☆ 4.7 Article

Insight into the Mechanism of Interactions between the LL-37 Peptide and Model Membranes of Legionella gormanii Bacteria

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Microbiology

Genomic characterization and assessment of pathogenic potential of Legionella spp. isolates from environmental monitoring

Ema Svetlicic et al.

Summary: Using high-throughput sequencing and genomic analysis, this study identified several potential new species in the genus Legionella, which have not yet been biochemically and morphologically characterized. Functional annotations were also performed on the sequenced genomes, revealing their virulence and antimicrobial resistance. This research contributes to the understanding of little-known non-pneumophila species present in man-made water systems.

FRONTIERS IN MICROBIOLOGY (2023)

添加到收藏夹

Article Green & Sustainable Science & Technology

Influence of the Antimicrobial LL-37 Peptide on Legionella dumoffii Phospholipids Adsorbed at the Air-Liquid Interface

Katarzyna Pastuszak et al.

Summary: Legionella dumoffii is an intracellular pathogen capable of infecting mammalian cells and causing Legionnaires' disease. The pathomechanism of infection development depends on factors including the structure and properties of macromolecules in the cell envelope. Phospholipids play a significant role in membrane integrity and host cell interactions. L. dumoffii can change its lipid profile in response to external factors, such as the presence of exogenous choline.

SUSTAINABILITY (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Physicochemical Characteristics of Model Membranes Composed of Legionella gormanii Lipids

Katarzyna Pastuszak et al.

Summary: This study investigates the effect of exogenous choline on the properties of L. gormanii phospholipid membranes at the liquid/air interface. The findings provide insights into the adaptation mechanisms of this pathogen and its ability to bypass antimicrobial compounds and host immune attack.

MEMBRANES (2023)

添加到收藏夹

Article Medicine, General & Internal

Case Report: Community-Acquired Legionella gormanii Pneumonia in an Immunocompetent Patient Detected by Metagenomic Next-Generation Sequencing

Cheng Lei et al.

Summary: This article reports a case of Legionella gormanii pneumonia diagnosed by metagenomic next-generation sequencing (mNGS). The use of mNGS in diagnosing Legionella infection provides a high-resolution and sensitive assay, especially for non-Legionella pneumophila serogroup 1 strains.

FRONTIERS IN MEDICINE (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Unusual Lipid Components of Legionella gormanii Membranes

Elzbieta Chmiel et al.

Summary: This study characterized the lipidome of L. gormanii membranes and identified unique lipid components, including ceramides and hexosylceramides. The findings provide insights into the bacterial chemotaxonomy of L. gormanii and its lipid metabolism.

METABOLITES (2022)

添加到收藏夹

Review Pharmacology & Pharmacy

Renovation as innovation: Repurposing human antibacterial peptide LL-37 for cancer therapy

Fatai Lu et al.

Summary: This article discusses the diverse effects of antimicrobial peptide LL37 in host defense, including antibacterial properties, tissue repair, and inflammatory responses, and explores its complex role in promoting or inhibiting tumor growth. The strategies to enhance delivery of this peptide and selectivity for cancer cells are also discussed.

FRONTIERS IN PHARMACOLOGY (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Langmuir Monolayer Techniques for the Investigation of Model Bacterial Membranes and Antibiotic Biodegradation Mechanisms

Monika Rojewska et al.

Summary: The widespread presence of antibiotics in the environment has caused various issues that negatively impact the world of bacteria. Understanding the interaction mechanism of antibiotics with bacterial membranes is crucial for addressing these problems.

MEMBRANES (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Electrical Properties of Membrane Phospholipids in Langmuir Monolayers

Anna Chachaj-Brekiesz et al.

Summary: Experimental surface pressure and electric surface potential isotherms were measured for membrane lipids, with discrepancies between calculated and experimental values leading to the development of a new methodology incorporating density functional theory (DFT) molecular modeling. The study determined contributions to apparent dipole moments and highlighted the importance of local dielectric permittivity in the vicinity of polar and apolar groups.

MEMBRANES (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Interaction of LL-37 human cathelicidin peptide with a model microbial-like lipid membrane

Marta Majewska et al.

Summary: The study investigates the interaction between LL-37 and a model microbial-like membrane, revealing that LL-37 causes changes in phospholipid molecules conformation and orientation, leading to membrane disintegration and significantly affecting membrane electrical parameters. This research provides valuable insights into the influence of LL-37 on multicomponent model membranes and offers a promising contribution to the development of LL-37-derived therapeutic agents against drug-resistant bacteria.

BIOELECTROCHEMISTRY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Structural Plasticity of LL-37 Indicates Elaborate Functional Adaptation Mechanisms to Bacterial Target Structures

Kornelius Zeth et al.

Summary: The human cathelicidin LL-37 is a versatile peptide with antimicrobial activity, playing a crucial role in targeting microorganisms. Recent structural studies have revealed the diversity and adaptability of LL-37 in interacting with lipid-like molecules. Complexes of LL-37 with detergents provide insights into mimicking lipids and inducing oligomerization and fibrillation, opening avenues for designing LL-37-derived peptides with enhanced antibiotic properties.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Analysis of Molecular Interactions between Components in Phospholipid-Immunosuppressant-Antioxidant Mixed Langmuir Films

Malgorzata Jurak et al.

