Research Progress of Macromolecules in the Prevention and Treatment of Sepsis

Article Cell Biology

Annexin A1 (Ac2-26)-dependent Fpr2 receptor alleviates sepsis-induced acute kidney injury by inhibiting inflammation and apoptosis in vivo and in vitro

Yanlei Zheng et al.

Summary: This study demonstrates that the protective effect of ANXA1 (Ac2-26) on SI-AKI largely depends on the negative regulation of inflammation and apoptosis via the Fpr2 receptor.

INFLAMMATION RESEARCH (2023)

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Article Pharmacology & Pharmacy

Beneficial effects of tannic acid on comorbid anxiety in cecal ligation and puncture-induced sepsis in rats and potential underlying mechanisms

Mina Ranjbaran et al.

Summary: This study investigated the anxiolytic effects of tannic acid, an anti-inflammatory agent, in sepsis-induced encephalopathy. The results demonstrated that tannic acid significantly improved hypotension and anxiety-related behaviors caused by sepsis, and also regulated brain inflammation and oxidative stress markers.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2023)

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Article Critical Care Medicine

APELIN-13 AMELIORATES LPS-INDUCED ENDOTHELIAL-TO-MESENCHYMAL TRANSITION AND POST-ACUTE LUNG INJURY PULMONARY FIBROSIS BY SUPPRESSING TRANSFORMING GROWTH FACTOR-B1 SIGNALING

Huang Liu et al.

Summary: The pathophysiology of ARDS involves cytokine storms, alveolar-capillary barrier destruction, and fibrotic progression. Apelin-13, an endogenous active polypeptide, shows promise in attenuating EndMT and post-ALI pulmonary fibrosis by suppressing the Smad signaling pathway. Elevated levels of apelin-13 were found in sepsis-associated ARDS patients, suggesting it may be a novel biomarker. These findings provide insights into potential therapeutic strategies for ARDS.

SHOCK (2023)

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Article Pharmacology & Pharmacy

Fibroblast growth factor 2 (FGF2) ameliorates the coagulation abnormalities in sepsis

Yuanyuan Sun et al.

Summary: This study demonstrates the therapeutic role of Fibroblast growth factor-2 (FGF2) in ameliorating coagulation abnormalities during sepsis. FGF2 administration inhibits coagulation activity, reduces organ damage, and increases survival in septic mice. FGF2 also regulates the expression of coagulation-related factors through the AKT/mTOR/S6K1 signaling pathway.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2023)

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Article Critical Care Medicine

Intravenously administered interleukin-7 to reverse lymphopenia in patients with septic shock: a double-blind, randomized, placebo-controlled trial

Thomas Daix et al.

Summary: CYT107 is effective in improving lymphocyte function and reversing lymphopenia in septic patients. However, intravenous administration of CYT107 may cause adverse reactions, making intramuscular administration a more preferable option.

ANNALS OF INTENSIVE CARE (2023)

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Article Pharmacology & Pharmacy

Effectiveness of early heparin therapy on outcomes in critically ill patients with sepsis-induced coagulopathy

Jia-Jia Huang et al.

Summary: This study aimed to investigate whether early unfractionated heparin (UFH) administration provides a survival advantage for patients with sepsis-induced coagulopathy (SIC). The results showed that early UFH therapy appears to be associated with improved outcomes.

FRONTIERS IN PHARMACOLOGY (2023)

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Review Pharmacology & Pharmacy

Solidification and oral delivery of biologics to the colon- A review

Katharina Tatjana Kopp et al.

Summary: The oral delivery of biologics for the treatment of colon related diseases is an important method, but the degradation of these macromolecules in liquid state is a major challenge. This review focuses on the state-of-the-art solidification techniques required to obtain a stable solid dosage form for oral administration, as well as the use of suitable excipients for stabilization. The possibility of oral delivery systems for biologics in the colon is also discussed.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2023)

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Article Pharmacology & Pharmacy

Efficacy of Intravenous Immunoglobulin Therapy for Patients With Sepsis and Low Immunoglobulin G Levels: A Single-Center Retrospective Study

Masayuki Akatsuka et al.

