4.7 Article

Genome-Wide DNA Methylation Profiles in Whole-Blood and Buccal Samples-Cross-Sectional, Longitudinal, and across Platforms

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell Biology

Exercise is associated with younger methylome and transcriptome profiles in human skeletal muscle

Sarah Voisin et al.

Summary: Exercise training can prevent age-related decline in muscle function by targeting epigenetic aging. A meta-analysis of human skeletal muscle samples revealed that individuals with higher aerobic fitness have younger epigenetic and transcriptomic profiles. Exercise training can shift these profiles towards a younger state, while muscle disuse leads to aging of the transcriptome. This comprehensive analysis provides valuable insights for future studies on optimizing longevity through the combination of therapeutics and exercise regimes.

AGING CELL (2023)

Article Biochemical Research Methods

A pan-tissue DNA methylation atlas enables in silico decomposition of human tissue methylomes at cell-type resolution

Tianyu Zhu et al.

Summary: Bulk-tissue DNA methylomes represent an average over many different cell types, limiting our understanding of cell-type-specific contributions to disease development. This study leverages high-resolution tissue-specific single-cell RNA-sequencing datasets to construct a DNA methylation atlas for 13 solid tissue types and 40 cell types. The atlas accurately predicts the cell of origin for various cancer types and discovers new prognostic associations in olfactory neuroblastoma and stage 2 melanoma.

NATURE METHODS (2022)

Review Genetics & Heredity

Making sense of the ageing methylome

Kirsten Seale et al.

Summary: This article reviews the changes in DNA methylation during aging and the statistical tools used to quantify them. It also explores the evidence linking DNA methylation to aging phenotypes and strategies for extending healthspan and lifespan. Finally, it discusses theories on the mechanistic causes of epigenetic aging.

NATURE REVIEWS GENETICS (2022)

Article Oncology

Low reliability of DNA methylation across Illumina Infinium platforms in cord blood: implications for replication studies and meta-analyses of prenatal exposures

Emilie Willoch Olstad et al.

Summary: This study investigates the concordance between two different platforms for measuring DNA methylation levels in cord blood, and finds differences between the platforms. These findings have important implications for future epigenome-wide association studies.

CLINICAL EPIGENETICS (2022)

Article Biochemistry & Molecular Biology

Correlation of Infinium HumanMethylation450K and MethylationEPIC BeadChip arrays in cartilage

Kathleen Cheung et al.

EPIGENETICS (2020)

Article Computer Science, Artificial Intelligence

Patterns of Reliability: Assessing the Reproducibility and Integrity of DNA Methylation Measurement

Karen Sugden et al.

PATTERNS (2020)

Article Geriatrics & Gerontology

Tracking the Epigenetic Clock Across the Human Life Course: A Meta-analysis of Longitudinal Cohort Data

Riccardo E. Marioni et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2019)

Article Biochemistry & Molecular Biology

Comparison of Illumina 450K and EPIC arrays in placental DNA methylation

Nora Fernandez-Jimenez et al.

EPIGENETICS (2019)

Article Biochemistry & Molecular Biology

EWAS Atlas: a curated knowledgebase of epigenome-wide association studies

Mengwei Li et al.

NUCLEIC ACIDS RESEARCH (2019)

Review Pharmacology & Pharmacy

The role of DNA methylation in epigenetics of aging

Archana Unnikrishnan et al.

PHARMACOLOGY & THERAPEUTICS (2019)

Review Biotechnology & Applied Microbiology

DNA methylation aging clocks: challenges and recommendations

Christopher G. Bell et al.

GENOME BIOLOGY (2019)

Article Biochemical Research Methods

omicsPrint: detection of data linkage errors in multiple omics studies

Maarten van Iterson et al.

BIOINFORMATICS (2018)

Article Biochemical Research Methods

Meffil: efficient normalization and analysis of very large DNA methylation datasets

J. L. Min et al.

BIOINFORMATICS (2018)

Review Genetics & Heredity

DNA methylation-based biomarkers and the epigenetic clock theory of ageing

Steve Horvath et al.

NATURE REVIEWS GENETICS (2018)

Article Genetics & Heredity

Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception

Roderick C. Slieker et al.

EPIGENETICS & CHROMATIN (2018)

Article Genetics & Heredity

Genome-wide analysis of DNA methylation in buccal cells: a study of monozygotic twins and mQTLs

Jenny van Dongen et al.

EPIGENETICS & CHROMATIN (2018)

Article Genetics & Heredity

Disease variants alter transcription factor levels and methylation of their binding sites

Marc Jan Bonder et al.

NATURE GENETICS (2017)

Review Biochemistry & Molecular Biology

Cell-type deconvolution from DNA methylation: a review of recent applications

Alexander J. Titus et al.

HUMAN MOLECULAR GENETICS (2017)

Review Genetics & Heredity

Cell-type deconvolution in epigenome-wide association studies: a review and recommendations

Andrew E. Teschendorff et al.

EPIGENOMICS (2017)

Article Multidisciplinary Sciences

Genetic and environmental influences interact with age and sex in shaping the human methylome

Jenny van Dongen et al.

NATURE COMMUNICATIONS (2016)

Article Biochemical Research Methods

Analysis pipelines and packages for Infinium HumanMethylation450 Bead Chip (450k) data

Tiffany J. Morris et al.

METHODS (2015)

Article Biochemical Research Methods

MethylAid: visual and interactive quality control of large Illumina 450k datasets

Maarten van Iterson et al.

BIOINFORMATICS (2014)

Article Biotechnology & Applied Microbiology

Functional normalization of 450k methylation array data improves replication in large cancer studies

Jean-Philippe Fortin et al.

GENOME BIOLOGY (2014)

Review Genetics & Heredity

DNA methylation: roles in mammalian development

Zachary D. Smith et al.

NATURE REVIEWS GENETICS (2013)

Review Neurosciences

DNA Methylation and Its Basic Function

Lisa D. Moore et al.

NEUROPSYCHOPHARMACOLOGY (2013)

Article Multidisciplinary Sciences

Continuous Aging of the Human DNA Methylome Throughout the Human Lifespan

Asa Johansson et al.

PLOS ONE (2013)

Article Biotechnology & Applied Microbiology

DNA methylation age of human tissues and cell types

Steve Horvath

GENOME BIOLOGY (2013)

Article Geriatrics & Gerontology

The Role of DNA Methylation in Aging, Rejuvenation, and Age-Related Disease

Adiv A. Johnson et al.

REJUVENATION RESEARCH (2012)

Article Respiratory System

Genetic and environmental influences on objective intermediate asthma phenotypes in Dutch twins

T. Wu et al.

EUROPEAN RESPIRATORY JOURNAL (2010)

Article Genetics & Heredity

The Netherlands Twin Register Biobank: A Resource for Genetic Epidemiological Studies

Gonneke Willemsen et al.

TWIN RESEARCH AND HUMAN GENETICS (2010)

Article Obstetrics & Gynecology

Epigenetics: Definition, Mechanisms and Clinical Perspective

Catherine Dupont et al.

SEMINARS IN REPRODUCTIVE MEDICINE (2009)