4.7 Article

ERAP1 and ERAP2 Haplotypes Influence Suboptimal HLA-B*27:05-Restricted Anti-Viral CD8+T Cell Responses Cross-Reactive to Self-Epitopes

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Rheumatology

Both Disease Activity and HLA-B27 Status Are Associated With Gut Microbiome Dysbiosis in Spondyloarthritis Patients

Magali Berland et al.

Summary: This study further characterized the gut microbiota in patients with SpA and found dysbiosis compared to healthy controls. Disease activity and genetic background were shown to influence the composition of the gut microbiota in SpA patients.

ARTHRITIS & RHEUMATOLOGY (2023)

Review Rheumatology

EULAR study group on 'MHC-I-opathy': identifying disease-overarching mechanisms across disciplines and borders

Jonas J. W. Kuiper et al.

Summary: The 'MHC-I-opathy' concept describes a group of inflammatory diseases with overlapping clinical manifestations and a strong genetic link to the MHC-I antigen presentation pathway. However, the understanding and treatment of these disorders is limited due to patient heterogeneity and lack of systematic investigation. Therefore, interdisciplinary collaboration is needed to decipher the underlying disease mechanisms.

ANNALS OF THE RHEUMATIC DISEASES (2023)

Article Cell Biology

HLA Allele Frequencies and Association with Severity of COVID-19 Infection in Northern Italian Patients

Franca Rosa Guerini et al.

Summary: The distribution of HLA alleles in a group of COVID-19 patients from Northern Italy was analyzed, and a significant correlation was found between HLA-B and HLA-C loci and disease severity. The HLA-B07 supertype was associated with severe disease, while the HLA-B27 supertype and C*12:02 allele were associated with milder disease.
Article Multidisciplinary Sciences

Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides

Xinbo Yang et al.

Summary: The human leucocyte antigen B*27 (HLA-B*27) is strongly associated with inflammatory diseases of the spine and pelvis and the eye. The mechanism by which HLA-B*27 facilitates disease remains unknown, but it may involve the presentation of pathogenic peptides to CD8(+) T cells. In this study, orphan T cell receptors (TCRs) expressing a disease-associated public beta-chain variable region-complementary-determining region 3 beta (BV9-CDR3 beta) motif were isolated from blood and synovial fluid T cells from individuals with ankylosing spondylitis (AS) and from the eye in individuals with acute anterior uveitis (AAU). These TCRs showed consistent alpha-chain variable region (AV21) chain pairing and were clonally expanded in the joint and eye. Using peptide libraries, self-peptides and microbial peptides that activated the AS- and AAU-derived TCRs were identified. Structural analysis revealed that TCR cross-reactivity for peptide-MHC was rooted in a shared binding motif present in both self-antigens and microbial antigens that engages the BV9-CDR3 beta TCRs. These findings suggest that both microbial antigens and self-antigens could play a pathogenic role in HLA-B*27-associated disease.

NATURE (2022)

Article Rheumatology

T cell Repertoire Profiling and the Mechanism by which HLA-B27 Causes Ankylosing Spondylitis

Jose Garrido-Mesa et al.

Summary: The expansion of a restricted pool of CD8 lymphocytes is commonly found in AS patients, but only in a small proportion of healthy HLA-B27 carriers. These findings strongly support the theory that AS is driven by the presentation of antigenic peptides to the adaptive immune system by HLA-B27.

CURRENT RHEUMATOLOGY REPORTS (2022)

Review Immunology

The emerging multifunctional roles of ERAP1, ERAP2 and IRAP between antigen processing and renin-angiotensin system modulation

Benedetta Mattorre et al.

Summary: The role of ERAP1, ERAP2, and IRAP in antigen processing is being refined, with a specific focus on ERAP2. Besides antigen presentation, ERAP2 is involved in regulating the Renin Angiotensin System (RAS). Recent evidence suggests that ERAP2 interacts with IRAP to modulate the RAS system.

FRONTIERS IN IMMUNOLOGY (2022)

Review Biochemistry & Molecular Biology

The pockets guide to HLA class I molecules

Andrea T. Nguyen et al.

Summary: Human leukocyte antigens (HLA) are cell-surface proteins that present peptides to T cells. The binding specificity of pockets B and F are strong determinants of peptide binding and have been used to classify HLA into supertypes. Peptide binding prediction has become more reliable over the years by using binding affinity and mass spectrometry data.

BIOCHEMICAL SOCIETY TRANSACTIONS (2021)

Article Immunology

ERAP1 Controls the Autoimmune Response against Melanocytes in Psoriasis by Generating the Melanocyte Autoantigen and Regulating Its Amount for HLA-C*06:02 Presentation

Akiko Arakawa et al.

Summary: In psoriasis, ERAP1 trims peptide precursors to generate melanocyte autoantigen, with the risk haplotype producing it more efficiently. This increases HLA-C expression and TCR stimulation, leading to activation of autoreactive T cells and autoimmune disease. ERAP1 function emerges as a central checkpoint and potential therapeutic target in psoriasis and other HLA class I-associated diseases.

JOURNAL OF IMMUNOLOGY (2021)

Article Immunology

The HLA Ligandome Comprises a Limited Repertoire of O-GlcNAcylated Antigens Preferentially Associated With HLA-B*07:02

Soumya Mukherjee et al.

