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Molecular and Cellular Mechanisms of Osteoporosis

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Biochemistry & Molecular Biology

Free radicals: Relationship to Human Diseases and Potential Therapeutic applications

Bozidarka L. Zaric et al.

Summary: This review provides a systematic summary of the biochemical characteristics of various types of reactive species and specifies their localization and mechanisms of production in cells. Additionally, it discusses the specific roles of free radicals in cellular physiology, focusing on the current research aiming to identify the cascades of reactions initiated by reactive oxygen species that result in adaptive or pathological cellular responses. Finally, recent findings regarding therapeutic modulations of intracellular levels of reactive oxygen species are presented, which may have significant implications for developing novel agents for treating several diseases.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2023)

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Article Agriculture, Multidisciplinary

A Novel Anti-Osteoporosis Mechanism of VK2: Interfering with Ferroptosis via AMPK/SIRT1 Pathway in Type 2 Diabetic Osteoporosis

Chen Jin et al.

Summary: Type 2 diabetic osteoporosis (T2DOP) is a chronic bone metabolic disease associated with increased risk of fracture and osteonecrosis. Vitamin K2 (VK2) has been clinically used to prevent osteoporosis and improve coagulation. This study explored the role and mechanism of VK2 in high glucose-mediated ferroptosis.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2023)

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Article Biochemistry & Molecular Biology

Oxidative stress in the mitochondrial matrix underlies ischemia/reperfusion-induced mitochondrial instability

Soroosh Solhjoo et al.

Summary: Ischemia and reperfusion affect multiple elements of cardiomyocyte electrophysiology, especially within the mitochondria. Here, through confocal microscopy, we investigate the mechanisms underlying the postischemic Delta Psi oscillations, focusing on the role of Ca2+ and oxidative stress. We found that transient bouts of increased mitochondrial oxidative stress underlie postischemic Delta Psi oscillations, regardless of Ca2+ dynamics.

JOURNAL OF BIOLOGICAL CHEMISTRY (2023)

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Article Endocrinology & Metabolism

Genotypic and Phenotypic Spectrum and Pathogenesis of WNT1 Variants in a Large Cohort of Patients With OI/Osteoporosis

Jing Hu et al.

Summary: Mutations in the WNT1 gene can cause rare inherited disorders such as osteogenesis imperfecta (OI) and early-onset osteoporosis (EOOP), with biallelic nonsense or frameshift mutations leading to earlier occurrence of fragility fractures and more severe skeletal phenotypes. Rare comorbidities including cerebral abnormalities, hematologic diseases, and pituitary adenoma were identified in patients with WNT1 mutations.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2023)

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Review Immunology

Targeting STING: From antiviral immunity to treat osteoporosis

Zhonghua Gao et al.

Summary: The cGAS-STING signaling pathway detects dsDNA to trigger innate immune responses and has emerged as a critical mediator of inflammation. Activating the STING/IFN-beta pathway reduces bone resorption, while activation of STING/NF-kappa B increases bone resorption and decreases bone formation, leading to osteoporosis.

FRONTIERS IN IMMUNOLOGY (2023)

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Review Biochemistry & Molecular Biology

Oxidative Stress and Natural Antioxidants in Osteoporosis: Novel Preventive and Therapeutic Approaches

Gemma Marcucci et al.

Summary: This review provides a detailed report on the cellular and molecular mechanisms involved in bone remodeling, specifically in relation to oxidative stress, inflammatory factors, and estrogen deficiency. Oxidative stress is a key factor in the development of osteoporosis, leading to osteocyte apoptosis and impaired bone remodeling and resorption. Recent studies have shown that natural antioxidants found in the diet can effectively prevent and reduce the negative effects of oxidative stress on bone health. These antioxidants target osteocytes and their molecular factors, promoting bone regeneration and preventing bone loss. This suggests that incorporating antioxidants into therapeutic approaches may improve the prevention and treatment of osteoporosis and related bone diseases.

ANTIOXIDANTS (2023)

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Review Orthopedics

Osteoporosis: An Update on Screening, Diagnosis, Evaluation, and Treatment

Shahbaaz A. Sabri et al.

Summary: Osteoporosis screening, diagnosis, and treatment have been the focus of attention in the healthcare community in the past 20 years. Multispecialty awareness programs and improved diagnostic protocols have been developed. Genetic predisposition and new drug therapies offer more options for managing at-risk patients. However, adherence to protocols by healthcare practitioners has been low. Continued awareness and education are crucial to care for the aging population.

ORTHOPEDICS (2023)

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Article Geriatrics & Gerontology

Cross-sectional study and bioinformatics analysis to reveal the correlations of osteoporosis in patients with Parkinson's disease

Cong Ma et al.

Summary: This study revealed the clinical and genetic correlations between Parkinson's disease (PD) and osteoporosis. PD patients had lower bone density and poorer bone mass diagnosis compared to healthy controls. PD diagnosis acted as an independent risk factor for osteoporosis.

EXPERIMENTAL GERONTOLOGY (2023)

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Review Biochemistry & Molecular Biology

Oxidative Stress and Inflammation in Osteoporosis: Molecular Mechanisms Involved and the Relationship with microRNAs

Teresa Iantomasi et al.

Summary: Osteoporosis is a condition characterized by an imbalance in bone homeostasis, which involves oxidative stress, inflammation, and dysregulation of microRNA expression. Oxidative stress and inflammation enhance bone resorption and reduce bone formation through the activation of MAPK and transcription factors. This review summarizes the molecular mechanisms of oxidative stress and inflammation in osteoporosis and highlights the interplay between altered microRNA expression, oxidative stress, and inflammation. It also discusses the potential for targeting these mechanisms in the development of new therapeutic approaches to osteoporosis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Biochemistry & Molecular Biology

(S)-2-(Cyclobutylamino)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)isonicotinamide Attenuates RANKL-Induced Osteoclast Differentiation by Inhibiting NF-?B Nuclear Translocation

Mina Ding et al.

Summary: In this study, the effects of EPZ compounds, PRMT5 inhibitors, on RANKL-induced osteoclast differentiation were investigated. EPZ015866 attenuated osteoclast differentiation more effectively than EPZ015666. The compounds inhibited the nuclear translocation of NF-kappa B, preventing osteoclast differentiation and bone resorption. EPZ015866 may be a potential drug candidate for the treatment of osteoporosis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Review Biochemistry & Molecular Biology

Hormone-Related and Drug-Induced Osteoporosis: A Cellular and Molecular Overview

Li-Ting Wang et al.

Summary: Osteoporosis, caused by an imbalance of bone turnover, is a significant global health issue. Estrogen deficiency is the main cause of hormone-related osteoporosis in postmenopausal women, while glucocorticoid-induced osteoporosis is the most common drug-induced type. This review discusses the mechanisms of bone turnover, the pathophysiology of osteoporosis, and its treatment options.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Biotechnology & Applied Microbiology

WNT-modulating gene silencers as a gene therapy for osteoporosis, bone fracture, and critical-sized bone defects

Won-Taek Oh et al.

Summary: Recombinant adeno-associated virus (rAAV)-mediated gene therapy shows promise as a long-lasting and targeted treatment for osteoporosis and associated bone fractures. By silencing the expression of WNT antagonists, SHN3 and SOST, and enhancing WNT/β-catenin signaling, osteoblast function, and bone formation, this approach effectively reverses bone loss and improves fracture healing. These findings demonstrate the clinical potential of bone-specific gene silencers for treating skeletal disorders.

MOLECULAR THERAPY (2023)

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Article Rheumatology

Mechanisms underlying the long-term and withdrawal effects of denosumab therapy on bone

Serge Ferrari et al.

Summary: Denosumab, a human monoclonal antibody against RANKL, inhibits osteoclast differentiation and activity, leading to anti-resorptive properties and anti-fracture efficacy. Compared with bisphosphonates, denosumab results in continuous bone mineral density gain during long-term treatment and rapid bone loss upon withdrawal. The underlying mechanisms for these effects are not fully understood, but emerging data suggest that denosumab may affect both osteoclasts and osteoblasts, causing sustained bone gain and bone loss. Future studies and clinical implications are discussed in this Perspective.

