4.7 Article

Osteocytes Exposed to Titanium Particles Inhibit Osteoblastic Cell Differentiation via Connexin 43

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biotechnology & Applied Microbiology

NOX4 blockade suppresses titanium nanoparticle-induced bone destruction via activation of the Nrf2 signaling pathway

Wei Wang et al.

Summary: This study reveals the important role of NOX4 in the progression of periprosthetic osteolysis (PPO) triggered by wear particles. NOX4 blockade suppresses osteoclastogenesis and enhances the scavenging of intracellular ROS. The study also demonstrates that NOX4 blockade can prevent titanium nanoparticle-induced bone destruction through activation of the Nrf2 signaling pathway, suggesting it as a potential therapeutic approach for preventing PPO.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

Article Cell Biology

Osteocytic cells exposed to titanium particles increase sclerostin expression and inhibit osteoblastic cell differentiation mostly via direct cell-to-cell contact

Hao Chai et al.

Summary: This study investigated the effects of titanium particles on MLO-Y4 osteocytic cells and their impact on osteoblastic cells. The results showed that titanium particles increased osteocytic marker expression, apoptosis, and the expression of inflammatory factors. The particles also inhibited the differentiation of osteoblastic cells through direct cell-to-cell contact. Silencing of SOST/sclerostin attenuated these effects. These findings highlight the extensive impact of titanium particles on osteocytic cells and the importance of SOST/sclerostin in cell interaction.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2022)

Review Biochemistry & Molecular Biology

Regulation of Proliferation, Differentiation and Functions of Osteoblasts by Runx2

Toshihisa Komori

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Biochemistry & Molecular Biology

Intracellular trafficking pathways of Cx43 gap junction channels

Irina Epifantseva et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2018)

Article Medicine, General & Internal

Mechanical Properties and Porosity of Acrylic Cement Bone Loaded with Alendronate Powder

Guo-Xin Qu et al.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2018)

Article Engineering, Biomedical

Pro-osteoclastic in vitro effect of Polyethylene-like nanoparticles: Involvement in the pathogenesis of implant aseptic loosening

Kevin Brulefert et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2016)

Article Biochemistry & Molecular Biology

Osteocytes up-regulate the terminal differentiation of pre-osteoblasts via gap junctions

Yoichi Nishikawa et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

Article Endocrinology & Metabolism

Connexin 43 Channels are Essential for Normal Bone Structure and Osteocyte Viability

Huiyun Xu et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2015)

Article Engineering, Biomedical

p38 signaling in titanium particle-induced MMP-2 secretion and activation in differentiating MC3T3-E1 cells

Ming Chen et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2014)

Review Endocrinology & Metabolism

Shifting Paradigms on the Role of Connexin43 in the Skeletal Response to Mechanical Load

Shane A. Lloyd et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2014)

Review Endocrinology & Metabolism

Beyond gap junctions: Connexin43 and bone cell signaling

Lilian I. Plotkin et al.

Article Orthopedics

Absence of Cx43 selectively from osteocytes enhances responsiveness to mechanical force in mice

Nicoletta Bivi et al.

JOURNAL OF ORTHOPAEDIC RESEARCH (2013)

Review Endocrinology & Metabolism

Osteocyte regulation of bone mineral: a little give and take

G. J. Atkins et al.

OSTEOPOROSIS INTERNATIONAL (2012)

Article Cell Biology

Osteoblast connexin43 modulates skeletal architecture by regulating both arms of bone remodeling

Marcus Watkins et al.

MOLECULAR BIOLOGY OF THE CELL (2011)

Article Biochemistry & Molecular Biology

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

Tomoki Nakashima et al.

NATURE MEDICINE (2011)

Article Orthopedics

Osteocyte-derived sclerostin inhibits bone formation:: Its role in bone morphogenetic protein and Wnt signaling

Peter ten Dijke et al.

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME (2008)

Article Endocrinology & Metabolism

Attenuated response to in vivo mechanical loading in mice with conditional osteoblast ablation of the connexin43 gene (Gja1)

Susan K. Grimston et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2008)