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Lessons from Animal Models in Sj & ouml;gren's Syndrome

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Summary: The study reveals a causal relationship between gut microbiota composition and Sjogren's Syndrome risk, with some microbial species positively correlated and others negatively correlated. Additionally, four genes related to gut microbiota were found to have a causal effect on Sjogren's Syndrome.

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Disease mechanisms in Sjogren's syndrome: What do we know?

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Summary: Exploring and studying disease mechanisms is crucial, especially in complex pathogenesis without a direct causal agent like in syndromes with multiple organ involvements. Understanding the mechanisms of Sjogren's syndrome can help reveal its etiology, identify biomarkers for diagnosis and assessment, determine treatment targets, and define critical items in classification criteria.

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Summary: Sjogren's syndrome is a chronic autoimmune disease characterized by dryness in the eyes and mouth, with systemic manifestations and unclear pathogenesis. Diagnosis is based on clinical symptoms and specific tests, while treatment ranges from local to systemic medications. New classification criteria and disease activity scores have been developed for research and clinical practice.

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Gastrointestinal microbiome and primary Sjogren's syndrome: a review of the literature and conclusions

Yu-Feng Yao et al.

Summary: The impact of the human gastrointestinal microbiome on human autoimmune diseases, including primary Sjogren's syndrome, has been recognized through deeper research. This review summarizes the latest knowledge about the relationship between the microbiome and pSS, providing insights into potential mechanisms and highlighting the significance for the development of new therapies targeting dry eye associated with pSS.

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A Glimpse Into the Microbiome of Sjogren's Syndrome

Chuiwen Deng et al.

Summary: Sjogren's syndrome, a common chronic autoimmune disease, is associated with microbial dysbiosis. The alterations in the microbiota correlate with disease severity.

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Th17 cells in primary Sjogren's syndrome negatively correlate with increased Roseburia and Coprococcus

Xiaohong Xin et al.

Summary: Primary Sjogren's syndrome can lead to decreased gut microbial diversity and richness. The proportions of Th17 and Treg cells induced by microbiota are predictive of pSS manifestations and account for the severity of pSS.

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Genetics and epigenetics in primary Sjogren's syndrome

Juliana Imgenberg-Kreuz et al.

Summary: Primary Sjogren's syndrome (pSS) is a multifactorial disease with underlying genetic predisposition, epigenetic mechanisms and environmental factors playing roles in disease development. The strongest association signal lies within the HLA genes, with most genetic risk variants found at intergenic regions whose functional impact remains unclear. Epigenetic mechanisms like DNA methylation and histone modifications modulate gene expression, forming a dynamic link between the genome and phenotypic manifestations in pSS.

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The role of stroma and epithelial cells in primary Sjogren's syndrome

Saba Asam et al.

Summary: Primary Sjögren's Syndrome (pSS) is a chronic autoimmune condition characterized by infiltration of the exocrine glands and systemic B cell hyperactivation. The interaction between stromal cells and infiltrating lymphocytes plays a crucial role in the pathogenesis of pSS. Targeting stromal cells may be necessary to modulate the local inflammatory environment in pSS, in addition to traditional immunosuppression therapies.

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The Involvement of Innate and Adaptive Immunity in the Initiation and Perpetuation of Sjogren's Syndrome

Clara Chivasso et al.

Summary: Sjogren's syndrome is a chronic autoimmune disease characterized by infiltration of exocrine glands, leading to dry eyes and mouth symptoms. The pathophysiology of the disease is not well understood, but evidence suggests that different factors interact to initiate and perpetuate the disease. Immune system, both innate and adaptive, play a crucial role in the pathogenesis of SS.

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Upregulated Chemokine and Rho-GTPase Genes Define Immune Cell Emigration into Salivary Glands of Sjogren's Syndrome-Susceptible C57BL/6.NOD-Aec1Aec2 Mice

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TLR7 Signaling Drives the Development of Sjogren's Syndrome

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