NATURE REVIEWS RHEUMATOLOGY (2023)

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Article Multidisciplinary Sciences

Clinical features and shared mechanisms of chronic gastritis and osteoporosis

Tao Han et al.

Summary: This study explores the clinical characteristics and shared mechanisms of chronic gastritis (CG) patients combined with osteoporosis (OP). The results show that smoking history, serum PTH and serum beta-CTX are positively correlated with OP in CG patients, while serum P1NP and eating fruit are negatively correlated with OP in CG patients. Additionally, several core genes and related pathways involved in the occurrence and development of CG and OP have been identified.

SCIENTIFIC REPORTS (2023)

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Article Biochemistry & Molecular Biology

Obesity-induced oxidative stress and mitochondrial dysfunction negatively affect sperm quality

Jia Jing et al.

Summary: Obesity is a metabolic disease that can cause male infertility or subfertility through oxidative stress. This study found that obesity impairs sperm mitochondrial integrity and function, leading to reduced sperm quality in overweight/obese men and mice on a high-fat diet. The excessive fat intake caused increased oxidative stress levels and decreased sperm motility by affecting mitochondrial structure and function. Clinical studies also supported these findings, showing a correlation between obesity and lower sperm quality. These results highlight the importance of maintaining a healthy weight for male fertility.

FEBS OPEN BIO (2023)

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Article Genetics & Heredity

Influence of the Osteogenomic Profile in Response to Alendronate Therapy in Postmenopausal Women with Osteoporosis: A Retrospective Cohort Study

Alejandra Villagomez Vega et al.

Summary: This study aimed to investigate the influence of combinations of potential risk alleles on the response to anti-osteoporotic treatment in postmenopausal women with primary osteoporosis. The results showed that patients with the G-C-G-C genetic profile were more likely to respond positively to alendronate therapy.

GENES (2023)

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Review Endocrinology & Metabolism

Endocrine, Metabolic, and Immune Pathogenesis of Postmenopausal Osteoporosis. Is there a Therapeutic Role in Natural Products?

Giuseppe Lisco et al.

Summary: Bone health is dependent on the balance between bone resorption and new bone generation. Postmenopausal osteoporosis is caused by estrogen deficiency, leading to increased bone resorption and higher risk of fractures. The high release of proinflammatory cytokines in osteoporosis suggests the involvement of the immune system in the disease pathogenesis (immunoporosis). This review aims to discuss the pathophysiology of osteoporosis from an endocrinological and immunological perspective and explore treatments, particularly nutraceuticals.

ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS (2023)

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Article Immunology

The genetically predicted causal relationship of inflammatory bowel disease with bone mineral density and osteoporosis: evidence from two-sample Mendelian randomization

Dengyong Xu et al.

Summary: This study conducted a two-sample Mendelian randomization analysis and found a causal relationship between inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), and low total body bone mineral density (BMD) and osteoporosis (OS).

FRONTIERS IN IMMUNOLOGY (2023)

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Article Clinical Neurology

Bibliometrics Analysis and Visualization of Sarcopenia Associated with Osteoporosis from 2000 to 2022

Jiyong Yang et al.

Summary: The study aimed to evaluate the current bibliometric characteristics and status of cross-sectional studies between osteoporosis and sarcopenia. The results showed that global research on osteoporosis and sarcopenia has rapidly increased from 2000 to 2022, and future research trends will focus on molecular mechanisms of crosstalk between muscles and bones, interventions with a dual effect on muscle and bone, and osteosarcopenia.

JOURNAL OF PAIN RESEARCH (2023)

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Review Chemistry, Multidisciplinary

Oxidative stress, free radicals and antioxidants: potential crosstalk in the pathophysiology of human diseases

Priya Chaudhary et al.

Summary: Free radicals are reactive oxygen species that circulate through the body and can contribute to the development of diseases when their natural removal mechanisms are disrupted.

FRONTIERS IN CHEMISTRY (2023)

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Review Medicine, General & Internal

Bridging the Gap: Pregnancy-And Lactation-Associated Osteoporosis

Mara Carsote et al.

Summary: Early diagnosis of pregnancy- and lactation-associated osteoporosis (PLO) is crucial, and an individualized strategy is needed due to the lack of standardized care guidelines. This review summarizes the clinical characteristics and potential contributing factors of PLO based on recent research. The findings suggest that up to 50% of PLO patients have mutations in specific genes, indicating the potential role of gene testing in the future.

DIAGNOSTICS (2023)

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Article Public, Environmental & Occupational Health

The prevalence of osteoporosis in China, a community based cohort study of osteoporosis

Jing Wang et al.

Summary: This study found significant regional differences in the prevalence of osteoporosis among middle-aged and elderly Chinese residents. Women, aged 60 or older, with low BMI, low education level, current regular smoking, and a history of fracture were more likely to have osteoporosis. Additional prevention and treatment resources should be targeted towards these high-risk populations.

FRONTIERS IN PUBLIC HEALTH (2023)

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Review Immunology

Bone regeneration in inflammation with aging and cell-based immunomodulatory therapy

Junichi Kushioka et al.

Summary: The aging population increases the prevalence of osteoporosis and fragility fractures, impacting patient quality of life and healthcare costs. Chronic inflammation in aging impairs bone regeneration and healing. This review focuses on the bone regeneration process and potential immunomodulatory therapies for improved bone healing in inflammaging.

INFLAMMATION AND REGENERATION (2023)

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Article Biochemistry & Molecular Biology

Hmga1-overexpressing lentivirus protects against osteoporosis by activating the Wnt/& beta;-catenin pathway in the osteogenic differentiation of BMSCs

Zhixin Wu et al.

Summary: This study identified six essential genes related to the osteogenic differentiation of BMSCs and osteoporosis: Fbn2, Lrrc17, Hspb7, Hmga1, Nexn, and Esm1. Hmga1 was found to prevent bone loss caused by ovariectomy-induced osteoporosis through the Wnt signaling pathway, suggesting Hmga1 as a potential therapeutic target for postmenopausal osteoporosis.

FASEB JOURNAL (2023)

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Article Endocrinology & Metabolism

GSTT1 as a Predictive Marker and Enhancer for Osteogenic Potential of Human Adipose-Derived Stromal/Stem Cells

Eugene Lee et al.

Summary: Adipose-derived stromal/stem cells (ASCs) are promising cell sources for bone regenerative medicine. This study identified GSTT1 as a marker to predict osteogenic potential of ASC clones. Knockdown of GSTT1 reduced mineralized matrix formation in highly osteogenic ASCs, while overexpression of GSTT1 enhanced osteogenic differentiation in low osteogenic ASCs. Metabolomic analysis confirmed changes in bone differentiation-related metabolites in GSTT1-transfected ASCs. In vivo experiments showed that GSTT1-transfected ASCs significantly improved bone regeneration compared to control vector-transfected ASCs. GSTT1 can serve as a marker and therapeutic factor to enhance osteogenic differentiation of ASCs.

JOURNAL OF BONE AND MINERAL RESEARCH (2023)

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Review Medicine, Research & Experimental

Mechanistic advances in osteoporosis and anti-osteoporosis therapies

Haiwei Wang et al.

Summary: Osteoporosis is a significant public health problem characterized by bone loss and deterioration of bone tissue. Classic pharmacological options can improve bone mineral density and resist fractures, but may have side effects. Therefore, research on new pathogenesis and potential therapeutic targets is important for the development of effective treatments. This study provides a comprehensive review of the current advances in osteoporosis, presenting mechanistic insights and updated therapies.

MEDCOMM (2023)

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Article Endocrinology & Metabolism

Comparison of anti-fracture effectiveness of zoledronate, ibandronate and alendronate versus denosumab in a registry-based cohort study

Judith Everts-Graber et al.

Summary: This registry-based study compared the anti-fracture effectiveness of denosumab and bisphosphonates in patients with osteoporosis. Denosumab showed significantly greater risk reduction for vertebral and any fractures compared to alendronate or ibandronate, while no difference in fracture risk reduction was found between zoledronate and denosumab.

OSTEOPOROSIS INTERNATIONAL (2023)

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Article Cell Biology

Alterations of SIRT1/SIRT3 subcellular distribution in aging undermine cardiometabolic homeostasis during ischemia and reperfusion

Jingwen Zhang et al.

