Effect of Diosmin on Selected Parameters of Oxygen Homeostasis

Chronic venous disease (CVD) is a condition characterized by functional disturbances in the microcirculation of the superficial and deep veins, affecting up to 30% of the global population. Diosmin, a phlebotropic drug, is commonly used in the treatment of CVD, and its beneficial effects have been described in numerous clinical studies. However, the precise molecular mechanism underlying the activity of diosmin is not yet fully understood. Therefore, the objective of our study was to investigate whether diosmin has an impact on oxygen management, as cardiovascular diseases are often associated with hypoxia. In our study, patients were administered a daily dosage of 2 Chi 600 mg of diosmin for 3 months, and we evaluated several factors associated with oxygen management, angiogenesis, and inflammation using biochemical assays. Our findings indicate that diosmin reduced the levels of fibroblast growth factors (FGF) and vascular endothelial growth factor (VEGF-C), while increasing endostatin and angiostatin levels, suggesting a potential influence on angiogenesis regulation. Furthermore, diosmin exhibited anti-inflammatory properties by suppressing the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin 1-beta (IL-1 beta), and interleukin 6 (IL-6), while promoting the production of interleukin 12 (IL-12). Additionally, diosmin significantly decreased the levels of hypoxia-inducible factor (HIF), anion gap (AG), and lactate, indicating its potential influence on the hypoxia-inducible factor pathway. These findings suggest that diosmin may play a crucial role in modulating oxygen management and inflammation in the context of chronic venous disease.

Automated summary

Chronic venous disease (CVD) affects up to 30% of the global population and is characterized by disturbances in the microcirculation of veins. Diosmin, a phlebotropic drug, has been used in the treatment of CVD, but its molecular mechanism of action is not fully understood. In this study, patients were administered diosmin and biochemical assays were used to evaluate its effects on oxygen management, angiogenesis, and inflammation. The findings suggest that diosmin may regulate angiogenesis, inflammation, and hypoxia-inducible factor pathway in CVD.