期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 24, 期 15, 页码 -出版社
MDPI
DOI: 10.3390/ijms241511900
关键词
muscle cancers; NF-& kappa;B; curcumin; catechin; resveratrol; quercetin; berberine; CAPE; cucurbitacin E
This review paper summarizes the current knowledge on the effects of natural compounds, including curcumin, resveratrol, quercetin, epigallocatechin-3-gallate, and berberine, on NF-κB signaling in muscle-derived cancers. These compounds have been shown to inhibit NF-κB signaling in rhabdomyosarcoma cells through various mechanisms. Natural compounds could be potential therapeutic agents for muscle-derived cancers, but more research is needed to fully understand their mechanisms of action and potential clinical applications.
The NF-?B-signaling pathway plays a crucial role in cancer progression, including muscle-derived cancers such as rhabdomyosarcoma or sarcoma. Several natural compounds have been studied for their ability to alter NF-?B signaling in these types of cancers. This review paper summarizes the current knowledge on the effects of natural compounds, including curcumin, resveratrol, quercetin, epigallocatechin-3-gallate, and berberine, on NF-?B signaling in muscle-derived cancers. These compounds have been shown to inhibit NF-?B signaling in rhabdomyosarcoma cells through various mechanisms, such as inhibiting the activation of the IKK complex and the NF-?B transcription factor. These findings suggest that natural compounds could be potential therapeutic agents for muscle-derived cancers. However, further research is needed to fully understand their mechanisms of action and potential clinical applications.
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