Summary: The age-related sensors SIRT1 and SIRT3 play a crucial role in the protective response during myocardial ischemia and reperfusion. Defects in cardiac SIRT1 or SIRT3 in aged hearts result in worsened cardiac deterioration and failed recovery after acute ischemic stress and reperfusion. SIRT1 translocates into mitochondria and recruits more SIRT3, enhancing their interaction and providing adaptive protection against mitochondria dysfunction. SIRT1 also maintains mitochondrial integrity through SIRT3-mediated substrate metabolism during acute ischemic and reperfusion stress.

AGING CELL (2023)

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Article Pharmacology & Pharmacy

Xl019, a novel JAK inhibitor, suppressed osteoclasts differentiation induced by RANKL through MAPK signaling pathway

Yi Mao et al.

Summary: In this study, the effects of XL019, a Janus kinase (JAK) inhibitor, on osteoclastogenesis and its mechanism pathway were investigated in vitro. It was found that XL019 could impair osteoclast formation, interfere with bone resorption ability, and downregulate osteoclast-specific gene and protein expression. Furthermore, it was demonstrated that XL019 inhibited RANKL-induced osteoclastogenesis by suppressing MAPK signaling through Western blot and molecular docking studies. In addition, a mouse experiment confirmed the beneficial effect of XL019 on bone metabolism. Overall, this study highlights the potential of XL019 as a pharmacological treatment for bone metabolic disorders by effectively inhibiting osteoclast activity via the MAPK signaling pathway.

BIOCHEMICAL PHARMACOLOGY (2023)

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Review Medicine, Research & Experimental

Oxidative stress: A common pathological state in a high-risk population for osteoporosis

Chi Zhang et al.

Summary: Osteoporosis is a major concern and high-risk populations need regular bone mineral density testing and appropriate preventive treatment. Oxidative stress, including the direct effect of reactive oxygen species and the reduction of antioxidant enzyme activity, plays a significant role in the development of osteoporosis. Understanding the impact of oxidative stress on osteoporosis can greatly optimize therapeutic schedules.

BIOMEDICINE & PHARMACOTHERAPY (2023)

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Article Orthopedics

Regular sling core stabilization training improves bone density based on calcium and vitamin D supplementation

Jing Liu et al.

Summary: Sling core stabilization training combined with calcium and vitamin D supplementation has a positive impact on bone mineral density in osteoporosis patients, relieving back pain and improving bone density.

BMC MUSCULOSKELETAL DISORDERS (2023)

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Review Endocrinology & Metabolism

A potential therapeutic drug for osteoporosis: prospect for osteogenic LncRNAs

Fanjin Meng et al.

Summary: Long non-coding RNAs (LncRNAs) are important in bone formation and are regulated by various signaling pathways and microRNAs (miRNAs). Current research studies on osteogenic LncRNAs face problems such as sophisticated techniques, high cost for in vivo experiments, and low homology between animal models and humans, hindering translational medicine research. However, new techniques and innovative ideas are being explored to address these problems, and LncRNAs hold promise as therapeutic drugs for osteoporosis in the future.

FRONTIERS IN ENDOCRINOLOGY (2023)

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Article

Assessment, treatment and prevention of vitamin D deficiency

Lucie Nield et al.

Nursing standard (Royal College of Nursing (Great Britain) : 1987) (2023)

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Article

Effects of Bazedoxifene/Vitamin D Combination Therapy on Serum Vitamin D Levels and Bone Turnover Markers in Postmenopausal Women with Osteopenia: A Randomized Controlled Trial

Chaiho Jeong et al.

Journal of Bone Metabolism (2023)

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Review Obstetrics & Gynecology

Recent Insights into Pregnancy and Lactation-Associated Osteoporosis (PLO)

Maria Florencia Scioscia et al.

Summary: During pregnancy and lactation, women undergo physiological changes to meet the calcium and phosphorus requirements of the fetus and newborn. Pregnancy and lactation-associated osteoporosis (PLO) is a rare condition characterized by non-traumatic fractures, most commonly vertebral, during the third trimester of pregnancy and/or the early postpartum period. Although the exact cause of PLO is not fully understood, risk factors for secondary osteoporosis and genetic factors have been implicated. There is limited literature on this condition, with most studies consisting of case reports and series. Treatment typically involves discontinuation of lactation and calcium and vitamin D supplementation, while long-term and/or pharmacological management remains controversial. Recent studies suggest the potential use of teriparatide in PLO patients.

INTERNATIONAL JOURNAL OF WOMENS HEALTH (2023)

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Review Rheumatology

Anti-sclerostin antibodies: a new frontier in fragility fractures treatment

Giovanni Iolascon et al.

Summary: Bone fragility is the key factor in increased risk of minimal trauma fracture and requires a multimodal approach including pharmacological therapy, physical exercise, and adequate nutrition. Antiresorptive and osteoanabolic drugs have shown to effectively reduce fracture risk in osteoporotic patients. The discovery of the Wnt signaling pathway and its role in regulating bone metabolism has led to the use of romosozumab, a monoclonal antibody that stimulates bone formation and inhibits bone resorption. Clinical trials have demonstrated the efficacy of romosozumab and suggest its use as an initial drug in the treatment of osteoporosis.

THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE (2023)

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Article Biochemistry & Molecular Biology

Structure-Based Discovery of Receptor Activator of Nuclear Factor-& kappa;B Ligand (RANKL)-Induced Osteoclastogenesis Inhibitors

Vagelis Rinotas et al.

Summary: Receptor activator of nuclear factor-& kappa;B ligand (RANKL) is a target for the treatment of osteoporosis. Through virtual screening and experimental evaluation, 11 commercially available compounds were identified as inhibitors of osteoclastogenesis, with 3 compounds showing low toxicity. Additionally, a scaffold based on a hit compound was synthesized and evaluated, resulting in 4 additional compounds that inhibit osteoclastogenesis, but were limited by cellular toxicity concerns.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Rehabilitation

Osteoporosis: Spotlight on current approaches to pharmacological treatment

Dilsad Sindel

Summary: Despite available anti-osteoporosis treatments, the disease remains undertreated, leading to an increase in fragility fractures. Treatment decisions should be guided by fracture risk assessment using tools like FRAX. Antiresorptive agents are usually the first choice for increasing bone density and reducing fracture risk.

TURKISH JOURNAL OF PHYSICAL MEDICINE AND REHABILITATION (2023)

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Article Endocrinology & Metabolism

Efficacy of switching from teriparatide to zoledronic acid or denosumab on bone mineral density and biochemical markers of bone turnover in older patients with severe osteoporosis: a real-life study

Giorgia Dito et al.

Summary: This study compared the efficacy of two different sequential treatment strategies (TPT + ZOL and TPT + Dmab) in severe osteoporotic patients. The results showed that both treatment strategies had similar effects in increasing bone density at the lumbar and hip levels, as well as reducing the risk of fracture.

ENDOCRINE (2023)

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Review Biochemistry & Molecular Biology

Targeting strategies for bone diseases: signaling pathways and clinical studies

Hao Xu et al.

Summary: Since the proposal of Paul Ehrlich's magic bullet concept over 100 years ago, tremendous advances have occurred in targeted therapy. Bone-targeted therapy has been considered a promising therapeutic approach for handling the challenges in drug therapy for skeletal diseases. Recent advances in therapeutic strategies based on bone targeting, including targeting strategies based on bone structure and remodeling biology, as well as bone-targeted therapeutic agents and drug delivery strategies, are discussed in this review.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2023)

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Article Endocrinology & Metabolism

Effect of Bone Resorption Inhibitors on Serum Cholesterol Level and Fracture Risk in Osteoporosis: Randomized Comparative Study Between Minodronic Acid and Raloxifene

Hiroaki Ohta et al.

Summary: The positive link between osteoporosis and hypercholesterolemia has been acknowledged, and bone resorption inhibitors, such as nitrogen-containing bisphosphonates (N-BP) and selective estrogen receptor modulators (SERMs), have been found to lower serum cholesterol levels. However, the association between baseline cholesterol level and incident fracture rate under treatment with these inhibitors has not been studied. This research investigated the relationship between vertebral fracture incidents and baseline cholesterol levels, as well as the cholesterol-lowering effects of N-BP and SERM in osteoporosis patients.

