4.7 Review

MiRNAs in Lung Adenocarcinoma: Role, Diagnosis, Prognosis, and Therapy

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Plasma extracellular vesicle microRNA profiling and the identification of a diagnostic signature for stage I lung adenocarcinoma

Shugeng Gao et al.

Summary: This study explored the profile of plasma EV-delivered miRNAs in patients with early-stage LUAD and developed a diagnostic signature comprising four EV-derived miRNAs for early detection of the disease, exhibiting high precision and the ability to recognize patients with AIS and MIA as well.

CANCER SCIENCE (2022)

Article Oncology

miR-31-5p modulates cell progression in lung adenocarcinoma through TNS1/p53 axis

Chaonan Zhu et al.

Summary: The study reveals that miR-31-5p promotes cell progression in lung adenocarcinoma (LUAD) through the TNS1/p53 axis.

STRAHLENTHERAPIE UND ONKOLOGIE (2022)

Article Biotechnology & Applied Microbiology

CircMMD_007 promotes oncogenic effects in the progression of lung adenocarcinoma through microRNA-197-3p/protein tyrosine phosphatase non-receptor type 9 axis

Lihuan Zhu et al.

Summary: Circular RNA circMMD_007 was found to be abnormally upregulated in lung adenocarcinoma and could promote the oncogenic effects in the progression of LC through the miR-197-3p/PTPN9 axis.

BIOENGINEERED (2022)

Article Biotechnology & Applied Microbiology

Long non-coding RNA 00960 promoted the aggressiveness of lung adenocarcinoma via the miR-124a/SphK1 axis

Zhipeng Ge et al.

Summary: LINC00960 is overexpressed in lung adenocarcinoma and inhibits the proliferation, migration, and invasion of tumor cells by regulating the miR-124a/SphK1 axis.

BIOENGINEERED (2022)

Article Genetics & Heredity

LncRNA VPS9D1-AS1 Promotes Malignant Progression of Lung Adenocarcinoma by Targeting miRNA-30a-5p/KIF11 Axis

Jiefeng Liu et al.

Summary: This study reveals the role of VPS9D1-AS1 in the malignant progression of LUAD through the regulation of the miRNA-30a-5p/KIF11 axis.

FRONTIERS IN GENETICS (2022)

Article Oncology

Identification and Validation Prognostic Impact of MiRNA-30a-5p in Lung Adenocarcinoma

Xiulin Jiang et al.

Summary: The expression of miRNA-30a-5p is significantly decreased in LUAD and is associated with clinical outcomes and immune cell infiltration. Furthermore, miRNA-30a-5p has been found to inhibit cell proliferation and migration in LUAD.

FRONTIERS IN ONCOLOGY (2022)

Article Biochemistry & Molecular Biology

MicroRNA-125b-5p Correlates With Prognosis and Lung Adenocarcinoma Progression

Lin Tang et al.

Summary: This study found that miR-125b-5p is downregulated in non-small cell lung cancer (LUAD) and is associated with poor prognosis. The study also revealed that miR-125b-5p is mainly involved in cell proliferation and immune regulation, playing an important role in the progression of LUAD. Moreover, overexpression of miR-125b-5p significantly inhibits cell proliferation, migration, and invasion, and induces cell apoptosis in LUAD.

FRONTIERS IN MOLECULAR BIOSCIENCES (2022)

Article Cell Biology

miR-126-5p enhances radiosensitivity of lung adenocarcinoma cells by inhibiting EZH2 via the KLF2/BIRC axis

Fushi Han et al.

Summary: This study aimed to investigate the role of miR-126-5p in mediating the radiosensitivity of lung adenocarcinoma cells through the EZH2/KLF2/BIRC5 axis. The results revealed that miR-126-5p downregulated EZH2 expression, thereby promoting KLF2 expression and inhibiting BIRC5 activation. This further enhanced the sensitivity of lung adenocarcinoma cells to radiotherapy.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2022)

Review Genetics & Heredity

Emerging concepts of miRNA therapeutics: from cells to clinic

Caroline Diener et al.

Summary: In this review, the main challenges and strategies for the therapeutic application of miRNAs are discussed, with particular emphasis on approaches that have already been studied clinically.