Summary: This single-center retrospective study found that intravenous immunoglobulin (IVIG) supplementation was associated with improved prognosis in patients with sepsis and low serum immunoglobulin G (IgG) levels. The 28-day and 90-day mortality rates were significantly lower in the IVIG group, and the number of days free from renal replacement therapy was significantly higher in the IVIG group compared with the non-IVIG group.

CLINICAL THERAPEUTICS (2022)

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Article Microbiology

Protective Effect of Poria Cocos Polysaccharides on Fecal Peritonitis-Induced Sepsis in Mice Through Inhibition of Oxidative Stress, Inflammation, Apoptosis, and Reduction of Treg Cells

Yu Wu et al.

Summary: Poria cocos polysaccharides (PCPs) have pharmacological and biological effects on fecal-induced peritonitis (FIP) mice, reducing inflammation, oxidative stress, and apoptosis, while improving resistance to peritonitis.

FRONTIERS IN MICROBIOLOGY (2022)

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Article Immunology

Granulocyte-Macrophage Colony-Stimulating Factor Modulates Myeloid-Derived Suppressor Cells and Treg Activity in Decompensated Cirrhotic Patients With Sepsis

Rashi Sehgal et al.

Summary: In cirrhosis patients with sepsis, MDSCs expand and inhibit immune response by increasing FOXP3(+)Tregs and suppressing CD4(+) T-cell proliferation. GM-CSF therapy can suppress MDSCs, improve T-cell functionality, and reduce the presence of Tregs.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Integrative & Complementary Medicine

Growth Differentiation Factor 7 Prevents Sepsis-Induced Acute Lung Injury in Mice

Ping Dong et al.

Summary: This study demonstrates that GDF7 can prevent sepsis-induced ALI by regulating the STING/AMPK pathway, inhibiting inflammation and oxidative stress, providing a potential novel approach for the treatment of ALI.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2022)

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Article Immunology

Apelin-13 Attenuates Lipopolysaccharide-Induced Inflammatory Responses and Acute Lung Injury by Regulating PFKFB3-Driven Glycolysis Induced by NOX4-Dependent ROS

Yafei Yuan et al.

Summary: Apelin-13 protects against LPS-induced inflammatory responses and ALI by regulating PFKFB3-driven glycolysis induced by NOX4-dependent ROS.

JOURNAL OF INFLAMMATION RESEARCH (2022)

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Article Medicine, Research & Experimental

Irisin attenuates sepsis-induced cardiac dysfunction by attenuating inflammation-induced pyroptosis through a mitochondrial ubiquitin ligase-dependent mechanism

Xiang Xiong et al.

Summary: This study investigates the role of irisin in septic cardiomyopathy and its underlying molecular mechanisms. The results demonstrate that irisin improves cardiac function by reducing inflammation and myocardial pyroptosis. The protective effect of irisin is mediated by MITOL activation and inhibition of GSDMD-dependent pyroptosis.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Article Multidisciplinary Sciences

MFG-E8 has guiding significance for the prognosis and treatment of sepsis

Wei Wu et al.

Summary: This study suggests that milk fat globule epidermal growth factor 8 (MFG-E8) plays an important role in sepsis. The research found that lower serum MFG-E8 levels are correlated with the severity of sepsis, and increasing MFG-E8 levels through treatment can suppress oxidative stress and ferroptosis in the livers of septic mice, leading to improved survival. Therefore, MFG-E8 could be a new predictive biomarker for sepsis and may have therapeutic potential in its treatment.

SCIENTIFIC REPORTS (2022)

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Article Pharmacology & Pharmacy

Association between different concentrations of human serum albumin and 28-day mortality in intensive care patients with sepsis: A propensity score matching analysis

Weigan Xu et al.

Summary: This study found that in patients with sepsis, receiving 5% HSA may be associated with a lower risk of 28-day mortality. Further research with randomized controlled trials is needed to confirm this association.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Chemistry, Multidisciplinary

KDEON WK-11: A short antipseudomonal peptide with promising potential

Bruno Casciaro et al.

Summary: Antimicrobial resistance continues to be a problem, but a newly designed peptide called KDEON WK-11 shows strong antimicrobial activity against Pseudomonas aeruginosa with low cytotoxicity and potential anti-lipopolysaccharide qualities, making it a promising agent against sepsis.