CALCIFIED TISSUE INTERNATIONAL (2023)

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Article Endocrinology & Metabolism

Loss of Nmp4 enhances bone gain from sclerostin antibody administration

Crystal Korff et al.

Summary: In this study, it was found that global Nmp4-/- mice exhibited an enhanced bone anabolic response to Scl-mAb treatment for severe osteoporosis. However, Nmp4 expression in MSPCs interferes with the bone formation response to anti-sclerostin therapy.

BONE (2023)

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Article Biochemistry & Molecular Biology

Melatonin alleviates hydrogen peroxide induced oxidative damage in MC3T3-E1 cells and promotes osteogenesis by activating SIRT1

He-Dong Liu et al.

Summary: Melatonin, with its antioxidant properties, promotes bone formation by activating SIRT1 and inhibiting p66Shc. These findings suggest that melatonin could be a potential therapeutic agent for osteoporosis-related bone metabolic diseases.

FREE RADICAL RESEARCH (2022)

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Review Biochemistry & Molecular Biology

Osteoporosis Due to Hormone Imbalance: An Overview of the Effects of Estrogen Deficiency and Glucocorticoid Overuse on Bone Turnover

Chu-Han Cheng et al.

Summary: This review summarizes the molecular mechanisms, risk factors, and treatment methods for estrogen deficiency related osteoporosis (EDOP) and glucocorticoid induced osteoporosis (GIOP) in postmenopausal women. Estrogen deficiency leads to increased bone resorption and decreased bone formation, while excessive glucocorticoid usage interferes with bone remodeling and promotes bone resorption. Treatment for EDOP and GIOP includes avoiding excessive glucocorticoid use and appropriate estrogen supplementation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Nutrition & Dietetics

The Short-Term Effect of Prunes in Improving Bone in Men

Kelli S. George et al.

Summary: This study found that daily consumption of either 100 g or 50 g of prunes for three months positively affects bone turnover in men, reducing inflammation and improving bone metabolism.

NUTRIENTS (2022)

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Review Materials Science, Biomaterials

Applications of Calcium-Based Nanomaterials in Osteoporosis Treatment

Yuan Deng et al.

Summary: With the rapidly aging population, osteoporosis has become a global public health problem. Calcium-based nanomaterials (CBNMs) have unique advantages in osteoporosis treatment and can be applied locally or systemically. Local CBNMs for bone regeneration develop faster, while innovations are being made in the construction strategies and preparation methods of systemically administered CBNMs. Research into systemically administered CBNMs for antiosteoporosis treatment has more development prospects.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2022)

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Review Medicine, General & Internal

The Role of Sclerostin in Bone Diseases

Elias S. Vasiliadis et al.

Summary: Sclerostin is an important regulator of bone homeostasis through inhibition of the Wnt-signaling pathway and is involved in the pathogenesis of various skeletal diseases. Ongoing research highlights the therapeutic implications of sclerostin in different pathological conditions. Antisclerostin antibodies have been approved for osteoporosis treatment, and studies are being conducted to evaluate their effectiveness in other skeletal disorders and cancer.

JOURNAL OF CLINICAL MEDICINE (2022)

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Review Biochemistry & Molecular Biology

Activation and Function of NLRP3 Inflammasome in Bone and Joint-Related Diseases

Tomohiko Murakami et al.

Summary: Inflammation plays a crucial role in the pathogenesis of bone and joint diseases, with proinflammatory cytokines accelerating bone resorption and cartilage destruction. IL-1, an important inflammatory cytokine, significantly affects the development of bone and joint diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biochemistry & Molecular Biology

Locally Secreted Semaphorin 4D Is Engaged in Both Pathogenic Bone Resorption and Retarded Bone Regeneration in a Ligature-Induced Mouse Model of Periodontitis

Takenobu Ishii et al.

Summary: Further investigation is needed to understand the pathological role of Sema4D in periodontitis. In a mouse model, inhibition of Sema4D promoted bone regeneration without affecting local TNF-alpha and RANKL production or systemic skeletal bone remodeling.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Cell Biology

Osteoimmunology: The correlation between osteoclasts and the Th17/Treg balance in osteoporosis

Fei Huang et al.

Summary: Osteoporosis, a bone disease with a high disability rate, has been a hot topic in bone biology research. Previous understanding of osteoporosis was limited, but recent studies have shown the correlation between the skeletal and immune systems. Investigating the roles of RANKL and the Th17/Treg balance can provide new insights for the treatment of osteoporosis.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2022)

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Article Medicine, Research & Experimental

Melatonin increases bone mass in normal, perimenopausal, and postmenopausal osteoporotic rats via the promotion of osteogenesis

Huanshuai Guan et al.

Summary: Melatonin plays a protective role in osteoporosis at different stages of menopause by promoting osteogenic differentiation in bone marrow mesenchymal stem cells.

JOURNAL OF TRANSLATIONAL MEDICINE (2022)

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Article Cell Biology

Orcinol Glucoside Improves Senile Osteoporosis through Attenuating Oxidative Stress and Autophagy of Osteoclast via Activating Nrf2/Keap1 and mTOR Signaling Pathway

Wan Gong et al.

Summary: The phenolic glycoside orcinol glucoside (OG) was found to attenuate bone loss in mice with senile osteoporosis by activating the Nrf2/Keap1 and mTOR signaling pathways. It inhibited the formation, differentiation, and bone resorption activities of osteoclasts, as well as reduced oxidative stress and autophagy levels.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Review Cell Biology

Interaction between bone and immune cells: Implications for postmenopausal osteoporosis

Verena Fischer et al.

Summary: Postmenopausal osteoporosis is a systemic disease caused by the loss of bone mass and increased fracture risk, resulting from reduced estrogen levels after menopause. The alterations of immune cells contribute to the development of bone destruction in addition to the direct negative effects of estrogen-deficiency on bone.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2022)

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Article Plant Sciences

Exogenous Melatonin Alleviates Alkaline Stress by Removing Reactive Oxygen Species and Promoting Antioxidant Defence in Rice Seedlings

Xuping Lu et al.

Summary: In this study, the effects of exogenous melatonin on rice seedlings under alkaline stress were analyzed. It was found that melatonin can enhance antioxidant enzyme activity, protect cell membranes, and increase chlorophyll content, thereby alleviating the damage caused by alkaline stress on rice.

FRONTIERS IN PLANT SCIENCE (2022)

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Article Pharmacology & Pharmacy

α-Asarone Attenuates Osteoclastogenesis and Prevents Against Oestrogen-Deficiency Induced Osteoporosis

Hao Tian et al.

Summary: This study found that alpha-asarone (ASA), a compound derived from the traditional Chinese medicinal herb Acorus tatarinowii, can inhibit the activity of overactivated osteoclasts and reduce bone resorption. ASA's effects on osteoclastogenesis are dose-dependent and mediated through multiple signaling pathways. In an estrogen-deficiency-induced osteoporosis model, ASA also improved bone microstructure.

FRONTIERS IN PHARMACOLOGY (2022)

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Editorial Material Biochemistry & Molecular Biology

Melatonin and Related Compounds: Antioxidant and Anti-Inflammatory Actions

Maria Bantounou et al.

ANTIOXIDANTS (2022)

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Review Endocrinology & Metabolism

Fecal microbiota transplantation as a promising treatment option for osteoporosis

Yuan-Wei Zhang et al.

Summary: Osteoporosis is a bone disease related to gut microbiota imbalance. Fecal microbiota transplantation (FMT) as a novel therapeutic option can reshape gut microbiota and potentially treat osteoporosis.

JOURNAL OF BONE AND MINERAL METABOLISM (2022)

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Article Genetics & Heredity

Can Polymorphisms in NLRP3 Inflammasome Complex Be Associated with Postmenopausal Osteoporosis Severity?

Werbson Lima Guarana et al.

Summary: The immune system plays a critical role in the pathophysiology of postmenopausal osteoporosis. This study found associations between single-nucleotide variants in NLRP3 inflammasome complex genes and bone mineral density, suggesting their involvement in bone metabolism and dysregulation.