TRENDS IN GENETICS (2022)

Article Biochemistry & Molecular Biology

The reversion of DNA methylation-induced miRNA silence via biomimetic nanoparticles-mediated gene delivery for efficient lung adenocarcinoma therapy

Lu Liang et al.

Summary: Researchers have developed novel biomimetic nanoparticles activated by matrix metalloproteinase 2 (MMP2) to effectively deliver miRNA to lung cancer cells. These nanoparticles, camouflaged with red blood cell (RBC) membranes, have the advantages of extended circulation time, lower toxicity, better biocompatibility, and immune escape. In vitro and in vivo experiments have demonstrated the ability of these nanoparticles to induce apoptosis in lung cancer cells and inhibit the development and progression of lung adenocarcinoma by targeting ADAM9.

MOLECULAR CANCER (2022)

Article Cell Biology

Effects of MicroRNA-195-5p on Biological Behaviors and Radiosensitivity of Lung Adenocarcinoma Cells via Targeting HOXA10

Cheng Yuan et al.

Summary: miR-195-5p inhibits cell proliferation, invasion, and migration, induces G1 phase arrest and apoptosis, and enhances radiosensitivity in lung adenocarcinoma cells by targeting HOXA10, suggesting its potential as a candidate for LUAD treatment.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

Article Oncology

The Potential Roles of Exosomal miR-214 in Bone Metastasis of Lung Adenocarcinoma

Jian Zhang et al.

Summary: This article discusses the role of exosomal miR-214 in bone metastasis of lung adenocarcinoma, suggesting that exosomal miR-214 may disrupt bone homeostasis by enhancing bone resorption, leading to bone metastasis. Furthermore, exosomal miR-214 facilitates intercellular communication between lung adenocarcinoma cells and osteoclasts, promoting the colonization and proliferation of cancer cells in the bone.

FRONTIERS IN ONCOLOGY (2021)

Article Oncology

Let-7b-3p inhibits tumor growth and metastasis by targeting the BRF2-mediated MAPK/ERK pathway in human lung adenocarcinoma

Yongmeng Li et al.

Summary: Let-7b-3p, downregulated in lung adenocarcinoma cells and tissues, is associated with poor prognosis in patients. It inhibits proliferation and metastasis of lung adenocarcinoma cells by targeting the BRF2-mediated MAPK/ERK pathway.

TRANSLATIONAL LUNG CANCER RESEARCH (2021)

Article Cell Biology

miR-200 deficiency promotes lung cancer metastasis by activating Notch signaling in cancer-associated fibroblasts

Bin Xue et al.

Summary: miR-200 miRNAs have been identified as potent suppressors of lung adenocarcinoma metastasis, with their expression specifically repressed in metastatic lung adenocarcinomas and their decrease strongly correlating with poor patient survival. miR-200 deficiency promotes the proliferation and activation of adjacent cancer-associated fibroblasts, which in turn increases the metastatic potential of lung cancer cells. The functional interaction between cancer cells and CAFs, regulated by miR-200 targeting Notch ligands, constitutes an essential mechanism to promote metastatic potential.

GENES & DEVELOPMENT (2021)

Review Biochemistry & Molecular Biology

Current and Future Development in Lung Cancer Diagnosis

Reem Nooreldeen et al.

Summary: Lung cancer is the leading cause of cancer-related deaths in North America and other developed countries, emphasizing the importance of early diagnosis. Current diagnostic methods have limitations and necessitate the search for new biomarkers to improve early detection rates.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Medicine, Research & Experimental

Hsa_circ_0001361 facilitates the progress of lung adenocarcinoma cells via targeting miR-525-5p/VMA21 axis

Hong-Yu Shen et al.

Summary: The study revealed that Circ_0001361 was up-regulated in LUAD tissues and cells, while miR-525-5p was down-regulated. Functional experiments demonstrated that Circ_0001361 promoted LUAD cell growth and metastasis. Mechanistically, Circ_0001361 acted as a sponge for miR-525-5p to up-regulate the downstream target VMA21 level, contributing to the malignant phenotypes of LUAD cells.

JOURNAL OF TRANSLATIONAL MEDICINE (2021)

Article Oncology

Targeting USP22 with miR-30-5p to inhibit the hypoxia-induced expression of PD-L1 in lung adenocarcinoma cells

Xiaoyang Hua et al.

