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Shedding Light on Skin Autoimmunity: More than Just Skin Deep

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

The Antimicrobial Peptide Cathelicidin Exerts Immunomodulatory Effects via Scavenger Receptors

Ryo Amagai et al.

Summary: This study aimed to determine the cellular pathways by which LL-37 amplifies inflammation induced by damage-associated molecular patterns (DAMPs). It was found that LL-37 modulates inflammation via scavenger receptors and interacts with DAMPs. The results suggest that scavenger receptors may be potential targets for treating inflammatory diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Review Biochemistry & Molecular Biology

In Vitro, Ex Vivo, and In Vivo Models for the Study of Pemphigus

Roberta Lotti et al.

Summary: Pemphigus is a life-threatening autoimmune disease characterized by pathogenic autoantibodies targeting specific desmoglein proteins, leading to keratinocyte separation. Various disease models, including in vitro, ex vivo and in vivo mouse models, allow for testing different hypotheses regarding disease initiation and evaluating the efficacy of experimental therapies. These models also help in assessing the pathogenicity of specific Pemphigus autoantibodies and investigating previously unidentified autoantigens.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biochemistry & Molecular Biology

Serum Levels of Vascular Endothelial Growth Factor, Platelet Activating Factor and Eosinophil-Derived Neurotoxin in Chronic Spontaneous Urticaria-A Pilot Study in Adult Patients

Krzysztof Gomulka et al.

Summary: This study aimed to investigate the serum levels of VEGF, PAF, and EDN in relation to disease activity and pruritus intensity in adult patients with CSU. The results showed higher levels of VEGF, PAF, and EDN in CSU patients compared with healthy subjects, but these cytokines were not significantly correlated with disease activity or pruritus intensity.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biochemistry & Molecular Biology

The Extracts of Dendrobium Alleviate Dry Eye Disease in Rat Model by Regulating Aquaporin Expression and MAPKs/NF-κB Signalling

Jiawei Ling et al.

Summary: Dendrobium extracts have anti-inflammatory effects and promote cell migration, improving tear production and protecting the ocular surface. They may be potential therapeutic agents for dry eye.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Biochemistry & Molecular Biology

Modulation of Immune Cells as a Therapy for Cutaneous Lupus Erythematosus

Jorge A. Soto et al.

Summary: CLE is an autoimmune disorder characterized by autoantibody secretion and immune cell recruitment, similar to SLE. It can be divided into different types with varying severity of skin lesions. Type I IFN plays a significant role in the development of CLE. Research aims to develop effective treatments.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Shedding Light on Skin Autoimmunity: More than Just Skin Deep

相关参考文献

The Antimicrobial Peptide Cathelicidin Exerts Immunomodulatory Effects via Scavenger Receptors

In Vitro, Ex Vivo, and In Vivo Models for the Study of Pemphigus

Serum Levels of Vascular Endothelial Growth Factor, Platelet Activating Factor and Eosinophil-Derived Neurotoxin in Chronic Spontaneous Urticaria-A Pilot Study in Adult Patients

The Extracts of Dendrobium Alleviate Dry Eye Disease in Rat Model by Regulating Aquaporin Expression and MAPKs/NF-κB Signalling

Modulation of Immune Cells as a Therapy for Cutaneous Lupus Erythematosus

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