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Article
Biochemistry & Molecular Biology
Mrakic-Sposta Simona et al.
Summary: This study presents a NMR and EPR spectroscopy approach to assess kidney viability and metabolism. The metabolism and oxidative damage of porcine kidney models were examined during organ retrieval, preservation, and transplantation. The results showed higher ROS production and concentration of metabolites in the ex vivo machine perfusion (HMP) group compared to the static cold storage (SCS) group. The HMP group also exhibited better functional recovery after transplantation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Kazutoshi Murotomi et al.
Summary: Reactive oxygen species, particularly singlet oxygen, have significant implications in the development of diseases and aging. Singlet oxygen can be formed through various reactions, both enzymatic and non-enzymatic, and its accumulation can result in oxidative stress and damage to biomolecules. This review explores the mechanisms of singlet oxygen production and methods for evaluating its induced damage. Additionally, it discusses the involvement of singlet oxygen in skin and eye diseases and the potential of singlet oxygen-derived products as biomarkers. Furthermore, recent advancements in singlet oxygen scavengers for disease prevention are described.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Alessia Remigante et al.
Summary: Oxidative stress and immune response are important factors in the development of cancers, including melanoma. Ion channels, which are aberrantly expressed in tumor cells, play a role in neoplastic transformation, malignant progression, and resistance to therapy. These ion channels, located in cellular membranes, are targets of oxidative stress, which is particularly elevated in melanoma. They also represent promising targets for therapeutic intervention in melanoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Pasquale Perrone et al.
Summary: Mercury exposure induces oxidative stress in red blood cells (RBCs), but natural antioxidants like hydroxytyrosol (HT) and homovanillyl alcohol (HVA) from extra-virgin olive oil (EVOO) have shown potential protective effects. In this study, RBCs treated with HgCl2 were examined, and it was found that HT and/or HVA pre-treatment impaired acanthocytes formation and oxidative stress injury induced by mercury, while restoring the endogenous antioxidant system. These findings suggest that dietary supplementation with polyphenols could be beneficial for populations exposed to mercury poisoning.
Review
Biochemistry & Molecular Biology
Zhenzhou Huang et al.
Summary: Oxidative stress, caused by an imbalance between reactive oxygen species (ROS) formation and antioxidant defense mechanisms, can lead to the damage of critical biomolecules and the development of various diseases. Cylindromatosis (CYLD), a gene associated with familial cylindromatosis, has a well-established role in tumor inhibition and anti-inflammatory processes. However, emerging evidence suggests that CYLD, as a deubiquitination enzyme, also plays a crucial role in key signaling pathways and is implicated in the pathogenesis of oxidative stress-driven diseases. This review systematically examines the current research on CYLD's function and pathogenesis in diseases induced by oxidative stress, and suggests that therapeutic interventions targeting CYLD may hold promise for treating such diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Julia Sutter et al.
Summary: Herpes simplex virus type 1 (HSV-1) is a contagious pathogen that causes lifelong infections. Current antiviral therapies are effective against HSV-1 replication in epithelial cells but not in neurons where the virus can remain dormant. Non-thermal plasma (NTP) therapy shows promise in controlling HSV-1 by manipulating oxidative stress responses and stimulating antiviral immune responses. NTP application can decrease the size of the viral reservoir in the nervous system, addressing the challenge of latency.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Benedetta Fibbi et al.
Summary: This article reviews the multiple biological activities of Apelin, such as regulating vascular tone, platelet aggregation, leukocytes adhesion, myocardial activity, inflammation, insulin resistance, and cell proliferation and invasion. As an endogenous ligand for APJ, Apelin can modulate various intracellular signaling pathways and play a crucial role in the pathogenesis of degenerative and proliferative conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yuhong Chen et al.
Summary: This study explored the effects and mechanisms of two monomers of Camellia sinensis seed saponins, TE1 and ASA, on a resistant Candida albicans strain. Results showed that TE1 and ASA increased cell membrane permeability, disrupted membrane integrity, induced accumulation of ROS, and decreased mitochondrial membrane potential. Transcriptome analysis revealed differential gene expression related to cell wall, plasma membrane, glycolysis, and ergosterol synthesis pathways. In conclusion, the antifungal mechanisms of TE1 and ASA involved interference with ergosterol biosynthesis, mitochondrial damage, as well as regulation of energy and lipid metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Changjie Ren et al.
Summary: The antioxidative agent CAPE derived from propolis suppresses mitochondrial ROS production in ARPE-19 cells by regulating UCP2, providing long-term protection to retinal pigment epithelial cells against oxidative stress-induced apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ewa Jowko et al.
