4.7 Article

Mitotic Dysregulation at Tumor Initiation Creates a Therapeutic Vulnerability to Combination Anti-Mitotic and Pro-Apoptotic Agents for MYCN-Driven Neuroblastoma

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Combining selinexor with alisertib to target the p53 pathway in neuroblastoma

Rosa Nguyen et al.

Summary: This study suggests a potential therapeutic benefit in using selinexor and alisertib to synergistically increase p53-mediated cytotoxicity of high-risk neuroblastoma.

NEOPLASIA (2022)

Article Cell Biology

Single-cell profiling of peripheral neuroblastic tumors identifies an aggressive transitional state that bridges an adrenergic-mesenchymal trajectory

Xiaojun Yuan et al.

Summary: Peripheral neuroblastic tumors (PNTs) exhibit extensive transcriptomic heterogeneity, with malignant neuroblasts transitioning between adrenergic and mesenchymal cell states. Transitional cells, expressing programs related to sympathoadrenal development, are associated with aggressive tumor phenotypes and poor prognosis. The identification of transitional gene expression as a potential biomarker and therapeutic target highlights the phenotypic plasticity in PNTs.

CELL REPORTS (2022)

Article Oncology

MEIS2 Is an Adrenergic Core Regulatory Transcription Factor Involved in Early Initiation of TH-MYCN-Driven Neuroblastoma Formation

Jolien De Wyn et al.

Summary: Research on neuroblastoma has identified key factors related to tumor initiation and progression, as well as potential novel drug targets. The study found that roughly half of high-risk neuroblastoma patients exhibit MYCN gene amplification, and certain genes were significantly upregulated during tumor formation, suggesting their potential as targets for therapeutic intervention.

CANCERS (2021)

Article Genetics & Heredity

Single-cell transcriptomic analyses provide insights into the developmental origins of neuroblastoma

Selina Jansky et al.

Summary: Single-cell transcriptomic analysis reveals cell types and lineage trajectories during different developmental stages in neuroblastomas and healthy adrenal glands. The transcriptomes of neuroblastoma cells closely resemble developing neuroblasts of the adrenal gland.

NATURE GENETICS (2021)

Review Pharmacology & Pharmacy

Future prospects for mitosis-targeted antitumor therapies

Alfonso Serrano-del Valle et al.

Summary: Developing new therapies targeting cell cycle regulation and mitosis has shown potential, despite many being discontinued during clinical trials. Future efforts could focus on increasing cell death signals, targeting senescent cells, and promoting antitumor immune response to enhance the efficacy of these treatments.

BIOCHEMICAL PHARMACOLOGY (2021)

Article Multidisciplinary Sciences

Single-nuclei transcriptomes from human adrenal gland reveal distinct cellular identities of low and high-risk neuroblastoma tumors

O. C. Bedoya-Reina et al.

Summary: The study shows that childhood neuroblastoma can be separated into high and low risk groups with different cell identities and malignancy potential, indicating two distinct disease entities. Low-risk neuroblastoma resembles sympatho- and chromaffin cells in terms of transcriptome, while the malignant cells in high-risk neuroblastoma resemble a subtype of cholinergic progenitor population in human post-natal gland. The findings reveal different gene expression programs for worst and better survival in correlation with age at diagnosis, reflecting clinical heterogeneity and outcome of neuroblastoma tumors.

NATURE COMMUNICATIONS (2021)

Article Oncology

Combined inhibition of Aurora-A and ATR kinases results in regression of MYCN-amplified neuroblastoma

Isabelle Roeschert et al.

Summary: Aurora-A suppresses transcription-replication conflicts in MYCN-driven neuroblastoma, and combined inhibition of Aurora-A and ATR kinases leads to tumor regression in mouse models. MYCN activates Aurora-A, promotes histone phosphorylation, and suppresses transcription-replication conflicts.

NATURE CANCER (2021)

Article Multidisciplinary Sciences

In silico discovery of a FOXM1 driven embryonal signaling pathway in therapy resistant neuroblastoma tumors

Suzanne Vanhauwaert et al.

SCIENTIFIC REPORTS (2018)

Article Genetics & Heredity

Neuroblastoma is composed of two super-enhancer-associated differentiation states

Tim van Groningen et al.

NATURE GENETICS (2017)

Article Genetics & Heredity

Heterogeneity of neuroblastoma cell identity defined by transcriptional circuitries

Valentina Boeva et al.

NATURE GENETICS (2017)

Article Biochemical Research Methods

Complex heatmaps reveal patterns and correlations in multidimensional genomic data

Zuguang Gu et al.

BIOINFORMATICS (2016)

Article Multidisciplinary Sciences

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

Andras Kotschy et al.

NATURE (2016)

Article Medicine, General & Internal

Neuroblastoma

Katherine K. Matthay et al.

NATURE REVIEWS DISEASE PRIMERS (2016)

Article Oncology

MYC Is a Major Determinant of Mitotic Cell Fate

Caroline Topham et al.

CANCER CELL (2015)

Article Oncology

MYCN-driven regulatory mechanisms controlling LIN28B in neuroblastoma

Anneleen Beckers et al.

CANCER LETTERS (2015)

Article Cell Biology

Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma

Daniel R. Carter et al.

SCIENCE TRANSLATIONAL MEDICINE (2015)

Article Biotechnology & Applied Microbiology

The concordance between RNA-seq and microarray data depends on chemical treatment and transcript abundance

Charles Wang et al.

NATURE BIOTECHNOLOGY (2014)

Review Oncology

The prenatal origins of cancer

Glenn M. Marshall et al.

NATURE REVIEWS CANCER (2014)

Article Biochemistry & Molecular Biology

Prophylactic treatment with the BH3 mimetic ABT-737 impedes Myc-driven lymphomagenesis in mice

P. N. Kelly et al.

CELL DEATH AND DIFFERENTIATION (2013)

Article Biochemistry & Molecular Biology

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

Andrew J. Souers et al.

NATURE MEDICINE (2013)

Review Oncology

Neuroblastoma: developmental biology, cancer genomics and immunotherapy

Nai-Kong V. Cheung et al.

NATURE REVIEWS CANCER (2013)

Article Biochemical Research Methods

Fast gapped-read alignment with Bowtie 2

Ben Langmead et al.

NATURE METHODS (2012)

Article Biotechnology & Applied Microbiology

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

Guangchuang Yu et al.

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2012)

Review Medicine, General & Internal

Medical Progress: Recent Advances in Neuroblastoma.

John M. Maris

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Article Biochemical Research Methods

The Sequence Alignment/Map format and SAMtools

Heng Li et al.

BIOINFORMATICS (2009)

Article Oncology

ABT-263: A potent and orally bioavailable Bcl-2 family inhibitor

Christin Tse et al.

CANCER RESEARCH (2008)

Article Biotechnology & Applied Microbiology

Model-based Analysis of ChIP-Seq (MACS)

Yong Zhang et al.

GENOME BIOLOGY (2008)

Article Biochemical Research Methods

Analysis of apoptosis by propidium iodide staining and flow cytometry

Carlo Riccardi et al.

NATURE PROTOCOLS (2006)

Article Multidisciplinary Sciences

Mechanisms of embryonal tumor initiation:: Distinct roles for MycN expression and MYCN amplification

LM Hansford et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)