4.7 Review

EU's green taxonomy analysis incorporated with energy-mix by machine learning for climate mitigations

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Review Biochemistry & Molecular Biology

The serotonin theory of depression: a systematic umbrella review of the evidence

Joanna Moncrieff et al.

Summary: The serotonin hypothesis of depression, which suggests that depression is caused by lowered serotonin activity or concentrations, lacks consistent evidence based on the synthesis and evaluation of research in this field. This umbrella review found no substantial association between serotonin and depression, while suggesting that long-term antidepressant use may reduce serotonin concentration.

MOLECULAR PSYCHIATRY (2023)

Article Plant Sciences

Antidepressant-Like Effect of Aromatherapy with Magnolia sieboldii Essential Oils on Depression Mice

Yong Ai et al.

Summary: This study demonstrates that the essential oils of M. sieboldii can modulate the expression of BDNF and 5-HT in serum, leading to significant improvement in depressive behavior in mice. Furthermore, a medium concentration of M. sieboldii essential oils can effectively alleviate depressive-like behavior and increase the serum levels of 5-HT1A and BDNF.

RECORDS OF NATURAL PRODUCTS (2023)

Article Integrative & Complementary Medicine

Antispasmodic, antidepressant and anxiolytic effects of extracts from Schinus lentiscifolius Marchand leaves

Catalina Vanegas Andrade et al.

Summary: The study found that extracts from Schinus lentiscifolius leaves have antispasmodic effects on the intestines, urinary system, and uterus, and also exhibit anxiolytic and antidepressant properties. Different extracts showed slight variations in their effects.

JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE (2022)

Review Biochemistry & Molecular Biology

Overcoming Depression with 5-HT2A Receptor Ligands

Agata Zieba et al.

Summary: This article summarizes the applicability of 5-HT2A receptor signaling modulators in the treatment of depression and provides insights into the structural and physiological features of this receptor. It also presents an overview of recent virtual screening campaigns and additional data on synthesized ligands acting through this protein.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Review Biochemistry & Molecular Biology

Neurobiological Highlights of Cognitive Impairment in Psychiatric Disorders

Anna Morozova et al.

Summary: This review focuses on the cognitive impairment as a significant component in various psychiatric disorders and its impact on the quality of life. It summarizes the current understanding of the underlying neurobiological mechanisms of cognitive impairment in individuals with schizophrenia, depression, mild cognitive impairment, and dementia (including Alzheimer's disease). The review also provides data on the prevalence of cognitive impairment in individuals with mental illness and the associated biological markers.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Multidisciplinary Sciences

The impact of the COVID-19 pandemic on scientific research in the life sciences

Massimo Riccaboni et al.

Summary: The COVID-19 outbreak has had a significant impact on scientific production in the life sciences, with a substantial increase in COVID-19-related research output and a decrease in unrelated research output. Clinical trial publications have been delayed, and funding has been redirected from non-COVID-19 research areas.

PLOS ONE (2022)

Article Nursing

Effects of Inhalation Aromatherapy With Rosa damascena (Damask Rose) on the State Anxiety and Sleep Quality of Operating Room Personnel During the COVID-19 Pandemic: A Randomized Controlled Trial

Bahareh Mahdood et al.

Summary: This study explored the effects of damask rose aromatherapy on state anxiety and sleep quality among Iranian operating room personnel during the COVID-19 pandemic. The results indicated that damask rose can reduce anxiety and improve sleep quality in these individuals.

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Review Neurosciences

Linalool as a Therapeutic and Medicinal Tool in Depression Treatment: A Review

Everton Renan Quaresma dos Santos et al.

Summary: This review discusses the antidepressant action mechanisms of linalool as a natural compound, highlighting its intervention in various pathophysiological factors and providing important references for future research.

CURRENT NEUROPHARMACOLOGY (2022)

Article Neurosciences

Flower essential oil of Tagetes minuta mitigates oxidative stress and restores BDNF-Akt/ERK2 signaling attenuating inflammation- and stress-induced depressive-like behavior in mice

Paloma T. Birmann et al.

Summary: This study demonstrated the potential therapeutic effects of flower essential oil from Tagetes minuta in attenuating depressive-like behavior induced by stress or inflammation. The oil reversed oxidative stress, decreased corticosterone levels, and restored the expression of neurotrophic factors, suggesting its promising antidepressant properties.

