4.7 Article

L-Carnitine Suppresses Transient Receptor Potential Vanilloid Type 1 Activation in Human Corneal Epithelial Cells

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Ophthalmology

Evidence for a phenotypic switch in corneal afferents after lacrimal gland excision

Cara Sullivan et al.

Summary: This study investigated corneal innervation, ongoing pain, and alterations in corneal afferent phenotypes in a mouse model of severe aqueous tear deficiency. The results showed that dry eye-induced damage to corneal afferents led to corneal epithelial damage and ongoing ocular irritation. The corneal neurons underwent a regenerative process after injury, which was more significant in male animals. Additionally, dry eye also caused alterations in IB4-positive neurons, which may enhance neuroprotective mechanisms.

EXPERIMENTAL EYE RESEARCH (2022)

Article Ophthalmology

Effects of a New Formulation of Multiple-Action Tear Substitute on Objective Ocular Surface Parameters and Ocular Discomfort Symptoms in Patients with Dry Eye Disease

Luca Vigo et al.

Summary: This study evaluated the efficacy and tolerability of Trimix eye drops in patients with dry eye disease. The results showed that two-month treatment with the Trimix formulation improved objective signs and subjective symptoms of the disease, and had good tolerability.

OPHTHALMOLOGY AND THERAPY (2022)

Article Ophthalmology

Visual health and prevalence of dry eye syndrome among university students in Iraq and Jordan

Dina M. Abdulmannan et al.

Summary: This study investigated the visual health and prevalence of dry eye syndrome (DES) among university students in Iraq and Jordan. The results showed that approximately one third of the students had been diagnosed with DES. Students aged 27-29 years, those at their fifth year of study, and those who wear contact lenses were found to be at higher risk of developing DES. Further research is needed to identify other risk factors associated with DES.

BMC OPHTHALMOLOGY (2022)

Article Biochemistry & Molecular Biology

Nerve-associated transient receptor potential ion channels can contribute to intrinsic resistance to bacterial adhesion in vivo

Stephanie J. Wan et al.

Summary: The study revealed that corneal nerves and TRPA1/TRPV1 play important roles in preventing bacterial adhesion in the eye by supporting immune cells and maintaining epithelial barrier function to protect the cornea from bacterial invasion.

FASEB JOURNAL (2021)

Article Medicine, Research & Experimental

L-carnitine suppresses transient receptor potential vanilloid type 1 activity and myofibroblast transdifferentiation in human corneal keratocytes

Elizabeth Turan et al.

Summary: Human corneal keratocytes (HCK) are essential for maintaining corneal structure and transparency. This study shows that the natural antioxidant L-carnitine inhibits stromal scarring by suppressing injury-induced intrinsic transient receptor potential vanilloid type 1 (TRPV1) activity that is linked to induction of myofibroblast transdifferentiation in HCK cells. Blocking TRPV1 activation on keratocytes may therefore be a viable approach to suppress corneal opacification in a clinical setting.

LABORATORY INVESTIGATION (2021)

Article Immunology

Capsazepine decreases corneal pain syndrome in severe dry eye disease

Darine Fakih et al.

Summary: The study evaluated the effectiveness of TRPV1 blockade in alleviating ocular pain, neuroinflammation, and anxiety-like behaviors associated with severe DED. Results showed that TRPV1 antagonist reduced corneal responsiveness to various stimuli and inhibited the upregulation of genes involved in neuropathic and inflammatory pain in the TG, leading to reduced ocular pain sensation and anxiety-like behaviors in severe DED.

JOURNAL OF NEUROINFLAMMATION (2021)

Article Ophthalmology

Distribution of Corneal TRPV1 and Its Association With Immune Cells During Homeostasis and Injury

Haihan Jiao et al.

Summary: The study found that following corneal injury, TRPV1(+) nerves accounted for a higher proportion of corneal nerves. The close interactions of TRPV1(+) nerves with intraepithelial immune cells, and the expression of TRPV1 by stromal macrophages, provide important insights into neuroimmune interactions in the cornea.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2021)

Article Multidisciplinary Sciences

A single TRPV1 amino acid controls species sensitivity to capsaicin

Ying Chu et al.

