123552
关键词
Cancer; Multifunctional nanoparticles; IR780; Reduced graphene oxide; Photodynamic/Photothermal therapy
Nanomaterials that can absorb near infrared light and exhibit a photothermal-photodynamic response have shown promise in cancer therapy. In this study, a novel nanosystem was developed by functionalizing dopamine-reduced graphene oxide with sulfobetaine methacrylate-brushes and loading it with IR780. The resulting hybrid nanosystem demonstrated optimal size distribution, surface charge, and colloidal stability. When exposed to near infrared light, the nanosystem exhibited a photothermal effect and generated singlet oxygen, leading to a significant decrease in breast cancer cell viability.
Nanomaterials with near infrared light absorption can mediate an antitumoral photothermal-photodynamic response that is weakly affected by cancer cells' resistance mechanisms. Such nanosystems are commonly pre-pared by loading photosensitizers into nanomaterials displaying photothermal capacity, followed by function-alization to achieve biological compatibility. However, the translation of these multifunctional nanomaterials has been limited by the fact that many of the photosensitizers are not responsive to near infrared light. Furthermore, the reliance on poly(ethylene glycol) for functionalizing the nanomaterials is also not ideal due to some immunogenicity reports. Herein, a novel photoeffective near infrared light-responsive nanosystem for cancer photothermal-photodynamic therapy was assembled. For such, dopamine-reduced graphene oxide was, for the first time, functionalized with sulfobetaine methacrylate-brushes, and then loaded with IR780 (IR780/SB/ DOPA-rGO). This hybrid system revealed a nanometric size distribution, optimal surface charge and colloidal stability. The interaction of IR780/SB/DOPA-rGO with near infrared light prompted a temperature increase (photothermal effect) and production of singlet oxygen (photodynamic effect). In in vitro studies, the IR780/SB/ DOPA-rGO per se did not elicit cytotoxicity (viability > 78 %). In contrast, the combination of IR780/SB/DOPA-rGO with near infrared light decreased breast cancer cells' viability to just 21 %, at a very low nanomaterial dose, highlighting its potential for cancer photothermal-photodynamic therapy.
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