BRAIN RESEARCH (2022)

Review Biochemistry & Molecular Biology

Toxicity of Selected Monoterpenes and Essential Oils Rich in These Compounds

Karolina A. Wojtunik-Kulesza

Summary: Monoterpenes, the largest group of plant secondary metabolites, have antioxidative, antibacterial, sedative and anti-inflammatory activity, making them widely used in medicine, food and cosmetic industries. However, long-term studies have revealed their toxic properties and potential side effects on human health.

MOLECULES (2022)

Article Chemistry, Multidisciplinary

Elucidating the Interactions of Fluoxetine with Human Transferrin Employing Spectroscopic, Calorimetric, and In Silico Approaches: Implications of a Potent Alzheimer's Drug

Mohd Shahnawaz Khan et al.

Summary: This study investigates the binding of fluoxetine (FXT) to transferrin (Tf) using structure-based docking, molecular dynamics simulations, and principal component analysis. The results demonstrate stable and significant interactions between FXT and Tf, suggesting potential implications for the clinical management of neurological disorders, including Alzheimer's disease.

ACS OMEGA (2022)

Review Public, Environmental & Occupational Health

The Effects of Aromatherapy on Anxiety and Depression in People With Cancer: A Systematic Review and Meta-Analysis

Dan Li et al.

Summary: Aromatherapy was effective in relieving anxiety for cancer patients, but showed no beneficial effect on depression and psychological wellbeing.

FRONTIERS IN PUBLIC HEALTH (2022)

Article Chemistry, Medicinal

Antidepressant-like Activity of Patchouli Oil var. Tapak Tuan (Pogostemon cablin Benth) via Elevated Dopamine Level: A Study Using Rat Model

Puji Astuti et al.

Summary: This study investigated the antidepressant potential of patchouli oil containing high concentrations of patchouli alcohol, obtained through vacuum distillation with different temperature ranges. Results showed that the oil with the highest patchouli alcohol content had significant antidepressant effects in a rat model, possibly through increased brain dopamine levels.

PHARMACEUTICALS (2022)

Article Plant Sciences

β-Caryophyllene suppresses ferroptosis induced by cerebral ischemia reperfusion via activation of the NRF2/HO-1 signaling pathway in MCAO/R rats

Qingwen Hu et al.

Summary: This study suggests that ferroptosis plays a critical role in the pathogenesis of acute ischemic stroke. β-Caryophyllene (BCP) has neuroprotective effects by regulating ferroptosis and activating the NRF2/HO-1 signaling pathway to improve cerebral ischemia injury.

PHYTOMEDICINE (2022)

Article Behavioral Sciences

The effect of β-caryophyllene on food addiction and its related behaviors: A randomized, double-blind, placebo-controlled trial

Shahab Alizadeh et al.

Summary: Beta-caryophyllene supplementation may have beneficial effects on improving Yale Food Addiction Scale Score in women with obesity diagnosed with food addiction, but has no significant impact on body composition, appetite, eating behavior, and mental health.

APPETITE (2022)

Article Pharmacology & Pharmacy

Anti-depression effectiveness of essential oil from the fruits of Zanthoxylum bungeanum maxim. on chronic unpredictable mild stress-induced depression behavior in mice

Dandan Tang et al.

Summary: The essential oil of Zanthoxylum bungeanum Maxim. (HEO) has antidepressant effects and can reduce neuronal apoptosis by regulating the HPA axis and activating the PI3K/Akt signaling pathway.

FRONTIERS IN PHARMACOLOGY (2022)

Article Pharmacology & Pharmacy

Essential oil from the roots of Paeonia lactiflora pall. has protective effect against corticosterone-induced depression in mice via modulation of PI3K/Akt signaling pathway

Jia-Yi Sun et al.

Summary: This study systematically investigated the antidepressant effect of essential oil from Paeonia lactiflora Pall (PLP), demonstrating its ability to alleviate symptoms of corticosterone-induced depression and protect hippocampal neurons from injury. The study also revealed that the PI3K/Akt/Nrf2 signaling pathway may contribute to the antidepressant effect of the essential oil.

FRONTIERS IN PHARMACOLOGY (2022)

Article Medicine, Research & Experimental

Antidepressant- and anxiolytic-like activities of Rosmarinus officinalis extract in rodent models: Involvement of oxytocinergic system

Kazunori Sasaki et al.

Summary: The study shows that Rosemary extract can significantly improve depressive and anxiety-like behavior in mice by modulating the oxytocinergic system in the brain, as well as reversing stress-induced alterations in gene expressions related to neurotransmitter pathways and inflammatory processes.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Article Biochemistry & Molecular Biology

Antidepressant drugs act by directly binding to TRKB neurotrophin receptors

Plinio C. Casarotto et al.

