Nanodrugs for the Treatment of Ischemic Stroke: A Systematic Review

Ischemic stroke, a significant neurovascular disorder, currently lacks effective restorative medication. However, recently developed nanomedicines bring renewed promise for alleviating ischemia's effects and facilitating the healing of neurological and physical functions. The aim of this systematic review was to evaluate the efficacy of nanotherapies in animal models of stroke and their potential impact on future stroke therapies. We also assessed the scientific quality of current research focused on nanoparticle-based treatments for ischemic stroke in animal models. We summarized the effectiveness of nanotherapies in these models, considering multiple factors such as their anti-inflammatory, antioxidant, and angiogenetic properties, as well as their safety and biodistribution. We conclude that the application of nanomedicines may reduce infarct size and improve neurological function post-stroke without causing significant organ toxicity.

Automated summary

Ischemic stroke treatment can be improved with the use of nanomedicines, which have been shown to reduce infarct size and improve neurological function in animal models. This systematic review evaluates the efficacy of nanoparticle-based treatments for ischemic stroke and their potential impact on future therapies. The review also assesses the scientific quality of current research in this field.