Summary: Mass-spectrometry based immunopeptidomics has revealed a vast ligandome of self and cancer neoantigens, with a focus on a small subset of post-translationally modified HLA Class I peptides, primarily derived from nuclear proteins such as transcription factors. These O-GlcNAcylated HLA Class I peptides are preferentially presented by the HLA-B*07:02 allele, which has a Proline residue anchor and a binding groove that accommodates the consensus sequence for O-GlcNAcylation. These observations may aid in predicting novel O-GlcNAcylated HLA antigens best presented by patients with HLA-B*07:02 or related alleles using Proline as an anchoring residue.

FRONTIERS IN IMMUNOLOGY (2021)

Article Biology

Connecting MHC-I-binding motifs with HLA alleles via deep learning

Ko-Han Lee et al.

Summary: The study developed a deep learning-based framework called MHCfovea to connect HLA alleles with binding motifs, expanding the knowledge of MHC-I binding motifs and revealing critical polymorphic residues that determine binding preference. It provided valuable information for antigen discovery and vaccine design in terms of allele specificity.

COMMUNICATIONS BIOLOGY (2021)

Review Immunology

Hallmarks of T cell aging

Maria Mittelbrunn et al.

Summary: In this Review, Mittelbrunn and Kroemer propose ten molecular hallmarks as common denominators of T cell aging, which include primary and secondary hallmarks explaining the manifestation of T cell aging and its impact on overall deterioration. The challenge now is to weigh the relative impact of these hallmarks on T cell aging and understand their interconnections, with the goal of defining molecular targets for interventions in the aging process.

NATURE IMMUNOLOGY (2021)

Review Rheumatology

Ankylosing spondylitis: an autoimmune or autoinflammatory disease?

Daniele Mauro et al.

Summary: Ankylosing spondylitis (AS) is a chronic inflammatory disease with features of both autoimmune and autoinflammatory processes. While the innate immune system plays a dominant role in AS, factors such as the intestine and biomechanical elements may also contribute to the disease's pathogenesis. Studies suggest a combination of autoinflammation and autoimmunity in AS, with evidence supporting both hypotheses.

NATURE REVIEWS RHEUMATOLOGY (2021)

Article Biochemical Research Methods

Modulation of Natural HLA-B*27:05 Ligandome by Ankylosing Spondylitis-associated Endoplasmic Reticulum Aminopeptidase 2 (ERAP2)

Elena Lorente et al.

MOLECULAR & CELLULAR PROTEOMICS (2020)

Review Biochemistry & Molecular Biology

The Impact of the 'Mis-Peptidome' on HLA Class I-Mediated Diseases: Contribution of ERAP1 and ERAP2 and Effects on the Immune Response

Valentina Tedeschi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Rheumatology

Gut dysbiosis in Spondyloarthritis: Cause or effect?

Daniele Mauro et al.

BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY (2019)

Review Virology

Primary Epstein-Barr virus infection

Samantha K. Dunmire et al.

JOURNAL OF CLINICAL VIROLOGY (2018)

Article Biochemical Research Methods

The Peptide Repertoire of HLA-B27 may include Ligands with Lysine at P2 Anchor Position

Shira Yair-Sabag et al.

PROTEOMICS (2018)

Review Biochemistry & Molecular Biology

The role of polymorphic ERAP1 in autoinflammatory disease

Emma Reeves et al.

BIOSCIENCE REPORTS (2018)

Review Immunology

How ERAP1 and ERAP2 Shape the Peptidomes of Disease-Associated MHC-I Proteins

Jose A. Lopez de Castro

FRONTIERS IN IMMUNOLOGY (2018)

Review Rheumatology

Pathogenesis of ankylosing spondylitis - recent advances and future directions

Vidya Ranganathan et al.

NATURE REVIEWS RHEUMATOLOGY (2017)

Letter Rheumatology

ERAP2 is associated with ankylosing spondylitis in HLA-B27-positive and HLA-B27-negative patients

Philip C. Robinson et al.

ANNALS OF THE RHEUMATIC DISEASES (2015)

Review Rheumatology

Endoplasmic reticulum-associated amino-peptidase 1 and rheumatic disease: genetics

Michael J. Ombrello et al.

CURRENT OPINION IN RHEUMATOLOGY (2015)

Article Biochemistry & Molecular Biology

Natural HLA-B*2705 Protein Ligands with Glutamine as Anchor Motif IMPLICATIONS FOR HLA-B27 ASSOCIATION WITH SPONDYLOARTHROPATHY

Susana Infantes et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Chemistry, Multidisciplinary

CHARMM36 all-atom additive protein force field: Validation based on comparison to NMR data

Jing Huang et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2013)

Article Biochemistry & Molecular Biology

Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides

Efthalia Zervoudi et al.

BIOCHEMICAL JOURNAL (2011)

Article Chemistry, Multidisciplinary

Software News and Updates MDAnalysis: A Toolkit for the Analysis of Molecular Dynamics Simulations

Naveen Michaud-Agrawal et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2011)

Article Chemistry, Physical

Canonical sampling through velocity rescaling

Giovanni Bussi et al.

JOURNAL OF CHEMICAL PHYSICS (2007)

Article Chemistry, Physical

Structure and dynamics of the TIP3P, SPC, and SPC/E water models at 298 K

P Mark et al.

JOURNAL OF PHYSICAL CHEMISTRY A (2001)