FRONTIERS IN CHEMISTRY (2022)

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Article Cell Biology

Vaspin Alleviates Sepsis-Induced Cardiac Injury and Cardiac Inflammation by Inhibiting Kallikrein 7 in Mice

Na Yin et al.

Summary: This study shows that vaspin plays an important role in sepsis-induced cardiac injury by reducing KLK7 expression and alleviating cardiac inflammation.

MEDIATORS OF INFLAMMATION (2022)

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Article Microbiology

Toxicological and Safety Pharmacological Profiling of the Anti-Infective and Anti-Inflammatory Peptide Pep19-2.5

Clemens Moeller et al.

Summary: This study analyzed the toxic behavior of Aspidasept and Aspidasept II and their part structures in various cellular models, as well as conducting electrophysiological experiments targeting the hERG channel and experiments on mouse neurobehavior and local lymph nodes. The data provided conclusive information about the potential toxic effects of these peptides, specifying a therapeutic window for their clinical application.

MICROORGANISMS (2022)

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Article Infectious Diseases

Antifungal and Anti-Inflammatory Activities of PS1-2 Peptide against Fluconazole-Resistant Candida albicans

Jong-Kook Lee et al.

Summary: In this study, peptides were designed to exhibit potent antifungal activities against fluconazole-resistant Candida albicans and demonstrated anti-fungal and anti-inflammatory effects in a mouse model of Candida albicans-induced intratracheal infection.

ANTIBIOTICS-BASEL (2022)

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Article Infectious Diseases

Potent Anti-Inflammatory Effects of a Helix-to-Helix Peptide against Pseudomonas aeruginosa Endotoxin-Mediated Sepsis

Hyosuk Son et al.

Summary: This study investigated the anti-inflammatory potential of 10 designed XI(W)K (X: lysine, arginine, or glutamic acid) alpha-helical peptides in macrophages and a mouse model against endotoxin. WIKE-14 peptide, with a helix-to-helix structure and glutamic acid substitution at the 12th amino acid, suppressed pro-inflammatory cytokines in macrophages by inhibiting the binding between LPS and macrophages. WIKE-14 peptide also exhibited potent anti-inflammatory activity in a mouse model of inflammation in the ears and lungs induced by LPS.

ANTIBIOTICS-BASEL (2022)

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Article Multidisciplinary Sciences

ACE2-like enzyme B38-CAP suppresses abdominal sepsis and severe acute lung injury

Takafumi Minato et al.

Summary: This article investigated the therapeutic effect of an ACE2-like enzyme called B38-CAP on acute lung injury. The results showed that B38-CAP could decrease angiotensin II levels, increase angiotensin 1-7 levels, improve lung inflammation and dysfunction, and increase the survival rate of infected mice with sepsis.

PLOS ONE (2022)

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Article Immunology

FGF15 Protects Septic Mice by Inhibiting Inflammation and Modulating Treg Responses

Xing Li et al.

Summary: FGF15 treatment through FGFR4 ameliorated hepatic inflammation and its compensative Treg responses, which were associated with protecting from septic death in mice.

JOURNAL OF INFLAMMATION RESEARCH (2022)

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Article Multidisciplinary Sciences

Protective effects of S100A8 on sepsis mortality: Links to sepsis risk in obesity and diabetes

Daisuke Miyashita et al.

Summary: S100A8 plays a protective role in septic mice with obesity and diabetes, prolonging their survival and inhibiting the expression of proinflammatory cytokines.

ISCIENCE (2022)

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Article Immunology

Interleukin-22 protects from endotoxemia by inducing suppressive F4/80+Ly6GhiLy6Chi cells population

Chang Yu et al.

Summary: The study found that IL-22 plays a protective role in endotoxemia by inducing the development of immunosuppressive cells. Compared to mice in the control group, mice injected with F-652 showed more immune cell infiltration after LPS treatment, suggesting that F-652 may lead to impaired immune responses.

BMC IMMUNOLOGY (2022)

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Article Biochemistry & Molecular Biology

Priming of Cardiopulmonary Bypass with Human Albumin Decreases Endothelial Dysfunction after Pulmonary Ischemia-Reperfusion in an Animal Model

Jean Selim et al.

