☆ 4.7 Review

Research Progress of DcR3 in the Diagnosis and Treatment of Sepsis

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Sepsis and antibiotics: When should we deploy a parachute?

Sharon Einav et al.

Summary: Guidelines recommend early administration of antimicrobial therapy in sepsis and septic shock, based on observational studies suggesting improved outcomes. However, front-line physicians face pressure to quickly decide on antibiotic use in uncertain sepsis cases. Overuse of antibiotics contributes to the emergence of multidrug-resistant bacteria, and this article discusses the situation of physicians criticized for unnecessary or delayed antibiotic use and offers options to assist bedside decision-making.

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MDSCs in sepsis-induced immunosuppression and its potential therapeutic targets

Wanying Zhang et al.

Summary: Sepsis is a life-threatening condition resulting from an uncontrolled host response to infection. Myeloid-derived suppressor cells (MDSCs), which consist of pathologically activated neutrophils and monocytes, play an important role in inhibiting innate and adaptive immune responses. This review explores the characteristics and suppressive mechanisms of MDSCs, and discusses their potential applications as biomarkers and targets for clinical treatment of sepsis.

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Neutrophil, neutrophil extracellular traps and endothelial cell dysfunction in sepsis

Hao Zhang et al.

Summary: Sepsis is a life-threatening condition characterized by dysfunction of the immune system and multiple organ failure due to exaggerated response to infection. Endothelial dysfunction is a hallmark of sepsis. Excessive neutrophil activation and release of neutrophil extracellular traps (NETs) contribute to endothelial cell pro-inflammatory and pro-coagulant phenotype, leading to compromised microcirculation, tissue hypoperfusion, and organ failure.

CLINICAL AND TRANSLATIONAL MEDICINE (2023)

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Butyrylcholinesterase levels as a predictive factor of septic complications development in the postoperative period of colorectal patients: Univariate analysis and predictive modeling

Francesk Mulita et al.

EJSO (2023)

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Evaluation of the role of serum DcR3 levels in the early clinical prognosis of patients with Crimean-Congo hemorrhagic fever

Ferhan Kerget et al.

Summary: This study aimed to determine the relationship between early serum Decoy receptor-3 (DcR3) level and clinical severity in patients with Crimean-Congo hemorrhagic fever (CCHF). The results showed that symptoms such as fever, hemorrhage, nausea, headache, diarrhea, and hypoxia were significantly more common in severe CCHF patients. Serum DcR3 levels were higher in severe CCHF patients compared to mild/moderate patients and healthy individuals. Serum DcR3 may serve as a potential indicator for early immunomodulatory therapy in CCHF.

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Matteo Guarino et al.

Summary: This review aims to update physicians on the main pillars of treatment for sepsis/septic shock, which include empirical antimicrobial treatment, fluid replacement, and the use of vasoactive agents. Other treatments such as mechanical ventilation, anticoagulation, and glycemic control are also recommended but their efficacy is debated.

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Syndecan-2 enriches for hematopoietic stem cells and regulates stem cell repopulating capacity

Christina M. Termini et al.

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Sharad Patel et al.

Summary: The definition of sepsis has evolved significantly over the past three decades, now defined as a dysregulated host immune response to microbial invasion leading to end organ dysfunction. Early recognition and intervention remain key in sepsis management.

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Progress in Diagnosis and Treatment of Neonatal Sepsis: A Review Article

Pratibha Yadav et al.

Summary: Neonatal sepsis is a serious condition that can have harmful effects on the health of newborns. It is categorized into early onset and late onset based on the time of onset. Although the incidence of early-onset group B streptococcal infection has decreased, it remains a major cause of neonatal sepsis. Early diagnosis and prompt treatment still present a challenge.

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Decoy Receptor 3 Suppresses T-Cell Priming and Promotes Apoptosis of Effector T-Cells in Acute Cell-Mediated Rejection: The Role of Reverse Signaling

Shuo-Chun Weng et al.

Summary: DcR3 protects renal tubular epithelial cells from acute T-cell attack during T-cell priming by interfering with TNF ligand-mediated reverse signaling and promoting effector T-cell apoptosis. These findings support the role of decoy receptors in T-cell modulation in kidney transplant rejection.

FRONTIERS IN IMMUNOLOGY (2022)

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A LIGHT-HVEM/LTβR axis contributes to the fibrosis of intrauterine adhesion

Ayitila Abudukeyoumu et al.

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FRONTIERS IN IMMUNOLOGY (2022)

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Traditional Chinese Medicine: A promising strategy to regulate inflammation, intestinal disorders and impaired immune function due to sepsis

Xu-Hua Wang et al.

Summary: This paper discusses the interaction between intestinal microbiota and sepsis, and explores the use of traditional Chinese medicine (TCM) in the treatment of sepsis.

FRONTIERS IN PHARMACOLOGY (2022)

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Dysregulation of neutrophil death in sepsis

Cheng-long Zhu et al.

Summary: Sepsis is a common disease with high mortality rates and long-term morbidity. Neutrophil cell death, including various types like necrosis, apoptosis, necroptosis, pyroptosis, NETosis, and autophagy, plays a crucial role in the development and progression of sepsis. However, the exact role and mechanisms of neutrophil cell death in sepsis still need further investigation.

FRONTIERS IN IMMUNOLOGY (2022)

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Ivana Srzic et al.

Summary: Sepsis is a life-threatening organ dysfunction caused by an unregulated response of a host. Septic shock is its most severe form. It is still one of the leading causes of mortality worldwide. Improving the definition of sepsis and developing guidelines for its treatment have led to better outcomes for patients. Timely diagnosis is crucial for the outcomes for patients with sepsis and septic shock.

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Di Liu et al.

