期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 24, 期 19, 页码 -出版社
MDPI
DOI: 10.3390/ijms241914619
关键词
inflammatory bowel diseases; omics; polyphenols; inflammation; antioxidative properties; gut dysbiosis
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder that affects the gastrointestinal tract (GT) and is caused by genetic, microbial, and environmental factors. Dysbiosis, characterized by a decrease in beneficial bacteria and an increase in pathogenic species, is closely related to inflammation and oxidative stress. Dietary polyphenols, as natural antioxidants, can maintain redox equilibrium in the GT and prevent gut damage and inflammatory responses.
Inflammatory bowel disease (IBD) is a chronic and progressive inflammatory disorder affecting the gastrointestinal tract (GT) caused by a wide range of genetic, microbial, and environmental factors. IBD is characterized by chronic inflammation and decreased gut microbial diversity, dysbiosis, with a lower number of beneficial bacteria and a concomitant increase in pathogenic species. It is well known that dysbiosis is closely related to the induction of inflammation and oxidative stress, the latter caused by an imbalance between reactive oxygen species (ROS) production and cellular antioxidant capacity, leading to cellular ROS accumulation. ROS are responsible for intestinal epithelium oxidative damage and the increased intestinal permeability found in IBD patients, and their reduction could represent a potential therapeutic strategy to limit IBD progression and alleviate its symptoms. Recent evidence has highlighted that dietary polyphenols, the natural antioxidants, can maintain redox equilibrium in the GT, preventing gut dysbiosis, intestinal epithelium damage, and radical inflammatory responses. Here, we suggest that the relatively new foodomics approaches, together with new technologies for promoting the antioxidative properties of dietary polyphenols, including novel delivery systems, chemical modifications, and combination strategies, may provide critical insights to determine the clinical value of polyphenols for IBD therapy and a comprehensive perspective for implementing natural antioxidants as potential IBD candidate treatment.
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