Summary: The use of human albumin and hypertonic sodium lactate as priming agents during mechanical circulatory support in lung transplantation can reduce pulmonary endothelial dysfunction. However, hypertonic sodium lactate may lead to the development of pulmonary edema.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Pharmacology & Pharmacy

Crotoxin modulates inflammation and macrophages? functions in a murine sepsis model

Marisa Langeani Bretones et al.

Summary: CTX treatment improves survival rate and modulates cytokine and eicosanoid production in septic animals. It also affects macrophage functions, including phagocytosis capacity and inflammatory mediator production.

TOXICON (2022)

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Article Chemistry, Medicinal

Alpha-Chymotrypsin Protects Against Acute Lung, Kidney, and Liver Injuries and Increases Survival in CLP-Induced Sepsis in Rats Through Inhibition of TLR4/NF-ΚB Pathway

Shaymaa Ramzy Senousy et al.

Summary: Alpha-chymotrypsin has protective potential against sepsis by inhibiting oxidative stress and inflammatory responses, reducing lung, liver, and kidney injuries, and improving survival rates.

DRUG DESIGN DEVELOPMENT AND THERAPY (2022)

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Article Multidisciplinary Sciences

MicroRNA-25-5p negatively regulates TXNIP expression and relieves inflammatory responses of brain induced by lipopolysaccharide

Jiabing Wang et al.

Summary: In this study, miR-25-5p was found to downregulate LPS-induced inflammatory responses, reactive oxygen species production, and brain damage, suggesting it as a candidate treatment for septic encephalopathy.

SCIENTIFIC REPORTS (2022)

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Review Immunology

A potential new pathway for heparin treatment of sepsis-induced lung injury: inhibition of pulmonary endothelial cell pyroptosis by blocking hMGB1-LPS-induced caspase-11 activation

Rui Yang et al.

Summary: Sepsis is a significant cause of mortality in critically ill patients, with acute lung injury being a leading cause of death in these patients. This paper discusses the potential novel role of heparin in the treatment of septic ALI by inhibiting the unique mechanism of pulmonary endothelial cell pyroptosis.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

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Article Medicine, General & Internal

Prevalence of polymyxin-induced nephrotoxicity and its predictors in critically ill adult patients: A meta-analysis

Jiang-Lin Wang et al.

Summary: This systematic review and meta-analysis examined the prevalence and potential predictors of polymyxin-induced nephrotoxicity in adult ICU patients. The results showed a high incidence of polymyxin-induced nephrotoxicity, and factors such as dosing interval, nephrotoxicity criteria, age, publication year, study quality, and sample size were significantly associated with nephrotoxicity.

WORLD JOURNAL OF CLINICAL CASES (2022)

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Review Infectious Diseases

Antimicrobial Peptides-Mechanisms of Action, Antimicrobial Effects and Clinical Applications

Jasminka Talapko et al.

Summary: The emergence of antimicrobial resistance is a global problem, and innovative therapeutic options are needed. Antimicrobial peptides have broad antimicrobial activity and lower propensity for resistance development, making them promising candidates for infectious disease treatment. However, their use in clinical practice presents challenges.

ANTIBIOTICS-BASEL (2022)

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Article Multidisciplinary Sciences

Recombinant thrombomodulin may protect cardiac capillary endothelial glycocalyx through promoting Glypican-1 expression under experimental endotoxemia

Yoshinori Kakino et al.

Summary: The study found that rhTM attenuates myocardial dysfunction in patients with sepsis by protecting the endothelial glycocalyx. The experimental results showed that the survival rate of the rhTM group was higher, the level of troponin I was lower, the expression of interleukin-6 was reduced, the damage to the glycocalyx was significantly decreased, and the severity of vascular endothelial injury was milder.

HELIYON (2022)

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Review Immunology

Outcomes of ICU patients treated with intravenous immunoglobulin for sepsis or autoimmune diseases

Milena Tocut et al.

Summary: This study evaluated the outcomes of patients in two intensive care units (ICU) treated with intravenous immunoglobulin (IVIg) added to standard-of-care therapy. The results showed that IVIg treatment improved the outcomes for patients with sepsis, but did not have a favorable outcome for patients with autoimmune diseases.

AUTOIMMUNITY REVIEWS (2022)

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Article Medicine, Research & Experimental

Protective effect of Secukinumab on severe sepsis model rats by neutralizing IL-17A to inhibit IKBα/NFκB inflammatory signal pathway

Xingsheng Wang et al.