Summary: The aim of this study was to identify relevant factors that affect bone mineral content (BMC) and bone mineral density (BMD) in young, healthy men reaching peak bone mass. The results showed that age, BMI, engaging in combat and team sports at a competitive level, and certain genetic polymorphisms were significant predictors of BMD/BMC at different skeletal sites. Specifically, the SOD2 AG genotype was associated with lower BMC values, while the VDR FokI GG genotype was associated with lower BMD. However, the CALCR AG genotype was linked to higher arm BMD. These findings suggest that sports training may mitigate the negative impact of genetic factors on bone tissue and reduce the risk of osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ksenija Durgo et al.
Summary: This study investigates the toxicity and cellular response to metal ions released by fixed orthodontic appliances on gastrointestinal tract cells. The eluates of archwires, brackets, ligatures, and bands were tested for their prooxidant effect, cytotoxicity, and genotoxicity on four different cell lines. The results show that most eluates were toxic to CAL 27 cells and that CaCo-2 cells were the most resistant. The eluates induced free radical formation in AGS and Hep-G2 cells, and eluates containing Cr, Mn, and Al showed slight prooxidant effect and genotoxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Piero Giuseppe Meliante et al.
Summary: Obstructive sleep apnea syndrome (OSAS) is a disease characterized by intermittent hypoxia (IH) during sleep due to recurrent upper airway obstruction. The associated oxidative stress (OS) leads to various complications that affect both sleep-wake rhythm and systemic functions. This literature review investigates the molecular changes, diagnostic markers, and potential medical therapies for OSAS. The findings suggest that IH increases oxygen free radicals (ROS) and impairs antioxidant capacities, resulting in endothelial dysfunction, osteoporosis, systemic inflammation, increased cardiovascular risk, pulmonary remodeling, and neurological alterations in OSAS patients. The most promising pharmacological therapies include N-acetylcysteine (NAC), Vitamin C, Leptin, Dronabinol, or Atomoxetine + Oxybutynin, but further research is needed. Continuous positive airway pressure (CPAP) remains the approved therapy for reversing most molecular changes, while future drugs may target the remaining dysfunctions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sara Spinelli et al.
Summary: The study aims to investigate the effects of Acai extract in a model of aging in human red blood cells. The results show that Acai extract can restore the phosphorylation of membrane proteins and partially reverse the structural changes in cytoskeletal proteins. Additionally, Acai extract can improve the deformability of red blood cell membranes. These findings are important for understanding the mechanisms of aging in human red blood cells and suggest that flavonoid substances can be used as natural antioxidants for the treatment and prevention of oxidative-stress-related diseases.
Article
Biochemistry & Molecular Biology
Piotr Hydzik et al.
Summary: In conventional clinical toxicology practice, the blood level of carboxyhemoglobin is commonly used as a biomarker for carbon monoxide poisoning. However, this does not reflect the complete clinical picture and severity of the poisoning. This article aims to explore the potential use of oxidative-stress-related parameters as biomarkers for evaluating CO poisoning severity and guiding treatment decisions. Preliminary studies involving CO-poisoned patients showed significant changes in antioxidative parameters, such as catalase and glutathione levels, but further research is needed to fully understand their role as biomarkers for CO poisoning severity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Iva Pukles et al.
Summary: This study presents a new strategy for the determination of active compounds in health supplements using contactless conductivity detection on microchip technology. The method allows for the electrophoretic determination of L-carnosine in complex health supplement formulations without pre-concentration and derivatization steps. The method showed excellent reproducibility and accuracy in detecting L-carnosine in different health supplement samples.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Nadeem Akhter et al.
Summary: Obesity and metabolic syndrome are associated with metabolic inflammation, endotoxin, and free fatty acids. The study found that the interaction between metabolic stress and endoplasmic reticulum (ER) stress promotes inflammation and triggers TNF-alpha production through the ROS/CHOP/HIF-1 alpha and MAPK/NF-kappa B pathways. Antioxidants show therapeutic potential in inflammatory conditions involving metabolic/ER stresses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Vesela Yordanova et al.
Summary: The interplay between inflammatory and redox processes is an important phenomenon in cell biology, involving various biological factors. This study investigated the modulation of secretory phospholipases A(2) (sPLA(2)) activity by OxPCs in different types of PC vesicles. The results showed that OxPCs can decrease membrane lipid order, modulate sPLA(2) activity, and have varying effects depending on the specific OxPC species and lipid mixing protocol. Evaluation: 9/10.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Physiology
Alessia Remigante et al.
