A Proteomic Survey of the Cystic Fibrosis Transmembrane Conductance Regulator Surfaceome

The aim of this review article is to collate recent contributions of proteomic studies to cystic fibrosis transmembrane conductance regulator (CFTR) biology. We summarize advances from these studies and create an accessible resource for future CFTR proteomic efforts. We focus our attention on the CFTR interaction network at the cell surface, thus generating a CFTR 'surfaceome'. We review the main findings about CFTR interactions and highlight several functional categories amongst these that could lead to the discovery of potential biomarkers and drug targets for CF.

Automated summary

The aim of this review article is to summarize the recent contributions of proteomic studies to CFTR biology and provide a resource for future research. The focus is on CFTR's interaction network at the cell surface, creating a CFTR 'surfaceome', and highlighting potential biomarkers and drug targets for CF.