4.7 Review

Hematopoiesis and Mast Cell Development

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Article Immunology

New perspectives on the origins and heterogeneity of mast cells

Ashley L. St. John et al.

Summary: Mast cells are complex immune cells that exhibit diverse phenotypes and functions, influenced by both their ontogeny and the specialized tissue microenvironments they reside in.

NATURE REVIEWS IMMUNOLOGY (2023)

Article Biotechnology & Applied Microbiology

A comparison of transcriptome analysis methods with reference genome

Xu Liu et al.

Summary: This study compared the performance of six different RNA-seq analysis procedures and evaluated their performance in different species datasets. The results showed that high and low expression level genes contribute to the major differences in gene expression values. The biological validation rates of differentially expressed genes (DEGs) were similar among all six procedures for genes with medium expression levels.

BMC GENOMICS (2022)

Article Hematology

Single-cell transcriptomics reveals the identity and regulators of human mast cell progenitors

Chenyan Wu et al.

Summary: Mast cell accumulation is a characteristic of various diseases, and this study utilized single-cell transcriptomics analysis to determine the timing of FcεRI appearance during mast cell progenitor stage. External stimuli were also shown to regulate FcεRI expression in mast cell progenitors.

BLOOD ADVANCES (2022)

Review Biochemistry & Molecular Biology

Mast Cells and Interleukins

Antonio Giovanni Solimando et al.

Summary: Mast cells are crucial for inflammatory diseases and tumor growth, as they can secrete a wide range of biologically active cytokines. This review article aims to analyze the complex involvement of mast cells in interleukin secretion and the role of interleukins in regulating mast cell activities.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Review Allergy

Defining mast cell differentiation and heterogeneity through single-cell transcriptomics analysis

Tahereh Derakhshan et al.

Summary: This article provides an overview of the differentiation and characteristics of mast cell (MC) progenitors, as well as the heterogeneity of MCs in health and disease. Single-cell profiling technologies offer a powerful approach to decipher complex cellular functions and interactions, and to identify candidate factors for targeted therapies.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

Article Allergy

Single-cell molecular profiling provides a high-resolution map of basophil and mast cell development

Fiona K. Hamey et al.

Summary: The study explored the differentiation pathways of basophils and mast cells at the single-cell level in mice using multicolor flow cytometry, high-coverage single-cell RNA sequencing, and cell fate assays. The results provided a detailed map of differentiation and revealed gene expression changes during the process. Flow cytometry and transcriptional profiling successfully predicted the bipotent phenotype of a previously uncharacterized population of peritoneal basophil-mast cell progenitors.

ALLERGY (2021)

Review Cell & Tissue Engineering

Fetal liver hematopoiesis: from development to delivery

Kyle Lewis et al.

Summary: This review discusses the importance of the fetal liver niche in HSC expansion, which occurs during development and has great clinical potential. Emerging approaches to generate expandable HSC in cell culture are also discussed, including the use of cells or organoid models in combination with engineering and systems biology approaches. Delivery of HSC by understanding the molecular and biological interactions between HSCs and fetal liver cells for their controlled maturation and expansion will be beneficial.

STEM CELL RESEARCH & THERAPY (2021)

Review Cell Biology

Fetal-Derived Immune Cells at the Roots of Lifelong Pathophysiology

Elvira Mass et al.

Summary: It is increasingly recognized that tissue-resident innate immune cells, particularly those derived from fetal sources, play a crucial role in the formation of the adult immune system and disease susceptibility. This review delves into the impact of developmental programming events on macrophages and mast cells, suggesting their involvement in lifelong diseases. The study highlights the importance of understanding fetal hematopoiesis and its long-term consequences in shaping immune responses and disease outcomes.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Review Immunology

Anatomy of Hematopoiesis and Local Microenvironments in the Bone Marrow. Where to?

Qingqing Wu et al.