SCIENTIFIC REPORTS (2020)

Article Ophthalmology

Protective Effects of L-Carnitine Against Oxidative Injury by Hyperosmolarity in Human Corneal Epithelial Cells

Xia Hua et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2015)

Article Ophthalmology

Rethinking Dry Eye Disease: A Perspective on Clinical Implications

Anthony J. Bron et al.

Ocular Surface (2014)

Article Medicine, Research & Experimental

Iatrogenic dry eye disease: An eledoisin/carnitine and osmolyte drops study

Marcella Nebbioso et al.

BIOMEDICINE & PHARMACOTHERAPY (2013)

Article Ophthalmology

Functional TRPV1 expression in human corneal fibroblasts

Yuanquan Yang et al.

EXPERIMENTAL EYE RESEARCH (2013)

Article Pathology

TRPV1 Involvement in Inflammatory Tissue Fibrosis in Mice

Yuka Okada et al.

AMERICAN JOURNAL OF PATHOLOGY (2011)

Article Cell Biology

Thermosensitive Transient Receptor Potential Channels in Human Corneal Epithelial Cells

Stefan Mergler et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2011)

Article Ophthalmology

Comparison of Three Lubricant Eye Drop Solutions in Dry Eye Patients

Mariasilva Evangelista et al.

OPTOMETRY AND VISION SCIENCE (2011)

Article Multidisciplinary Sciences

An aquaporin-4/transient receptor potential vanilloid 4 (AQP4/TRPV4) complex is essential for cell-volume control in astrocytes

Valentina Benfenati et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Ophthalmology

Effect of Systane and Optive on Aqueous Tear Evaporation in Patients With Dry Eye Disease

Jadwiga C. Wojtowicz et al.

EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE (2010)

Article Neurosciences

TRPV1 Is Activated by Both Acidic and Basic pH

Ajay Dhaka et al.

JOURNAL OF NEUROSCIENCE (2009)

Review Pharmacology & Pharmacy

Pharmacology of Vanilloid Transient Receptor Potential Cation Channels

Joris Vriens et al.

MOLECULAR PHARMACOLOGY (2009)

Article Ophthalmology

L-Carnitine and Short Chain Ester in Tears from Patients with Dry Eye

Nicola Pescosolido et al.

OPTOMETRY AND VISION SCIENCE (2009)

Article Ophthalmology

A Link between Tear Instability and Hyperosmolarity in Dry Eye

Haixia Liu et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2009)

Article Ophthalmology

Osmoprotection as a new therapeutic principle

E. M. Messmer

OPHTHALMOLOGE (2007)

Article Medicine, General & Internal

Evaluation of an isotonic tear in combination with topical cyclosporine for the treatment of ocular surface disease

David R. Hardten et al.

CURRENT MEDICAL RESEARCH AND OPINION (2007)

Article Cell Biology

TRPM7 is a stretch- and swelling-activated cation channel involved in volume regulation in human epithelial cells

Tomohiro Numata et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2007)

Article Ophthalmology

L-carnitine protects human retinal pigment epithelial cells from oxidative damage

Farrukh A. Shamsi et al.

CURRENT EYE RESEARCH (2007)

Article Neurosciences

An N-terminal variant of Trpv1 channel is required for osmosensory transduction

RS Naeini et al.

NATURE NEUROSCIENCE (2006)

Article Biochemistry & Molecular Biology

Characterization of regulatory volume behavior by fluorescence quenching in human corneal epithelial cells

JE Capo-Aponte et al.

JOURNAL OF MEMBRANE BIOLOGY (2005)

Article Neurosciences

Thermosensation and pain

M Tominaga et al.

JOURNAL OF NEUROBIOLOGY (2004)

Article Ophthalmology

Prevalence of dry eye syndrome among US women

DA Schaumberg et al.

AMERICAN JOURNAL OF OPHTHALMOLOGY (2003)