Evaluation of Nitrosative/Oxidative Stress and Inflammation in Heart Failure with Preserved and Reduced Ejection Fraction

Heart failure (HF) is a complex syndrome characterized by impaired cardiac function. Two common subtypes of HF include heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF). In this study, we aimed to evaluate and compare the plasma levels of 3-nitrotyrosine (3-NT)-as a marker of nitrosative/oxidative stress and myeloperoxidase (MPO)-as an indicator of inflammation between HFpEF and HFrEF. Twenty-seven patients diagnosed with HFpEF and twenty-two with HFrEF were enrolled in this study. Additionally, forty-one patients were recruited for the control group. An echocardiographic assessment was conducted, followed by the collection of blood samples from all participants. Subsequently, the levels of 3-NT and MPO were quantified using the ELISA method. Comprehensive clinical characteristics and medical histories were obtained. Circulating levels of 3-NT were significantly higher in the HFpEF patients than in the control and the HFrEF groups. Nitrosative/oxidative stress is significantly intensified in HFpEF but not in HFrEF.

Automated summary

Heart failure (HF) is a complex syndrome characterized by impaired cardiac function, with two common subtypes being heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF). This study aimed to evaluate and compare plasma levels of 3-nitrotyrosine (3-NT) as a marker of nitrosative/oxidative stress and myeloperoxidase (MPO) as an indicator of inflammation between HFpEF and HFrEF patients. The results showed significantly higher levels of 3-NT in HFpEF patients compared to the control group and the HFrEF group, indicating intensified nitrosative/oxidative stress in HFpEF but not in HFrEF patients.