Cyanidin-3-O-glucoside as a Nutrigenomic Factor in Type 2 Diabetes and Its Prominent Impact on Health

Type 2 diabetes (T2D) accounts for a global health problem. It is a complex disease as a result of the combination of environmental as well as genetic factors. Morbidity is still increasing across the world. One of the possibilities for the prevention and mitigation of the negative consequences of type 2 diabetes is a nutritional diet rich in bioactive compounds such as polyphenols. This review is focused on cyanidin-3-O-glucosidase (C3G), which belongs to the anthocyanins subclass, and its anti-diabetic properties. There are numerous pieces of evidence that C3G exerts positive effects on diabetic parameters, including in vitro and in vivo studies. It is involved in alleviating inflammation, reducing blood glucose, controlling postprandial hyperglycemia, and gene expression related to the development of T2D. C3G is one of the beneficial polyphenolic compounds that may help to overcome the public health problems associated with T2D.

Automated summary

Type 2 diabetes is a global health problem caused by a combination of environmental and genetic factors. In order to prevent and mitigate the negative consequences of type 2 diabetes, a nutritional diet rich in bioactive compounds such as polyphenols, including cyanidin-3-O-glucosidase (C3G), can be beneficial. C3G has been shown to have positive effects on diabetic parameters, including reducing inflammation, blood glucose levels, and postprandial hyperglycemia, as well as regulating gene expression related to the development of type 2 diabetes.