Summary: Lung cancer, especially lung adenocarcinoma (LUAD), remains a significant challenge in terms of prognosis. A study has revealed that targeting USP22 via the miR-30-5p family can inhibit PD-L1 expression in hypoxic conditions, providing a potential new treatment strategy for LUAD.

ONCOLOGY REPORTS (2021)

Article Biochemistry & Molecular Biology

SNX20AR/MiRNA-301a-3p/SNX20 Axis Associated With Cell Proliferation and Immune Infiltration in Lung Adenocarcinoma

Yixiao Yuan et al.

Summary: Studies have shown that SNX20 is down-regulated in lung adenocarcinoma, correlated with poor prognosis and immune cell infiltration in lung cancer, over-expression of SNX20 can inhibit NSCLC cell proliferation and migration, and the decrease of SNX20 may be caused by DNA hypermethylation.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

Article Oncology

Circular RNA circCSNK1G3 induces HOXA10 signaling and promotes the growth and metastasis of lung adenocarcinoma cells through hsa-miR-143-3p sponging

Tong Lu et al.

Summary: In this study, the researchers investigated the role of circCSNK1G3 in lung adenocarcinoma (LUAD) development by examining its expression, interaction with miR-143-3p, regulation of HOXA10 expression, and effects on LUAD cell proliferation and metastasis. The findings suggest that circCSNK1G3 may promote LUAD tumorigenesis by inducing HOXA10 expression and acting as a sponge for hsa-miR-143-3p. This highlights the potential targetability of the circCSNK1G3/miR-143-3p/HOXA10 signaling axis in treating patients with LUAD.

CELLULAR ONCOLOGY (2021)

Article Respiratory System

Lung Cancer 2020 Epidemiology, Etiology, and Prevention

Brett C. Bade et al.

CLINICS IN CHEST MEDICINE (2020)

Article Biochemistry & Molecular Biology

Tumor Necrosis Factor-Induced miR-146a Upregulation Promotes Human Lung Adenocarcinoma Metastasis by Targeting Merlin

Nilda C. Sanchez et al.

DNA AND CELL BIOLOGY (2020)

Article Oncology

Circular RNA hsa_circ_0000326 acts as a miR-338-3p sponge to facilitate lung adenocarcinoma progression

Yuzhu Xu et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

Article Biology

Web-based tools for miRNA studies analysis

Fatemeh Shaker et al.

COMPUTERS IN BIOLOGY AND MEDICINE (2020)

Article Oncology

Up-regulation of VANGL1 by IGF2BPs and miR-29b-3p attenuates the detrimental effect of irradiation on lung adenocarcinoma

Chun-cheng Hao et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

Article Medicine, Research & Experimental

Prediction of MiR-21-5p in Promoting the Development of Lung Adenocarcinoma via PDZD2 Regulation

Shengjin Cui et al.

MEDICAL SCIENCE MONITOR (2020)

Article Medicine, General & Internal

Tumor-derived circulating exosomal miR-342-5p and miR-574-5p as promising diagnostic biomarkers for early-stage Lung Adenocarcinoma

Zhijun Han et al.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2020)

Article Oncology

Targeting of SGK1 by miR-576-3p Inhibits Lung Adenocarcinoma Migration and Invasion

Evan J. Greenawalt et al.

MOLECULAR CANCER RESEARCH (2019)

Article Biochemistry & Molecular Biology

Involvement of Dual Strands of miR-143 (miR-143-5p and miR-143-3p) and Their Target Oncogenes in the Molecular Pathogenesis of Lung Adenocarcinoma

Hiroki Sanada et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Medicine, Research & Experimental

miR-21-5p promotes lung adenocarcinoma progression partially through targeting SET/TAF-Iα

Jiacheng Zhong et al.

LIFE SCIENCES (2019)

Article Biochemistry & Molecular Biology

The novel circular RNA circ-CAMK2A enhances lung adenocarcinoma metastasis by regulating the miR-615-5p/fibronectin 1 pathway

Jiahui Du et al.

CELLULAR & MOLECULAR BIOLOGY LETTERS (2019)

Article Medicine, Research & Experimental

miR-608 and miR-4513 significantly contribute to the prognosis of lung adenocarcinoma treated with EGFR-TKIs

Nasha Zhang et al.

LABORATORY INVESTIGATION (2019)

Article Medicine, General & Internal

MiR-218-5p Suppresses the Killing Effect of Natural Killer Cell to Lung Adenocarcinoma by Targeting SHMT1

Quanjun Yang et al.