GENES (2022)

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Article Biochemistry & Molecular Biology

Probucol promotes osteoblasts differentiation and prevents osteoporosis development through reducing oxidative stress

Zhou-Shan Tao et al.

Summary: The study found that Probucol (PBC) can suppress cellular resistance to oxidative stress, promote osteogenic differentiation, and improve osteoporosis by inhibiting oxidative stress. This provides a new perspective for the treatment of osteoporosis.

MOLECULAR MEDICINE (2022)

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Article Multidisciplinary Sciences

Functional modulation of PTH1R activation and signaling by RAMP2

Katarina Nemec et al.

Summary: This study discovered that receptor-activity-modifying protein 2 (RAMP2) acts as a specific allosteric modulator of parathyroid hormone 1 receptor (PTH1R), shifting it to a preactivated state and affecting its downstream signaling. These findings provide a new avenue for modulating GPCR function and drug design.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

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Article Biotechnology & Applied Microbiology

A Novel Inhibitor INF 39 Promotes Osteogenesis via Blocking the NLRP3/IL-1β Axis

Wenxiang Chen et al.

Summary: The aim of this study was to investigate the effect of a novel NLRP3 inhibitor INF 39 on bone formation and bone resorption. The results showed that INF 39 promotes osteoblast differentiation by inhibiting NLRP3 and reducing the production of IL-1 beta dependent on NLRP3. However, INF 39 had no impact on osteoclast differentiation.

BIOMED RESEARCH INTERNATIONAL (2022)

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Article Endocrinology & Metabolism

Comparing Clinical and Genetic Characteristics of De Novo and Inherited COL1A1/COL1A2 Variants in a Large Chinese Cohort of Osteogenesis Imperfecta

Yazhao Mei et al.

Summary: The study found that compared to inherited mutations, de novo mutations had significantly higher proportions of clinical type III and clinical scores, indicating that de novo mutations are more damaging as they have not undergone purifying selection.

FRONTIERS IN ENDOCRINOLOGY (2022)

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Review Biochemistry & Molecular Biology

Osteoporosis pathogenesis and treatment: existing and emerging avenues

Bo Liang et al.

Summary: Osteoporotic fractures result in increased disability and mortality in the elderly population. Effective treatments for osteoporosis and osteoporotic fractures are urgently needed due to the rise in the aging population globally. The underlying molecular mechanisms of osteoporosis involve an imbalance in the bone remodeling process, characterized by increased osteoclast activity and decreased osteoblast activity. This article reviews the latest research on bone remodeling mechanisms and explores potential novel treatments such as cytokine immunotherapy, gene therapy, and stem cell therapy.

CELLULAR & MOLECULAR BIOLOGY LETTERS (2022)

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Review Pharmacology & Pharmacy

The role of melatonin in the development of postmenopausal osteoporosis

Keda Yang et al.

Summary: This review analyzes the role of melatonin in bone metabolism and suggests that serum melatonin levels are closely related to bone mass and play a direct role in bone remodeling, biological rhythm regulation, and modulation of the bone microenvironment. As an alternative drug, melatonin can improve gut ecology, substance absorption, and maintain metabolic balance, benefiting the health of bone structure.

FRONTIERS IN PHARMACOLOGY (2022)

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Article

Blosozumab in the treatment of postmenopausal women with osteoporosis: a systematic review and meta-analysis

Yanlin Su et al.

Annals of Palliative Medicine (2022)

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Review Medicine, General & Internal

Exploring the regulatory mechanism of osteoporosis based on intestinal flora: A review

Kasimu Awuti et al.

Summary: Osteoporosis is a common bone metabolism disease in China, particularly among the aging population. Traditional therapies can cause serious adverse effects, so alternative therapies with fewer side effects are needed. Recent studies have shown a strong association between intestinal flora and bone metabolism, providing new ideas and treatments for osteoporosis prevention and treatment.

MEDICINE (2022)

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Review Endocrinology & Metabolism

Anabolic therapy for osteoporosis: update on efficacy and safety

Leonardo Bandeira et al.

Summary: Anabolic agents increase bone density, improve bone strength, and reduce fracture risk. They work by increasing osteoblastic bone formation, distinguishing them from antiresorptive drugs. However, the bone forming effects of anabolic therapy are self-limited, necessitating the use of antiresorptive therapy to enhance the benefits achieved.

ARCHIVES OF ENDOCRINOLOGY METABOLISM (2022)

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Review Endocrinology & Metabolism

Epigenetic therapies of osteoporosis

Filomena de Nigris et al.

Summary: The study of epigenetics has reached its 50th anniversary, with clinical trials exploring various epigenetic therapies for osteoporosis. Main therapeutic approaches include bisphosphonates, targeted therapy blocking the RANK/RANKL pathway, and anti-sclerostin antibody. Future large trials will determine the effectiveness of epigenetic therapies in the real-world management of osteoporosis patients.

BONE (2021)

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Review Biochemistry & Molecular Biology

Molecular and spatial mechanisms governing STING signalling

Katherine R. Balka et al.

Summary: The cGAS-STING pathway plays a crucial role in host defense against viral and bacterial infections by promoting the secretion of type I interferons and proinflammatory cytokines. Activation of key transcription factor IRF3 and NF-kappa B is mediated by the chief signaling receptor protein STING, which undergoes significant trafficking events across multiple subcellular locations. While studies have provided a comprehensive view of the regulation and role of the IRF3-IFN pathway downstream of STING, many aspects of STING signaling remain poorly defined.

FEBS JOURNAL (2021)

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Article Biochemistry & Molecular Biology

Hydroxytyrosol prevents periodontitis-induced bone loss by regulating mitochondrial function and mitogen-activated protein kinase signaling of bone cells

Xiaorong Zhang et al.

Summary: Researches have shown that hydroxytyrosol (HT) can inhibit osteoclast differentiation and prevent alveolar bone loss in periodontitis by regulating mitochondrial function and signaling pathways, increasing bone forming activity, and has therapeutic potential in preventing and treating periodontitis.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

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Review Biochemistry & Molecular Biology

Mechanisms and Regulation of Cellular Senescence

Laureline Roger et al.

Summary: Cellular senescence is an essentially irreversible proliferative arrest state where cells release pro-inflammatory and proteolytic factors. Different types of senescent cells accumulate in various tissues and organs with unique functions. Understanding how cells undergo extensive changes to induce a common cellular state is crucial for cancer prevention and improving health during aging.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Endocrinology & Metabolism

Correlation of oxidative stress-related biomarkers with postmenopausal osteoporosis: a systematic review and meta-analysis

Fulong Zhao et al.

Summary: This study aimed to quantitatively and comprehensively assess the roles of OS-related biomarkers in postmenopausal osteoporosis. A total of 36 studies involving 16 OS-related biomarkers were investigated, showing significant differences in certain markers in patients with postmenopausal osteoporosis.

ARCHIVES OF OSTEOPOROSIS (2021)

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Review Cell Biology

The Roles of Epigenetics Regulation in Bone Metabolism and Osteoporosis

Fei Xu et al.

Summary: Osteoporosis is a metabolic disease characterized by decreased bone mineral density and bone microstructure destruction. Epigenetics, including DNA methylation, histone modification, and non-coding RNAs, play an important role in post-transcriptional regulation and are closely related to bone metabolism processes such as osteogenic differentiation and bone remodeling. Abnormal epigenetic regulation can lead to bone metabolism-related diseases like osteoporosis, highlighting the importance of understanding epigenetic mechanisms for potential treatments.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Endocrinology & Metabolism

Dendritic cells development into osteoclast-type APCs by 4T1 breast tumor T cells milieu boost bone consumption

Ana Carolina Monteiro et al.

Summary: Bone metastases in patients with advanced breast cancer are common, leading to severe morbidity and increased mortality due to osteolytic lesions driven by osteoclasts in the bone marrow microenvironment. The primary tumor can actively modify the bone marrow microenvironment before metastatic spread, with specific T cells playing a crucial role in this process.

BONE (2021)

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Review Endocrinology & Metabolism

Physiological and Pharmacological Roles of PTH and PTHrP in Bone Using Their Shared Receptor, PTH1R

T. John Martin et al.

Summary: PTH and PTHrP share a common G protein-coupled receptor, but have different physiological and pharmacological effects. PTHrP is essential for fetal bone development, while PTH mainly regulates calcium homeostasis. Both peptides have anabolic effects on bone formation pharmacologically.