Summary: This study found that high-dose secukinumab can inhibit the activation of the IKB alpha/NF kappa B inflammatory pathway by neutralizing IL-17A, reducing the levels of inflammatory cytokines in lung tissue and plasma, thereby reducing the damage of lung tissue in severe sepsis model rats and improving the systemic inflammatory response.

EUROPEAN JOURNAL OF MEDICAL RESEARCH (2022)

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Review Emergency Medicine

The effect of early vasopressin use on patients with septic shock: A systematic review and meta-analysis

Haijun Huang et al.

Summary: The study found that early initiation of vasopressin within 6 hours after diagnosis of septic shock did not significantly affect short-term mortality in patients, but could reduce the use of renal replacement therapy. Other outcomes including new onset arrhythmias, ICU length of stay, and length of hospitalization showed no significant differences between the two groups.

AMERICAN JOURNAL OF EMERGENCY MEDICINE (2021)

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Article Oncology

Atezolizumab alleviates the immunosuppression induced by PD-L1-positive neutrophils and improves the survival of mice during sepsis

Jianxin Chen et al.

Summary: The study found that treatment with atezolizumab can effectively alleviate immunosuppression induced by sepsis in a mouse model, reducing endotoxin concentration, improving intestinal permeability, and potentially prolonging survival time.

MOLECULAR MEDICINE REPORTS (2021)

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Review Immunology

The immunology of sepsis

Tom van der Poll et al.

Summary: Sepsis is a life-threatening condition caused by infection-induced organ dysfunction, characterized by unbalanced hyperinflammation and immune suppression. Current research aims to stratify sepsis patients into more similar subgroups to better identify those who are likely to benefit from specific immune interventions.

IMMUNITY (2021)

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Article Critical Care Medicine

Safety and tolerability of non-neutralizing adrenomedullin antibody adrecizumab (HAM8101) in septic shock patients: the AdrenOSS-2 phase 2a biomarker-guided trial

Pierre-Francois Laterre et al.

Summary: The study aimed to investigate the safety and tolerability of adrecizumab in septic shock patients with high adrenomedullin levels. The results showed that adrecizumab was well tolerated and did not significantly impact safety endpoints or efficacy endpoints. However, further randomized controlled trials are needed to confirm the efficacy and safety of adrecizumab in septic shock patients.

INTENSIVE CARE MEDICINE (2021)

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Article Medicine, Research & Experimental

MicroRNA-490-3p inhibits inflammatory responses in LPS-induced acute lung injury of neonatal rats by suppressing the IRAK1/TRAF6 pathway

Guang Yang et al.

Summary: The study demonstrated that miR-490-3p overexpression significantly inhibited LPS-induced ALI and inflammatory responses by targeting and attenuating IRAK1 expression, thus inactivating the LPS-mediated TRAF6/NF-kappa B pathway. MiR-490-3p was found to be downregulated in the LPS-induced ALI model, while pro-inflammatory factors and IRAK1 were upregulated, negatively correlated with miR-490-3p expression. Overexpression of miR-490-3p inhibited lung epithelial cell injury and inflammatory response.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

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Article Pharmacology & Pharmacy

Lycium barbarum Polysaccharide Antagonizes LPS-Induced Inflammation by Altering the Glycolysis and Differentiation of Macrophages by Triggering the Degradation of PKM2

Huan Ding et al.

Summary: The study found that Lycium barbarum polysaccharide can suppress LPS-induced inflammation by modulating glycolysis and M1 differentiation of macrophages. This effect is mediated by downregulating PKM2 expression and enhancing ubiquitination.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2021)

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Article Cell Biology

IL-38 Alleviates Inflammation in Sepsis in Mice by Inhibiting Macrophage Apoptosis and Activation of the NLRP3 Inflammasome

Yun Ge et al.

Summary: IL-38 is a potent immune modulator in sepsis, restraining the inflammatory response by suppressing macrophage apoptosis and activation of the NLRP3 inflammasome, thus reducing proinflammatory cytokine levels and improving survival.