Summary: The study reveals that antidepressant drugs bind directly to the TRKB receptor, facilitating its activation at the synapse and potentially explaining the mechanism behind antidepressant action.
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Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic

Damian F. Santomauro et al.

Summary: This study aimed to quantify the impact of the COVID-19 pandemic on the prevalence and burden of major depressive disorder and anxiety disorders globally in 2020. The findings showed that the pandemic led to increased prevalence of major depressive disorder and anxiety disorders, with females and younger age groups being more affected. The pandemic has created an increased urgency to strengthen mental health systems in most countries and mitigation strategies are needed to address the burden of these mental disorders.

LANCET (2021)

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α-Pinene: A never-ending story

Martina Allenspach et al.

Summary: Alpha-pinene, a monoterpene found in higher plants, has been historically used for treating respiratory tract infections and is essential in the fragrance and flavor industry. Recent research focuses on synthesizing new compounds with pharmacological and herbicidal activities based on the alpha-pinene core, as well as investigating the enantioselective activities of alpha-pinene. Furthermore, approaches for authenticity control of essential oils based on their enantiomeric profile are also discussed.

PHYTOCHEMISTRY (2021)

Review Biotechnology & Applied Microbiology

Natural products in drug discovery: advances and opportunities

Atanas G. Atanasov et al.

Summary: Natural products and their analogues have historically played a significant role in pharmacotherapy, however, they also present challenges. Recent technological and scientific developments are addressing these challenges and revitalizing interest in natural products as drug leads, particularly for combating antimicrobial resistance.

NATURE REVIEWS DRUG DISCOVERY (2021)

Review Pharmacology & Pharmacy

Natural volatile oils derived from herbal medicines: A promising therapy way for treating depressive disorder

Yulu Zhang et al.

Summary: This review summarizes the classification of depression and the history of using volatile oils to fight depression in some countries. It focuses on the anti-depressive natural volatile oils and their mechanisms, comparing them to antidepressant drugs and discussing their clinical application.

PHARMACOLOGICAL RESEARCH (2021)

Article Biochemistry & Molecular Biology

Evaluation of Motor Coordination and Antidepressant Activities of Cinnamomum osmophloeum ct. Linalool Leaf Oil in Rodent Model

Hui-Ting Chang et al.

Summary: The study found that the essential oil of Cinnamomum osmophloeum ct. linalool has potential therapeutic benefits for minor/medium depressive syndromes, without causing weight gain and with antidepressant and motor coordination effects. The main component of the leaf oil is linalool, and long-term oral administration did not lead to additional body weight gain.

MOLECULES (2021)

Article Chemistry, Medicinal

Antidepressant-like effects of Foeniculum vulgare essential oil and potential involvement of dopaminergic and serotonergic systems on mice in the forced swim test

Saeid Abbasi-Maleki et al.

Summary: The study found that Foeniculum vulgare essential oil (FVEO) exhibited antidepressant-like effects in mice, attributed at least partly to dopaminergic and serotonergic systems, not to the noradrenergic system.

PHARMANUTRITION (2021)

Review Psychiatry

COVID-19 mental health impact and responses in low-income and middle-income countries: reimagining global mental health

Lola Kola et al.

Summary: This review examines the impact of the COVID-19 pandemic on mental health in low-income and middle-income countries, highlighting high rates of psychological distress and early signs of increasing mental health disorders. It suggests opportunities for reshaping global mental health, such as shifting power dynamics and emphasizing community-oriented psychosocial perspectives. This vision includes key strategies like integrating mental health into universal health coverage, leveraging digital technologies, and addressing the needs of neglected populations.

LANCET PSYCHIATRY (2021)

Article Multidisciplinary Sciences

Anxiolytic and antidepressant-like effects of essential oil from the fruits of Piper nigrum Linn. (Black pepper) in mice: involvement of serotonergic but not GABAergic transmission system

Sourav Ghosh et al.

Summary: The study demonstrated that Piper nigrum essential oil exhibited dual anxiolytic and antidepressant-like effects in mice, possibly through serotonin transmission. Furthermore, no signs of locomotor impairment or toxicity were observed after treatment with PNEO, except for a significant decrease in total cholesterol levels.

HELIYON (2021)

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Essential Oils as Antiviral Agents, Potential of Essential Oils to Treat SARS-CoV-2 Infection: An In-Silico Investigation

Joyce Kelly R. da Silva et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019

David J. Newman et al.