ENDOCRINE REVIEWS (2021)

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Article Cell Biology

The role of senolytics in osteoporosis and other skeletal pathologies

Madison L. Doolittle et al.

Summary: The skeletal system undergoes irreversible structural deterioration with aging, leading to increased fracture risk and detrimental changes in mobility, posture, and gait. Clearance of senescent cells may improve bone mass and microarchitecture, preventing age-related bone loss.

MECHANISMS OF AGEING AND DEVELOPMENT (2021)

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Article Medicine, Research & Experimental

Ovariectomy Improves Metabolic and Oxidative Stress Marker Disruption in Androgenized Rats: Possible Approach to Postmenopausal Polycystic Ovary Syndrome

Lady Katerine Serrano Mujica et al.

Summary: The study evaluated metabolic and oxidative stress markers in a postmenopausal rat model of PCOS. It was found that ovariectomy improved these markers, and that androgenization led to metabolic abnormalities.

METABOLIC SYNDROME AND RELATED DISORDERS (2021)

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Review Endocrinology & Metabolism

NLRP3 Inflammasome: A New Target for Prevention and Control of Osteoporosis?

Na Jiang et al.

Summary: The NLRP3 inflammasome plays a crucial role in the pathogenesis of osteoporosis by affecting the differentiation of osteoblasts and osteoclasts, resulting in accelerated bone resorption and inhibited bone formation. Abnormal activation of the inflammasome can lead to inflammation, pyroptosis, and dysfunction of osteoblasts, highlighting it as a potential therapeutic target for managing osteoporosis.

FRONTIERS IN ENDOCRINOLOGY (2021)

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Review Biochemistry & Molecular Biology

DNA Methylation Signatures of Bone Metabolism in Osteoporosis and Osteoarthritis Aging-Related Diseases: An Updated Review

Virginia Veronica Visconti et al.

Summary: DNA methylation is a crucial epigenetic mechanism in regulating gene expression, and plays an important role in aging-bone diseases such as osteoporosis and osteoarthritis. Recent studies have shown new discoveries on the involvement of DNA methylation in the pathogenesis of these diseases, highlighting the significance of investigating the specific tissues associated with them.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Cell Biology

m6A Methylation Regulates Osteoblastic Differentiation and Bone Remodeling

Mei Huang et al.

Summary: Osteoporosis is a common bone disease in the elderly, characterized by decreased bone mass due to bone metabolism imbalance. The m6A modification, through epigenetic regulation, affects the biological processes of bone-related cells and related signaling pathways.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Biotechnology & Applied Microbiology

Estrogen Receptor α Signaling in Osteoblasts is Required for Mechanotransduction in Bone Fracture Healing

Lena Steppe et al.

Summary: Biomechanical stimulation by whole-body low-magnitude high-frequency vibration has shown to have anabolic effects on bone metabolism. Specifically, osteoblast lineage-specific ER alpha plays a critical role in LMHFV-induced effects on fracture healing, with WNT and Cox2/PGE(2) signaling pathways involved in the mechanotransduction process.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Article Endocrinology & Metabolism

SIRT7 regulates lipogenesis in adipocytes through deacetylation of PPARγ2

Fatema Akter et al.

Summary: SIRT7 interacts with and deacetylates PPAR gamma 2 at the K382 residue, leading to decreased lipid accumulation and dysregulation of lipogenesis-related genes. The findings suggest that SIRT7-dependent deacetylation of PPAR gamma 2 at K382 controls lipogenesis in adipocytes.

JOURNAL OF DIABETES INVESTIGATION (2021)

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Article Biochemistry & Molecular Biology

Sirt3-mediated mitophagy regulates AGEs-induced BMSCs senescence and senile osteoporosis

Yuanyuan Guo et al.

Summary: Senile osteoporosis (SOP) is a typical aging-related disease characterized by a decrease in bone mass. Sirt3 plays a protective role against AGEs-induced BMSCs senescence and SOP by improving mitophagy, suggesting it as a potential therapeutic target for AGEs-associated SOP.

REDOX BIOLOGY (2021)

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Review Cell Biology

Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype

Ruchi Kumari et al.

Summary: Cellular senescence is a stable cell cycle arrest triggered in response to various stimuli, characterized by dynamic changes in senescent cells. It has both positive effects on tissue repair and anti-cancer mechanisms, but can also negatively impact organismal health. Multiple pathways, including p53/p21 and p16/pRB, play central roles in regulating this process.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Biochemistry & Molecular Biology

The Smad Dependent TGF-β and BMP Signaling Pathway in Bone Remodeling and Therapies

Ming-Li Zou et al.

Summary: Bone remodeling is a continuous process crucial for maintaining skeletal homeostasis, with Smad signaling pathway playing a key role in regulating osteoblast and osteoclast functions during this process. Targeting Smad signaling pathway could be a promising therapeutic strategy for treating osteoporosis.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

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Article Oncology

A novel modified RANKL variant can prevent osteoporosis by acting as a vaccine and an inhibitor

Young Jong Ko et al.

Summary: The discovery of a novel RANKL variant that blocks RANKL via LGR4 signaling and generates anti-RANKL antibodies presents an innovative strategy in the development of general immunotherapy for osteoporosis. The modified RANKL variant showed inhibitory effects on osteoclastogenesis by suppressing NFATc1 expression and activity, ultimately leading to the inhibition of osteoporosis in ovariectomized mouse models. Generated anti-RANKL antibodies demonstrated high inhibitory effects on osteoclastogenesis both in vivo and in vitro.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

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Article Cell Biology

The lncRNA H19/miR-541-3p/Wnt/β-catenin axis plays a vital role in melatonin-mediated osteogenic differentiation of bone marrow mesenchymal stem cells

Hui Han et al.

Aging-US (2021)

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Article Biochemistry & Molecular Biology

Estrogen receptor α in mature osteoblasts regulates the late stage of bone regeneration

Aoi Ikedo et al.

Summary: Estrogen deficiency impairs fracture healing by affecting the expression ratio of estrogen receptors, especially ERα, in callus during the process. The study clarified the significance of ERs during fracture healing using osteoblast-specific ER knockout mice, showing that ERα in osteocalcin-positive osteoblasts may contribute to the late stage of bone regeneration.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

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Correction Endocrinology & Metabolism

Identification of an Epigenetic Signature of Osteoporosis in Blood DNA of Postmenopausal Women (vol 33, pg 1980, 2018)

David Cheishvili et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2021)

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Article Biochemistry & Molecular Biology

PKD1 alleviates oxidative stress-inhibited osteogenesis of rat bone marrow-derived mesenchymal stem cells through TAZ activation

Tongtong Chen et al.

Summary: This study reveals that under oxidative stress conditions, PKD1 may alleviate the inhibitory effect of oxidative stress on osteogenesis of rat BM-MSCs through TAZ activation.

JOURNAL OF CELLULAR BIOCHEMISTRY (2021)

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Review Nutrition & Dietetics

Effects of Hormone Therapy and Flavonoids Capable on Reversal of Menopausal Immune Senescence

Nikolaos Vrachnis et al.

Summary: Menopause is a significant natural change in a woman's life, marked by cessation of ovarian hormone production. Hormone replacement therapy and flavonoids are commonly used to alleviate menopausal symptoms and possibly reverse immune senescence. These treatments may also have anti-inflammatory effects on various cytokines, providing a potential direction for future research and development.

NUTRIENTS (2021)

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Review Cell & Tissue Engineering

Twelve years of GWAS discoveries for osteoporosis and related traits: advances, challenges and applications

Xiaowei Zhu et al.

Summary: Osteoporosis, a common skeletal disease, is influenced by various factors such as diet, physical activity, endocrine status, coexisting diseases, and genetic factors. Genome-wide association studies (GWASs) in the past 12 years have identified many loci associated with bone health, but more genetic studies in diverse populations are needed for better disease prediction.

BONE RESEARCH (2021)

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Article Pharmacology & Pharmacy

Melatonin up-regulates bone marrow mesenchymal stem cells osteogenic action but suppresses their mediated osteoclastogenesis via MT2-inactivated NF-κB pathway

Yi Zhou et al.