MEDIATORS OF INFLAMMATION (2021)

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Review Engineering, Environmental

Polysaccharides; Classification, Chemical Properties, and Future Perspective Applications in Fields of Pharmacology and Biological Medicine (A Review of Current Applications and Upcoming Potentialities)

Aiman Saleh A. Mohammed et al.

Summary: Polysaccharides, essential macromolecules with important biological functions, have drawn increasing attention due to their wide range of biological and pharmacological activities. They can be obtained from various sources and modified to enhance their properties, making them promising candidates in biomedical and pharmaceutical fields. Challenges and limitations in their pharmaceutical utilities are also discussed.

JOURNAL OF POLYMERS AND THE ENVIRONMENT (2021)

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Article Multidisciplinary Sciences

Impact of polymyxin B hemoperfusion therapy on high endotoxin activity level patients after successful infection source control: a prospective cohort study

Won Young Lee et al.

Summary: This study showed that PMX-HP treatment significantly decreased endotoxin levels and improved SOFA scores in patients with abdominal septic shock, providing a protective effect against in-hospital death.

SCIENTIFIC REPORTS (2021)

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Article Immunology

Lentinan Attenuates Damage of the Small Intestinal Mucosa, Liver, and Lung in Mice with Gut-Origin Sepsis

Zhongshen Kuang et al.

Journal of Immunology Research (2021)

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Article Biotechnology & Applied Microbiology

Hsp22 ameliorates lipopolysaccharide-induced myocardial injury by inhibiting inflammation, oxidative stress, and apoptosis

Yun Yu et al.

Summary: The study reveals that Hsp22 plays a protective role against LPS-induced myocardial injury by targeting inflammation, oxidative stress, and cardiomyocyte apoptosis, suggesting its potential therapeutic value in sepsis-induced myocardial dysfunction.

BIOENGINEERED (2021)

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Article Cell Biology

Repurposing of High-Dose Erythropoietin as a Potential Drug Attenuates Sepsis in Preconditioning Renal Injury

Wiwat Chancharoenthana et al.

Summary: The study found that high-dose EPO can attenuate sepsis in mice with preconditioning renal injury by reducing inflammatory responses, which may be beneficial for some patients.

CELLS (2021)

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Article Critical Care Medicine

Efficacy and safety of human soluble thrombomodulin (ART-123) for treatment of patients in France with sepsis-associated coagulopathy: post hoc analysis of SCARLET

Bruno Francois et al.

Summary: Comparative analysis between French patients and patients from other regions showed that ART-123 may have greater efficacy in patients with sustained coagulopathy who are not receiving heparin treatment. Further studies with stricter inclusion criteria are needed to confirm this finding.

ANNALS OF INTENSIVE CARE (2021)

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Article Pharmacology & Pharmacy

Adiponectin Attenuates Lipopolysaccharide-induced Apoptosis by Regulating the Cx43/PI3K/AKT Pathway

Luqian Liu et al.

Summary: This study confirmed the protective effect of adiponectin (APN) against lipopolysaccharide (LPS)-induced cardiomyocyte apoptosis, potentially through regulating the connexin43 (Cx43) and phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT) signaling pathways.

FRONTIERS IN PHARMACOLOGY (2021)

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Article

Interactions of multidomain pro-apoptotic and anti-apoptotic proteins in cancer cell death

Alexander Chota et al.

Oncotarget (2021)

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Review Pharmacology & Pharmacy

MicroRNA as an Important Target for Anticancer Drug Development

Zhiwen Fu et al.

Summary: miRNAs play a crucial role in cancer treatment by regulating gene expression and influencing the growth and survival of cancer cells. They are considered an attractive target for anticancer drug development and have shown promising results in research and therapy.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Immunology

Human Chorionic Gonadotropin and Related Peptides: Candidate Anti-Inflammatory Therapy in Early Stages of Sepsis

Sun Koo Yoo et al.

Summary: Sepsis remains a major inflammatory disorder that leads to high morbidity, mortality, and post-recovery disability in patients. Current therapies for sepsis are often ineffective, so there is a need for more pre-clinical studies to explore new anti-inflammatory treatments.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Hematology

Effect of Recombinant Human Soluble Thrombomodulin on Coagulation-Related Variables in Patients With Sepsis-Induced Disseminated Intravascular Coagulation: A Retrospective Observational Study

Chieko Mitaka et al.