YONSEI MEDICAL JOURNAL (2019)

Article Medicine, Research & Experimental

DNMT1/miR-200a/GOLM1 signaling pathway regulates lung adenocarcinoma cells proliferation

Longqiu Yang et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Article Multidisciplinary Sciences

MicroRNA-21 in cancer-associated fibroblasts supports lung adenocarcinoma progression

Akiko Kunita et al.

SCIENTIFIC REPORTS (2018)

Article Biochemistry & Molecular Biology

Zeb1 Regulates the Symmetric Division of Mouse Lewis Lung Carcinoma Stem Cells through Numb mediated by miR-31

Jianyu Wang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2018)

Article Biochemical Research Methods

Inflammasome-Derived Exosomes Activate NF-kappa B Signaling in Macrophages

Yuehui Zhang et al.

JOURNAL OF PROTEOME RESEARCH (2017)

Article Pathology

The association between miR-34 dysregulation and distant metastases formation in lung adenocarcinoma

Iben Daugaard et al.

EXPERIMENTAL AND MOLECULAR PATHOLOGY (2017)

Article Oncology

Analysis of primary-miRNA-3662 and its mature form may improve detection of the lung adenocarcinoma

Tomasz Powrozek et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2017)

Article Biochemistry & Molecular Biology

MicroRNA-29c functions as a tumor suppressor by targeting VEGFA in lung adenocarcinoma

Lipin Liu et al.

MOLECULAR CANCER (2017)

Article Biotechnology & Applied Microbiology

Seven-microRNA panel for lung adenocarcinoma early diagnosis in patients presenting with ground-glass nodules

Yayi He et al.

ONCOTARGETS AND THERAPY (2017)

Review Pharmacology & Pharmacy

Role of miRNA in Lung Cancer-Potential Biomarkers and Therapies

Xiaohong Du et al.

CURRENT PHARMACEUTICAL DESIGN (2017)

Article Oncology

Role of microRNA-33a in regulating the expression of PD-1 in lung adenocarcinoma

Laura Boldrini et al.

CANCER CELL INTERNATIONAL (2017)

Article Medicine, Research & Experimental

MicroRNA-31 initiates lung turnorigenesis and promotes mutant KRAS-driven lung cancer

Mick D. Edmonds et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Article Oncology

PDL1 Regulation by p53 via miR-34

Maria Angelica Cortez et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2016)

Article Oncology

PDL1 Regulation by p53 via miR-34

Maria Angelica Cortez et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2016)

Article Cell Biology

miR-297 acts as an oncogene by targeting GPC5 in lung adenocarcinoma

Yunchuan Sun et al.

CELL PROLIFERATION (2016)

Review Genetics & Heredity

Endogenous microRNA sponges: evidence and controversy

Daniel W. Thomson et al.

NATURE REVIEWS GENETICS (2016)

Article Multidisciplinary Sciences

Blood-borne miRNA profile-based diagnostic classifier for lung adenocarcinoma

Mei Chee Tai et al.

SCIENTIFIC REPORTS (2016)

Article Oncology

Global Cancer Statistics, 2012

Lindsey A. Torre et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2015)

Editorial Material Biotechnology & Applied Microbiology

MicroRNAs in cancer therapeutics: from the bench to the bedside

Paloma del C. Monroig-Bosque et al.

EXPERT OPINION ON BIOLOGICAL THERAPY (2015)

Article Biochemistry & Molecular Biology

MicroRNA-200 promotes lung cancer cell growth through FOG2-independent AKT activation

Lixia Guo et al.

IUBMB LIFE (2015)

Article Biochemistry & Molecular Biology

BMP4 depletion by miR-200 inhibits tumorigenesis and metastasis of lung adenocarcinoma cells

Jeong Seon Kim et al.

MOLECULAR CANCER (2015)

Article Medical Laboratory Technology

Plasma circulating microRNA-944 and microRNA-3662 as potential histologic type-specific early lung cancer biomarkers

Tomasz Powrozek et al.

TRANSLATIONAL RESEARCH (2015)

Article Biochemistry & Molecular Biology

miR-138-5p reverses gefitinib resistance in non-small cell lung cancer cells via negatively regulating G protein-coupled receptor 124

Yi Gao et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)

Article Cell Biology

A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression

Nobuhiro Okada et al.

