期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 24, 期 14, 页码 -出版社
MDPI
DOI: 10.3390/ijms241411802
关键词
endometriosis; hormonal therapy; combined oral contraceptives; estroprogestin treatment; coagulation; circulating microparticles; tissue factor
There is increasing interest in studying the pathogenic mechanisms of endometriosis, especially in relation to the coagulation/fibrinolysis system and its connection with inflammation and tissue remodeling. This study aimed to evaluate the impact of hormonal treatments on microparticle levels in deep-infiltrating endometriosis (DE) patients. The results showed that DE patients receiving a continuous combined oral contraceptive regimen (CCOCR) had lower levels of total circulating microparticles (cMPs), indicating a decrease in chronic inflammation. However, cMP-TF levels were higher in DE patients receiving CCOCR, suggesting a suppression of the inhibitory pathway of tissue factor (TF) by estrogen-containing treatments.
There has been increasing interest in the study of new pathogenic mechanisms in endometriosis (END), including the coagulation/fibrinolysis system and its link with inflammation and tissue remodeling. It has been suggested that END patients, especially with deep-infiltrating (DE) forms, could present a hypercoagulable state revealing higher levels of proinflammatory and procoagulant markers, such as total circulating microparticles (cMPs) and cMP-TF (tissue factor), released by cells in response to damage, activation, or apoptosis. However, no previous study has assessed the effect of END hormonal treatments on cMP and cMP-TF levels. Therefore, the aim of this study was to evaluate the impact of these treatments on cMP and cMP-TF levels in DE patients. Three groups were compared: DE patients receiving a continuous combined oral contraceptive regimen (CCOCR) (n = 41), DE patients without CCOCR (n = 45), and a control group (n = 43). cMP and cMP-TF levels were evaluated in platelet-free plasma. A significant decrease in the total cMP levels was found in the DE group with CCOCR versus the group without CCOCR, reflecting a higher chronic inflammatory status in DE patients that decreased with the treatment. cMP-TF levels were higher in DE patients receiving CCOCR versus those not receiving CCOCR, suggesting that treatments containing estrogens play a predominant role in suppressing the inhibitory pathway of TF.
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