Summary: The study investigated the miscibility of Langmuir monolayers incorporating DOPC, CsA, and LG, revealing that the 1:1:2 molar ratio had the strongest attraction and highest thermodynamic stability. This combination showed great potential for improving biocompatibility of implant device surfaces.

LANGMUIR (2021)

添加到收藏夹

Review Infectious Diseases

The Potential of Human Peptide LL-37 as an Antimicrobial and Anti-Biofilm Agent

Kylen E. Ridyard et al.

Summary: LL-37 shows promise as an alternative to conventional antibiotics due to its broad spectrum antibacterial and immunomodulatory properties, but faces limitations such as high cost and toxicity to human cells.

ANTIBIOTICS-BASEL (2021)

添加到收藏夹

Article Chemistry, Medicinal

Salmonella Membrane Structural Remodeling Increases Resistance to Antimicrobial Peptide LL-37

Michael W. Martynowycz et al.

ACS INFECTIOUS DISEASES (2019)

添加到收藏夹

Article Immunology

Genetic diversity of Legionella pcs and pmtA genes and the effect of utilization of choline by Legionella spp. on induction of proinflammatory cytokines

Marta Palusinska-Szysz et al.

PATHOGENS AND DISEASE (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Interaction of a Polyarginine Peptide with Membranes of Different Mechanical Properties

Matias A. Crosio et al.

BIOMOLECULES (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Properties of Artificial Phospholipid Membranes Containing Lauryl Gallate or Cholesterol

Malgorzata Jurak et al.

JOURNAL OF MEMBRANE BIOLOGY (2018)

添加到收藏夹

Article Microbiology

Distribution of Secretion Systems in the Genus Legionella and Its Correlation with Pathogenicity

Tian Qin et al.

FRONTIERS IN MICROBIOLOGY (2017)

添加到收藏夹

Review Biochemical Research Methods

Synthetic Random Copolymers as a Molecular Platform To Mimic Host-Defense Antimicrobial Peptides

Haruko Takahashi et al.

BIOCONJUGATE CHEMISTRY (2017)

添加到收藏夹

Article Microbiology

Microbiological and Clinical Studies of Legionellosis in 33 Patients with Cancer

Xiang Y. Han et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2015)

添加到收藏夹

Article Microbiology

Characterization and resuscitation of 'non-culturable' cells of Legionella pneumophila

Adrien Ducret et al.

BMC MICROBIOLOGY (2014)

添加到收藏夹

Article Biochemical Research Methods

Penetration of Milk-Derived Antimicrobial Peptides into Phospholipid Monolayers as Model Biomembranes

Wanda Barzyk et al.

BIOCHEMISTRY RESEARCH INTERNATIONAL (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

Cathelicidins: family of antimicrobial peptides. A review

Ewa M. Kosciuczuk et al.

MOLECULAR BIOLOGY REPORTS (2012)

添加到收藏夹

Article Respiratory System

Legionella pneumophila induces human beta Defensin-3 in pulmonary cells

Stefanie Scharf et al.

RESPIRATORY RESEARCH (2010)

添加到收藏夹

Article Biochemistry & Molecular Biology

Phospholipase PlaB of Legionella pneumophila Represents a Novel Lipase Family PROTEIN RESIDUES ESSENTIAL FOR LIPOLYTIC ACTIVITY, SUBSTRATE SPECIFICITY, AND HEMOLYSIS

Jennifer Bender et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

添加到收藏夹

Review Biochemistry & Molecular Biology

Domains in bacterial membranes and the action of antimicrobial agents

Richard M. Epand et al.

MOLECULAR BIOSYSTEMS (2009)

添加到收藏夹

Article Biochemistry & Molecular Biology

Binding of LL-37 to model biomembranes:: Insight into target vs host cell recognition

Rohit Sood et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2008)

添加到收藏夹

Article Biophysics

Interaction of LL-37 with model membrane systems of different complexity: Influence of the lipid matrix

E. Sevcsik et al.

BIOPHYSICAL JOURNAL (2008)

添加到收藏夹

Article Biochemistry & Molecular Biology

How lipids influence the mode of action of membrane-active peptides

E. Sevcsik et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2007)

添加到收藏夹

Article Biophysics

Lipid headgroup discrimination by antimicrobial peptide LL-37: Insight into mechanism of action

F Neville et al.

BIOPHYSICAL JOURNAL (2006)

添加到收藏夹

Article Biophysics

Interactions between phosphatidylcholines and cholesterol in monolayers at the air/water interface

P Dynarowicz-Latka et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2004)

添加到收藏夹

Article Biochemistry & Molecular Biology

Perturbation of the hydrophobic core of lipid bilayers by the human antimicrobial peptide LL-37

KA Henzler-Wildman et al.

BIOCHEMISTRY (2004)

添加到收藏夹

Article Biochemistry & Molecular Biology

Legioliulin, a new isocoumarin compound responsible for blue-white autofluorescence in Legionella (Fluoribacter) dumoffii under long-wavelength UV light

J Amemura-Maekawa et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)

添加到收藏夹

Article Biochemistry & Molecular Biology

Phosphatidylethanolamine and phosphatidylglycerol are segregated into different domains in bacterial membrane. A study with pyrene-labelled phospholipids

S Vanounou et al.

MOLECULAR MICROBIOLOGY (2003)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.