BRITISH JOURNAL OF PHARMACOLOGY (2020)

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Article Endocrinology & Metabolism

Ovariectomy Activates Chronic Low-Grade Inflammation Mediated by Memory T Cells, Which Promotes Osteoporosis in Mice

Anna Cline-Smith et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2020)

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Review Biochemistry & Molecular Biology

Control of mesenchymal stem cell biology by histone modifications

Jianhan Ren et al.

CELL AND BIOSCIENCE (2020)

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Article Medicine, Research & Experimental

Resveratrol promotes osteogenesis via activating SIRT1/FoxO1 pathway in osteoporosis mice

Yixuan Jiang et al.

LIFE SCIENCES (2020)

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Review Cell Biology

Healthful aging mediated by inhibition of oxidative stress

Stephen F. Vatner et al.

AGEING RESEARCH REVIEWS (2020)

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Review Medicine, Research & Experimental

The biological function of BMAL1 in skeleton development and disorders

Guangjin Chen et al.

LIFE SCIENCES (2020)

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Review Cell & Tissue Engineering

Epigenetic Regulation in Mesenchymal Stem Cell Aging and Differentiation and Osteoporosis

Ruoxi Wang et al.

STEM CELLS INTERNATIONAL (2020)

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Review Endocrinology & Metabolism

Human Amniotic Mesenchymal Stem Cells Promote Endogenous Bone Regeneration

Jin Li et al.

FRONTIERS IN ENDOCRINOLOGY (2020)

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Article Endocrinology & Metabolism

Oral Treatment With Bisphosphonates of Osteoporosis Does Not Increase the Risk of Severe Gastrointestinal Side Effects: A Meta-Analysis of Randomized Controlled Trials

Zsuzsa Reka Domotor et al.

FRONTIERS IN ENDOCRINOLOGY (2020)

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Review Immunology

RANKL biology: bone metabolism, the immune system, and beyond

Takehito Ono et al.

INFLAMMATION AND REGENERATION (2020)

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Review Biotechnology & Applied Microbiology

New insights into the epigenetics of osteoporosis

Jean-Guillaume Letarouilly et al.

GENOMICS (2019)

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Article Biotechnology & Applied Microbiology

MiR-26b-3p regulates osteoblast differentiation via targeting estrogen receptor α

Yu Lin et al.

GENOMICS (2019)

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Review Endocrinology & Metabolism

Atypical Femur Fractures: Review of Epidemiology, Relationship to Bisphosphonates, Prevention, and Clinical Management

Dennis M. Black et al.

ENDOCRINE REVIEWS (2019)

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Article Biochemistry & Molecular Biology

Melatonin supports alendronate in preserving bone matrix and prevents gastric inflammation in ovariectomized rats

Esra Bihter Gurler et al.

CELL BIOCHEMISTRY AND FUNCTION (2019)

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Article Endocrinology & Metabolism

Pharmacological Management of Osteoporosis in Postmenopausal Women: An Endocrine Society Clinical Practice Guideline

Richard Eastell et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2019)

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Article Biochemistry & Molecular Biology

Epigenetic regulation of BMP2 gene in osteoporosis: a DNA methylation study

Mehrunnisa M. Raje et al.

MOLECULAR BIOLOGY REPORTS (2019)

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Review Endocrinology & Metabolism

New Insights Into Monogenic Causes of Osteoporosis

Riikka E. Makitie et al.

FRONTIERS IN ENDOCRINOLOGY (2019)

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Article Endocrinology & Metabolism

Cellular senescence in bone

Joshua N. Farr et al.

BONE (2019)

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Review Physiology

CELLULAR SENESCENCE: AGING, CANCER, AND INJURY

Arianna Calcinotto et al.

PHYSIOLOGICAL REVIEWS (2019)

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Review Biochemistry & Molecular Biology

Reactive Oxygen Species in Osteoclast Differentiation and Possible Pharmaceutical Targets of ROS-Mediated Osteoclast Diseases

Taiwo Samuel Agidigbi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Biochemistry & Molecular Biology

Melatonin prevents bone destruction in mice with retinoic acid-induced osteoporosis

Xudong Wang et al.

MOLECULAR MEDICINE (2019)

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Article Multidisciplinary Sciences

Bone metabolism genes variation and response to bisphosphonate treatment in women with postmenopausal osteoporosis

Pavel Marozik et al.

PLOS ONE (2019)

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Article Allergy

Osteoprotegerin mediate RANK/RANKL signaling inhibition eases asthma inflammatory reaction by affecting the survival and function of dendritic cells

X. Yang et al.

ALLERGOLOGIA ET IMMUNOPATHOLOGIA (2019)

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Article Endocrinology & Metabolism

One Year of Romosozumab Followed by Two Years of Denosumab Maintains Fracture Risk Reductions: Results of the FRAME Extension Study

E. Michael Lewiecki et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2019)

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Article Geriatrics & Gerontology

Advanced Glycation End Product Accumulation Is Associated With Low Skeletal Muscle Mass, Weak Muscle Strength, and Reduced Bone Density: The Nagahama Study

Yasuharu Tabara et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2019)

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Article Biochemistry & Molecular Biology

Pyrroloquinoline Quinone Prevents Estrogen Deficiency-Induced Osteoporosis by Inhibiting Oxidative Stress and Osteocyte Senescence

Qinghe Geng et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2019)

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Article Medicine, Research & Experimental

Pseurotin A Inhibits Osteoclastogenesis and Prevents Ovariectomized-Induced Bone Loss by Suppressing Reactive Oxygen Species

Kai Chen et al.

THERANOSTICS (2019)

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Article Endocrinology & Metabolism

Primary Osteoporosis Is Not Reflected by Disease-Specific DNA Methylation or Accelerated Epigenetic Age in Blood

Eduardo Fernandez-Rebollo et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2018)

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Article Cell Biology

Oxidative stress induces imbalance of adipogenic/osteoblastic lineage commitment in mesenchymal stem cells through decreasing SIRT1 functions

Chia-Hua Lin et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2018)

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Article Endocrinology & Metabolism

Significant bone loss after stopping long-term denosumab treatment: a post FREEDOM study

M. B. Zanchetta et al.

OSTEOPOROSIS INTERNATIONAL (2018)

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Article Endocrinology & Metabolism

Efficacy of anti-IL-23 monotherapy versus combination therapy with anti-IL-17 in estrogen deficiency induced bone loss conditions

Priyanka Shulda et al.

BONE (2018)

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Review Immunology

Oxidative stress as a possible pathogenic cofactor of post-menopausal osteoporosis: Existing evidence in support of the axis oestrogen deficiency-redox imbalance-bone loss

Gloria Bonaccorsi et al.

INDIAN JOURNAL OF MEDICAL RESEARCH (2018)

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Article Multidisciplinary Sciences

Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss

Sebastien Lucas et al.

NATURE COMMUNICATIONS (2018)

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Article Cell & Tissue Engineering

Changes in phenotype and differentiation potential of human mesenchymal stem cells aging in vitro

Yueh-Hsun Kevin Yang et al.

STEM CELL RESEARCH & THERAPY (2018)

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Article Endocrinology & Metabolism

Comparative Effect of rhPTH(1-84) on Bone Mineral Density and Trabecular Bone Score in Hypoparathyroidism and Postmenopausal Osteoporosis

Cristiana Cipriani et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2018)

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Article Multidisciplinary Sciences

Mettl3-mediated m(6)A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis

Yunshu Wu et al.

NATURE COMMUNICATIONS (2018)

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Article Biochemistry & Molecular Biology

Distinct DNA methylation profiles in bone and blood of osteoporotic and healthy postmenopausal women

Sjur Reppe et al.

EPIGENETICS (2017)

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Article Endocrinology & Metabolism

BPS804 Anti-Sclerostin Antibody in Adults With Moderate Osteogenesis Imperfecta: Results of a Randomized Phase 2a Trial

Francis H. Glorieux et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2017)

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Article Geriatrics & Gerontology

The Clinical Potential of Senolytic Drugs

James L. Kirkland et al.