Summary: Understanding the anatomy of tissue is crucial for comprehending cell differentiation and the interactions between different cells in tissues. Hematopoiesis involves the progressive differentiation of stem cells and progenitors in the bone marrow, which are influenced by a heterogeneous microenvironment. Recent studies have shown a complex spatial organization in hematopoiesis where specific subsets of hematopoietic stem cells and progenitors are spatially organized and regulated by local microenvironments.

FRONTIERS IN IMMUNOLOGY (2021)

Review Cell Biology

Mast Cells as Important Regulators in Autoimmunity and Cancer Development

Christine N. Noto et al.

Summary: Mast cells play crucial roles in immune responses and tumor microenvironments by regulating inflammatory responses, promoting vascular permeability, recruiting immune cells, and expressing immune checkpoint molecules. They have disease-modifying roles in autoimmune diseases and cancers through their immune modulating activities.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Review Medicine, Research & Experimental

Angiocrine endothelium: from physiology to cancer

Jennifer Pasquier et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

Review Biochemistry & Molecular Biology

Future Needs in Mast Cell Biology

Gilda Varricchi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Allergy

New Insights into Clonal Mast Cell Disorders Including Mastocytosis

Sofija Volertas et al.

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA (2018)

Article Cell Biology

Human haematopoietic stem cell lineage commitment is a continuous process

Lars Velten et al.

NATURE CELL BIOLOGY (2017)

Review Cell Biology

Haematopoietic stem cells: past, present and future

Ashley P. Ng et al.

CELL DEATH DISCOVERY (2017)

Article Immunology

Immunoregulatory effect of mast cells influenced by microbes in neurodegenerative diseases

Francesco Girolamo et al.

BRAIN BEHAVIOR AND IMMUNITY (2017)

Article Multidisciplinary Sciences

Specification of tissue-resident macrophages during organogenesis

Elvira Mass et al.

SCIENCE (2016)

Article Cell & Tissue Engineering

Distinguishing Mast Cell Progenitors from Mature Mast Cells in Mice

Joakim S. Dahlin et al.

STEM CELLS AND DEVELOPMENT (2015)

Article Multidisciplinary Sciences

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

Elisa Gomez Perdiguero et al.

NATURE (2015)

Article Multidisciplinary Sciences

Endothelial and perivascular cells maintain haematopoietic stem cells

Lei Ding et al.

NATURE (2012)

Article Multidisciplinary Sciences

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

Simon Mendez-Ferrer et al.

NATURE (2010)

Article Multidisciplinary Sciences

Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche

Cristina Lo Celso et al.

NATURE (2009)

Article Biochemistry & Molecular Biology

Bone marrow long label-retaining cells reside in the sinusoidal hypoxic niche

Yoshiaki Kubota et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)

Article Multidisciplinary Sciences

Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia

Kalindi Parmar et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Review Biochemistry & Molecular Biology

Differentiation of bone marrow stroma-derived mesenchymal cells

D. Benayahu et al.

CURRENT MEDICINAL CHEMISTRY (2007)

Review Biochemistry & Molecular Biology

Understanding hematopoietic stem-cell microenvironments

Zhixing Li et al.

TRENDS IN BIOCHEMICAL SCIENCES (2006)

Article Multidisciplinary Sciences

Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells

CJ Luckey et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Review Immunology

Bone-marrow haematopoietic-stem-cell niches

A Wilson et al.

NATURE REVIEWS IMMUNOLOGY (2006)

Article Multidisciplinary Sciences

Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis

Y Arinobu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Multidisciplinary Sciences

Identification of mast cell progenitors in adult mice

CC Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Multidisciplinary Sciences

Osteoblastic cells regulate the haematopoietic stem cell niche

LM Calvi et al.

NATURE (2003)

Article Multidisciplinary Sciences

Physiological migration of hematopoietic stem and progenitor Celts

DE Wright et al.

SCIENCE (2001)

Review Allergy

Human mast cell transcriptome project

H Saito et al.

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2001)