Anti-Inflammatory Effects of Spirodela polyrhiza (L.) S-CHLEID. Extract on Contact Dermatitis in Mice-Its Active Compounds and Molecular Targets

Article Chemistry, Medicinal

Therapeutic Effects of Pinus koraiensis on 1-Fluoro-2,4-Dinitrofluorobenzene-induced Contact Dermatitis in Mice

Yuntae Kang et al.

Summary: The ethanol extract of Korean pine nuts showed therapeutic effects on animal contact dermatitis, reducing skin symptoms and inflammation. It has the potential to be used as a treatment for inflammatory skin diseases.

PHARMACOGNOSY MAGAZINE (2023)

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Article Biochemistry & Molecular Biology

The Related Mechanisms Predicted through Network-Based Pharmacological Analysis and the Anti-Inflammatory Effects of Fraxinus rhynchophylla Hance Bark on Contact Dermatitis in Mice

Sura Kim et al.

Summary: This study investigated the mechanism and therapeutic effect of Fraxinus rhynchophylla Hance bark on mice with contact dermatitis. The results showed that Fraxinus rhynchophylla Hance bark has the potential to be used as a therapeutic or cosmetic agent due to its ability to suppress inflammatory mediators and improve skin symptoms.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Dermatology

Translation-dependent skin hyperplasia is promoted by type 1/17 inflammation in psoriasis

Rui Xu et al.

Summary: This study investigates the role of eIF4E in keratinocyte abnormal differentiation in psoriasis. The results show that patients with psoriasis have higher expression of eIF4E in skin lesions compared to normal skin, and this expression is positively correlated with epidermal thickness. In a mouse model, inhibition of eIF4E activity attenuates skin hyperplasia and eIF4E activities. Furthermore, the inflammatory mediators IFN-gamma and IL-17A induce abnormal differentiation of normal human epidermal keratinocytes, which can be disrupted by inhibiting eIF4E activity.

JOURNAL OF DERMATOLOGICAL SCIENCE (2023)

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Letter Biochemistry & Molecular Biology

TCMBank-the largest TCM database provides deep learning-based Chinese-Western medicine exclusion prediction

Qiujie Lv et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2023)

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Review Biochemistry & Molecular Biology

Luteolin as a modulator of skin aging and inflammation

Fabian Gendrisch et al.

Summary: Luteolin, a flavonoid found in plants, possesses antioxidant and anti-inflammatory activities, modulating various inflammatory processes in the skin. It shows promise in the development of formulations for treating inflammatory skin diseases.

BIOFACTORS (2021)

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Article Clinical Neurology

Central opioid receptors mediate morphine-induced itch and chronic itch via disinhibition

Zilong Wang et al.

Summary: The study demonstrates that intrathecal opioids can induce itching by acting on MOR on spinal inhibitory interneurons, resulting in disinhibition of the spinal itch circuit. In addition, spinal ablation of GRPR(+) neurons can reduce opioid-induced itch, while intrathecal NPY administration can suppress itch response.

BRAIN (2021)

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Article Biochemistry & Molecular Biology

UniProt: the universal protein knowledgebase in 2021

Alex Bateman et al.

Summary: The UniProt Knowledgebase aims to provide users with a comprehensive, high-quality set of protein sequences annotated with functional information. Updates over the past two years have increased the number of sequences to approximately 190 million, with new methods to assess proteome completeness and quality. UniProtKB has responded to the COVID-19 pandemic by expertly curating relevant entries and making them rapidly available through a dedicated portal.

NUCLEIC ACIDS RESEARCH (2021)

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Article Clinical Neurology

Central opioid receptors mediate morphine-induced itch and chronic itch via disinhibition

Zilong Wang et al.

Summary: The study revealed that intrathecal morphine induces itch by acting on MOR on spinal inhibitory interneurons, leading to disinhibition of spinal itch circuit. The data provide mechanistic insights into the treatment of chronic itch with opioid receptor antagonists like naloxone.

BRAIN (2021)

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Article Clinical Neurology

Stepwise crosstalk between aberrant Nf1, Tp53 and Rb signalling pathways induces gliomagenesis in zebrafish

Juanjuan Luo et al.

Summary: The molecular pathogenesis of glioblastoma is critical for human gliomagenesis, with RTK/Ras/PI3K, RB, and TP53 pathways playing key roles. Using transgenic zebrafish with single or multiple gene deletions, researchers induced gliomagenesis and found that nf1 mutation alone had low efficiency, but combined deletions of nf1;tp53 and rb1;tp53 resulted in higher tumor incidences with advanced histology. Bioinformatics analysis revealed alterations in critical pathways like RTK/Ras/PI3K, cell cycle, and focal adhesion, highlighting their importance in gliomagenesis initiation and development. Tumors in zebrafish models showed significant similarities to human gliomas, and temozolomide treatment effectively suppressed gliomagenesis, mimicking responses seen in clinical glioma treatment. This study provides a potential tool for genetically studying gliomagenesis and screening targeted anti-tumor compounds for glioma treatment.

BRAIN (2021)

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Article Plant Sciences