GENES & DEVELOPMENT (2014)

Article Biotechnology & Applied Microbiology

Multifunctional Aptamer-miRNA Conjugates for Targeted Cancer Therapy

Carla L. Esposito et al.

MOLECULAR THERAPY (2014)

Review Cell Biology

Physiological roles of long noncoding RNAs: insight from knockout mice

Lingjie Li et al.

TRENDS IN CELL BIOLOGY (2014)

Article Oncology

Global analysis of serum microRNAs as potential biomarkers for lung adenocarcinoma

Sweta Rani et al.

CANCER BIOLOGY & THERAPY (2013)

Article Biochemistry & Molecular Biology

Let-7c inhibits A549 cell proliferation through oncogenic TRIB2 related factors

Ping-Yu Wang et al.

FEBS LETTERS (2013)

Article Critical Care Medicine

Two MicroRNA Panels to Discriminate Three Subtypes of Lung Carcinoma in Bronchial Brushing Specimens

Wei Huang et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2012)

Article Oncology

MicroRNA-381 Represses ID1 and is Deregulated in Lung Adenocarcinoma

Sacha I. Rothschild et al.

JOURNAL OF THORACIC ONCOLOGY (2012)

Article Medicine, General & Internal

Non-Small Cell Lung Cancer: Epidemiology, Risk Factors, Treatment, and Survivorship

Julian R. Molina et al.

MAYO CLINIC PROCEEDINGS (2012)

Article Multidisciplinary Sciences

MicroRNA Expression Profiles of Whole Blood in Lung Adenocarcinoma

Santosh K. Patnaik et al.

PLOS ONE (2012)

Article Biochemistry & Molecular Biology

A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?

Leonardo Salmena et al.

Article Medicine, Research & Experimental

The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200-dependent pathway in mice

Yanan Yang et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

Article Biochemistry & Molecular Biology

MiR-145 inhibits cell proliferation of human lung adenocarcinoma by targeting EGFR and NUDT1

William C. S. Cho et al.

RNA BIOLOGY (2011)

Article Oncology

MicroRNA Expression Differentiates Histology and Predicts Survival of Lung Cancer

Maria Teresa Landi et al.

CLINICAL CANCER RESEARCH (2010)

Article Oncology

Early detection of lung adenocarcinoma in sputum by a panel of microRNA markers

Lei Yu et al.

INTERNATIONAL JOURNAL OF CANCER (2010)

Article Oncology

miR-181b modulates multidrug resistance by targeting BCL2 in human cancer cell lines

Wei Zhu et al.

INTERNATIONAL JOURNAL OF CANCER (2010)

Review Pathology

MicroRNAs in Cancer

Yong Sun Lee et al.

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2009)

Article Medicine, General & Internal

Screening for Epidermal Growth Factor Receptor Mutations in Lung Cancer.

Rafael Rosell et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

Article Multidisciplinary Sciences

MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers

Masahiro Seike et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Cell Biology

The let-7 microRNA reduces tumor growth in mouse models of lung cancer

Aurora Esquela-Kerscher et al.

CELL CYCLE (2008)

Article Multidisciplinary Sciences

Switching from repression to activation: MicroRNAs can up-regulate translation

Shobha Vasudevan et al.

SCIENCE (2007)

Review Oncology

Oncomirs - microRNAs with a role in cancer

A Esquela-Kerscher et al.

NATURE REVIEWS CANCER (2006)

Article Multidisciplinary Sciences

MicroRNA expression profiles classify human cancers

J Lu et al.

NATURE (2005)

Article Multidisciplinary Sciences

Nuclear export of microRNA precursors

E Lund et al.

SCIENCE (2004)

Article Multidisciplinary Sciences

Processing of primary microRNAs by the Microprocessor complex

AM Denli et al.

NATURE (2004)

Article Multidisciplinary Sciences

The Microprocessor complex mediates the genesis of microRNAs

RI Gregory et al.

NATURE (2004)

Article Biochemistry & Molecular Biology

MicroRNA genes are transcribed by RNA polymerase II

Y Lee et al.

EMBO JOURNAL (2004)

Article Multidisciplinary Sciences

The nuclear RNase III Drosha initiates microRNA processing

Y Lee et al.

NATURE (2003)