Summary: Sepsis is a common complication of combat injuries and trauma, characterized by life-threatening organ dysfunction caused by a dysregulated host response to infection. Immunosuppression, one of the major causes of septic death, can be reversed and host resistance can be established by targeting it.

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Summary: Sepsis-induced immune depression is a significant factor leading to severe infection and death. However, detecting the immune dysfunction caused by sepsis is challenging, highlighting the importance of specific biomarkers in clinical practice. Stratifying septic patients with an immunosuppressive state can contribute to personalized treatment.

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Decoy receptor 3 is involved in epidermal keratinocyte commitment to terminal differentiation via EGFR and PKC activation

Nan-Lin Wu et al.

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Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021

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Survival and Pulmonary Injury After Neonatal Sepsis: PD1/PDL1's Contributions to Mouse and Human Immunopathology

Eleanor A. Fallon et al.

Summary: Research findings indicate that PD1(-/-) neonatal mice show improved survival rates in experimental sepsis, while PDL1(-/-) mice did not show significant improvement in survival. Focus on the impact of PD1 gene deficiency on lung injury reveals a potential regulatory role of the PD1/PDL1 pathway in the neonatal pulmonary immune response to septic insult. Investigation on human neonatal lung tissue also suggests the therapeutic potential of targeting PD1/PDL1 checkpoint proteins in septic neonates.

FRONTIERS IN IMMUNOLOGY (2021)

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Decoy Receptor 3 Inhibits Monosodium Urate-Induced NLRP3 Inflammasome Activation via Reduction of Reactive Oxygen Species Production and Lysosomal Rupture

Yi-Gen Pan et al.

Summary: The study demonstrated that DcR3's HBD can reduce MSU crystal-induced NLRP3 inflammasome activation by regulating mitochondrial and lysosomal functions, suggesting a potential new therapeutic approach for gout.

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TIPE Regulates DcR3 Expression and Function by Activating the PI3K/AKT Signaling Pathway in CRC

Mengya Zhong et al.

Summary: The study revealed that both TIPE and DcR3 are highly expressed in colorectal cancer (CRC) patients with their levels showing a positive correlation. DcR3 was found to be highly expressed in the plasma of cancer patients. TIPE regulates the expression of DcR3 by activating the PI3K/AKT signaling pathway in CRC, promoting cell proliferation and migration while inhibiting apoptosis.

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Review Immunology

Emerging mechanisms of immunocoagulation in sepsis and septic shock

Daolin Tang et al.

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Divergent Sepsis Pathophysiology in Older Adults

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Summary: The incidence and mortality rates of sepsis increase significantly with age, especially in older adults. However, there is currently a lack of effective therapeutic strategies targeting older patients with severe sepsis, despite ongoing research efforts. Further research using aged animal models with clinically relevant treatments is essential for future progress in this area.

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Review Medicine, Research & Experimental

Roles of Coagulation Abnormalities and Microthrombosis in Sepsis: Pathophysiology, Diagnosis, and Treatment

Toshiaki Iba et al.

Summary: The diagnostic criteria for overt DIC were established by ISTH in 2001, with recent research shedding light on the role of coagulation disorders in sepsis progression. The introduction of SIC as a pragmatic scoring system aims to detect early-stage sepsis-associated DIC, while globally agreed anticoagulant therapy for DIC is still lacking. International collaborative studies are deemed necessary for future advancements in diagnostic tools and treatment strategies.

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Serum decoy receptor 3 (DcR3): a promising biomarker for atopic asthma in children

Asmaa Kamal et al.

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Level of Decoy Receptor 3 for Monitoring Clinical Progression of Severe Burn Patients

Dong Min et al.

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Long Non-Coding RNAs as Biomarkers and Therapeutic Targets in Sepsis

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FRONTIERS IN IMMUNOLOGY (2021)

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Inflammation and Cell Death of the Innate and Adaptive Immune System during Sepsis

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Yun-yu Zhang et al.

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DcR3, a new biomarker for sepsis, correlates with infection severity and procalcitonin

Liqin Gao et al.

Oncotarget (2017)

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Review Medicine, Research & Experimental

Sepsis: A Review of Advances in Management

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ADVANCES IN THERAPY (2017)

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Review Immunology

The immunopathology of sepsis and potential therapeutic targets

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NATURE REVIEWS IMMUNOLOGY (2017)

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Review Cell Biology

Decoy receptor 3: an endogenous immunomodulator in cancer growth and inflammatory reactions

Shie-Liang Hsieh et al.

JOURNAL OF BIOMEDICAL SCIENCE (2017)

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Article Medicine, General & Internal

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

Mervyn Singer et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2016)

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Article Immunology

The immunomodulator decoy receptor 3 improves locomotor functional recovery after spinal cord injury

Chuan-Wen Chiu et al.

JOURNAL OF NEUROINFLAMMATION (2016)

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Article Medicine, Research & Experimental

Immunotherapeutic targeting of LIGHT/LTβR/HVEM pathway fully recapitulates the reduced cytotoxic phenotype of LIGHT-deficient T cells

Maria-Luisa del Rio et al.

MABS (2016)

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Article Genetics & Heredity

DcR3 suppresses influenza virus-induced macrophage activation and attenuates pulmonary inflammation and lethality

Ming-Ting Huang et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2015)

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Article Multidisciplinary Sciences

Decoy Receptor 3 Improves Survival in Experimental Sepsis by Suppressing the Inflammatory Response and Lymphocyte Apoptosis

DongYu Liang et al.

PLOS ONE (2015)

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Article Oncology

DcR3 binds to ovarian cancer via heparan sulfate proteoglycans and modulates tumor cells response to platinum with corresponding alteration in the expression of BRCA1

Joseph P. Connor et al.

BMC CANCER (2012)

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