Summary: The aim of this study was to verify the potential protective role of bergamot peel and juice extract in a model of aging represented by human red blood cells (RBCs) exposed to D-Galactose (DGal). The results showed that bergamot peel and juice extract effectively prevented the production of reactive oxygen species (ROS) and oxidative stress injury, restored the distribution and ion transport kinetics of band 3, blunted A1c production, impeded the over-activation of the endogenous antioxidant enzymes, and prevented the activation of G6PDH in RBCs.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Iuliia Azarova et al.
Summary: Numerous studies have shown that oxidative stress plays a major role in the development and progression of type 2 diabetes (T2D). This review summarizes the current understanding of the role of abnormal redox homeostasis in the molecular mechanisms of T2D and discusses the genetic studies investigating the contribution of polymorphisms in genes encoding redox state-regulating enzymes to the disease pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Rachid Akki et al.
Summary: Studies have shown that cells and tissues may enhance their resistance to more severe ischaemic injuries by undergoing ischemic preconditioning under low oxidative stress conditions. This review summarizes the latest knowledge on adaptive mechanisms, signaling transduction pathways, antioxidant systems, and in vivo adaptation strategies in response to ischemia/reperfusion and brain trauma events.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Review
Physiology
Alessia Remigante et al.
Summary: Bicarbonate, a major anion in mammalian tissues and fluids, plays a critical role in cell and systemic pH homeostasis and is involved in transporting ions and substrates across cell membranes. Chloride/bicarbonate exchangers, abundant in erythrocytes and epithelial cells, are particularly susceptible to oxidative stress. This review focuses on the physiological functions and pathophysiological changes of Cl-/HCO3- exchangers belonging to the SLC4 and SLC26 superfamilies in relation to oxidative stress.
Article
Biochemistry & Molecular Biology
Anji Song et al.
Summary: The effect of resveratrol on tinnitus has not been reported. This study found that resveratrol attenuated salicylate-induced tinnitus in both in vitro and in vivo experiments. It reduced the expression of certain genes associated with tinnitus and showed potential as a therapeutic option.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hui Zou et al.
Summary: Cadmium is a potential pathogenic factor in kidney diseases, and microplastics are major carriers of contaminants. In vivo experiments showed that microplastics aggravated cadmium-induced kidney injury, potentially through oxidative stress, autophagy, apoptosis, and fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Biochemistry & Molecular Biology
Alessia Remigante et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Alessia Remigante et al.
Summary: This study aimed to verify the protective role of Quercetin in a d-Galactose-induced model of aging in human erythrocytes. It was found that Quercetin preferentially improved lipid peroxidation rather than protein oxidation and prevented glycated hemoglobin formation. These findings suggest that the Band 3 protein could be a potential target for antioxidant treatments against aging-related disturbances.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Alessia Remigante et al.
Summary: This study aims to investigate the response of red blood cells to oxidative stress and evaluate the potential beneficial effects of the natural antioxidant quercetin. The results indicate that pre-treatment with quercetin is more effective in protecting red blood cells against oxidative stress and preventing damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Xueting Li et al.
Summary: Lead is an important raw material for industrial production, but it poses serious harm to aquatic ecosystems, especially causing spinal malformations in zebrafish embryos, which is mainly attributed to Pb2+-induced endoplasmic reticulum stress and apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Aram Yegiazaryan et al.
Summary: Coronaviruses, including COVID-19, are highly contagious respiratory diseases transmitted through close contact and respiratory droplets. Glutathione, a naturally occurring antioxidant, plays an important role in immune response and cellular detoxification, and is targeted by proinflammatory cytokines and transcription factors during infection. Exploring the role of glutathione in COVID-19 may lead to potential treatment mechanisms and alleviate severe symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yuan-Hong Jiang et al.
Summary: This study investigated the usefulness of urinary biomarkers in assessing bladder condition and histopathology in IC/BPS patients. The results show that urinary biomarker levels are associated with symptoms and pathological manifestations, helpful in identifying HIC and NHIC subtypes, but most biomarkers are not strongly correlated with specific bladder histopathological findings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Loretta Ferrera et al.
Summary: The response to oxidative stimulation in melanoma cells involves the activation of potassium currents and an increase in intracellular calcium levels, mediated by BK, KCa3.1, and TRPM2 channels. Differences in the expression levels of these channels in different cell lines may play a crucial role in melanoma progression. Targeting these ion channels pharmacologically could be a novel strategy to reduce the metastatic potential of melanoma cells alongside traditional treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Rachid Akki et al.
CELL BIOCHEMISTRY AND FUNCTION
(2018)