Summary: This retrospective study on sepsis-induced DIC patients treated with rTM found that improvement in coagulation-related variables after treatment was associated with DIC resolution and reduced mortality. Specifically, survivors showed significant improvement in platelet count, PT-INR, and FDP levels, while PT-INR levels before rTM treatment were lower in survivors and patients who achieved DIC resolution, leading to lower 28-day mortality rates. It suggests that early initiation of rTM treatment before significant PT-INR elevation may be crucial for improving outcomes in patients with sepsis-induced DIC. Conversely, treatment in patients with higher PT-INR levels may be less effective.

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS (2021)

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Article Biochemistry & Molecular Biology

Kombucha ameliorates LPS-induced sepsis in a mouse model

Penghui Wang et al.

Summary: Kombucha, as a traditional fermented beverage, shows anti-inflammatory effects by improving survival rates and reducing inflammatory markers in sepsis-induced mice, while also positively impacting the gut microbiota.

FOOD & FUNCTION (2021)

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Article Cell Biology

Interleukin-38 protects against sepsis by augmenting immunosuppressive activity of CD4+CD25+ regulatory T cells

Yun Ge et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Article Cell Biology

MG53 Protects against Sepsis-Induced Myocardial Dysfunction by Upregulating Peroxisome Proliferator-Activated Receptor-alpha

Xue Han et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

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Article Biotechnology & Applied Microbiology

Protective Role of Coenzyme Q10 in Acute Sepsis-Induced Liver Injury in BALB/c Mice

Qian-wei Li et al.

BIOMED RESEARCH INTERNATIONAL (2020)

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Article Immunology

Maf1 Ameliorates Sepsis-Associated Encephalopathy by Suppressing the NF-kB/NLRP3 Inflammasome Signaling Pathway

Shenglong Chen et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Hematology

Comparison of Protective Effects of Recombinant Antithrombin Gamma and Plasma-Derived Antithrombin on Sepsis-Induced Disseminated Intravascular Coagulation and Multiple Organ Failure

Hiromitsu Kuroda et al.

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS (2020)

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Article Cell Biology

IL-22 ameliorates LPS-induced acute liver injury by autophagy activation through ATF4-ATG7 signaling

Lujing Shao et al.

CELL DEATH & DISEASE (2020)

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Article Respiratory System

HGF alleviates septic endothelial injury by inhibiting pyroptosis via the mTOR signalling pathway

Fei Peng et al.

RESPIRATORY RESEARCH (2020)

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Article Medicine, Research & Experimental

miR-146a targeted to splenic macrophages prevents sepsis-induced multiple organ injury

Yoshio Funahashi et al.

LABORATORY INVESTIGATION (2019)

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Review Critical Care Medicine

Vasopressin in septic shock: an individual patient data meta-analysis of randomised controlled trials

Myura Nagendran et al.

INTENSIVE CARE MEDICINE (2019)

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Article Medicine, Research & Experimental

Treatment with Recombinant Interleukin-15 (IL-15) Increases the Number of T Cells and Natural Killer (NK) Cells and Levels of Interferon-γ (IFN-γ) in a Rat Model of Sepsis

Xianyuan Zhao et al.

MEDICAL SCIENCE MONITOR (2019)

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Article Biochemistry & Molecular Biology

Labile heme impairs hepatic microcirculation and promotes hepatic injury

Franziska A. Englert et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2019)

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Article Pharmacology & Pharmacy

Fucoxanthin, a Marine Xanthophyll Isolated From Conticribra weissflogii ND-8: Preventive Anti-Inflammatory Effect in a Mouse Model of Sepsis

Jingqian Su et al.

FRONTIERS IN PHARMACOLOGY (2019)

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Review Biochemistry & Molecular Biology

The Pathogenesis of Sepsis and Potential Therapeutic Targets

Min Huang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Medicine, General & Internal

Effect of Selepressin vs Placebo on Ventilator- and Vasopressor-Free Days in Patients With Septic Shock: The SEPSIS-ACT Randomized Clinical Trial

Pierre-Francois Laterre et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2019)

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Article Clinical Neurology

Effects of early administration of insulin-like growth factor-1 on cognitive function in septic encephalopathy

Yang Yang et al.

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