期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 24, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/ijms24098263
关键词
osteoblasts; osteogenesis; hormones; endocrine toxicity; endocrine-disrupting chemicals; bone defects
Hormones play a vital role in bone development, growth, and maintenance. Recent discoveries in endocrinology have advanced the fields of bone biology and toxicology by uncovering the effects of endocrine-disrupting chemicals (EDCs) on hormone pathways and bone morphological changes. Understanding how EDCs interfere with bone formation contributes to a comprehensive toxicological profile of chemicals.
Hormones are indispensable for bone development, growth, and maintenance. While many of the genes associated with osteogenesis are well established, it is the recent findings in endocrinology that are advancing the fields of bone biology and toxicology. Endocrine-disrupting chemicals (EDCs) are defined as chemicals that interfere with the function of the endocrine system. Here, we report recent discoveries describing key hormone pathways involved in osteogenesis and the EDCs that alter these pathways. EDCs can lead to bone morphological changes via altering hormone receptors, signaling pathways, and gene expression. The objective of this review is to highlight the recent discoveries of the harmful effects of environmental toxicants on bone formation and the pathways impacted. Understanding the mechanisms of how EDCs interfere with bone formation contributes to providing a comprehensive toxicological profile of a chemical.
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