JOURNAL OF NATURAL PRODUCTS (2020)

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Drug Resistance in Epilepsy: Clinical Impact, Potential Mechanisms, and New Innovative Treatment Options

Wolfgang Loescher et al.

PHARMACOLOGICAL REVIEWS (2020)

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Selected essential oils and their mechanisms for therapeutic use against public health disorders. An overview

Ingrid Leherbauer et al.

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L. Harper et al.

Journal of Pediatric Urology (2020)

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Protective Effects of (E)-β-Caryophyllene (BCP) in Chronic Inflammation

Rosaria Scandiffio et al.

NUTRIENTS (2020)

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Potential benefits of patchouli alcohol in prevention of human diseases: A mechanistic review

Hee-Seop Lee et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Ashley J. Farrar et al.

NURSING CLINICS OF NORTH AMERICA (2020)

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The antidepressant-like effects of Origanum majorana essential oil on mice through monoaminergic modulation using the forced swimming test

Saeid Abbasi-Maleki et al.

JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE (2020)

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Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation

Bruno Lima Giacobbo et al.

MOLECULAR NEUROBIOLOGY (2019)

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Antidepressant-like Effect of Citrus sinensis (L.) Osbeck Essential Oil and Its Main Component Limonene on Mice

Lu-Lu Zhang et al.

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Article Integrative & Complementary Medicine

The effects of aromatherapy using rose oil (Rosa damascena Mill.) on preoperative anxiety: A prospective randomized clinical trial

Recai Dagli et al.

EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE (2019)

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Molecular aspects of depression: A review from neurobiology to treatment

Gustavo Roberto Villas Boas et al.

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Lavender (Lavandula angustifolia Mill.) Essential Oil Alleviates Neuropathic Pain in Mice With Spared Nerve Injury

Maria Domenica Senna et al.

FRONTIERS IN PHARMACOLOGY (2019)

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Anxiolytic Effect of Essential Oils and Their Constituents: A Review

Nan Zhang et al.

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Brain-derived neurotrophic factor and schizophrenia

Pasquale Di Carlo et al.

PSYCHIATRIC GENETICS (2019)

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Docosahexaenoic acid enhances amphiregulin-mediated bronchial epithelial cell repair processes following organic dust exposure

Tara M. Nordgren et al.

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Linalool-rich essential oils from the Amazon display antidepressant-type effect in rodents

Everton Renan Q. dos Santos et al.

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Structural basis for recognition of diverse antidepressants by the human serotonin transporter

Jonathan A. Coleman et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Structural basis for recognition of diverse antidepressants by the human serotonin transporter

Jonathan A. Coleman et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)

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Antidepressant-Like Effect of Lippia sidoides CHAM (Verbenaceae) Essential Oil and Its Major Compound Thymol in Mice

Michele Sanford Rangel Parente et al.

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Effects of oregano essential oil on brain TLR4 and TLR2 gene expression and depressive-like behavior in a rat model

Azam Amiresmaeili et al.

RESEARCH IN PHARMACEUTICAL SCIENCES (2018)

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Hepatotoxicity of monoterpenes and sesquiterpenes

Tomas Zarybnicky et al.

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Prevalence of anxiety disorders as a cause of workers' absence

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Can Ocimum basilicum relieve chronic unpredictable mild stress-induced depression in mice?

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Essential Oils and Their Constituents: An Alternative Source for Novel Antidepressants

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The antidepressant-like effect of Ocimum basilicum in an animal model of depression

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Anthriscus nemorosa essential oil inhalation prevents memory impairment, anxiety and depression in scopolamine-treated rats

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BIOMEDICINE & PHARMACOTHERAPY (2016)

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More lessons from linalool: insights gained from a ubiquitous floral volatile

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CURRENT OPINION IN PLANT BIOLOGY (2016)

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Antidepressant and tolerance: Determinants and management of major side effects

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Essential oils from Apiaceae as valuable resources in neurological disorders: Foeniculi vulgare aetheroleum

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Antidepressant drug interactions: evidence and clinical significance

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Neuroimmune mechanisms of depression

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Antidepressant-like effect of essential oil isolated from Toona ciliata Roem. var. yunnanensis

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JOURNAL OF NATURAL MEDICINES (2015)

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Ketamine for chronic pain: risks and benefits

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CH-pi hydrogen bonds in biological macromolecules

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Molecular Basis for Selective Serotonin Reuptake Inhibition by the Antidepressant Agent Fluoxetine (Prozac)

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Natural products as sources of new drugs over the last 25 years

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