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2017)

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Article Veterinary Sciences

The differentially DNA-methylated region responsible for expression of runt-related transcription factor 2

Shoichi Wakitani et al.

JOURNAL OF VETERINARY MEDICAL SCIENCE (2017)

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Article Multidisciplinary Sciences

SIRT1 is a positive regulator of in vivo bone mass and a therapeutic target for osteoporosis

Kayvan Zainabadi et al.

PLOS ONE (2017)

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Article Endocrinology & Metabolism

Combination of PTH (1-34) with anti-IL17 prevents bone loss by inhibiting IL-17/N-cadherin mediated disruption of PTHR1/LRP-6 interaction

Mohd Nizam Mansoori et al.

BONE (2017)

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Article Cell Biology

DNA damage and senescence in osteoprogenitors expressing Qsx1 may cause their decrease with age

Ha-Neui Kim et al.

AGING CELL (2017)

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Review Rheumatology

An overview and management of osteoporosis

Tumay Sozen et al.

EUROPEAN JOURNAL OF RHEUMATOLOGY (2017)

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Article Endocrinology & Metabolism

Upregulated Cellular Expression of IL-17 by CD4+T-Cells in Osteoporotic Postmenopausal Women

Renqing Zhao et al.

ANNALS OF NUTRITION AND METABOLISM (2016)

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Review Medical Laboratory Technology

Oxidative damage and the pathogenesis of menopause related disturbances and diseases

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CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2016)

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Aging impairs osteoblast differentiation of mesenchymal stem cells grown on titanium by favoring adipogenesis

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JOURNAL OF APPLIED ORAL SCIENCE (2016)

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Article Biotechnology & Applied Microbiology

Suppression of EZH2 Prevents the Shift of Osteoporotic MSC Fate to Adipocyte and Enhances Bone Formation During Osteoporosis

Huan Jing et al.

MOLECULAR THERAPY (2016)

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Article Cell & Tissue Engineering

Identification of Novel EZH2 Targets Regulating Osteogenic Differentiation in Mesenchymal Stem Cells

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STEM CELLS AND DEVELOPMENT (2016)

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Article Oncology

Long non-coding RNA HoxA-AS3 interacts with EZH2 to regulate lineage commitment of mesenchymal stem cells

Xin-Xing Zhu et al.

ONCOTARGET (2016)

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Article Cell & Tissue Engineering

The Influence of Aging on the Regenerative Potential of Human Adipose Derived Mesenchymal Stem Cells

Monika Maredziak et al.

STEM CELLS INTERNATIONAL (2016)

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Article Anatomy & Morphology

Tamoxifen stimulates calcitonin-producing thyroid C-cells and prevents trabecular bone loss in a rat model of androgen deficiency

Branko Filipovic et al.

JOURNAL OF ANATOMY (2015)

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Article Multidisciplinary Sciences

Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture

Hou-Feng Zheng et al.

NATURE (2015)

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Article Cell Biology

The Effect of Age on Osteogenic and Adipogenic Differentiation Potential of Human Adipose Derived Stromal Stem Cells (hASCs) and the Impact of Stress Factors in the Course of the Differentiation Process

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OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2015)

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Article Endocrinology & Metabolism

Changes of serum cytokines-related Th1/Th2/Th17 concentration in patients with postmenopausal osteoporosis

Jing Zhang et al.

GYNECOLOGICAL ENDOCRINOLOGY (2015)

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Article Medicine, General & Internal

Increased Levels of Circulating Advanced Glycation End-Products in Menopausal Women with Osteoporosis

Deng-Ho Yang et al.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2014)

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Article Endocrinology & Metabolism

IL-17A-mediated sRANK ligand elevation involved in postmenopausal osteoporosis

I. Molnar et al.

OSTEOPOROSIS INTERNATIONAL (2014)

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Review Pharmacology & Pharmacy

The use of raloxifene in osteoporosis treatment

Patrizia D'Amelio et al.

EXPERT OPINION ON PHARMACOTHERAPY (2013)

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Sirt1-deficient mice exhibit an altered cartilage phenotype

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JOINT BONE SPINE (2013)

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Article Anatomy & Morphology

The effects of sex steroids on thyroid C cells and trabecular bone structure in the rat model of male osteoporosis

Branko Filipovic et al.

JOURNAL OF ANATOMY (2013)

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Article Endocrinology & Metabolism

Missense polymorphisms of the WNT16 gene are associated with bone mass, hip geometry and fractures

C. Garcia-Ibarbia et al.

OSTEOPOROSIS INTERNATIONAL (2013)

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Article Multidisciplinary Sciences

Anti-Sclerostin Antibody Inhibits Internalization of Sclerostin and Sclerostin-Mediated Antagonism of Wnt/LRP6 Signaling

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PLOS ONE (2013)

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Article Pharmacology & Pharmacy

Parathyroid Hormone (PTH) and PTH-Related Peptide Domains Contributing to Activation of Different PTH Receptor-Mediated Signaling Pathways

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JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2013)

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Article Endocrinology & Metabolism

Evidence of a Functional Estrogen Receptor in Parathyroid Adenomas

Felix Haglund et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2012)

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Osteoprotection by semaphorin 3A

Mikihito Hayashi et al.

NATURE (2012)

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Article Genetics & Heredity

Mitochondria-Wide Association Study of Common Variants in Osteoporosis

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ANNALS OF HUMAN GENETICS (2011)

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Review Endocrinology & Metabolism

The relationship between the chemistry and biological activity of the bisphosphonates

Frank H. Ebetino et al.

BONE (2011)

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Article Biochemistry & Molecular Biology

Suppression of bone formation by osteoclastic expression of semaphorin 4D

Takako Negishi-Koga et al.

NATURE MEDICINE (2011)

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Article Genetics & Heredity

Genome-Wide Association Study Using Extreme Truncate Selection Identifies Novel Genes Affecting Bone Mineral Density and Fracture Risk

Emma L. Duncan et al.

PLOS GENETICS (2011)

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Article Multidisciplinary Sciences

European Bone Mineral Density Loci Are Also Associated with BMD in East-Asian Populations

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PLOS ONE (2010)

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Article Cell Biology

Donor age and cell passage affects differentiation potential of murine bone marrow-derived stem cells

James D. Kretlow et al.

BMC CELL BIOLOGY (2008)

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Article Medicine, General & Internal

Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study

J. B. Richards et al.

LANCET (2008)

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Review Medicine, General & Internal

Bisphosphonates: Mechanism of action and role in clinical practice

Mathew T. Drake et al.

MAYO CLINIC PROCEEDINGS (2008)

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Review Endocrinology & Metabolism

Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy

R. G. G. Russell et al.

OSTEOPOROSIS INTERNATIONAL (2008)

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Article Rheumatology

The effect of oral calcitonin on cartilage turnover and surface erosion in an ovariectomized rat model

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ARTHRITIS AND RHEUMATISM (2007)

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Article Anatomy & Morphology

Rapid inactivation and apoptosis of osteoclasts in the maternal skeleton during the bone remodeling reversal at the end of lactation

Scott C. Miller et al.

ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY (2007)

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Calcitonin plays a critical role in regulating skeletal mineral metabolism during lactation

Janine P. Woodrow et al.

ENDOCRINOLOGY (2006)

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Article Multidisciplinary Sciences

The molecular mechanism of nitrogen-containing bisphosphonates as anti osteoporosis drugs

Kathryn L. Kavanagh et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

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Article Cell Biology

Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation

DA Glass et al.

DEVELOPMENTAL CELL (2005)

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Article Cell Biology

Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells:: the role of PPAR-γ2 transcription factor and TGF-β/BMP signaling pathways

EJ Moerman et al.

AGING CELL (2004)

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Article Medicine, Research & Experimental

Increased bone mass is an unexpected phenotype associated with deletion of the calcitonin gene

AO Hoff et al.

JOURNAL OF CLINICAL INVESTIGATION (2002)

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Article Multidisciplinary Sciences

Up-regulation of TNF-producing T cells in the bone marrow:: A key mechanism by which estrogen deficiency induces bone loss in vivo

C Roggia et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

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Article Medicine, Research & Experimental

Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-α

S Cenci et al.

JOURNAL OF CLINICAL INVESTIGATION (2000)

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