期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 24, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/ijms24119394
关键词
high-fat diet; neuroplasticity; microglia; adolescence; mental disorders; mPFC
The association between a high-fat diet consumption and emotional/cognitive disorders is well-documented. The prefrontal cortex, a brain region responsible for emotion and cognition, undergoes protracted maturation during adolescence and is highly vulnerable to environmental factors. A study on adolescent mice fed a high-fat diet found that it led to anxiety- and depression-like behavior, as well as abnormalities in the prefrontal cortex structure, suggesting a link between high-fat diet and mood disorders in adolescents.
The association between a high-fat diet (HFD) consumption and emotional/cognitive disorders is widely documented. One distinctive feature of the prefrontal cortex (PFC), a kernel emotion- and cognition-related brain region, is its protracted adolescent maturation, which makes it highly vulnerable to the detrimental effects of environmental factors during adolescence. Disruption of the PFC structure and function is linked to emotional/cognitive disorders, especially those that emerge in late adolescence. A HFD consumption is common among adolescents, yet its potential effects on PFC-related neurobehavior in late adolescence and any related underlying mechanisms are yet to be established. In the present study, adolescent (postnatal days 28-56) male C57BL/6J mice were fed a control diet (CD) or a HFD and underwent behavioral tests in addition to Golgi staining and immunofluorescence targeting of the medial PFC (mPFC). The HFD-fed adolescent mice exhibited anxiety- and depression-like behavior and abnormal mPFC pyramidal neuronal morphology accompanied by alterations in microglial morphology indicative of a heightened state of activation and increased microglial PSD95(+) inclusions signifying excessive phagocytosis of the synaptic material in the mPFC. These findings offer novel insights into the neurobehavioral effects due to adolescent HFD consumption and suggest a contributing role in microglial dysfunction and prefrontal neuroplasticity deficits for HFD-associated mood disorders in adolescents.
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